| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Li, K Nagai, A E Koromila. A diminished activation capacity of the interferon-inducible protein kinase PKR in human T lymphocytes. European journal of biochemistry. vol 267. issue 6. 2000-05-11. PMID:10712589. |
the double-stranded (ds) rna activated protein kinase pkr is an interferon (ifn)-inducible serine/threonine protein that regulates protein synthesis through the phosphorylation of the alpha subunit of translation initiation factor 2 (eif-2alpha). |
2000-05-11 |
2023-08-12 |
human |
| T Ito, M Yang, W S Ma. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. The Journal of biological chemistry. vol 274. issue 22. 1999-06-29. PMID:10336432. |
the double-stranded (ds) rna-dependent protein kinase (pkr) regulates protein synthesis by phosphorylating the alpha subunit of eukaryotic initiation factor-2. |
1999-06-29 |
2023-08-12 |
mouse |
| C Gjertson, K S Sturm, C N Berge. Hematopoietic deficiencies and core binding factor expression in murine Ts16, an animal model for Down syndrome. Clinical immunology (Orlando, Fla.). vol 91. issue 1. 1999-05-17. PMID:10219254. |
of the genes found within the ds chromosomal region, core binding factor alpha (cbfa) is a candidate whose overexpression could affect hematopoietic development. |
1999-05-17 |
2023-08-12 |
mouse |
| L Somova, L Mackraj, S Chett. Sympathetic and platelet adrenergic activity and salt sensitivity: an experimental study. Methods and findings in experimental and clinical pharmacology. vol 20. issue 8. 1999-05-12. PMID:9922981. |
iv) platelet activity of ds rats was increased as reflected in collagen-induced nonstimulated and adrenaline-stimulated aggregation, and an increased plasma t x b2/6-keto pgf1 alpha ratio. |
1999-05-12 |
2023-08-12 |
rat |
| L Somova, L Mackraj, S Chett. Sympathetic and platelet adrenergic activity and salt sensitivity: an experimental study. Methods and findings in experimental and clinical pharmacology. vol 20. issue 8. 1999-05-12. PMID:9922981. |
v) both dr and ds rat platelets displayed alpha 2-adrenoceptors (a2) of low binding capacity (bmax 25 and 35 fmol/mg protein, respectively) and low affinity (kd 5.6 nm for both groups), suggesting that platelet alpha 2 adrenoceptors in this strain of rats might not play a significant biological role in their increased platelet activity. |
1999-05-12 |
2023-08-12 |
rat |
| L Somova, L Mackraj, S Chett. Sympathetic and platelet adrenergic activity and salt sensitivity: an experimental study. Methods and findings in experimental and clinical pharmacology. vol 20. issue 8. 1999-05-12. PMID:9922981. |
the fact that platelet alpha 2-adrenoceptors do not define the stimulation of sns in ds rat do not exclude their participation in development of salt-dependent hypertension, since a genetic defect(s) of these ubiquitous receptors (brain, kidney, blood vessels) could still contribute to the pathogenesis of the disease. |
1999-05-12 |
2023-08-12 |
rat |
| M Z Berkman, T A Zirh, K Berkman, M N Pami. Tizanidine is an effective agent in the prevention of focal cerebral ischemia in rats: an experimental study. Surgical neurology. vol 50. issue 3. 1998-09-23. PMID:9736090. |
tizanidine (sandoz compound ds 103-282, 5-chloro4,2 (2-imidazolin-2-yl-amino)-2,1,3-benzothiazol hydrochloride) is a selective alpha 2 adrenoreceptor agonist which shows its effect by stimulating presynaptic alpha 2 adrenoreceptors in central aspergic and gluergic system by inhibiting aspartic acid and glutamic acid release. |
1998-09-23 |
2023-08-12 |
rat |
| C X George, D C Thomis, S J McCormack, C M Svahn, C E Samue. Characterization of the heparin-mediated activation of PKR, the interferon-inducible RNA-dependent protein kinase. Virology. vol 221. issue 1. 1996-08-14. PMID:8661426. |
heparin can substitute for double-stranded (ds) rna in the autophosphorylation and activation of the interferon-inducible, rna-dependent elf-2 alpha protein kinase (pkr). |
1996-08-14 |
2023-08-12 |
human |
| D E Orosz, U Hopfe. Pathophysiological consequences of changes in the coupling ratio of Na,K-ATPase for renal sodium reabsorption and its implications for hypertension. Hypertension (Dallas, Tex. : 1979). vol 27. issue 2. 1996-03-06. PMID:8567044. |
recent reports indicate that alpha 1-na,k-atpase from dahl salt-sensitive (ds) rats contains a glutamine for leucine substitution associated with increased na-k coupling at unchanged maximal velocity. |
1996-03-06 |
2023-08-12 |
rat |
| D E Orosz, U Hopfe. Pathophysiological consequences of changes in the coupling ratio of Na,K-ATPase for renal sodium reabsorption and its implications for hypertension. Hypertension (Dallas, Tex. : 1979). vol 27. issue 2. 1996-03-06. PMID:8567044. |
however, an increase in the na-k coupling from 3:2 to 3:1, reported for the mutant alpha 1-na,k-atpase in ds rats, was associated with greater na+ reabsorption. |
1996-03-06 |
2023-08-12 |
rat |
| D E Orosz, U Hopfe. Pathophysiological consequences of changes in the coupling ratio of Na,K-ATPase for renal sodium reabsorption and its implications for hypertension. Hypertension (Dallas, Tex. : 1979). vol 27. issue 2. 1996-03-06. PMID:8567044. |
the simulations thereby lend support for a unifying explanation for the salt sensitivity of ds rats, which has been proposed to stem from a mutation in the alpha 1-na,k-atpase. |
1996-03-06 |
2023-08-12 |
rat |
| D Marona-Lewicka, D E Nichol. Complex stimulus properties of LSD: a drug discrimination study with alpha 2-adrenoceptor agonists and antagonists. Psychopharmacology. vol 120. issue 4. 1996-02-07. PMID:8539318. |
the influence of several alpha 2-adrenergic agents on the discriminative stimulus (ds) properties of lysergic acid diethylamide (lsd) was studied in rats trained to discriminate 0.08 mg/kg (186 nmol/kg) of lsd from saline in a two-lever operant paradigm. |
1996-02-07 |
2023-08-12 |
rat |
| T Eldar-Geva, A Hochberg, N deGroot, D Weinstei. High maternal serum chorionic gonadotropin level in Downs' syndrome pregnancies is caused by elevation of both subunits messenger ribonucleic acid level in trophoblasts. The Journal of clinical endocrinology and metabolism. vol 80. issue 12. 1996-01-31. PMID:8530594. |
we conclude that at least one cause of high second-trimester maternal blood cg in ds pregnancies is a rise in alpha and beta cg messenger rna levels in the trophoblast. |
1996-01-31 |
2023-08-12 |
human |
| R D Spealma. Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562595. |
pretreatment with the alpha-2 blocker efaroxan, the nonselective alpha blocker phentolamine and the beta blocker propranolol failed to alter the ds effects of cocaine consistently under either condition in which they were studied. |
1995-11-21 |
2023-08-12 |
human |
| M C Macintosh, R Iles, B Teisner, K Sharma, T Chard, J G Grudzinskas, R H Ward, F Mulle. Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A, markers for fetal Down syndrome at 8-14 weeks. Prenatal diagnosis. vol 14. issue 3. 1994-09-08. PMID:7519773. |
levels of alpha hcg were similar in both the control and the ds pregnancies. |
1994-09-08 |
2023-08-12 |
human |
| M C Macintosh, R Iles, B Teisner, K Sharma, T Chard, J G Grudzinskas, R H Ward, F Mulle. Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A, markers for fetal Down syndrome at 8-14 weeks. Prenatal diagnosis. vol 14. issue 3. 1994-09-08. PMID:7519773. |
however, after the exclusion of ds cases diagnosed at cvs, the median intact hcg (1.56 mom), free beta hcg (2.27 mom), and alpha hcg (1.8 mom) were all raised in ds pregnancies. |
1994-09-08 |
2023-08-12 |
human |
| A Nishi, A M Bertorello, A Aperi. Renal Na+,K(+)-ATPase in Dahl salt-sensitive rats: K+ dependence, effect of cell environment and protein kinases. Acta physiologica Scandinavica. vol 149. issue 3. 1994-03-14. PMID:8310842. |
protein kinase c and camp-dependent protein kinase phosphorylated na+,k(+)-atpase alpha subunit in ds and dr rats, and the phosphorylation by protein kinase c was associated with an inhibition of enzyme activity. |
1994-03-14 |
2023-08-12 |
rat |
| M Böhm, C Gräbel, R Kirchmayr, H Lensche, E Erdmann, P Gierschi. C-terminal modifications of pertussis toxin-sensitive G-protein alpha-subunits differentially affect immunoreactivity. Evidence against endogenous ADP-ribosylation in human heart, lung, thrombocytes and adipose tissue. Biochemical pharmacology. vol 46. issue 12. 1994-01-31. PMID:8274148. |
pertussis toxin treatment increased immunoreactivity to different antisera raised against the c-terminal decapeptide of transducin alpha (kenlkdcglf, ds 1-4, as). |
1994-01-31 |
2023-08-12 |
human |
| C E Johanson, J E Barret. The discriminative stimulus effects of cocaine in pigeons. The Journal of pharmacology and experimental therapeutics. vol 267. issue 1. 1993-11-29. PMID:8229735. |
in addition, prazosin, an alpha 1 adrenergic antagonist, sch 23390, a d1 antagonist; raclopride, a d2 antagonist and 1-(2-methoxyphenyl)-4-[4-(2-phthalimmido)butyl]piperazine (nan-190), a putative 5-ht1a antagonist, were given in combination with cocaine to determine their ability to block the discriminative stimulus (ds) effects of cocaine, i.e., reduce drug-appropriate responding to 20% or less. |
1993-11-29 |
2023-08-12 |
Not clear |
| Y On. EEG changes with aging in adults with Down syndrome. The Japanese journal of psychiatry and neurology. vol 47. issue 1. 1993-11-16. PMID:8411794. |
the frequencies of the occipital alpha rhythms decreased with age in the ds subjects, and were significantly slower than the mr subjects over 35 years old. |
1993-11-16 |
2023-08-12 |
human |