| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E F Gillard, E Solomo. Acute promyelocytic leukaemia and the t(15;17) translocation. Seminars in cancer biology. vol 4. issue 6. 1994-05-04. PMID:8142621. |
molecular analysis of the apl breakpoint has revealed the involvement of the retinoic acid receptor alpha (rara) gene on chromosome 17 and the promyelocytic leukaemia (pml) gene on chromosome 15. |
1994-05-04 |
2023-08-12 |
Not clear |
| C D McKinney, W L Golden, N W Gemma, S H Swerdlow, M E William. RARA and PML gene rearrangements in acute promyelocytic leukemia with complex translocations and atypical features. Genes, chromosomes & cancer. vol 9. issue 1. 1994-03-10. PMID:7507700. |
the translocation t(15;17) associated with acute promyelocytic leukemia (apl) results in fusion of the retinoic acid receptor alpha (rara) gene on chromosome 17 with the putative transcription factor gene, pml, on chromosome 15. |
1994-03-10 |
2023-08-12 |
Not clear |
| Z Chen, F Guidez, P Rousselot, A Agadir, S J Chen, Z Y Wang, L Degos, A Zelent, S Waxman, C Chomienn. PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 3. 1994-03-08. PMID:8302850. |
recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (apl) which juxtaposes plzf, a gene encoding a zinc finger protein, to rara, encoding retinoic acid receptor alpha (rar alpha). |
1994-03-08 |
2023-08-12 |
Not clear |
| S Dong, J H Tong, W Huang, S J Chen, Z Chen, Z Y Wang, J P Geng, Z W Q. Molecular study on the chromosome 15 breakpoints in the translocation t(15; 17) in acute promyelocytic leukemia (APL). Science in China. Series B, Chemistry, life sciences & earth sciences. vol 36. issue 9. 1994-02-08. PMID:8274203. |
it has been shown that the retinoic acid receptor alpha (rara) gene, normally located on chromosome 17, was fused with a new transcription unit pml, normally localized on chromosome 15. |
1994-02-08 |
2023-08-12 |
Not clear |
| J Simard, J Feunteun, G Lenoir, P Tonin, T Normand, V Luu The, A Vivier, D Lasko, K Morgan, G A Roulea. Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12-21: exclusion of candidate genes EDH17B2 and RARA. Human molecular genetics. vol 2. issue 8. 1993-11-05. PMID:8401501. |
candidate genes in this region include edh17b2, which encodes estradiol 17 beta-hydroxysteroid dehydrogenase ii (17 beta-hsd ii), and rara, the gene for retinoic acid receptor alpha. |
1993-11-05 |
2023-08-12 |
Not clear |
| J Borrow, E Solomo. Molecular analysis of the t(15;17) translocation in acute promyelocytic leukaemia. Bailliere's clinical haematology. vol 5. issue 4. 1993-09-24. PMID:1339190. |
the recent cloning of the breakpoints by three groups has demonstrated that the retinoic acid receptor alpha gene (rara) on chromosome 17 is fused to a previously undescribed transcription factor gene, pml, on chromosome 15. |
1993-09-24 |
2023-08-11 |
Not clear |
| S Dong, J P Geng, J H Tong, Y Wu, J R Cai, G L Sun, S R Chen, Z Y Wang, C J Larsen, R Berge. Breakpoint clusters of the PML gene in acute promyelocytic leukemia: primary structure of the reciprocal products of the PML-RARA gene in a patient with t(15;17). Genes, chromosomes & cancer. vol 6. issue 3. 1993-05-07. PMID:7682097. |
dna studies of the translocation t(15;17) in acute promyelocytic leukemia (apl) have shown that the retinoic acid receptor alpha (rara) gene on chromosome 17 is juxtaposed to the promyelocytic leukemia (pml) gene on chromosome 15. |
1993-05-07 |
2023-08-12 |
Not clear |
| L Baranger, M Gardembas, J Hillion, C Foussard, N Ifrah, M Boasson, R Berge. Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia. Genes, chromosomes & cancer. vol 6. issue 2. 1993-04-22. PMID:7680887. |
acute promyelocytic leukemia (apl) is usually associated with the translocation t(15;17)(q22;q12-21), which disrupts the retinoic acid receptor alpha (rara) gene on chromosome 17 and the pml gene on chromosome 15. |
1993-04-22 |
2023-08-12 |
Not clear |
| Z Chen, S J Che. RARA and PML genes in acute promyelocytic leukemia. Leukemia & lymphoma. vol 8. issue 4-5. 1993-03-29. PMID:1337847. |
recently, using molecular biology techniques, a number of laboratories have demonstrated that the gene coding for the retinoic acid receptor alpha (rara), normally located on chromosome 17, is disrupted by the t(15;17) and fused with the pml gene on chromosome 15. |
1993-03-29 |
2023-08-11 |
Not clear |
| J Borrow, A D Goddard, B Gibbons, F Katz, D Swirsky, T Fioretos, I Dube, D A Winfield, J Kingston, A Hagemeije. Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts. British journal of haematology. vol 82. issue 3. 1993-02-19. PMID:1486033. |
acute promyelocytic leukaemia (apl; aml m3) is identified by a unique t(15;17) translocation which fuses the pml gene to the retinoic acid receptor alpha gene (rara). |
1993-02-19 |
2023-08-11 |
Not clear |
| J P Geng, J H Tong, S Dong, Z Y Wang, S J Chen, Z Chen, A Zelent, R Berger, C J Larse. Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients. Leukemia. vol 7. issue 1. 1993-02-02. PMID:8380300. |
translocation (15;17)(q22;q12-q21) is a chromosome aberration specifically found in acute promyelocytic leukemia (apl), that generates a chimeric gene between the promyelocytic leukemia (pml) gene on chromosome 15 and the retinoic acid receptor alpha (rara) gene, on chromosome 17. |
1993-02-02 |
2023-08-12 |
Not clear |
| Y Zh. [Retinoic acid receptor alpha gene rearrangement as specific marker of acute promyelocytic leukemia and its use in the study of cell differentiation]. Zhonghua yi xue za zhi. vol 72. issue 4. 1992-11-12. PMID:1327453. |
the chromosomal translocation t (15; 17), hallmark of human acute promyelocytic leukemia (apl), has been shown to disrupt the retinoic acid receptor alpha (rara) gene. |
1992-11-12 |
2023-08-11 |
human |
| T Takashima, S Misaw. [Retinoic acid receptor alpha gene in t (15; 17) APL]. Nihon rinsho. Japanese journal of clinical medicine. vol 50. issue 6. 1992-10-06. PMID:1325570. |
this translocation constructs fusion genes between retinoic acid receptor alpha (rara) at 17q21 and pml at 15q22. |
1992-10-06 |
2023-08-11 |
Not clear |
| J H Tong, S Dong, J P Geng, W Huang, Z Y Wang, G L Sun, S J Chen, Z Chen, C J Larsen, R Berge. Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. Oncogene. vol 7. issue 2. 1992-04-20. PMID:1312695. |
genomic dna probes generated from the retinoic acid receptor alpha (rara) gene located on chromosome 17 and from the myl gene located on chromosome 15 were used to study the chromosome 15 breakpoints resulting from the t(15; 17) translocation in 26 patients with acute promyelocytic leukemia (apl). |
1992-04-20 |
2023-08-11 |
Not clear |
| A D Goddard, J Borrow, P S Freemont, E Solomo. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science (New York, N.Y.). vol 254. issue 5036. 1992-01-08. PMID:1720570. |
the translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (rara) gene to the pml gene. |
1992-01-08 |
2023-08-11 |
Not clear |
| M G Mattei, M Rivière, A Krust, S Ingvarsson, B Vennström, M Q Islam, G Levan, P Kautner, A Zelent, P Chambo. Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. Genomics. vol 10. issue 4. 1991-11-04. PMID:1655630. |
the human genes encoding the alpha and beta forms of the retinoic acid receptor are known to be located on chromosomes 17 (band q21.1:rara) and 3 (band p24:rarb). |
1991-11-04 |
2023-08-11 |
mouse |
| J Borrow, A D Goddard, D Sheer, E Solomo. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science (New York, N.Y.). vol 249. issue 4976. 1990-11-08. PMID:2218500. |
the region is the first intron of the retinoic acid receptor alpha gene (rara). |
1990-11-08 |
2023-08-11 |
Not clear |