| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yukiya Yamamoto, Sachiko Tsuzuki, Motohiro Tsuzuki, Kousuke Handa, Yoko Inaguma, Nobuhiko Em. BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia. Blood. vol 116. issue 20. 2010-12-21. PMID:20807888. |
these included: (1) the same break point in rara cdna; (2) self-association; (3) retinoid x receptor alpha is necessary for bcor-rara to associate with the rara responsive element; (4) action in a dominant-negative manner on rara transcriptional activation; and (5) aberrant subcellular relocalization. |
2010-12-21 |
2023-08-12 |
human |
| Pauline Isakson, Magnar Bjørås, Stig Ove Bøe, Anne Simonse. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood. vol 116. issue 13. 2010-10-29. PMID:20574048. |
treatment of acute promyelocytic leukemia (apl) with all-trans retinoic acid and/or arsenic trioxide represents a paradigm in targeted cancer therapy because these drugs cause clinical remission by affecting the stability of the fusion oncoprotein promyelocytic leukemia (pml)/retinoic acid receptor alpha (rara). |
2010-10-29 |
2023-08-12 |
Not clear |
| Anna D Asleson, Vickie Morgan, Stephen Smith, Gopalrao V N Velagalet. Amplification of the RARA gene in acute myeloid leukemia: significant finding or coincidental observation? Cancer genetics and cytogenetics. vol 202. issue 1. 2010-09-23. PMID:20804918. |
retinoic acid receptor alpha (rara) and other target sequences at 17p11.2 often represent the amplicons expressed in breast cancer, not in aml. |
2010-09-23 |
2023-08-12 |
Not clear |
| Anuja Chattopadhyay, Robert L Redne. Cryptic insertion of PML-RARA into the 3p25 locus in an acute promyelocytic leukemia with t(3;17)(p25;q21). Cancer genetics and cytogenetics. vol 201. issue 1. 2010-07-29. PMID:20633765. |
fluorescence in situ hybridization failed to show rearrangement of the pml (promyelocytic leukemia protein) locus but did demonstrate relocalization of the retinoic acid receptor alpha (rara) to chromosome 3. |
2010-07-29 |
2023-08-12 |
Not clear |
| Li Zhu, Nadine C Santos, Kwan Hee Ki. Disulfide isomerase glucose-regulated protein 58 is required for the nuclear localization and degradation of retinoic acid receptor alpha. Reproduction (Cambridge, England). vol 139. issue 4. 2010-07-05. PMID:20130111. |
retinoic acid receptor alpha (rara) is critical for spermatogenesis, as shown by a sterility phenotype observed in rara knockout mice. |
2010-07-05 |
2023-08-12 |
mouse |
| Timothy J Doyle, Asa J Oudes, Kwan Hee Ki. Temporal profiling of rat transcriptomes in retinol-replenished vitamin A-deficient testis. Systems biology in reproductive medicine. vol 55. issue 4. 2010-01-14. PMID:19886770. |
removal of dietary vitamin a or a targeted deletion of retinoic acid receptor alpha gene (rara), the receptor for retinoic acid, in mice, led to testicular degeneration by a dramatic loss of germ cells and a loss of control of the spermatogenic cycle. |
2010-01-14 |
2023-08-12 |
mouse |
| S Veerappan, M Schäche, K K Pertile, F M A Islam, C Y Chen, P Mitchell, M Dirani, P N Bair. The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures. Molecular vision. vol 15. 2009-10-27. PMID:19626135. |
the retinoic acid receptor alpha (rara) gene is not associated with myopia, hypermetropia, and ocular biometric measures. |
2009-10-27 |
2023-08-12 |
Not clear |
| S Veerappan, M Schäche, K K Pertile, F M A Islam, C Y Chen, P Mitchell, M Dirani, P N Bair. The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures. Molecular vision. vol 15. 2009-10-27. PMID:19626135. |
the retinoic acid receptor alpha (rara) gene is a potential candidate gene for myopia due to its differential expression in animal models during experimentally induced myopia. |
2009-10-27 |
2023-08-12 |
Not clear |
| Jacqueline E Payton, Nicole R Grieselhuber, Li-Wei Chang, Mark Murakami, Gary K Geiss, Daniel C Link, Rakesh Nagarajan, Mark A Watson, Timothy J Le. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19451695. |
acute promyelocytic leukemia (apl) is characterized by the t(15;17) chromosomal translocation, which results in fusion of the retinoic acid receptor alpha (rara) gene to another gene, most commonly promyelocytic leukemia (pml). |
2009-07-24 |
2023-08-12 |
mouse |
| Hirokazu Kanegane, Keiko Nomura, Akihiro Abe, Teruhiko Makino, Shin Ishizawa, Tadamichi Shimizu, Tomoki Naoe, Toshio Miyawak. Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. International journal of hematology. vol 89. issue 1. 2009-06-17. PMID:19052694. |
interestingly, a cytogenetic analysis disclosed a leukemia clone with the karyotype of 46, xy, t(5;17)(q35;q12), which generated nucleophosmin (npm)-retinoic acid receptor alpha fusion (rara) fusion transcripts. |
2009-06-17 |
2023-08-12 |
Not clear |
| Nicola J M Brown, Michal Ramalho, Eva W Pedersen, Eva Moravcsik, Ellen Solomon, David Grimwad. PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders? Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273155. |
strikingly, over a decade ago, pml-nbs were found to be disrupted in acute promyelocytic leukemia (apl) in which pml is fused to the gene encoding retinoic acid receptor alpha (rara) due to the t(15;17) chromosomal translocation, generating the pml-rara chimeric protein. |
2009-04-07 |
2023-08-12 |
Not clear |
| Shori Abe, Idumi Ishikawa, Hideo Harigae, Tomohiro Sugawar. A new complex translocation t(5;17;15)(q11;q21;q22) in acute promyelocytic leukemia. Cancer genetics and cytogenetics. vol 184. issue 1. 2008-08-07. PMID:18558288. |
acute promyelocytic leukemia (apl) is associated with the t(15;17)(q22;q21) translocation which causes the fusion of the retinoic acid alpha gene (rara) on 17q21 to the promyelocytic leukemia gene (pml) on 15q22. |
2008-08-07 |
2023-08-12 |
Not clear |
| Annegret Glasow, Angela Barrett, Kevin Petrie, Rajeev Gupta, Manuel Boix-Chornet, Da-Cheng Zhou, David Grimwade, Robert Gallagher, Marieke von Lindern, Samuel Waxman, Tariq Enver, Guido Hildebrandt, Arthur Zelen. DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia. Blood. vol 111. issue 4. 2008-05-21. PMID:17993618. |
the retinoic acid receptor (rar) alpha gene (rara) encodes 2 major isoforms and mediates positive effects of all-trans retinoic acid (atra) on myelomonocytic differentiation. |
2008-05-21 |
2023-08-12 |
Not clear |
| Manabu Kusakabe, Kazumi Suzukawa, Toru Nanmoku, Naoshi Obara, Yasushi Okoshi, Harumi Y Mukai, Yuichi Hasegawa, Hiroshi Kojima, Yasushi Kawakami, Haruhiko Ninomiya, Toshiro Nagasaw. Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding. European journal of haematology. vol 80. issue 5. 2008-04-28. PMID:18221386. |
acute promyelocytic leukemia (apl) is characterized by chromosomal rearrangements of 17q21, leading to fusion of the gene-encoding retinoic acid receptor alpha (rara) with a number of alternative partner genes. |
2008-04-28 |
2023-08-12 |
Not clear |
| Konstantin Khetchoumian, Marius Teletin, Johan Tisserand, Manuel Mark, Benjamin Herquel, Mihaela Ignat, Jessica Zucman-Rossi, Florence Cammas, Thierry Lerouge, Christelle Thibault, Daniel Metzger, Pierre Chambon, Régine Losso. Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nature genetics. vol 39. issue 12. 2007-12-11. PMID:18026104. |
we further show that deletion of a single retinoic acid receptor alpha (rara) allele in a trim24-null background suppresses hcc development and restores wild-type expression of retinoic acid-responsive genes in the liver, thus demonstrating that in this genetic background rara expresses an oncogenic activity correlating with a dysregulation of the retinoic acid signaling pathway. |
2007-12-11 |
2023-08-12 |
mouse |
| Emily J Su, You-Hong Cheng, Robert T Chatterton, Zhi-Hong Lin, Ping Yin, Scott Reierstad, Joy Innes, Serdar E Bulu. Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells. Biology of reproduction. vol 77. issue 3. 2007-10-19. PMID:17538076. |
maximal stimulation occurred at hour 48 at an ra concentration of 10(-6) m. both retinoic acid receptor alpha (rara) and retinoid x receptor alpha (rxra) were readily detected by immunoblotting in isolated placental endothelial cells. |
2007-10-19 |
2023-08-12 |
human |
| Jin-Yeong Han, Kyong-Eun Kim, Kyeong-Hee Kim, Joo-In Park, Jae-Seok Ki. Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH. Leukemia research. vol 31. issue 2. 2007-10-12. PMID:16797070. |
acute promyelocytic leukemia (apl) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara). |
2007-10-12 |
2023-08-12 |
Not clear |
| Firoz Ahmad, Rupa Dalvi, Swarna Mandava, Bibhu Ranjan Da. Acute Myelogeneous Leukemia (M0/M1) with novel chromosomal abnormality of t(14;17) (q32; q11.2). American journal of hematology. vol 82. issue 7. 2007-08-31. PMID:17177193. |
this rearrangement may include certain cancer associated oncogene(s) or genes involved in the differentiation like retionic acid receptor alpha (rara), which may confer differentiation blockage and/or proliferation advantage. |
2007-08-31 |
2023-08-12 |
Not clear |
| Fabian Runkel, Marion Michels, Sebastian Franken, Thomas Fran. Specific expression of annexin A8 in adult murine stratified epithelia. Journal of molecular histology. vol 37. issue 8-9. 2007-05-10. PMID:17082908. |
we also investigated the expression of retinoic acid receptor alpha protein (rara) and anxa8 in the epidermis immunohistochemically. |
2007-05-10 |
2023-08-12 |
mouse |
| Nadège Vernet, Christine Dennefeld, Florian Guillou, Pierre Chambon, Norbert B Ghyselinck, Manuel Mar. Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. The EMBO journal. vol 25. issue 24. 2007-02-06. PMID:17124491. |
we show here that selective ablation of ra receptor alpha (raralpha) gene in mouse sc, singly (rara(ser-/-) mutation) or in combination with rarbeta and rargamma genes (rara/b/g(ser-/-) mutation), abolishes cyclical gene expression in these cells. |
2007-02-06 |
2023-08-12 |
mouse |