| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junko Iwasaki, Takeshi Kondo, Stephanie Darmanin, Makoto Ibata, Masahiro Onozawa, Daigo Hashimoto, Naoya Sakamoto, Takanori Teshim. FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia. Annals of hematology. vol 93. issue 9. 2014-09-25. PMID:24763514. |
fip1-like 1 (fip1l1) is associated with two leukemogenic fusion genes: fip1l1-retinoic acid receptor alpha (rara) and fip1l1-platelet-derived growth factor receptor alpha (pdgfra). |
2014-09-25 |
2023-08-13 |
Not clear |
| Tao Yang, Le Meng, Xinxing Wang, Longlong Wang, Kui Jia. Direct electrochemical DNA detection originated from the self-redox signal of sulfonated polyaniline enhanced by graphene oxide in neutral solution. ACS applied materials & interfaces. vol 5. issue 21. 2014-06-16. PMID:24088603. |
as an initial application of this system, the pml/rara fusion gene sequence formed from promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara) was successfully detected. |
2014-06-16 |
2023-08-12 |
Not clear |
| R Yasmeen, J M Meyers, C E Alvarez, J L Thomas, A Bonnegarde-Bernard, H Alder, T L Papenfuss, D M Benson, P N Boyaka, O Ziouzenkov. Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations. Biochimica et biophysica acta. vol 1833. issue 12. 2014-02-24. PMID:24080087. |
aldh1a1 regulated transcription factors during b cell differentiation in a sequential manner: 1) retinoic acid receptor alpha (rara) in igg1(+)/cd19(-) and 2) zinc finger protein zfp423 and peroxisome proliferator-activated receptor gamma (pparg) in igg1(+)/cd19(+) splenocytes. |
2014-02-24 |
2023-08-12 |
mouse |
| W-C Yang, H-M Shi. The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. Oncogene. vol 32. issue 43. 2013-12-31. PMID:23208507. |
acute promyelocytic leukemia (apl) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (rara) gene and the promyelocytic leukemia (pml) or promyelocytic leukemia zinc finger (plzf) gene. |
2013-12-31 |
2023-08-12 |
mouse |
| Karem H Alzoubi, Omar F Khabour, Razan E Hassan, Feras Qarqaz, Sayer Al-Azzam, Nizar Mhaida. The effect of genetic polymorphisms of RARA gene on the adverse effects profile of isotretinoin-treated acne patients. International journal of clinical pharmacology and therapeutics. vol 51. issue 8. 2013-09-17. PMID:23782583. |
in this study, we examined the association between rs9303285, rs2715554 and rs4890109 genetic polymorphisms in the retinoic acid receptor alpha (rara), one of the main targets of isotretinoin, and the adverse effects of oral isotretinoin therapy. |
2013-09-17 |
2023-08-12 |
Not clear |
| Garry L Coles, Kate G Ackerma. Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 21. 2013-08-06. PMID:23650387. |
knockdown of kif7, and retinoic acid receptors alpha (rara), beta (rarb), and gamma (rarg) indicated that ra signaling is dependent on these genes to promote tendonogenesis within the embryonic diaphragm. |
2013-08-06 |
2023-08-12 |
mouse |
| Jason Koshy, You-Wen Qian, Gayathri Bhagwath, Maurice Willis, Todd W Kelley, Peter Papenhause. Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation. Cancer genetics. vol 205. issue 10. 2013-01-10. PMID:22982005. |
the t(15;17) results in the fusion of the promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara) genes. |
2013-01-10 |
2023-08-12 |
Not clear |
| Mangala Gowri, S K Kousar Jahan, Kavitha, Prasannakumari, Madhumathi, L Appaj. Acute promyelocytic leukemia with unusual karyotype. Indian journal of human genetics. vol 17. issue 3. 2012-10-02. PMID:22346000. |
acute myeloid leukemia (aml-m3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (rara) gene on chromosome 17 and the pml gene on chromosome 15. |
2012-10-02 |
2023-08-12 |
Not clear |
| G Paroni, M Fratelli, G Gardini, C Bassano, M Flora, A Zanetti, V Guarnaccia, P Ubezio, F Centritto, M Terao, E Garattin. Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA. Oncogene. vol 31. issue 29. 2012-09-25. PMID:22056878. |
here, we demonstrate that 23-32% of the human erbb2(+) breast cancers show coamplification of retinoic acid receptor alpha (rara), encoding the retinoic acid receptor, rarα. |
2012-09-25 |
2023-08-12 |
human |
| Percy Luk Yeung, Natalia G Denissova, Cara Nasello, Zhanna Hakhverdyan, J Don Chen, Mark A Brennema. Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination. Journal of cellular biochemistry. vol 113. issue 5. 2012-09-17. PMID:22213200. |
in most cases of acute promyelocytic leukemia, the pml and retinoic acid receptor alpha (rara) genes are translocated, resulting in expression of oncogenic pml-rarα fusion proteins. |
2012-09-17 |
2023-08-12 |
Not clear |
| Kyong Eun Kim, Sung Hyun Kim, Jin Yeong Ha. [Acute Monocytic Leukemia with t(11;17)(q23;q21) Involving a Rearrangement of Mixed Lineage Leukemia Gene.]. The Korean journal of laboratory medicine. vol 26. issue 5. 2012-08-23. PMID:18156746. |
fluorescence in situ hybridization (fish) analysis identified a mixed lineage leukemia (mll) gene rearrangement, but not visible disruptions of promyelocytic leukemia (pml) or retinoic acid receptor alpha (rara) genes. |
2012-08-23 |
2023-08-12 |
Not clear |
| Bandar Ali Suliman, Dakang Xu, Bryan Raymond George William. The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. Frontiers in oncology. vol 2. 2012-08-23. PMID:22822476. |
the promyelocytic leukemia zinc finger (plzf) protein, also known as zbtb16 or zfp145, was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with the rara gene encoding retinoic acid receptor alpha. |
2012-08-23 |
2023-08-12 |
Not clear |
| Pratibha Kadam Amare, Chanda Baisane, Reena Nair, Hari Menon, Shripad Banavali, Sharayu Kabre, Sumit Gujral, P Subramania. Characterization of cryptic rearrangements, deletion, complex variants of PML, RARA in acute promyelocytic leukemia. Indian journal of human genetics. vol 17. issue 2. 2011-11-23. PMID:22090713. |
acute promyelocytic leukemia (apl) is characterized by a reciprocal translocation t(15;17)(q22;q21) leading to the disruption of promyelocytic leukemia (pml) and retionic acid receptor alpha (rara) followed by reciprocal pml-rara fusion in 90% of the cases. |
2011-11-23 |
2023-08-12 |
Not clear |
| Syed Khizer Hasan, Francesco Lo-Coc. Utilization of molecular phenotypes to detect relapse and optimize the management of acute promyelocytic leukemia. Clinical lymphoma, myeloma & leukemia. vol 10 Suppl 3. 2011-08-04. PMID:21115433. |
translocation breakpoints are located within the promyelocytic leukemia (pml) locus on chromosome 15 and the retinoic acid receptor alpha (rara) locus on chromosome 17. |
2011-08-04 |
2023-08-12 |
human |
| Keng Thye Woo, Yeow Kok Lau, Yi Zhao, Kim Yoong Puong, Hwee Boon Tan, Stephanie Fook-Chong, Kok Seng Wong, Choong Meng Cha. Urotensin 2 and retinoic acid receptor alpha (RARA) gene expression in IgA nephropathy. Annals of the Academy of Medicine, Singapore. vol 39. issue 9. 2011-06-22. PMID:20957306. |
urotensin 2 and retinoic acid receptor alpha (rara) gene expression in iga nephropathy. |
2011-06-22 |
2023-08-12 |
Not clear |
| John S Welch, Jeffery M Klco, Nobish Varghese, Rakesh Nagarajan, Timothy J Le. Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice. Blood. vol 117. issue 8. 2011-05-12. PMID:21190992. |
rara (retinoic acid receptor alpha) haploinsufficiency is an invariable consequence of t(15;17)(q22;q21) translocations in acute promyelocytic leukemia (apl). |
2011-05-12 |
2023-08-12 |
mouse |
| Stig Ove Bøe, Anne Simonse. Autophagic degradation of an oncoprotein. Autophagy. vol 6. issue 7. 2011-03-01. PMID:20724820. |
acute promyelocytic leukemia (apl) is characterized by a chromosomal t(15;17) translocation that fuses the gene encoding the promyelocytic leukemia protein (pml) to that encoding retinoic acid receptor alpha (rara). |
2011-03-01 |
2023-08-12 |
Not clear |
| Li Zhu, Timothy J Doyle, Kwan Hee Ki. Retinoic acid modulates the subcellular localization of small ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis. Journal of andrology. vol 31. issue 4. 2011-01-04. PMID:20075418. |
moreover, treatment of sertoli cells with a retinoic acid receptor alpha (rara)-specific agonist changed the subcellular localization of sumo-2/3 from the nucleus to the cytoplasm. |
2011-01-04 |
2023-08-12 |
mouse |
| Li Zhu, Timothy J Doyle, Kwan Hee Ki. Retinoic acid modulates the subcellular localization of small ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis. Journal of andrology. vol 31. issue 4. 2011-01-04. PMID:20075418. |
furthermore, disruption of the retinoic acid receptor alpha (rara) gene in the testis resulted in alteration of sumo-2/3 subcellular localization, indicating that its protein rara might have a role in the nuclear trafficking of sumo-2/3. |
2011-01-04 |
2023-08-12 |
mouse |
| Yukiya Yamamoto, Sachiko Tsuzuki, Motohiro Tsuzuki, Kousuke Handa, Yoko Inaguma, Nobuhiko Em. BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia. Blood. vol 116. issue 20. 2010-12-21. PMID:20807888. |
the majority of acute promyelocytic leukemia (apl) cases are characterized by the presence of a promyelocytic leukemia-retinoic acid receptor alpha(rara) fusion gene. |
2010-12-21 |
2023-08-12 |
human |