| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P P Scaglioni, P P Pandolf. The theory of APL revisited. Current topics in microbiology and immunology. vol 313. 2007-02-06. PMID:17217040. |
acute promyelocytic leukemia (apl) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor alpha (rara) gene on chromosome 17 and variable partner genes (x genes) on distinct chromosomes. |
2007-02-06 |
2023-08-12 |
Not clear |
| Mohtashim Naeem, Kathleen Harrison, Kevin Barton, Sucha Nand, Serhan Alka. A unique case of acute promyelocytic leukemia showing monocytic differentiation after ATRA (all-trans retinoic acid) therapy. European journal of haematology. vol 76. issue 2. 2006-03-28. PMID:16405439. |
acute promyelocytic leukemia (pml) is characterized by a reciprocal translocation between chromosomes 15 and 17 resulting in a chimeric pml and retinoic acid receptor alpha (rara) oncogene. |
2006-03-28 |
2023-08-12 |
Not clear |
| C F Classen, A Teigler-Schlegel, S Röttgers, D Reinhardt, K Döhner, K M Debati. AML bearing the translocation t(11;17)(q23;q21): involvement of MLL and a region close to RARA, with no differentiation response to retinoic acid. Annals of hematology. vol 84. issue 12. 2006-03-02. PMID:16044313. |
further analysis of the translocation revealed an involvement of the mixed-lineage leukemia (mll) gene and a region closely proximal to the retinoic acid (ra) receptor alpha (rara) gene. |
2006-03-02 |
2023-08-12 |
Not clear |
| C-S Chim, S-Y Wong, A Pang, P Chu, J S Lau, K-F Wong, Y-L Kwon. Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia. Leukemia. vol 19. issue 12. 2006-01-19. PMID:16239915. |
the retinoic acid receptor alpha (rara) gene is disrupted by pml/rara fusion in acute promyelocytic leukemia (apl). |
2006-01-19 |
2023-08-12 |
Not clear |
| Qiaojun He, Hui Peng, Steven J Collins, Timothy J Triche, Lingtao W. Retinoid-modulated MAT1 ubiquitination and CAK activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 14. 2005-05-17. PMID:15345685. |
recent studies demonstrate that retinoic acid (ra)-induced human hl60 cell proliferation/differentiation (p/d) transition is accompanied by mat1 degradation and decreased cak phosphorylation of retinoic acid receptor alpha (rara). |
2005-05-17 |
2023-08-12 |
human |
| Andreas Reiter, Eva Lengfelder, David Grimwad. Pathogenesis, diagnosis and monitoring of residual disease in acute promyelocytic leukaemia. Acta haematologica. vol 112. issue 1-2. 2004-07-08. PMID:15179005. |
apl is characterized by chromosomal rearrangements of 17q21 leading to the formation of fusion proteins involving retinoic acid receptor alpha (rara). |
2004-07-08 |
2023-08-12 |
Not clear |
| Laura E Mitchell, Jeffrey C Murray, Sarah O'Brien, Kaare Christense. Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: a population-based case-control study in Denmark, 1991-1994. American journal of epidemiology. vol 158. issue 1. 2003-07-29. PMID:12835288. |
one putative genetic risk factor for these conditions is the retinoic acid receptor alpha (rara) locus, which is involved in cell-specific responses to retinoic acid. |
2003-07-29 |
2023-08-12 |
Not clear |
| Supakit Peanchitlertkajorn, Margaret E Cooper, You-e Liu, L Leigh Field, Mary L Marazit. Chromosome 17: gene mapping studies of cleft lip with or without cleft palate in Chinese families. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. vol 40. issue 1. 2003-04-22. PMID:12498608. |
involvement of loci on chromosome 17, including retinoic acid receptor alpha (rara) in nonsyndromic oral clefts has been reported in caucasian populations, although never investigated in asian populations. |
2003-04-22 |
2023-08-12 |
Not clear |
| Kiyoshi Kanno, Yoichi Suzuki, Xuemei Yang, Atsushi Yamada, Yoko Aoki, Shigeo Kure, Yoichi Matsubar. Lack of evidence for a significant association between nonsyndromic cleft lip with or without cleft palate and the retinoic acid receptor alpha gene in the Japanese population. Journal of human genetics. vol 47. issue 6. 2002-12-16. PMID:12111375. |
the retinoic acid receptor alpha ( rara) is one of the candidate genes for the pathogenesis of nsclp. |
2002-12-16 |
2023-08-12 |
Not clear |
| Luca Scapoli, Marcella Martinelli, Furio Pezzetti, Francesco Carinci, Maria Bodo, Mauro Tognon, Paolo Carinc. Linkage disequilibrium between GABRB3 gene and nonsyndromic familial cleft lip with or without cleft palate. Human genetics. vol 110. issue 1. 2002-05-09. PMID:11810291. |
on these grounds, we have investigated, by linkage disequilibrium (ld) and parametric and nonparametric linkage analyses, five different candidate genes, including those for the beta3 subunit of the gamma-aminobutyric acid receptor (gabrb3), glutamic acid decarboxylase 1 (gad1), retinoic acid receptor alpha (rara), transforming growth factor beta3 (tgfb3), and msh ( drosophila) homeobox homolog 1 (msx1). |
2002-05-09 |
2023-08-12 |
mouse |
| G Zhou, R C Strom, V Giguere, R W William. Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice. Molecular vision. vol 7. 2001-12-05. PMID:11723443. |
we adapted sensitive quantitative trait locus (qtl) mapping methods to assess consequences of inactivating alleles of the alpha and beta receptors, rara and rarb, on eye and retinal development. |
2001-12-05 |
2023-08-12 |
mouse |
| C Mannhalter, D Koizar, G Mitterbaue. Evaluation of RNA isolation methods and reference genes for RT-PCR analyses of rare target RNA. Clinical chemistry and laboratory medicine. vol 38. issue 2. 2000-09-18. PMID:10834406. |
in rna samples extracted from lysed whole blood, the presence of amplifiable rna/cdna was confirmed by amplification of 4 selected reference genes (porphobilinogen deaminase (pbgd), abl, the gene spanning the bcr on chromosome 22 and retinoic acid receptor alpha (rara)) in a multiplex pcr. |
2000-09-18 |
2023-08-12 |
Not clear |
| J C Mattso. Acute promyelocytic leukemia. From morphology to molecular lesions. Clinics in laboratory medicine. vol 20. issue 1. 2000-03-23. PMID:10702898. |
the t(15;17) translocation, which is a hallmark of this disease, results in a transcriptionally active fusion gene-derived from the pml gene from chromosome 15 and the retinoic acid receptor alpha (rara) gene from chromosome 17. |
2000-03-23 |
2023-08-12 |
Not clear |
| C Arnould, C Philippe, V Bourdon, M J Gr goire, R Berger, P Jonveau. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. Human molecular genetics. vol 8. issue 9. 2000-01-27. PMID:10441338. |
acute promyelocytic leukaemia (apl) exhibits a characteristic t(15;17) translocation that fuses the promyelocytic leukaemia (pml) gene on 15q22 to the retinoic acid receptor alpha (rara) gene on 17q12-q21.1. |
2000-01-27 |
2023-08-12 |
human |
| T S Wan, C S Chim, C K So, L C Chan, S K M. Complex variant 15;17 translocations in acute promyelocytic leukemia. A case report and review of three-way translocations. Cancer genetics and cytogenetics. vol 111. issue 2. 1999-06-15. PMID:10347551. |
southern blot analysis showed retinoic acid receptor alpha (rara) gene rearrangement at intron 2. |
1999-06-15 |
2023-08-12 |
Not clear |
| G Martinelli, E Ottaviani, G Visani, N Testoni, V Montefusco, S Tur. Long-term disease-free acute promyelocytic leukemia patients really can be cured at molecular level. Haematologica. vol 83. issue 9. 1999-02-22. PMID:9825588. |
using pml and rara sequence specific primers, reverse transcription-polymerase chain reaction (rt-pcr) assays have been developed for detection of pml/rar alpha transcript in leukemic cells obtained from patients; these rt-pcr assays are more sensitive than conventional cytogenetic analysis. |
1999-02-22 |
2023-08-12 |
Not clear |
| M Gariboldi, V Vivat, L De Gregorio, G Manenti, E Chiariello, F S Falvella, M A Pierotti, T A Dragan. Analysis of the retinoic acid receptor alpha gene as a candidate for the pulmonary adenoma resistance 1 gene. Molecular carcinogenesis. vol 21. issue 1. 1998-03-02. PMID:9473767. |
the retinoic acid receptor alpha (rara) gene, which maps in the same region as the pulmonary adenoma resistance (par1) locus on mouse chromosome 11 (manenti g et al., nature genet 12:455-457, 1996), was tested as a candidate gene for par1. |
1998-03-02 |
2023-08-12 |
mouse |
| H Sato, T Koide, H Masuya, S Wakana, T Sagai, A Umezawa, S Ishiguro, M Tamai, T Shiroishi, M Tam. A new mutation Rim3 resembling Re(den) is mapped close to retinoic acid receptor alpha (Rara) gene on mouse chromosome 11. Mammalian genome : official journal of the International Mammalian Genome Society. vol 9. issue 1. 1998-02-26. PMID:9434940. |
a new mutation rim3 resembling re(den) is mapped close to retinoic acid receptor alpha (rara) gene on mouse chromosome 11. |
1998-02-26 |
2023-08-12 |
mouse |
| H Sato, T Koide, H Masuya, S Wakana, T Sagai, A Umezawa, S Ishiguro, M Tamai, T Shiroishi, M Tam. A new mutation Rim3 resembling Re(den) is mapped close to retinoic acid receptor alpha (Rara) gene on mouse chromosome 11. Mammalian genome : official journal of the International Mammalian Genome Society. vol 9. issue 1. 1998-02-26. PMID:9434940. |
large-scale linkage analysis with two kinds of intersubspecific backcrosses revealed that rim3 is mapped to the distal portion of chromosome (chr) 11, in which re(den) and bsk have been located, and is very close to the retinoic acid receptor, alpha (rara). |
1998-02-26 |
2023-08-12 |
mouse |
| L Z He, F Guidez, C Tribioli, D Peruzzi, M Ruthardt, A Zelent, P P Pandolf. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nature genetics. vol 18. issue 2. 1998-02-24. PMID:9462740. |
acute promyelocytic leukaemia (apl), associated with chromosomal translocations involving the retinoic acid receptor alpha gene (rara) and the pml gene, is sensitive to retinoic acid (ra) treatment, while apl patients harbouring translocations between rara and the plzf gene do not respond to ra. |
1998-02-24 |
2023-08-12 |
mouse |