| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefano Rossetti, Nicoletta Sacch. Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid. Cancers. vol 12. issue 8. 2020-09-28. PMID:32823855. |
in this review, we mostly focus on emerging ra-regulated epigenetic mechanisms involving ra receptor alpha (rara) and annexin a8 (anxa8), which is a member of the annexin family, as well as anxa8 regulatory micrornas (mirnas). |
2020-09-28 |
2023-08-13 |
mouse |
| Atef Nehdi, Rizwan Ali, Alshaimaa Alhallaj, Hajar Alzahrani, Nosaibah Samman, Abdullah Mashhour, Omar Baz, Tlili Barhoumi, Bandar Alghanem, Abdullatif Khan, Lolwah Alriyees, Mohamed Boudjela. Nuclear Receptors Are Differentially Expressed and Activated in KAIMRC1 Compared to MCF7 and MDA-MB231 Breast Cancer Cells. Molecules (Basel, Switzerland). vol 24. issue 11. 2019-11-20. PMID:31141879. |
retinoic acid-induced activation of retinoic acid receptor response element (rare)-tk-luciferase is dependent on exogenous expression of retinoic acid receptor alpha (rara)/rxra heterodimer in mda-mb 231 but not in mcf7 and kaimrc1 cell lines. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chengli Song, Lina Wang, Xiaoyan Wu, Kai Wang, Dan Xie, Qi Xiao, Songyu Li, Kui Jiang, Lujian Liao, John R Yates, Jiing-Dwan Lee, Qingkai Yan. PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent. Cancer research. vol 78. issue 10. 2019-06-12. PMID:29735542. |
this interaction was disrupted by the pml-rara t(15;17) mutation, which stems from chromosomal translocation between dna encoding the c-terminal domain of pml and the retinoic acid receptor alpha (rara) gene. |
2019-06-12 |
2023-08-13 |
Not clear |
| Ana Paula Percicote, Gabriel Lazaretti Mardegan, Elizabeth Schneider Gugelmim, Sergio Ossamu Ioshii, Ana Paula Kuczynski, Seigo Nagashima, Lúcia de Noronh. Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas. Diagnostic pathology. vol 13. issue 1. 2018-08-21. PMID:29378601. |
the aim of this study was to evaluate the immunohistochemical expression of retinoic acid receptor alpha (rara) and crabp2 in paraffin-embedded samples of nephroblastomas via semiquantitative and quantitative analyses and to correlate this expression with prognostic factors. |
2018-08-21 |
2023-08-13 |
Not clear |
| Xueju Wang, Surendra Dasari, Grzegorz S Nowakowski, Konstantinos N Lazaridis, Eric D Wieben, Marshall E Kadin, Andrew L Feldman, Rebecca L Boddicke. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. vol 8. issue 16. 2018-03-05. PMID:28412739. |
retinoic acid receptor alpha (rara) is a transcription factor that modulates cell growth and differentiation in response to retinoids. |
2018-03-05 |
2023-08-13 |
Not clear |
| Erin M Swaney, Anuja Chattopadhyay, Irina Abecassis, Elizabeth A Rush, Robert L Redne. The leukemic oncoprotein NPM1-RARA inhibits TP53 activity. Leukemia & lymphoma. vol 57. issue 8. 2017-12-29. PMID:26754533. |
the variant acute promyelocytic leukemia (apl) translocation t(5;17)(q35;q21) fuses the n-terminus of nucleophosmin (npm1) to the retinoic acid receptor alpha (rara). |
2017-12-29 |
2023-08-13 |
Not clear |
| David Mahato, Dipayan Samanta, Sudit S Mukhopadhyay, R Navanietha Krishnara. A systems biology approach for elucidating the interaction of curcumin with Fanconi anemia FANC G protein and the key disease targets of leukemia. Journal of receptor and signal transduction research. vol 37. issue 3. 2017-06-06. PMID:27608133. |
the proteins namely dot1l, farnesyl transferase (fdps), histone decetylase (ep3000), polo-like kinase (plk-2), aurora-like kinase (aukrb), tyrosine kinase (abl1), and retinoic acid receptor alpha (rara) were chosen as disease targets for leukemia and modeled structure of fanc g protein as the disease target for fa. |
2017-06-06 |
2023-08-13 |
Not clear |
| Anuja Chattopadhyay, Irina Abecassis, Robert L Redne. NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFκB and JNK. Leukemia & lymphoma. vol 56. issue 12. 2016-09-20. PMID:25791120. |
the t(5;17) variant of acute promeylocytic leukemia (apl) expresses a fusion of nucleophosmin (npm) with the retinoic acid receptor alpha (rara). |
2016-09-20 |
2023-08-13 |
Not clear |
| R Kolhe, A Mangaonkar, J Mansour, A Clemmons, J Shaw, B Dupont, L Walczak, A Mondal, A Rojiani, A Jillella, V Kot. Utility and impact of early t(15;17) identification by Fluorescence In Situ Hybridization (FISH) in clinical decision making for patients in Acute Promyelocytic Leukemia (APL). International journal of laboratory hematology. vol 37. issue 4. 2016-04-12. PMID:25639817. |
the aim of this project was to validate earlier time frames for the abbott molecular vysis lsi promyelocytic leukemia (pml)/ retinoic acid receptor alpha (rara) fluorescence in situ hybridization (fish) probe (asr 6-16 h). |
2016-04-12 |
2023-08-13 |
Not clear |
| Xiao-Shan Min, Peng Huang, Xu Liu, Chao Dong, Xiao-Lin Jiang, Zheng-Tai Yuan, Lin-Feng Mao, Shi Chan. Bioinformatics analyses of significant prognostic risk markers for thyroid papillary carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 10. 2016-02-02. PMID:25908172. |
among the 11 prognostic risk genes, v-maf avian musculoaponeurotic fibrosarcoma oncogene homologue f (maff), sry (sex-determining region y)-box 4 (sox4), and retinoic acid receptor, alpha (rara) encoded transcription factors. |
2016-02-02 |
2023-08-13 |
Not clear |
| Yinjun Lou, Yafang Ma, Jianai Sun, Xiujin Ye, Hanzhang Pan, Yungui Wang, Wenbin Qian, Haitao Meng, Wenyuan Mai, JingSong He, Hongyan Tong, Jie Ji. Evaluating frequency of PML-RARA mutations and conferring resistance to arsenic trioxide-based therapy in relapsed acute promyelocytic leukemia patients. Annals of hematology. vol 94. issue 11. 2015-12-18. PMID:26294332. |
the frequency and clinical significance of promyelocytic leukemia (pml)-retinoic acid receptor alpha (rara) mutational status using sanger sequencing were evaluated. |
2015-12-18 |
2023-08-13 |
Not clear |
| Ashok K Vaid, Sandeep Batra, Suman S Karanth, Sachin Gupt. Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed. Avicenna journal of medicine. vol 5. issue 4. 2015-12-02. PMID:26629469. |
though, complete blood picture revealed only mild hyperleukocytosis, bone marrow biopsy and aspiration revealed 60% blasts and a positive t (15,17)(q22,12) and pml retinoic acid receptor alpha (rara) fusion protein on molecular cytogenetics. |
2015-12-02 |
2023-08-13 |
Not clear |
| Ayano Doi, Kosuke Ishikawa, Nao Shibata, Emi Ito, Jiro Fujimoto, Mizuki Yamamoto, Hatsuki Shiga, Hiromi Mochizuki, Yoshifumi Kawamura, Naoki Goshima, Kentaro Semba, Shinya Watanab. Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures. Molecular oncology. vol 9. issue 2. 2015-09-16. PMID:25300573. |
enhanced expression of retinoic acid receptor alpha (rara) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures. |
2015-09-16 |
2023-08-13 |
Not clear |
| C Cameron Yin, Nitin Jain, Meenakshi Mehrotra, Jianhua Zhagn, Alexei Protopopov, Zhuang Zuo, Naveen Pemmaraju, Courtney DiNardo, Cheryl Hirsch-Ginsberg, Sa A Wang, L Jeffrey Medeiros, Lynda Chin, Keyur P Patel, Farhad Ravandi, Andrew Futreal, Carlos E Bueso-Ramo. Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia. Journal of the National Comprehensive Cancer Network : JNCCN. vol 13. issue 1. 2015-09-10. PMID:25583766. |
acute promyelocytic leukemia (apl) is characterized by the fusion of retinoic acid receptor alpha (rara) with promyelocytic leukemia (pml) or, rarely, other gene partners. |
2015-09-10 |
2023-08-13 |
Not clear |
| Kathleen Overholt, Terri L Guinipero, Nyla A Heerema, Michael R Loken, Samir B Kahwas. Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma. Case reports in hematology. vol 2015. 2015-09-09. PMID:26351594. |
a case of acute promyelocytic leukemia (apl) with runx1t1 insertion to 7q is described and compared to reported cases of apl with negative retinoic acid receptor alpha (rara) abnormality. |
2015-09-09 |
2023-08-13 |
Not clear |
| Jessica N Nichol, Nicolas Garnier, Wilson H Mille. Triple A therapy: the molecular underpinnings of the unique sensitivity of leukemic promyelocytes to anthracyclines, all-trans-retinoic acid and arsenic trioxide. Best practice & research. Clinical haematology. vol 27. issue 1. 2015-09-03. PMID:24907014. |
the presence of fusions involving the retinoic acid receptor alpha (rara) is without question the central player driving apl and dictating the response of this disease to these therapeutic agents. |
2015-09-03 |
2023-08-13 |
Not clear |
| Sheri L Pollock, Elizabeth A Rush, Robert L Redne. NPM-RAR, not the RAR-NPM reciprocal t(5;17)(q35;q21) acute promyelocytic leukemia fusion protein, inhibits myeloid differentiation. Leukemia & lymphoma. vol 55. issue 6. 2015-07-15. PMID:23927396. |
the t(5;17) variant of acute promyelocytic leukemia (apl) fuses the nucleophosmin (npm) gene at 5q35 with the retinoic acid receptor alpha (rara) at 17q12-22. |
2015-07-15 |
2023-08-12 |
Not clear |
| Xiong Wang, Lu Tan, Yanjun Lu, Jing Peng, Yaowu Zhu, Yadong Zhang, Ziyong Su. MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha. FEBS letters. vol 589. issue 6. 2015-04-29. PMID:25680531. |
furthermore, we confirm that retinoic acid receptor alpha (rara) is a direct target of mir-138, and supplement of rara substantially suppresses gsk-3β activity, and reduces tau phosphorylation induced by mir-138. |
2015-04-29 |
2023-08-13 |
Not clear |
| A Sharma, H Yun, N Jyotsana, A Chaturvedi, A Schwarzer, E Yung, C K Lai, F Kuchenbauer, B Argiropoulos, K Görlich, A Ganser, R K Humphries, M Heuse. Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling. Leukemia. vol 29. issue 1. 2015-03-24. PMID:24957708. |
as mn1 is a cofactor of meis1 and retinoic acid receptor alpha (rara), we compared chromatin occupancy between these genes. |
2015-03-24 |
2023-08-13 |
human |
| b' Julien Ablain, Hugues de Th\\xc3\\xa. Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia. International journal of cancer. vol 135. issue 10. 2014-11-18. PMID:25130873.' |
the discovery of retinoic acid receptor alpha (rara) was followed by the cloning of the chromosomal translocations driving apl, all of which involve rara. |
2014-11-18 |
2023-08-13 |
Not clear |