| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N E Maestri, T H Beaty, J Hetmanski, E A Smith, I McIntosh, D F Wyszynski, K Y Liang, D L Duffy, C VanderKol. Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. American journal of medical genetics. vol 73. issue 3. 1998-01-16. PMID:9415696. |
for four of these candidates [transforming growth factor alpha (tgfa), transforming growth factor beta 3 (tgfb3), retinoic acid receptor (rara), and the proto-oncogene bcl3], we detected modestly elevated odds ratios for the transmission of one marker allele to cleft probands when all the trios were analyzed together. |
1998-01-16 |
2023-08-12 |
Not clear |
| S Tashiro, Z Wang, N Kotomura, O Niwa, K Ueda, N Kamad. Nuclear proteins binding to the recombination hotspot region of the retinoic acid receptor alpha gene. Leukemia. vol 11 Suppl 3. 1997-08-07. PMID:9209366. |
acute promyelocytic leukemia (apl) has been characterized by 15;17 chromosomal translocation, which involves the retinoic acid receptor alpha (rara) gene on chromosome 17 and the pml gene on chromosome 15. |
1997-08-07 |
2023-08-12 |
mouse |
| S A Hibbert, J K Fiel. Molecular basis of familial cleft lip and palate. Oral diseases. vol 2. issue 3. 1997-04-02. PMID:9081766. |
moreover retinoic acid receptor alpha (rara) (17q), msxi (4p), 4q and bcl3 (19q) could all be implicated in certain clp families. |
1997-04-02 |
2023-08-12 |
Not clear |
| J A Squire, J P McPherson, B G Beatty, G J Goldenber. Allelic fusion of DNA topoisomerase II alpha and retinoic acid receptor alpha genes in adriamycin-resistant p388 murine leukemia revealed by fluorescence in situ hybridization. Cytogenetics and cell genetics. vol 75. issue 2-3. 1997-03-13. PMID:9040785. |
fluorescence in situ hybridization (fish) analysis of metaphase and decondensed free chromatin fibers from adriamycin (adr)-sensitive and adr-resistant murine cells demonstrated a close juxtaposition of topoisomerase ii alpha (top2a) and retinoic acid receptor alpha (rara) genes in adjacent chromatin in the drug-resistant cells, and a close but separate genetic proximity in normal murine chromatin. |
1997-03-13 |
2023-08-12 |
Not clear |
| V Brunel, M Lafage-Pochitaloff, M Alcalay, P G Pelicci, F Bir. Variant and masked translocations in acute promyelocytic leukemia. Leukemia & lymphoma. vol 22. issue 3-4. 1997-01-16. PMID:8819070. |
acute promyelocytic leukemia (apl) is characterized by a unique hemorrhagic syndrome, disseminated intravascular coagulation, and the association with the specific (15;17 chi q22-23:q12-21) translocation, which disrupts the retinoic acid receptor alpha (rara) and the promyelocytic leukemia (pml) genes. |
1997-01-16 |
2023-08-12 |
Not clear |
| J P Par. Shared synteny of human chromosome 17 loci in Canids. Cytogenetics and cell genetics. vol 74. issue 1-2. 1996-12-06. PMID:8893820. |
in this study, four gene probes (myeloperoxidase [mpo], miller-dieker [mdcr], erbb2, and retinoic acid receptor alpha [rara]) from human chromosome 17 were used in fluorescence in situ hybridizations with chromosomes of three different canids: two subspecies of the asiatic raccoon dog (nyctereutes) and the domestic dog (canis familiaris). |
1996-12-06 |
2023-08-12 |
human |
| M N Boddy, K Howe, L D Etkin, E Solomon, P S Freemon. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. Oncogene. vol 13. issue 5. 1996-11-05. PMID:8806687. |
acute promyelocytic leukaemia (apl) arises following a reciprocal translocation t(15;17) that fuses pml with retinoic acid receptor alpha (rara). |
1996-11-05 |
2023-08-12 |
mouse |
| H Yoshida, K Kitamura, K Tanaka, S Omura, T Miyazaki, T Hachiya, R Ohno, T Nao. Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer research. vol 56. issue 13. 1996-08-12. PMID:8674046. |
the pml-retinoic acid receptor alpha (rara) oncoprotein, which is generated by the translocation, blocks the differentiation, and atra is thought to modulate the dominant negative function of pml-rara. |
1996-08-12 |
2023-08-12 |
Not clear |
| R L Redner, E A Rush, S Faas, W A Rudert, S J Core. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood. vol 87. issue 3. 1996-03-01. PMID:8562957. |
this translocation fuses the gene for the nucleolar phosphoprotein nucleophosmin (npm) to the retinoic acid receptor alpha (rara). |
1996-03-01 |
2023-08-12 |
Not clear |
| A B Glassma. Cytogenetics, gene fusions, and cancer. Annals of clinical and laboratory science. vol 25. issue 5. 1995-12-13. PMID:7486813. |
this alters the promyelocytic leukemia (pml) and the retinoic acid receptor alpha (rara) gene sites. |
1995-12-13 |
2023-08-12 |
Not clear |
| L E Mitchell, S C Healey, G Chenevix-Trenc. Evidence for an association between nonsyndromic cleft lip with or without cleft palate and a gene located on the long arm of chromosome 4. American journal of human genetics. vol 57. issue 5. 1995-11-30. PMID:7485164. |
two potential cl +/- p susceptibility loci (csl), transforming growth factor alpha (tgfa) and retinoic acid receptor (rara), have been identified through association studies. |
1995-11-30 |
2023-08-12 |
human |
| H Fukutani, T Naoe, R Ohno, H Yoshida, S Miyawaki, C Shimazaki, T Miyake, Y Nakayama, H Kobayashi, S Got. Isoforms of PML-retinoic acid receptor alpha fused transcripts affect neither clinical features of acute promyelocytic leukemia nor prognosis after treatment with all-trans retinoic acid. The Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia. vol 9. issue 9. 1995-10-05. PMID:7658715. |
although the mechanism of its effectiveness upon apl remains unclear, the pml-retinoic acid receptor alpha (rara) chimeric protein produced by t(15;17) is assumed to underlie the sensitivity of apl cells to atra. |
1995-10-05 |
2023-08-12 |
Not clear |
| D M Juriloff, D G Ma. The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11. Mammalian genome : official journal of the International Mammalian Genome Society. vol 6. issue 2. 1995-07-05. PMID:7767007. |
this locus, here named clf1 (cleft lip) maps to chromosome (chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human cl(p) with the retinoic acid receptor alpha (rara) locus. |
1995-07-05 |
2023-08-12 |
mouse |
| H Fukutani, T Naoe, R Ohno, H Yoshida, H Kiyoi, S Miyawaki, H Morishita, F Sano, H Kamibayashi, K Matsu. Prognostic significance of the RT-PCR assay of PML-RARA transcripts in acute promyelocytic leukemia. The Leukemia Study Group of the Ministry of Health and Welfare (Kouseisho). Leukemia. vol 9. issue 4. 1995-05-23. PMID:7723389. |
minimal residual disease (mrd) was prospectively monitored at the 10(-5) level by the reverse transcriptase-polymerase chain reaction (rt-pcr) of pml-retinoic acid receptor alpha (rara) transcripts from 27 acute promyelocytic leukemia (apl) patients who achieved complete remission (cr) with all-trans retinoic acid and chemotherapy (previously untreated patients, 15; refractory to chemotherapy or relapsed, 12). |
1995-05-23 |
2023-08-12 |
Not clear |
| H Yoshida, T Naoe, H Fukutani, H Kiyoi, K Kubo, R Ohn. Analysis of the joining sequences of the t(15;17) translocation in human acute promyelocytic leukemia: sequence non-specific recombination between the PML and RARA genes within identical short stretches. Genes, chromosomes & cancer. vol 12. issue 1. 1995-04-20. PMID:7534109. |
molecular analysis of the t(15;17) translocation in 70 patients with acute promyelocytic leukemia (apl) confirmed that the breakpoints of chromosome 15 were located in two regions of the promyelocytic leukemia (pml) gene, mainly introns 3 and 6, whereas the breakpoints of chromosome 17 were consistently in intron 2 of the retinoic acid receptor alpha (rara) gene. |
1995-04-20 |
2023-08-12 |
human |
| C R Schad, C A Hanson, E Paietta, J Casper, S M Jalal, G W Dewal. Efficacy of fluorescence in situ hybridization for detecting PML/RARA gene fusion in treated and untreated acute promyelocytic leukemia. Mayo Clinic proceedings. vol 69. issue 11. 1994-12-08. PMID:7967757. |
to test the efficacy of fluorescence in situ hybridization (fish) for detection of fusion of the promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara) genes in patients with treated or untreated acute promyelocytic leukemia (apl). |
1994-12-08 |
2023-08-12 |
Not clear |
| V Najfeld, A Chen, A Scalise, E P Ambinder, G Fernandez, S Waxma. Myelodysplastic syndrome transforming to acute promyelocytic-like leukemia with trisomy and rearrangement of chromosome 11. Genes, chromosomes & cancer. vol 10. issue 1. 1994-09-12. PMID:7519869. |
molecular analysis by reverse transcriptase pcr analysis showed the presence of wild type retinoic acid receptor alpha (rara) and the absence of the pml-rara chimeric gene associated with t(15;17). |
1994-09-12 |
2023-08-12 |
Not clear |
| J Borrow, J Shipley, K Howe, F Kiely, A Goddard, D Sheer, A Srivastava, A C Antony, T Fioretos, F Mitelma. Molecular analysis of simple variant translocations in acute promyelocytic leukemia. Genes, chromosomes & cancer. vol 9. issue 4. 1994-08-29. PMID:7519045. |
the primary cytogenetic abnormality in acute promyelocytic leukemia (apl; fab m3) is a reciprocal translocation, t(15;17)(q22;q12), which serves to fuse the pml gene on chromosome 15 to the retinoic acid receptor alpha (rara) gene on chromosome 17. |
1994-08-29 |
2023-08-12 |
Not clear |
| T Haramoto, H Makino, S Ikeda, J Wieslander, Z Ot. Ultrastructural localization of the three major basement membrane components--type IV collagen, heparan sulfate proteoglycan and laminin--in human membranous glomerulonephritis. American journal of nephrology. vol 14. issue 1. 1994-07-22. PMID:8017478. |
in type iv collagen, the alpha 1-chain was rarely present on the newly synthesized basement membrane in the lamina rara externa, while alpha 3-chain was present on the subepithelial newly synthesized basement membrane. |
1994-07-22 |
2023-08-12 |
human |
| S Tashiro, N Kotomura, K Tanaka, K Suzuki, T Kyo, H Dohy, O Niwa, N Kamad. Identification of illegitimate recombination hot spot of the retinoic acid receptor alpha gene involved in 15;17 chromosomal translocation of acute promyelocytic leukemia. Oncogene. vol 9. issue 7. 1994-07-14. PMID:8208541. |
acute promyelocytic leukemia (apl) has been characterized by 15;17 chromosomal translocation, which involves the retinoic acid receptor alpha (rara) gene on chromosome 17 and the pml gene on chromosome 15. |
1994-07-14 |
2023-08-12 |
Not clear |