| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tahsin Nairuz, Jin-Chul Heo, Jong-Ha Le. Differential Glial Response and Neurodegenerative Patterns in CA1, CA3, and DG Hippocampal Regions of 5XFAD Mice. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596222. |
in this study, the distinct patterns of glial response and neurodegeneration within the ca1, ca3, and dentate gyrus (dg) regions of the hippocampus were examined in 5xfad mice at 6 and 12 months of age. |
2024-11-27 |
2024-11-29 |
mouse |
| Tahsin Nairuz, Jin-Chul Heo, Jong-Ha Le. Differential Glial Response and Neurodegenerative Patterns in CA1, CA3, and DG Hippocampal Regions of 5XFAD Mice. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596222. |
moreover, the ca1 and ca3 regions showed higher vulnerability, with signs of reactive astrogliosis such as increased astrocyte density and elevated gfap expression. |
2024-11-27 |
2024-11-29 |
mouse |
| Isaac Vingan, Shwetha Phatarpekar, Victoria Sook Keng Tung, Alejandro Iván Hernández, Oleg V Evgrafov, Juan Marcos Alarco. Spatially resolved transcriptomic signatures of hippocampal subregions and Frontiers in molecular neuroscience. vol 17. 2024-11-15. PMID:39544521. |
we found that recall induced differentially expressed genes (degs) in the ca1 and ca3 hippocampal subregions were enriched with genes involved in synaptic transmission and synaptic plasticity, while degs in the dentate gyrus (dg) were enriched with genes involved in energy balance and ribosomal function. |
2024-11-15 |
2024-11-17 |
Not clear |
| Wenyan Shi, Xingyan Wu, Chengdong Yuan, Tao Kuang, Xiangfan Xie, Wenlu Gong, Fujia Li, Lechen Shen, Yi Zhang, Xiaoli Lian. Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action. European journal of medical research. vol 29. issue 1. 2024-11-13. PMID:39533344. |
concurrently, the extent of caspase-3 upregulation, the number of neuronal apoptosis in ca1 and ca3 regions, a downward trend of psd95 and bdnf in the hippocampus, and the inhibition of ltp were highly consistent with the behavior of short-term memory impairment. |
2024-11-13 |
2024-11-17 |
mouse |
| Ding Quan Ng, Casey Hudson, Tracy Nguyen, Sukesh Kumar Gupta, Yong Qin Koh, Munjal M Acharya, Alexandre Cha. Dynamin-1 is a potential mediator in cancer-related cognitive impairment. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-11-08. PMID:39516074. |
in murine breast cancer-bearing mice receiving chemotherapy, we found a greater than 40 % decline (p < 0.0001) in dnm1 immunoreactivity in the hippocampal ca1 and ca3 subregions concurrent with a deterioration in spatial recognition memory (p < 0.02), compared to control mice without exposure to cancer and chemotherapy. |
2024-11-08 |
2024-11-17 |
mouse |
| Mingyang Zou, Yujue Zhang, Caiyao Du, Bilin Yang, Peiwen Guo, Huirong Liang, Yilin Zhang, Wenru Tian, Lingyuan Yang, Di Liu, Lijie Wu, Caihong Su. Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice. Molecular neurobiology. 2024-11-06. PMID:39503811. |
in addition, jzl184 reversed the observed overexpression of pro-apoptotic bax and underexpression of anti-apoptotic bcl-2 in btbr mice and enhanced neuronal numbers in hippocampal ca1 and ca3 regions. |
2024-11-06 |
2024-11-08 |
mouse |
| B G Gunn, B S Pruess, C M Gall, G Lync. Input / Output Relationships for the Primary Hippocampal Circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-11-05. PMID:39500578. |
using hippocampal slices derived from male mice, we have found that single-pulse lateral perforant path (lpp) stimulation produces a two-part ca1 response generated by lpp projections to ca3 ('direct path') and the dentate gyrus ('indirect path'). |
2024-11-05 |
2024-11-08 |
mouse |
| Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Ni. Fecal microbiota transplantation and short-chain fatty acids improve learning and memory in fluorosis mice by BDNF-PI3K/AKT pathway. Chemico-biological interactions. 2024-11-04. PMID:39491142. |
nissl and tunel staining presented that fluoride led to a decreased proportion of nissl bodies area in the hippocampal ca3 region and an increased apoptotic ratio of nerve cells in ca1, ca3 and dg areas, whereas fmt alleviated those pathological damages. |
2024-11-04 |
2024-11-06 |
mouse |
| Abigail L Paulson, Lu Zhang, Ashley M Prichard, Annabelle C Singe. 40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-11-01. PMID:39484571. |
we find that an hour of daily exposure to 40 hz audio-visual stimulation over 8 days leads to higher coordination between hippocampal subregions ca3 and ca1 during navigation. |
2024-11-01 |
2024-11-03 |
mouse |
| Veronika Kulik, Melissa K Edler, Mary Ann Raghanti, Aminu Imam, Chet C Sherwoo. Amyloid-Beta, Tau, and Microglial Activation in Aged Felid Brains. The Journal of comparative neurology. vol 532. issue 11. 2024-10-30. PMID:39474737. |
we performed immunohistochemistry to detect aβ40 and aβ42 in plaques and vessels and hyperphosphorylated tau in the temporal lobe gyrus sylvius and in the ca1 and ca3 subfields of the hippocampus. |
2024-10-30 |
2024-11-02 |
Not clear |
| Paola C Bello-Medina, Mauricio Díaz-Muñoz, Sandra Teresita Martín Del Campo, Fermín Paul Pacheco-Moisés, Claudia Flores Miguel, Raquel Cobián Cervantes, Perla Belén García Solano, Mónica Navarro-Mez. A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats. Journal of nutritional science. vol 13. 2024-10-29. PMID:39469193. |
significant decreases of hippocampal syn ratio in male offspring (decreases of 98% in hippocampal ca1 pyramidal and ca1 oriens, 83%, stratum pyramidal in ca3, 80%, stratum lucidum in ca3, and 81% stratum oriens in ca3). |
2024-10-29 |
2024-10-31 |
rat |
| Maysam Havasi Mehr, Shahein Momenabadi, Ali Vakili, Abbas Pakdel, Abbas Ali Vafae, Abedin Vakil. Neuroprotective effects of Daphnetin on hippocampal neurons and blood-brain barrier integrity in a mouse model of cerebral ischemia. Brain research bulletin. 2024-10-24. PMID:39447767. |
administering dap significantly increased neuron survival in the hippocampus ca1, ca3, and dentate gyrus (dg) regions and improved spatial memory dose-dependently (p<0.0001). |
2024-10-24 |
2024-10-28 |
mouse |
| Maysam Havasi Mehr, Shahein Momenabadi, Ali Vakili, Abbas Pakdel, Abbas Ali Vafae, Abedin Vakil. Neuroprotective effects of Daphnetin on hippocampal neurons and blood-brain barrier integrity in a mouse model of cerebral ischemia. Brain research bulletin. 2024-10-24. PMID:39447767. |
the research found that dap protected neurons in the ca1, ca3, and dg areas of the hippocampus, enhanced behavioral functions, and preserved bbb integrity in a cerebral ischemia model. |
2024-10-24 |
2024-10-28 |
mouse |
| Lei Wu, Jianhuai Chen, Qiao Yu, Chao Lu, Yachun Sh. Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus. ACS chemical neuroscience. 2024-10-23. PMID:39441118. |
moreover, hypoxanthine also suppressed the activations of glial cells including gfap and iba-1 in hippocampal ca1, ca3, and dentate gyrus (dg). |
2024-10-23 |
2024-10-25 |
mouse |
| Daniel S Scott, Muthumeenakshi Subramanian, Jun Yamamoto, Carol A Tamming. Schizophrenia pathology reverse-translated into mouse shows hippocampal hyperactivity, psychosis behaviors and hyper-synchronous events. Molecular psychiatry. 2024-10-15. PMID:39407000. |
post-mortem analyses of brain tissue from human schizophrenia brain show decreased expression of the nmdar subunit glun1 confined to the dentate gyrus with evidence of downstream hippocampal hyperactivity in ca3 and ca1. |
2024-10-15 |
2024-10-18 |
mouse |
| Daniel S Scott, Muthumeenakshi Subramanian, Jun Yamamoto, Carol A Tamming. Schizophrenia pathology reverse-translated into mouse shows hippocampal hyperactivity, psychosis behaviors and hyper-synchronous events. Molecular psychiatry. 2024-10-15. PMID:39407000. |
dg inhibition during adolescence generates an increase in hippocampal activity in ca3 and ca1, impairs social cognition and spatial working memory, as well as shows evidence of increased activity in local field potentials as spontaneous synchronous bursts of activity, which we term hyper-synchronous events (hses) in hippocampus. |
2024-10-15 |
2024-10-18 |
mouse |
| Sanggeon Park, Mijeong Park, Eun Joo Kim, Jeansok J Kim, Yeowool Huh, Jeiwon Ch. Distinct Disruptions in CA1 and CA3 Place Cell Function in Alzheimer's Disease Mice. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386433. |
our results suggest that distinct alteration in the physiological properties of ca1 and ca3 place cells, coupled with disrupted hippocampal theta rhythm in ca1, may collectively contribute to impaired hippocampal-dependent spatial learning and memory in ad. |
2024-10-10 |
2024-10-12 |
mouse |
| Noelia S de León Reyes, Maria Helena Bortolozzo-Gleich, Yuki Nomura, Cristina García Fregola, Marta Nieto, Joseph A Gogos, Félix Lero. Interhemispheric CA1 projections support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome. bioRxiv : the preprint server for biology. 2024-09-16. PMID:39282348. |
mossy cells from the hilus of the dentate gyrus project to the inner molecular layer of the contralateral dentate gyrus and ca3 and ca2 pyramidal neuron axonal collaterals to contralateral ca3, ca2 and ca1. |
2024-09-16 |
2024-09-19 |
mouse |
| Corinne J Montes-Rodríguez, Erika D Hernández-Reyes, Vanessa Piña-Díaz, Zeidy Muñoz-Torres, Itzel Pérez-Zarazúa, Emiliano Urteaga-Urías, Oscar Prospéro-Garcí. Activity-Dependent Synaptic Plasticity in the Medial Prefrontal Cortex of Male Rats Underlies Resilience-Related Behaviors to Social Adversity. Journal of neuroscience research. vol 102. issue 9. 2024-09-14. PMID:39275861. |
cfos evaluation showed that social interaction heightened plasticity in the prelimbic (prl) and infralimbic (il) cortices, dentate gyrus (dg), ca3, and ca1. |
2024-09-14 |
2024-09-17 |
rat |
| Edmund T Rolls, Chenfei Zhang, Jianfeng Fen. Hippocampal storage and recall of neocortical "What"-"Where" representations. Hippocampus. 2024-09-02. PMID:39221708. |
important factors that contributed to stability included increased inhibition in ca3 and ca1 to keep the firing rates low; and temporal adaptation of the neuronal firing and of active synapses, which are proposed to make an important contribution to stabilizing runaway excitation in cortical circuits in the brain. |
2024-09-02 |
2024-09-04 |
Not clear |