| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Grace Minogue, Allegra Kawles, Antonia Zouridakis, Rachel Keszycki, Alyssa Macomber, Vivienne Lubbat, Nathan Gill, Qinwen Mao, Margaret E Flanagan, Hui Zhang, Rudolph Castellani, Eileen H Bigio, M-Marsel Mesulam, Changiz Geula, Tamar Gefe. Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with TDP-43. Annals of neurology. 2023-08-18. PMID:37592884. |
here, we investigated neuronal integrity and pathologic burden of tdp-43 and tau along the well-charted trisynaptic hippocampal circuit [dentate gyrus (dg), ca3, and ca1] in participants with amnestic dementia due to ad/tdp, amnestic dementia due to ad alone, or non-amnestic dementia due to tdp-43 proteinopathy associated with frontotemporal lobar degeneration (ftld-tdp). |
2023-08-18 |
2023-09-07 |
human |
| Xue Wang, Ya-Jin Shi, Ting-Yuan Niu, Ting-Ting Chen, Han-Bing Li, Su-Hui Wu, Gen-Lin L. Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats. Neuroscience letters. 2023-08-14. PMID:37579868. |
ppd significantly reduced the cerebral infarction area and the activation of microglia in the cortex and hippocampal dg, ca1, and ca3 area. |
2023-08-14 |
2023-09-07 |
rat |
| Xue Wang, Ya-Jin Shi, Ting-Yuan Niu, Ting-Ting Chen, Han-Bing Li, Su-Hui Wu, Gen-Lin L. Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats. Neuroscience letters. 2023-08-14. PMID:37579868. |
ppd also significantly alleviated the neurotoxicity by decreasing the aβ and p-tau in hippocampal dg, ca1, and ca3 areas. |
2023-08-14 |
2023-09-07 |
rat |
| Tsvetomira Atanasova, Tiina Savonlehto, Tiina-Kaisa Kukko-Lukjanov, Zoia Kharybina, Wei-Chih Chang, Sari E Lauri, Tomi Tair. Progressive development of synchronous activity in the hippocampal neuronal network is modulated by GluK1 kainate receptors. Neuropharmacology. 2023-08-11. PMID:37567438. |
correlation analysis indicated that local knockdown of gluk1 locally in the ca3 neurons reduced their functional connectivity, while gluk1 overexpression increased the connectivity to both ca1 and dg. |
2023-08-11 |
2023-08-16 |
Not clear |
| Ting Wang, Yun-Qiang Zhou, Yong Wang, Liang Zhang, Xiang Zhu, Xiu-Yan Wang, Jing-Hui Wang, Lin-Kun Han, Jian Meng, Xian Zhang, Hong Luo, Qi-Lin Ma, Zhan-Xiang Wang, Yun-Wu Zhan. Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer's disease. Zoological research. vol 44. issue 5. 2023-08-03. PMID:37537141. |
herein, we induced ltp in the hippocampal ca1 region of wild-type (wt) and ad model mice by administering hfs to the ca3 region and then studied transcriptome changes in the ca1 region. |
2023-08-03 |
2023-08-14 |
mouse |
| Yuki Takeuchi, Kotaro Yamashiro, Asako Noguchi, Jiayan Liu, Shinichi Mitsui, Yuji Ikegaya, Nobuyoshi Matsumot. Machine learning-based segmentation of the rodent hippocampal CA2 area from Nissl-stained sections. Frontiers in neuroanatomy. vol 17. 2023-07-15. PMID:37449243. |
this region is divided into the ca1, ca2, and ca3 areas, which are anatomically different from each other. |
2023-07-15 |
2023-08-14 |
mouse |
| Saif A Alharthy, Torki A Zughaibi, Puneet Vij, Shams Tabrez, Majed N Almashjary, Sarah Alharthi, Turki Alamri, Badra S Alghamdi, Steve Harakeh, Sheren A Azhari, Reem M Farsi, Hanan S Althagafy, Emad H M Hassanei. Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals. Toxicology mechanisms and methods. 2023-07-05. PMID:37403423. |
compared to cd control rats, mzp attenuated histological abrasions in the cerebral cortex and ca1 and ca3 regions of the hippocampus as well as the dentate gyrus. |
2023-07-05 |
2023-08-14 |
human |
| Walaa Slouma Hamouda Abd El Naby, Cai Zong, Alzahraa Fergany, Frederick Adams Ekuban, Saleh Ahmed, Yousra Reda, Harue Sato, Sahoko Ichihara, Natsuko Kubota, Shinya Yanagita, Gaku Ichihar. Exposure to Benzo[a]pyrene Decreases Noradrenergic and Serotonergic Axons in Hippocampus of Mouse Brain. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373040. |
the density of noradrenergic and serotonergic axons was evaluated by immunohistochemistry in the hippocampal ca1 and ca3 areas. |
2023-06-28 |
2023-08-14 |
mouse |
| Walaa Slouma Hamouda Abd El Naby, Cai Zong, Alzahraa Fergany, Frederick Adams Ekuban, Saleh Ahmed, Yousra Reda, Harue Sato, Sahoko Ichihara, Natsuko Kubota, Shinya Yanagita, Gaku Ichihar. Exposure to Benzo[a]pyrene Decreases Noradrenergic and Serotonergic Axons in Hippocampus of Mouse Brain. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373040. |
exposure to b[a]p at 2.88 µg/mice or more decreased the density of noradrenergic or serotonergic axons in the ca1 area and the density of noradrenergic axons in the ca3 area in the hippocampus of mice. |
2023-06-28 |
2023-08-14 |
mouse |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
the major findings included: (1) hfd alone had minimal effect with no consistent pattern or interaction between the markers, (2) e-vapour (± nicotine) predominantly affected the ca2 subregion, decreasing α7 and β2 nachr subunits and iba-1, (3) nicotine e-vapour increased tunel across all subregions, and (4) hfd, in the presence of nicotine-free e-vapour, decreased caspase-3 and increased tunel across all regions, and decreased iba-1 in the ca subregions, while hfd and nicotine-containing e-vapour, subregion specifically affected the α3, α4 and α7 nachr subunits, with a protective effect against change in gfap in the dg and iba-1 in the ca1 and ca3. |
2023-06-21 |
2023-08-14 |
mouse |
| Emma J Diethorn, Elizabeth Goul. Development of the hippocampal CA2 region and the emergence of social recognition. Developmental neurobiology. 2023-06-16. PMID:37326250. |
we also consider the connectivity of the ca2 with other brain areas, including intrahippocampal regions, such as the dentate gyrus, ca3, and ca1 regions, and extrahippocampal regions, such as the hypothalamus, ventral tegmental area, basal forebrain, raphe nuclei, and the entorhinal cortex. |
2023-06-16 |
2023-08-14 |
mouse |
| Xiaoxiao Lin, Neeyaz Cyrus, Brenda Avila, Todd C Holmes, Xiangmin X. Hippocampal CA3 inhibitory neurons receive extensive noncanonical synaptic inputs from CA1 and subicular complex. The Journal of comparative neurology. 2023-06-14. PMID:37312626. |
in the present study, we have applied monosynaptic retrograde viral tracing to examine noncanonical synaptic inputs from ca1 and subicular complex to the inhibitory neuron in hippocampal ca3. |
2023-06-14 |
2023-08-14 |
Not clear |
| Siqi Peng, Wenzhen Gu, Wenxiu Zhu, Yan Zhuang, Xiuqi Yang, Yaochen Lv, Sibie Meng, Wei Xie, Moyi L. A new AAV tool for highly preferentially targeting hippocampal CA2. Molecular brain. vol 16. issue 1. 2023-06-11. PMID:37303064. |
mice hippocampus contains three prominent subregions, ca1, ca3 and dg and is well regarded as an essential multiple task processor for learning, memory and cognition based on tremendous studies on these three subregions. |
2023-06-11 |
2023-08-14 |
mouse |
| Siqi Peng, Wenzhen Gu, Wenxiu Zhu, Yan Zhuang, Xiuqi Yang, Yaochen Lv, Sibie Meng, Wei Xie, Moyi L. A new AAV tool for highly preferentially targeting hippocampal CA2. Molecular brain. vol 16. issue 1. 2023-06-11. PMID:37303064. |
the narrow region sandwiched between ca1 and ca3 called ca2 has been neglected for a long time. |
2023-06-11 |
2023-08-14 |
mouse |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
silent information regulator 1 (sirt1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa b (nf-κb), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β)), gene expression in the nucleus accumben (nac) and ca1 region of the hippocampus (e.g., nescient helix-loop-helix2 (nhlh2), monoamine oxidase (mao-a), and 5-hydroxyindole-3-acetic acid (5-hiaa)), and neuronal regeneration in the ca3 region of the hippocampus. |
2023-05-27 |
2023-08-14 |
Not clear |
| Ricardo Insausti, Monica Muñoz-López, Ana Maria Insaust. The CA2 hippocampal subfield in humans: A review. Hippocampus. 2023-05-19. PMID:37204159. |
the location and distinctiveness of ca2 is presented in relation with ca3 and ca1, based in a total of 23 human control cases serially sectioned throughout the whole longitudinal axis of the hippocampus, examined every 500 μm in nissl-stained sections. |
2023-05-19 |
2023-08-14 |
human |
| Charlene B Farmer, Erica L Roach, Lily R Bice, Madeleine E Falgout, Kattia G Mata, Joy K Roche, Rosalinda C Robert. Excitatory and inhibitory imbalances in the trisynaptic pathway in the hippocampus in schizophrenia: a postmortem ultrastructural study. Journal of neural transmission (Vienna, Austria : 1996). 2023-05-16. PMID:37193867. |
compared to controls, the schizophrenia group had decreased numbers of inhibitory synapses in ca3 and increased numbers of excitatory synapses in ca1; together, this indicates deficits in inhibition and an increase in excitation. |
2023-05-16 |
2023-08-14 |
Not clear |
| Rebecca A Piskorowski, Vivien Chevaleyr. Hippocampal area CA2: interneuron disfunction during pathological states. Frontiers in neural circuits. vol 17. 2023-05-15. PMID:37180763. |
hippocampal area ca2 plays a critical role in social recognition memory and has unique cellular and molecular properties that distinguish it from areas ca1 and ca3. |
2023-05-15 |
2023-08-14 |
mouse |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
significant neuronal cell death occurred in the ca3 and ca4 regions, and to a lesser extent, in the ca1 and ca2 regions. |
2023-05-14 |
2023-08-14 |
rat |
| Mohammadmehdi Hadipour, Soheila Refahi, Zohreh Jangravi, Gholam Hossein Meftah. Tarooneh extract relieves anxiety-like behaviors and cognitive deficits by inhibiting synaptic loss in the hippocampus and frontal cortex in rats subjected to chronic restraint stress. 3 Biotech. vol 13. issue 5. 2023-05-08. PMID:37152003. |
in this study, we evaluated the protective effects of tarooneh in the anxiety-like behavior, cognitive deficit, and neuronal damages in the ca1, ca3, and dentate gyrus (dg) regions of the hippocampus and frontal cortex neurons employing a rat model of chronic restraint stress. |
2023-05-08 |
2023-08-14 |
rat |