| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khodadad Namiranian, Christa D Brink, Jerry Clay Goodman, Claudia S Robertson, Robert M Brya. Traumatic brain injury in mice lacking the K channel, TREK-1. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 3. 2011-04-27. PMID:21157470. |
laser doppler perfusion (ldp) decreased by ∼80% in the injured cortex and remained at that level in both wt and trek-1 ko mice (n=10 and 11, respectively). |
2011-04-27 |
2023-08-12 |
mouse |
| Yue Zhang, Raelene Listhrop, Carolyn M Ecelbarger, Bellamkonda K Kishor. Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed a high-NaCl diet with/without aldosterone infusion. American journal of physiology. Renal physiology. vol 300. issue 3. 2011-04-20. PMID:21190950. |
clamping aldosterone (with hsd) led to significantly impaired natriuresis with elevated na/h exchanger isoform 3 in the cortex, and nkcc2 in the medulla, and modest but significantly lower levels of nkcc2, and α- and β-enac in the cortex of ko vs. wt mice. |
2011-04-20 |
2023-08-12 |
mouse |
| Shuzo Hamamoto, Shintaro Nomura, Takahiro Yasui, Atsushi Okada, Masahiro Hirose, Hideo Shimizu, Yasunori Itoh, Keiichi Tozawa, Kenjiro Kohr. Effects of impaired functional domains of osteopontin on renal crystal formation: Analyses of OPN transgenic and OPN knockout mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 25. issue 12. 2011-03-02. PMID:19453257. |
in the wt group, crystal deposits increased gradually at the renal corticomedullary junction in an orderly fashion, whereas those in the ko group were observed sporadically in the renal cortex. |
2011-03-02 |
2023-08-12 |
mouse |
| Carlos J Ballester-Rosado, Michael J Albright, Chia-Shan Wu, Chun-Chieh Liao, Jie Zhu, Jian Xu, Li-Jen Lee, Hui-Chen L. mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159961. |
in the s1 cortex of cortical-mglur5 ko, layer iv neurons are homogenously distributed and have no clear relationship to the location of tca clusters. |
2011-02-09 |
2023-08-12 |
mouse |
| Carole Mathis, Aileen Schröter, Michaela Thallmair, Martin E Schwa. Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 10. 2010-12-28. PMID:20093372. |
at e17.5, the normal transient accumulation of radially migrating precursors within the subventricular zone was not detectable in the nogo-a ko mouse cortex. |
2010-12-28 |
2023-08-12 |
mouse |
| M Lee Haselkorn, David K Shellington, Edwin K Jackson, Vincent A Vagni, Keri Janesko-Feldman, Raghvendra K Dubey, Delbert G Gillespie, Dongmei Cheng, Michael J Bell, Larry W Jenkins, Gregg E Homanics, Jurgen Schnermann, Patrick M Kochane. Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice. Journal of neurotrauma. vol 27. issue 5. 2010-12-14. PMID:20121416. |
a(1)ar ko mice exhibited enhanced microglial response; specifically, iba-1 + microglia were increased 20-50% more in a(1)ar ko versus wt in ipsilateral cortex, ca3, and thalamus, and contralateral cortex, ca1, and thalamus (p < 0.05). |
2010-12-14 |
2023-08-12 |
mouse |
| Michael W Brands, Amy K L Banes-Berceli, Edward W Inscho, Hind Al-Azawi, Ashlyn J Allen, Hicham Labaz. Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation. Hypertension (Dallas, Tex. : 1979). vol 56. issue 5. 2010-11-10. PMID:20921429. |
phosphorylation of janus kinase 2 and signal transducer and activator of transcription 3 in renal cortex homogenates increased significantly in ang ii-infused wt mice, and that effect was prevented completely in ang ii-infused il-6 ko mice. |
2010-11-10 |
2023-08-12 |
mouse |
| Tiina-Kaisa Kukko-Lukjanov, Minnamaija Lintunen, Niina Jalava, Hanna B Laurén, Francisco R Lopez-Picon, Kimmo A Michelsen, Pertti Panula, Irma E Holopaine. Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice. Epilepsy research. vol 90. issue 1-2. 2010-09-27. PMID:20359868. |
moreover, neuronal damage correlated with seizure severity, and it was significantly increased in the thalamus and retrosplenial granular cortex (rgc) of the ko mice. |
2010-09-27 |
2023-08-12 |
mouse |
| Andreas R Pfenning, Tae-Kyung Kim, James M Spotts, Martin Hemberg, Dan Su, Anne E Wes. Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. PloS one. vol 5. issue 5. 2010-09-07. PMID:20523734. |
finally we demonstrate that expression of a subset of these target genes is altered in the cortex of carf knockout (ko) mice. |
2010-09-07 |
2023-08-12 |
mouse |
| R Kenneth Czambel, Alexander Kharlamov, Stephen C Jone. Variations of brain endothelial nitric oxide synthase concentration in rat and mouse cortex. Nitric oxide : biology and chemistry. vol 22. issue 1. 2010-09-02. PMID:19948238. |
optimization of the kit elisa procedure using brain cortex homogenates from 3 normotensive rats and 1 wild-type and 1 enos(-/-) (ko) mouse included recovery evaluation for each sample and the use of an "enos-free" homogenate calibrator diluent obtained from a mutant enos-ko mouse. |
2010-09-02 |
2023-08-12 |
mouse |
| Tomoko Yoneyama-Sarnecky, Andrea D Olivas, Soraya Azari, Donna M Ferriero, Hovhannes M Manvelyan, Linda J Noble-Haeusslei. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Developmental neuroscience. vol 32. issue 1. 2010-07-09. PMID:20389079. |
nonheme iron preferentially accumulated in the ipsilateral cortex, hippocampus, and external capsule in both wt and ko brain-injured genotypes. |
2010-07-09 |
2023-08-12 |
mouse |
| Kelli A McDowell, Ashley N Hutchinson, Sarah J E Wong-Goodrich, Matthew M Presby, Dan Su, Ramona M Rodriguiz, Krystal C Law, Christina L Williams, William C Wetsel, Anne E Wes. Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 22. 2010-06-21. PMID:20519520. |
intriguingly, carf ko mice have selectively reduced expression of bdnf exon iv-containing mrna transcripts and bdnf protein in the cerebral cortex, whereas bdnf levels in the hippocampus and striatum remain unchanged, implicating carf as a brain region-selective regulator of bdnf expression. |
2010-06-21 |
2023-08-12 |
mouse |
| Ikuo Matsuda, Masahiro Fukaya, Harumi Nakao, Kazuki Nakao, Hideyuki Matsumoto, Kensaku Mori, Masahiko Watanabe, Atsu Aib. Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice. Neuroscience research. vol 66. issue 3. 2010-06-07. PMID:20006658. |
the barrel structure of the somatosensory cortex and the cerebellar neuroanatomy were not significantly altered in sema3f ko. |
2010-06-07 |
2023-08-12 |
mouse |
| Chengwen Zhou, Frances E Jensen, Nikolaus J Suche. Altered development of glutamatergic synapses in layer V pyramidal neurons in NR3A knockout mice. Molecular and cellular neurosciences. vol 42. issue 4. 2010-03-30. PMID:19782137. |
here we show that in the second postnatal week, layer v pyramidal neurons in the somatosensory cortex of wild type (wt) mice exhibited evoked excitatory postsynaptic currents (eepscs) with 3- to 6-fold lower mg2+ sensitivity than nr3a knockout (ko) mice and their reversal potential was approximately 2 mv more negative compared to ko mice consistent with decreased p(ca) of nmdars. |
2010-03-30 |
2023-08-12 |
mouse |
| Margery C Beinfeld, Lydiane Funkelstein, Thierry Foulon, Sandrine Cadel, Kouki Kitagawa, Thomas Toneff, Thomas Reinheckel, Christoph Peters, Vivian Hoo. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. vol 30. issue 10. 2010-02-01. PMID:19589362. |
in cathepsin l knockout (ko) mice, cck8 levels were substantially reduced in brain cortex by an average of 75%. |
2010-02-01 |
2023-08-12 |
mouse |
| Wei-Chi She, Charles Quairiaux, Michael J Albright, Yu-Chi Wang, Denisse E Sanchez, Poh-Shing Chang, Egbert Welker, Hui-Chen L. Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway. The European journal of neuroscience. vol 29. issue 7. 2009-08-27. PMID:19519626. |
we have therefore demonstrated that mglur5 is required for synaptic function/plasticity at tc synapses as barrels are forming, and we propose that these functional alterations at the tc synapse are the basis of the abnormal anatomical and functional development of the somatosensory cortex in the mglur5 ko mouse. |
2009-08-27 |
2023-08-12 |
mouse |
| Nobuki Nakanishi, Shichun Tu, Yeonsook Shin, Jiankun Cui, Toru Kurokawa, Dongxian Zhang, H-S Vincent Chen, Gary Tong, Stuart A Lipto. Neuroprotection by the NR3A subunit of the NMDA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 16. 2009-05-22. PMID:19386922. |
in vivo, neonatal, but not adult, wt mice contain nr3a in the cortex, and neonatal nr3a ko mice manifested more damage than wt after hypoxia-ischemia. |
2009-05-22 |
2023-08-12 |
mouse |
| K R Drasbek, I Vardya, M Delenclos, K M Gibson, K Jense. SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex. Journal of inherited metabolic disease. vol 31. issue 6. 2009-04-24. PMID:18696252. |
here, we used brain slice electrophysiology to investigate the alterations in gaba neurotransmission in ssadh ko mouse cortex. |
2009-04-24 |
2023-08-12 |
mouse |
| Wei Li, Shuangshuang Dai, Jianhong An, Renping Xiong, Ping Li, Xingyun Chen, Yan Zhao, Ping Liu, Hua Wang, Peifang Zhu, Jiangfan Chen, Yuanguo Zho. Genetic inactivation of adenosine A2A receptors attenuates acute traumatic brain injury in the mouse cortical impact model. Experimental neurology. vol 215. issue 1. 2009-04-08. PMID:18938161. |
consistent with the behavioral changes, the brain water contents as well as histological changes and the tunel-positive cells of the injured cortex of the ko mice were significantly lower than that of wt littermates. |
2009-04-08 |
2023-08-12 |
mouse |
| Régis Grailhe, Ana Cardona, Naïla Even, Isabelle Seif, Jean-Pierre Changeux, Isabelle Cloëz-Tayaran. Regional changes in the cholinergic system in mice lacking monoamine oxidase A. Brain research bulletin. vol 78. issue 6. 2009-03-13. PMID:19111597. |
a twofold increase in [(3)h]-hemicholinium-3 ([(3)h]-hc-3) binding to cht1 was observed in the caudate putamen, nucleus accumbens, and motor cortex in maoa ko mice as compared with wild-type (wt) mice. |
2009-03-13 |
2023-08-12 |
mouse |