| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C L Wellman, A Izquierdo, J E Garrett, K P Martin, J Carroll, R Millstein, K-P Lesch, D L Murphy, A Holme. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 3. 2007-02-06. PMID:17234600. |
we used a 5-htt knock-out (ko) mouse to examine the effects of genetically driven loss of 5-htt function for the following: (1) depression-related behavior in response to repeated stress, and pavlovian fear conditioning, extinction, and extinction recall; and (2) dendritic morphology and spine density of golgi-stained pyramidal neurons in the infralimbic cortex (il) and the basolateral amygdala (bla). |
2007-02-06 |
2023-08-12 |
mouse |
| Yuri Ikeda-Matsuo, Azusa Ota, Tetsuya Fukada, Satoshi Uematsu, Shizuo Akira, Yasuharu Sasak. Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 31. 2006-10-25. PMID:16864802. |
in mpges-1 knockout (ko) mice, in which the postischemic pge(2) production in the cortex was completely absent, the infarction, edema, apoptotic cell death, and caspase-3 activation in the cortex after ischemia were all reduced compared with those in wild-type (wt) mice. |
2006-10-25 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
in hippocampus and cortex, 5-ht1b agonists decreased and antagonists increased 5-ht release in wt, but not in 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
our data (i) confirm the absence of autoinhibition of 5-ht release in 5-ht1b-ko mice, (ii) demonstrate a reduced release of ach, and the absence of 5-ht1b-receptor-mediated inhibition of ach release, in the hippocampus and cortex of 5-ht1b-ko mice, and (iii) are compatible with an indirect role of cortical ach in the working memory impairment observed in these ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Milena Penkowa, Laura Tio, Mercedes Giralt, Albert Quintana, Amalia Molinero, Silvia Atrian, Milan Vasák, Juan Hidalg. Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury. Journal of neuroscience research. vol 83. issue 6. 2006-07-13. PMID:16493670. |
to gain insight in this regard, we have evaluated whether a distant, most likely single-domain mt (drosophila mtn) functions similarly to mammalian mt-i&ii (recombinant mouse mt-i and human mt-iia and native rabbit mt-ii) after cryogenic injury to the cortex in mt1&2 ko mice. |
2006-07-13 |
2023-08-12 |
mouse |
| Tae Gen Son, Yani Zou, Kyung Jin Jung, Byung Pal Yu, Akihito Ishigami, Naoki Maruyama, Jaewon Le. SMP30 deficiency causes increased oxidative stress in brain. Mechanisms of ageing and development. vol 127. issue 5. 2006-06-23. PMID:16500693. |
the increased oxidative status in these mice was further confirmed by increased oxidatively modified proteins such as dityrosine formation and carbonylation in the cortex of smp30 ko mice. |
2006-06-23 |
2023-08-12 |
mouse |
| Ruth F Watson, Raja M Abdel-Majid, Mark W Barnett, Brandon S Willis, Alla Katsnelson, Thomas H Gillingwater, G Stanley McKnight, Peter C Kind, Paul E Neuman. Involvement of protein kinase A in patterning of the mouse somatosensory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 20. 2006-06-08. PMID:16707791. |
mice lacking riibeta show reduced glutamate receptor a (glura) subunit insertion into the postsynaptic density in postnatal day 7 somatosensory cortex; however, glura ko mice developed normal barrels. |
2006-06-08 |
2023-08-12 |
mouse |
| Christopher W Tyler, Lora T Likova, Leonid L Kontsevich, Alex R Wad. The specificity of cortical region KO to depth structure. NeuroImage. vol 30. issue 1. 2006-05-26. PMID:16356738. |
functional mri studies have identified a cortical region designated as ko between retinotopic areas v3a/b and motion area v5 in human cortex as particularly responsive to motion-defined or kinetic borders. |
2006-05-26 |
2023-08-12 |
human |
| J G Dubroff, R T Stevens, J Hitt, C J Hodge, J S McCaslan. Anomalous functional organization of barrel cortex in GAP-43 deficient mice. NeuroImage. vol 29. issue 4. 2006-05-17. PMID:16309923. |
we found clear foci of activation in gap-43 ko cortex in response to single-whisker stimulation. |
2006-05-17 |
2023-08-12 |
mouse |
| Albert Quintana, Mercedes Giralt, Santiago Rojas, Milena Penkowa, Iain L Campbell, Juan Hidalgo, Amalia Moliner. Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. Journal of neuroscience research. vol 82. issue 5. 2006-04-28. PMID:16267827. |
in this work, the inflammatory response after a freeze injury (cryolesion) in the cortex was studied in wild-type (wt) animals and in mice lacking tnfr1 (tnfr1 ko) or tnfr2 (tnfr2 ko). |
2006-04-28 |
2023-08-12 |
mouse |
| S M A Rahman, A-M Van Dam, M Schultzberg, M Crisb. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. Journal of neuroimmunology. vol 169. issue 1-2. 2006-01-25. PMID:16198427. |
the density of il-6-positive cells was increased in the hippocampus (p<0.0001) and the dorsal part of the cortex (p<0.001) of ko and wt mice on hc diet (kohc and wthc mice, respectively) compared to ko and wt mice on nd (kond and wtnd mice, respectively). |
2006-01-25 |
2023-08-12 |
mouse |
| S M A Rahman, A-M Van Dam, M Schultzberg, M Crisb. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. Journal of neuroimmunology. vol 169. issue 1-2. 2006-01-25. PMID:16198427. |
there was a major increase in caspase-1 immunoreactivity and cell density in both the dosal part of the cortex (p<0.001) and the lateral part of the cortex (p<0.005) in ko and wt mice on hc diet compared to nd. |
2006-01-25 |
2023-08-12 |
mouse |
| Avron D Spier, Véronique Fabre, Luis de Lece. Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain. Regulatory peptides. vol 124. issue 1-3. 2005-10-06. PMID:15544857. |
in somatostatin receptor subtype-2 knock-out (ko) mice, autoradiographic iodinated somatostatin-14 binding was observed in the hippocampus and habenula but was removed in the cortex and amygdaloid nuclei, specific iodinated cortistatin-14 binding sites were found in the hippocampus, habenula and throughout the cortex. |
2005-10-06 |
2023-08-12 |
mouse |
| H Kitano, H Nishimura, H Tachibana, H Yoshikawa, T Matsuyam. ORP150 ameliorates ischemia/reperfusion injury from middle cerebral artery occlusion in mouse brain. Brain research. vol 1015. issue 1-2. 2004-10-15. PMID:15223375. |
to determine the role of orp150 in cerebral infarction following ischemia/reperfusion, orp150 transgenic (tg) and knockout (ko) mice were subjected to 1 or 3 h of middle cerebral artery (mca) occlusion followed by reperfusion for 24 h. at 24 h after 1 h of occlusion, significantly less infarct volume was evident in cerebral cortex, but not in striatum, in orp150tg than orp150ko mice (p<0.001). |
2004-10-15 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
pieces of atria, vasa deferentia, the occipito-parietal cortex and the hippocampus were prepared from either wildtype (wt) mice or mice in which both the alpha(2a)- and the alpha(2c)-adrenoceptor gene had been disrupted (alpha(2ac)ko). |
2004-06-17 |
2023-08-12 |
mouse |
| J A Gorski, S A Balogh, J M Wehner, K R Jone. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience. vol 121. issue 2. 2003-12-19. PMID:14521993. |
early-onset forebrain-restricted bdnf mutant mice (emx-bdnf(ko)) that develop in the absence of bdnf in the dorsal cortex, hippocampus, and parts of the ventral cortex and amygdala failed to learn the morris water maze task, a hippocampal-dependent visuo-spatial learning task. |
2003-12-19 |
2023-08-12 |
mouse |
| Zoltán Molnár, Shuji Higashi, Guillermina López-Bendit. Choreography of early thalamocortical development. Cerebral cortex (New York, N.Y. : 1991). vol 13. issue 6. 2003-07-01. PMID:12764042. |
regardless of their altered route, thalamic afferents in the reeler and l1 ko mice seem to be able to redistribute themselves on the cortical sheet and establish normal periphery-related representation in the somatosensory cortex. |
2003-07-01 |
2023-08-12 |
mouse |
| E M Jagoda, D O Kiesewetter, K Shimoji, L Ravasi, M Yamada, J Gomeza, J Wess, W C Eckelma. Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668051. |
using ex vivo autoradiography, the regional brain localization of [(18)f]fp-tztp in m2 knockout (m2 ko) was significantly decreased (51.3 to 61.4%; p<0.01) when compared to the wild-type (wt) mice in amygdala, brain stem, caudate putamen, cerebellum, cortex, hippocampus, hypothalamus, superior colliculus, and thalamus. |
2003-06-23 |
2023-08-12 |
mouse |
| Edward F Chang, Ronald J Wong, Hendrik J Vreman, Takuji Igarashi, Ethel Galo, Frank R Sharp, David K Stevenson, Linda J Noble-Haeusslei. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736340. |
cell loss was significantly greater in ko mice in areas including the cortex, the ca3 region of hippocampus, and the lateral dorsal thalamus. |
2003-06-19 |
2023-08-12 |
mouse |
| Zhong Chen, Zhengyan Li, Eiko Sakurai, Jalal Izadi Mobarakeh, Hiroshi Ohtsu, Takeshi Watanabe, Takehiko Watanabe, Kazuie Iinuma, Kazuhiko Yana. Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice. Brain research. vol 968. issue 1. 2003-06-04. PMID:12644274. |
the daily ptz-kindling increased histamine content in the cortex and diencephalon of h(1)ko mice, whereas the histamine content in the diencephalon of w/w(v) mice was decreased. |
2003-06-04 |
2023-08-12 |
mouse |