| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Lonart, X Tang, F Simsek-Duran, M Machida, L D Sanfor. The role of active zone protein Rab3 interacting molecule 1 alpha in the regulation of norepinephrine release, response to novelty, and sleep. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18495360. |
this difference in exploratory behavior correlated with genotype specific changes in rem and deregulated release of norepinephrine in the cortex and basal amygdala of the rim1 alpha ko mice. |
2008-08-29 |
2023-08-12 |
mouse |
| Lesley M Foley, T Kevin Hitchens, John A Melick, Hülya Bayir, Chien Ho, Patrick M Kochane. Effect of inducible nitric oxide synthase on cerebral blood flow after experimental traumatic brain injury in mice. Journal of neurotrauma. vol 25. issue 4. 2008-07-10. PMID:18373480. |
regional assessment of cbf at 72 h after injury demonstrated that recovery of cbf was reduced in the ipsilateral hippocampus, thalamus, and amygdala/piriform cortex in inos ko versus wt mice by 26%, 15%, and 21%, respectively; this attenuated recovery was restricted to structures outside the contusion. |
2008-07-10 |
2023-08-12 |
mouse |
| Ingrid Bureau, Gordon M G Shepherd, Karel Svobod. Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 20. 2008-06-19. PMID:18480274. |
although defects in synaptic plasticity in the cerebral cortex have been linked to cognitive impairments in fmr1 knock-out (ko) mice, the specific cortical circuits affected in the syndrome are unknown. |
2008-06-19 |
2023-08-12 |
mouse |
| Luca Bragina, Ivan Marchionni, Azar Omrani, Andrea Cozzi, Domenico E Pellegrini-Giampietro, Enrico Cherubini, Fiorenzo Cont. GAT-1 regulates both tonic and phasic GABA(A) receptor-mediated inhibition in the cerebral cortex. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18248614. |
these studies show that in the cerebral cortex of gat-1 ko mice gat-3 is not redistributed and gads are adaptively changed and indicate that gat-1 has a prominent role in both tonic and phasic gaba(a)r-mediated inhibition, in particular during sustained neuronal activity. |
2008-06-12 |
2023-08-12 |
mouse |
| Swasti Tiwari, Nikhil Sharma, Pritmohinder S Gill, Peter Igarashi, C Ronald Kahn, James B Wade, Carolyn M A Ecelbarge. Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 17. 2008-05-22. PMID:18424559. |
ko mice expressed significantly lower levels of ir mrna and protein in kidney cortex (49-56% of the wt) and medulla (32-47%) homogenates. |
2008-05-22 |
2023-08-12 |
mouse |
| Era Taoufik, Edwige Petit, Didier Divoux, Vivian Tseveleki, Manuela Mengozzi, Michael L Roberts, Samuel Valable, Pietro Ghezzi, John Quackenbush, Michael Brines, Anthony Cerami, Lesley Prober. TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 16. 2008-05-12. PMID:18413601. |
in the present study, we investigated the molecular mechanisms by which tnf receptor (tnfr)i mediates neuroprotection by comparing the gene expression profiles of lesioned cortex from wt and tnfri ko mice after permanent middle cerebral artery occlusion. |
2008-05-12 |
2023-08-12 |
mouse |
| Stacy L Donovan, James S McCaslan. GAP-43 is critical for normal targeting of thalamocortical and corticothalamic, but not trigeminothalamic axons in the whisker barrel system. Somatosensory & motor research. vol 25. issue 1. 2008-04-29. PMID:18344146. |
ko tcas showed delays of 1-2 days in initial ingrowth to cortex. |
2008-04-29 |
2023-08-12 |
mouse |
| Stacy L Donovan, James S McCaslan. GAP-43 is critical for normal targeting of thalamocortical and corticothalamic, but not trigeminothalamic axons in the whisker barrel system. Somatosensory & motor research. vol 25. issue 1. 2008-04-29. PMID:18344146. |
thus, the establishment of axonal projections between thalamus and cortex are disrupted in gap-43 ko mice. |
2008-04-29 |
2023-08-12 |
mouse |
| Hai-Ying Shen, Joana E Coelho, Nobuhisa Ohtsuka, Paula M Canas, Yuan-Ji Day, Qing-Yuan Huang, Nelson Rebola, Liqun Yu, Detlev Boison, Rodrigo A Cunha, Joel Linden, Joe Z Tsien, Jiang-Fan Che. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354001. |
in contrast to fb-a(2a)r ko (deleting a(2a)rs in the neurons of striatum as well as cerebral cortex and hippocampus), st-a(2a)r ko mice exhibited cre-mediated selective deletion of the a(2a)r gene, mrna, and proteins in the neurons (but not astrocytes and microglial cells) of the striatum only. |
2008-04-25 |
2023-08-12 |
mouse |
| Stéphanie Weiss, Marika Nosten-Bertrand, J Michael McIntosh, Bruno Giros, Marie-Pascale Martre. Nicotine improves cognitive deficits of dopamine transporter knockout mice without long-term tolerance. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17375139. |
we speculate that the procognitive effects of nicotine in dat ko mice are related to the upregulation of alpha7 nicotinic receptors in the hippocampus, amygdala, and prelimbic cortex, all areas involved in cognition. |
2008-02-14 |
2023-08-12 |
mouse |
| Hirokazu Fukui, Francisca Diaz, Sofia Garcia, Carlos T Morae. Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 35. 2007-10-17. PMID:17715058. |
these ko mice showed an age-dependent cox deficiency in the cerebral cortex and hippocampus. |
2007-10-17 |
2023-08-12 |
mouse |
| Jackson Souza-Menezes, Marcelo M Morales, Deepali N Tukaye, Sandra E Guggino, William B Guggin. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 5. 2007-09-27. PMID:17762172. |
also, we have shown by western blot analysis that expression of megalin is lower in the renal cortex of ko mice when compared to wt mice (n=3, p<0.05). |
2007-09-27 |
2023-08-12 |
mouse |
| D R Deng, S Djalali, M Höltje, G Grosse, T Stroh, I Voigt, H Kusserow, F Theuring, G Ahnert-Hilger, H Hörtnag. Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants. Neuroscience. vol 147. issue 2. 2007-09-18. PMID:17543467. |
however, the establishment of serotonergic projections to the mesencephalic tegmentum and hypothalamus was delayed at e12.5 in ko and oe animals and projections to the cerebral cortex between e16.5 and e18.5 were delayed in oe mice. |
2007-09-18 |
2023-08-12 |
mouse |
| D R Deng, S Djalali, M Höltje, G Grosse, T Stroh, I Voigt, H Kusserow, F Theuring, G Ahnert-Hilger, H Hörtnag. Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants. Neuroscience. vol 147. issue 2. 2007-09-18. PMID:17543467. |
moreover, oe mice caught up with wt and ko animals postnatally such that at p1.5 serotonergic innervation of the cortex was more extensive in the oe than in ko and wt mice. |
2007-09-18 |
2023-08-12 |
mouse |
| Grisha Pirianov, Katarina G Brywe, Carina Mallard, A David Edwards, Richard A Flavell, Henrik Hagberg, Huseyin Mehme. Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 27. issue 5. 2007-05-22. PMID:17063149. |
significant attenuation of injury was observed in the cerebral cortex, hippocampus, striatum, and thalamus of jnk3 ko compared with wt mice. |
2007-05-22 |
2023-08-12 |
mouse |
| Chunxia Li, Wenze Niu, Cecilia H Jiang, Yinghe H. Effects of enriched environment on gene expression and signal pathways in cortex of hippocampal CA1 specific NMDAR1 knockout mice. Brain research bulletin. vol 71. issue 6. 2007-04-23. PMID:17292799. |
to understand the molecular mechanisms of the memory impairments in the nmdar1-ko mice, we have examined gene expression profiles in cortex from the receptor ko mice compared to wild type mice. |
2007-04-23 |
2023-08-12 |
mouse |
| Chunxia Li, Wenze Niu, Cecilia H Jiang, Yinghe H. Effects of enriched environment on gene expression and signal pathways in cortex of hippocampal CA1 specific NMDAR1 knockout mice. Brain research bulletin. vol 71. issue 6. 2007-04-23. PMID:17292799. |
furthermore, since memory deficits were rescued after exposure of the nmdar1-ko mice to enriched environment, we also analyzed the gene expression in the cortex of the ko mice after 3 hours, 2 days and 2 weeks enrichment. |
2007-04-23 |
2023-08-12 |
mouse |
| Léa Stankovski, Chantal Alvarez, Tanja Ouimet, Tania Vitalis, Khalid H El-Hachimi, David Price, Evan Deneris, Patricia Gaspar, Olivier Case. Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 6. 2007-03-06. PMID:17287506. |
caspase-3 and -9 are over activated in the vmat2 ko cortex and bcl-x(l) is downregulated, whereas the apoptosis-inducing factor caspase-8 and fasl/fasr pathway are not involved. |
2007-03-06 |
2023-08-12 |
mouse |
| Léa Stankovski, Chantal Alvarez, Tanja Ouimet, Tania Vitalis, Khalid H El-Hachimi, David Price, Evan Deneris, Patricia Gaspar, Olivier Case. Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 6. 2007-03-06. PMID:17287506. |
trkb signaling is not implicated in the anti-apoptotic effects of maoa inhibition because bdnf mrna levels were unchanged in vmat2-maoa dko mice and because the massive cell death in the cerebral cortex of trkb ko mice is also reverted by genetic invalidation of the maoa gene. |
2007-03-06 |
2023-08-12 |
mouse |
| Kevin Chen, Olivier Cases, Igor Rebrin, Weihua Wu, Timothy K Gallaher, Isabelle Seif, Jean Chen Shi. Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17090537. |
furthermore, the disorganization of the somatosensory cortex barrel field structure associated with mao a ko mice was restored and became morphologically similar to wild type. |
2007-02-08 |
2023-08-12 |
mouse |