| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
neuronal subset-specific phosphatase and tensin homolog (pten) knockout (ko) mice display hyperactive mammalian target of rapamycin (mtor) signaling in the hippocampus, cerebellum, and cortex followed by seizures that increase in severity with age. |
2022-07-01 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
at 5 weeks, microglia/macrophage activation was greater in the cortex, p < 0.001, cerebellum, p < 0.001, and hippocampus, p < 0.001, of ko compared to wt mice. |
2022-07-01 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
at 10 weeks, activation was greatest in the cortex of ko mice, p < 0.001, in the cerebellum of wt mice, p < 0.001, but similar in the hippocampus, p > 0.05. |
2022-07-01 |
2023-08-14 |
mouse |
| Keegan Flanagan, Alireza Baradaran-Heravi, Qi Yin, Khanh Dao Duc, Allan C Spradling, Ethan J Greenblat. FMRP-dependent production of large dosage-sensitive proteins is highly conserved. Genetics. 2022-06-22. PMID:35731217. |
the steady state levels of several fmrp targets were reduced in the fmr1 ko mouse cortex, including a ∼2-fold reduction of auts2, a gene implicated in an autosomal dominant autism spectrum disorder. |
2022-06-22 |
2023-08-14 |
mouse |
| Tanishka S Saraf, Bo Yang, Ryan P McGlynn, Raymond G Booth, Clinton E Cana. Targeting 5-HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554571. |
recordings from above the left somatosensory cortex showed a significantly elevated high gamma (65-100 hz) power ratio in fmr1 ko mice relative to control mice at baseline (n=16, p=0.0357) and after vehicle injection (n=16, p=0.0066), a genotype difference that fpt eliminated (n=15-16, p=0.6279). |
2022-05-13 |
2023-08-13 |
mouse |
| Lama Al-Qusairi, Boyoung Kim, Ava M Zapf, Owen M Woodward, Paul A Wellin. Phosphorylation-Dependent Endocytosis of ROMK Limits Urinary Potassium Loss. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555040. |
arh ko mice exhibit an increase in glycosylated romk in the renal cortex without changes in the abundance of the core-glycosylated or unglycosylated forms, consistent with inhibition of post-endocytic degradation. |
2022-05-13 |
2023-08-13 |
mouse |
| Quinn Lee, Kevin Kruse, Shuangping Zhao, Leon Tai, Yulia Komarov. N-cadherin signaling stabilizes occludin tight junction via PI3K p110β signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556328. |
analysis of tight junction (tj) proteins occludin and claudins 1 and 5 in microvascular becs of the cortex demonstrated a significant reduction in the accumulation of occludin, but not claudins, at tjs of ko mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Philip H Iffland, Mariah E Everett, Katherine M Cobb-Pitstick, Lauren E Bowser, Allan E Barnes, Janice K Babus, Andrea J Romanowski, Marianna Baybis, Soad Elziny, Erik G Puffenberger, Claudia Gonzaga-Jauregui, Alexandros Poulopoulos, Vincent J Carson, Peter B Crin. NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination, and seizure threshold. Brain : a journal of neurology. 2022-02-09. PMID:35136953. |
to model human malformations of cortical development associated with nprl3 variants, we created a focal nprl3 ko in fetal mouse cortex by in utero electroporation and found altered cortical lamination and white matter heterotopic neurons, effects which were prevented with rapamycin treatment. |
2022-02-09 |
2023-08-13 |
mouse |
| Rika Kasuga, Chinatsu Shiraki, Ririka Horikawa, Ryoichi Yoshimura, Erkin Kurganov, Seiji Miyat. Role of TRPM8 in cold avoidance behaviors and brain activation during innocuous and nocuous cold stimuli. Physiology & behavior. 2022-02-08. PMID:35131300. |
therefore, we herein investigated cold avoidance behaviors and the neuronal activation of the hypothalamus and cerebral cortex in trpm8 knockout (ko) mice to innocuous and nocuous cold stimuli. |
2022-02-08 |
2023-08-13 |
mouse |
| Ava M Zapf, Paul R Grimm, Lama Al-Qusairi, Eric Delpire, Paul A Wellin. Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice. Frontiers in physiology. vol 12. 2022-01-24. PMID:35069250. |
we found that pge2 and the terminal pge2 synthase, mpges1, are increased in kidney cortex of ca-spak mice, compared to control or spak ko mice. |
2022-01-24 |
2023-08-13 |
mouse |
| Hyun-Wook Lee, Jill W Verlander, Gary E Shull, Autumn N Harris, I David Weine. Acid-Base Effects of Combined Renal Deletion of NBCe1-A and NBCe1-B. American journal of physiology. Renal physiology. 2022-01-10. PMID:35001662. |
pt-nbce1-a/b ko decreased expression of phosphate-dependent glutaminase (pdg) and phospho-enol-pyruvate carboxy-kinase (pepck) and increased expression of glutamine synthetase (gs), an ammonia recycling enzyme, in pt in both the cortex and om. |
2022-01-10 |
2023-08-13 |
mouse |
| Hyun-Wook Lee, Jill W Verlander, Gary E Shull, Autumn N Harris, I David Weine. Acid-Base Effects of Combined Renal Deletion of NBCe1-A and NBCe1-B. American journal of physiology. Renal physiology. 2022-01-10. PMID:35001662. |
pt-nbce1-a/b ko significantly blunted acid loading-induced changes in pdg, pepck, and gs expression in the proximal tubule in both the cortex and om. |
2022-01-10 |
2023-08-13 |
mouse |
| Yeri J Song, Bo Xing, Aaron J Barbour, Chengwen Zhou, Frances E Jense. Dysregulation of GABAA Receptor-Mediated Neurotransmission during the Auditory Cortex Critical Period in the Fragile X Syndrome Mouse Model. Cerebral cortex (New York, N.Y. : 1991). vol 32. issue 1. 2021-12-08. PMID:34223875. |
here, we examined gabaa receptor (gabaar)-mediated inhibitory synaptic transmission within the auditory cortex, characterizing normal intracortical circuit development patterns in wild-type (wt) mice and examining their dysregulation in developing fmr1 knock-out (ko) mice. |
2021-12-08 |
2023-08-13 |
mouse |
| Nicole Koch, Dennis Koch, Sarah Krueger, Jessica Tröger, Victor Sabanov, Tariq Ahmed, Laura E McMillan, David Wolf, Dirk Montag, Michael M Kessels, Detlef Balschun, Britta Qualman. Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 8. 2021-11-29. PMID:32147734. |
syndapin i knockout (ko) mice developed schizophrenia-related behaviors, such as hyperactivity, reduced anxiety, reduced response to social novelty, and an exaggerated novel object response and exhibited defects in dendritic arborization in the cortex. |
2021-11-29 |
2023-08-13 |
mouse |
| Malte Klüssendorf, Inseon Song, Lynn Schau, Fabio Morellini, Alexander Dityatev, Judith Koliwer, Hans-Jürgen Kreienkam. The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5. Molecular neurobiology. vol 58. issue 11. 2021-11-25. PMID:34383253. |
in the hippocampus and cortex of gopc ko animals, expression levels of gopc-associated receptors were not altered, while their subcellular localization was disturbed. |
2021-11-25 |
2023-08-13 |
mouse |
| Daniel Chaji, Varun S Venkatesh, Tomoaki Shirao, Darren J Day, Bart A Ellenbroe. Genetic Knockout of the Serotonin Reuptake Transporter Results in the Reduction of Dendritic Spines in In vitro Rat Cortical Neuronal Culture. Journal of molecular neuroscience : MN. vol 71. issue 11. 2021-11-12. PMID:33403594. |
to understand the effect of sert depletion on dendritic spine formation, neuronal cultures were established from the cortex of postnatal day 0-1 sert knockout (ko) rats. |
2021-11-12 |
2023-08-13 |
rat |
| Wenlu Pan, Jing Pan, Yan Zhao, Hongzheng Zhang, Jie Tan. Serotonin Transporter Defect Disturbs Structure and Function of the Auditory Cortex in Mice. Frontiers in neuroscience. vol 15. 2021-10-26. PMID:34690685. |
in the present study, we report on the neuronal morphology and function of auditory cortex in sert knockout (ko) mice. |
2021-10-26 |
2023-08-13 |
mouse |
| Wenlu Pan, Jing Pan, Yan Zhao, Hongzheng Zhang, Jie Tan. Serotonin Transporter Defect Disturbs Structure and Function of the Auditory Cortex in Mice. Frontiers in neuroscience. vol 15. 2021-10-26. PMID:34690685. |
we show that the dendritic length of the fourth layer (l-iv) pyramidal neurons and the second-to-third layer (l-ii/iii) interneurons were reduced in the auditory cortex of the sert ko mice. |
2021-10-26 |
2023-08-13 |
mouse |
| Wenlu Pan, Jing Pan, Yan Zhao, Hongzheng Zhang, Jie Tan. Serotonin Transporter Defect Disturbs Structure and Function of the Auditory Cortex in Mice. Frontiers in neuroscience. vol 15. 2021-10-26. PMID:34690685. |
also, the frequency-tonotopic organization of primary auditory cortex was disrupted in sert ko mice. |
2021-10-26 |
2023-08-13 |
mouse |
| Weifen Li, Tahir Ali, Chengyou Zheng, Kaiwu He, Zizhen Liu, Fawad Ali Shah, Ningning Li, Zhi-Jian Yu, Shupeng L. Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes. Molecular psychiatry. 2021-10-13. PMID:34642455. |
apn ko mice displayed increased cytokines (both pro and anti-inflammatory), accompanied by an impaired expression of adiponectin receptors (mrna/protein level) and decreasing iba-1 level in the cortex and primary microglia of lps treated apn ko mice. |
2021-10-13 |
2023-08-13 |
mouse |