| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weifen Li, Tahir Ali, Chengyou Zheng, Kaiwu He, Zizhen Liu, Fawad Ali Shah, Ningning Li, Zhi-Jian Yu, Shupeng L. Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes. Molecular psychiatry. 2021-10-13. PMID:34642455. |
however, the bay11-7082 treatment recovered p-nfκb expression in the cortex of apn ko mice in the presence of lps. |
2021-10-13 |
2023-08-13 |
mouse |
| Sehyoun Yoon, Nicolas H Piguel, Natalia Khalatyan, Leonardo E Dionisio, Jeffrey N Savas, Peter Penze. Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33398084. |
in addition, proteomic analysis of the cortex in homer1 ko and wild-type (wt) mice revealed a global reshaping of the postsynaptic proteome, surprisingly characterized by extensive upregulation of synaptic proteins. |
2021-10-11 |
2023-08-13 |
mouse |
| Jason Arsenault, Alexander W M Hooper, Shervin Gholizadeh, Tian Kong, Laura K Pacey, Enea Koxhioni, Yosuke Niibori, James H Eubanks, Lu-Yang Wang, David R Hampso. Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex. Human molecular genetics. vol 29. issue 23. 2021-09-28. PMID:33084871. |
we found that the level of mecp2 protein in the cerebral cortex was elevated in fmr1 ko mice, whereas mecp2 ko mice displayed reduced levels of fmrp, implicating interplay between the activities of mecp2 and fmrp. |
2021-09-28 |
2023-08-13 |
mouse |
| Jason Arsenault, Alexander W M Hooper, Shervin Gholizadeh, Tian Kong, Laura K Pacey, Enea Koxhioni, Yosuke Niibori, James H Eubanks, Lu-Yang Wang, David R Hampso. Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex. Human molecular genetics. vol 29. issue 23. 2021-09-28. PMID:33084871. |
additionally, the level of mecp2 in the posterior cortex correlated with the severity of the hyperactive phenotype in fmr1 ko mice. |
2021-09-28 |
2023-08-13 |
mouse |
| Jason Arsenault, Alexander W M Hooper, Shervin Gholizadeh, Tian Kong, Laura K Pacey, Enea Koxhioni, Yosuke Niibori, James H Eubanks, Lu-Yang Wang, David R Hampso. Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex. Human molecular genetics. vol 29. issue 23. 2021-09-28. PMID:33084871. |
our findings also suggest that mecp2 overexpression in fmr1 ko mouse posterior cerebral cortex may contribute to the fragile x locomotor hyperactivity phenotype. |
2021-09-28 |
2023-08-13 |
mouse |
| Yuki Yamazaki, Maho Moizumi, Jun Nagai, Yoshiki Hatashita, Tianhong Cai, Papachan Kolattukudy, Takafumi Inoue, Yoshio Goshima, Toshio Ohshim. Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4. Cerebral cortex (New York, N.Y. : 1991). 2021-07-23. PMID:34297816. |
the cerebral cortices of triple-mutant crmp1 knock-out (ko); crmp2 knock-in (ki)/ki; and crmp4 ko mice showed disturbed positioning of layers ii-v neurons in the cerebral cortex. |
2021-07-23 |
2023-08-13 |
mouse |
| Li Sun, Ruili Han, Fei Guo, Hai Chen, Wen Wang, Zhiyang Chen, Wei Liu, Xude Sun, Changjun Ga. Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway. Cell death discovery. vol 6. 2021-07-15. PMID:32818074. |
at 3 days after stroke, when il-17 expression peaked, il-17 knock out (ko) mice were used to observe cell proliferation and neurogenesis in ischemic cortex. |
2021-07-15 |
2023-08-13 |
mouse |
| Simona D'Antoni, Lidia de Bari, Daniela Valenti, Marina Borro, Carmela Maria Bonaccorso, Maurizio Simmaco, Rosa Anna Vacca, Maria Vincenza Catani. Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome. Biological chemistry. vol 401. issue 4. 2021-06-24. PMID:31702995. |
we checked brain energy status and some aspects of cell bioenergetics, namely the activity of key glycolytic enzymes, glycerol-3-phosphate shuttle and mitochondrial respiratory chain (mrc) complexes, in the cerebral cortex of the fmr1 knockout (ko) mouse model of fxs. |
2021-06-24 |
2023-08-13 |
mouse |
| Rose B Creed, Rosalinda C Roberts, Charlene B Farmer, Lori L McMahon, Matthew S Goldber. Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats. Neurobiology of disease. vol 150. 2021-06-14. PMID:33387634. |
while pink1 knockout (ko) rats have mitochondrial dysfunction, locomotor deficits, and α-synuclein aggregates in several brain regions such as cerebral cortex, dorsal striatum, and substantia nigra, the functional ramifications on synaptic circuits are unknown. |
2021-06-14 |
2023-08-13 |
rat |
| Jonathan W Lovelace, Maham Rais, Arnold R Palacios, Xinghao S Shuai, Steven Bishay, Otilia Popa, Patricia S Pirbhoy, Devin K Binder, David L Nelson, Iryna M Ethell, Khaleel A Raza. Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 3. 2021-06-08. PMID:31364704. |
we previously showed that elevated levels of matrix metalloproteinase-9 (mmp-9) may contribute to these phenotypes by affecting perineuronal nets (pnns) around parvalbumin (pv) interneurons in the auditory cortex of fmr1 ko mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Jonathan W Lovelace, Maham Rais, Arnold R Palacios, Xinghao S Shuai, Steven Bishay, Otilia Popa, Patricia S Pirbhoy, Devin K Binder, David L Nelson, Iryna M Ethell, Khaleel A Raza. Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 3. 2021-06-08. PMID:31364704. |
these results indicate that fragile x mental retardation protein changes in excitatory neurons in the cortex are sufficient to elicit cellular, electrophysiological, and behavioral phenotypes in fmr1 ko mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Rasha H Mehder, Brian M Bennett, R David Andre. Morphometric Analysis of Hippocampal and Neocortical Pyramidal Neurons in a Mouse Model of Late Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 74. issue 4. 2021-05-07. PMID:32144984. |
here we performed morphometric analyses in the dorsal and ventral hippocampal ca1 regions (dca1 and vca1) as well as in overlying primary sensory cortex to determine if altered neuronal structure can help account for the cognitive impairment in 12-month old ko mice. |
2021-05-07 |
2023-08-13 |
mouse |
| Rasha H Mehder, Brian M Bennett, R David Andre. Morphometric Analysis of Hippocampal and Neocortical Pyramidal Neurons in a Mouse Model of Late Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 74. issue 4. 2021-05-07. PMID:32144984. |
in contrast, pyramidal arborization in the vca1 and primary sensory cortex were only minimally reduced in ko versus wt mice. |
2021-05-07 |
2023-08-13 |
mouse |
| Katherine R Day, Alexis Coleman, Maria A Greenwood, Elizabeth A D Hammoc. AVPR1A distribution in the whole C57BL/6J mouse neonate. Scientific reports. vol 10. issue 1. 2021-03-08. PMID:32884025. |
using competitive autoradiography in wildtype (wt) and avpr1a knockout (ko) postnatal day 0 (p0) male and female mice on a c57bl/6j background, specific avpr1a ligand binding was observed in the neonatal mouse periphery in sensory tissues of the head (eyes, ears, various oronasal regions), bone, spinal cord, adrenal cortex, and the uro-anogenital region in the neonatal avpr1a wt mouse, as it was significantly reduced or absent in the control samples (avpr1a ko and competition). |
2021-03-08 |
2023-08-13 |
mouse |
| Patricia S Pirbhoy, Maham Rais, Jonathan W Lovelace, Walker Woodard, Khaleel A Razak, Devin K Binder, Iryna M Ethel. Acute pharmacological inhibition of matrix metalloproteinase-9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32374912. |
previously, we showed that elevated levels of matrix metalloproteinase-9 (mmp-9) may contribute to abnormal development of parvalbumin (pv) interneurons and perineuronal nets (pnns) in the developing auditory cortex (ac) of fmr1 knock-out (ko) mice, which likely underlie auditory hypersensitivity. |
2021-03-02 |
2023-08-13 |
mouse |
| Zheng Chen, Ruiwei Jiang, Mengxia Chen, Jiashuo Zheng, Min Chen, Nady Braidy, Shunli Liu, Guohao Liu, Zaitunamu Maimaitiming, Tianqi Shen, Joshua L Dunaief, Christopher D Vulpe, Gregory J Anderson, Huijun Che. Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes. Scientific reports. vol 9. issue 1. 2020-10-15. PMID:31263155. |
in this study, we enriched astrocytes and oligodendrocytes from the cerebral cortex of neonatal wild-type (wt), heph ko and cp ko mice. |
2020-10-15 |
2023-08-13 |
mouse |
| Gloria Blázquez, Anna Castañé, Ana Saavedra, Mercè Masana, Jordi Alberch, Esther Pérez-Navarr. Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase. Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30760987. |
since step is expressed in brain regions implicated in social behavior, namely the striatum, the ca2 region of the hippocampus, cortex and amygdala, here we investigated whether social memory and social patterns were altered in step knockout (ko) mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Emma Leishman, Ken Mackie, Heather B Bradsha. Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31213981. |
lipidomics analysis of the brainstem, cerebellum, cortex, hippocampus, hypothalamus, midbrain, striatum and thalamus from male young (3-4 months) and older (7 months) adult abhd12 ko and age-matched wild-type (wt) mice was performed on over 80 lipids via hplc/ms/ms, including ecbs, lipoamines, 2-acyl glycerols, free fatty acids, and prostaglandins (pgs). |
2020-09-29 |
2023-08-13 |
mouse |
| Jie Li, Chunyan Xue, Qingtao Gao, Jieqiong Tan, Zhengqing Wa. Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice. Biochemical and biophysical research communications. vol 521. issue 4. 2020-07-27. PMID:31727366. |
here, we isolated mitochondrial dna (mtdna) from cortex, striatum and substantia nigra of wildtype (wt), pink1 knockout (pink1 ko) and parkin knockout (parkin ko) mice to analyze mtdna heteroplasmy induced by pink1/parkin deficiency or aging. |
2020-07-27 |
2023-08-13 |
mouse |
| Jie Li, Chunyan Xue, Qingtao Gao, Jieqiong Tan, Zhengqing Wa. Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice. Biochemical and biophysical research communications. vol 521. issue 4. 2020-07-27. PMID:31727366. |
conversely, the early-onset somatic variants exhibited significant increase in the cortex and substantia nigra of pink1 ko mice than wt mice of the same age. |
2020-07-27 |
2023-08-13 |
mouse |