| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feifei Ma, Pablo Martínez-San Segundo, Verónica Barceló, Anna Morancho, Marina Gabriel-Salazar, Dolors Giralt, Joan Montaner, Anna Rosel. Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice. Neurobiology of disease. vol 91. 2018-02-20. PMID:27001146. |
permanent and transient cerebral ischemia models involving the cortex were induced in mmp-13 knock-out (ko) and wild-type (wt) mice. |
2018-02-20 |
2023-08-13 |
mouse |
| Feifei Ma, Pablo Martínez-San Segundo, Verónica Barceló, Anna Morancho, Marina Gabriel-Salazar, Dolors Giralt, Joan Montaner, Anna Rosel. Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice. Neurobiology of disease. vol 91. 2018-02-20. PMID:27001146. |
prior to these vascular alterations, the levels of pro-angiogenic factors, including g-csf, vegf-a and angiopoietin-2, were lower in the ischemic cortex of mmp-13 ko mice than in wt mice (p<0.05). |
2018-02-20 |
2023-08-13 |
mouse |
| Pan-Yue Deng, Vitaly A Klyachk. Increased Persistent Sodium Current Causes Neuronal Hyperexcitability in the Entorhinal Cortex of Fmr1 Knockout Mice. Cell reports. vol 16. issue 12. 2018-02-09. PMID:27653682. |
here, we find that pyramidal cells in the entorhinal cortex of fmr1 ko mice, an established fxs mouse model, display a decreased ap threshold and increased neuronal excitability. |
2018-02-09 |
2023-08-13 |
mouse |
| Lijun Li, Marcus Byrd, Kwame Doh, Patrice D Dixon, Hwal Lee, Swasti Tiwari, Carolyn M Ecelbarge. Absence of renal enlargement in fructose-fed proximal-tubule-select insulin receptor (IR), insulin-like-growth factor receptor (IGF1R) double knockout mice. Physiological reports. vol 4. issue 23. 2018-02-01. PMID:27923977. |
ko mice had slightly (~10%) reduced body and kidney weights, as well as, a reduction in mean protein-to-dna ratio in kidney cortex suggesting smaller cell size. |
2018-02-01 |
2023-08-13 |
mouse |
| Kirsty Sawicka, Alexander Pyronneau, Miranda Chao, Michael V L Bennett, R Suzanne Zuki. Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27663742. |
the fmr1 ko mouse, a model of fxs, exhibits elevated translation in the hippocampus and the cortex. |
2018-01-30 |
2023-08-13 |
mouse |
| Renjini Ramadasan-Nair, Jessica Hui, Pavel I Zimin, Leslie S Itsara, Philip G Morgan, Margaret M Sedensk. Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity. PloS one. vol 12. issue 11. 2017-12-11. PMID:29136012. |
knockdown of ndufs4 only in the parietal association cortex produced striking hypersensitivity for both endpoints, and accounted for half the total change seen in the global ko (ndufs4(ko)). |
2017-12-11 |
2023-08-13 |
mouse |
| Renjini Ramadasan-Nair, Jessica Hui, Pavel I Zimin, Leslie S Itsara, Philip G Morgan, Margaret M Sedensk. Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity. PloS one. vol 12. issue 11. 2017-12-11. PMID:29136012. |
excitatory synaptic transmission in the parietal association cortex in slices from ndufs4(ko) animals was hypersensitive to isoflurane compared to control slices. |
2017-12-11 |
2023-08-13 |
mouse |
| C R Easton, C W Dickey, S P Moen, K E Neuzil, Z Barger, T M Anderson, W J Moody, R F Hevne. Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Developmental neurobiology. vol 76. issue 7. 2017-10-13. PMID:26473411. |
distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by tbr1 ko. |
2017-10-13 |
2023-08-13 |
mouse |
| C R Easton, C W Dickey, S P Moen, K E Neuzil, Z Barger, T M Anderson, W J Moody, R F Hevne. Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Developmental neurobiology. vol 76. issue 7. 2017-10-13. PMID:26473411. |
it is known that glutamatergic cells are disordered with tbr1 ko such that normal laying of the cortex, with newer born cells residing in superficial layers, does not occur. |
2017-10-13 |
2023-08-13 |
mouse |
| Fengping Dong, Joanna Jiang, Colleen McSweeney, Donghua Zou, Long Liu, Yingwei Ma. Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects. Human molecular genetics. vol 25. issue 13. 2017-09-21. PMID:27131348. |
to determine the effect of ctnnb1 ko in overall neuronal activity, we found that c-fos was significantly reduced in the cortex, but not in the dentate gyrus and the amygdala. |
2017-09-21 |
2023-08-13 |
mouse |
| Carlos J Ballester-Rosado, Hao Sun, Jui-Yen Huang, Hui-Chen L. mGluR5 Exerts Cell-Autonomous Influences on the Functional and Anatomical Development of Layer IV Cortical Neurons in the Mouse Primary Somatosensory Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 34. 2017-07-17. PMID:27559164. |
in the s1 cortex of these mosaic brains, we found that most wild-type neurons were located in barrel rings encircling thalamocortical axon (tca) clusters while mglur5 knock-out (ko) neurons were placed in the septal area, the cell-sparse region separating barrels. |
2017-07-17 |
2023-08-13 |
mouse |
| Jia L Zhuo, H Kobori, Xiao C Li, R Satou, A Katsurada, L Gabriel Nava. Augmentation of angiotensinogen expression in the proximal tubule by intracellular angiotensin II via AT1a/MAPK/NF-кB signaling pathways. American journal of physiology. Renal physiology. vol 310. issue 10. 2017-06-27. PMID:26864937. |
the increased agt mrna and protein expressions in the cortex by ecfp/ang ii were blocked in at1a-knockout (ko) mice. |
2017-06-27 |
2023-08-13 |
mouse |
| Lucas J Sosa, James S Malter, Jie Hu, Florentyna Bustos Plonka, Mariana Oksdath, Alvaro F Nieto Guil, Santiago Quiroga, Karl H Pfenninge. Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization. Journal of neurochemistry. vol 137. issue 5. 2017-06-05. PMID:26991250. |
the pin1 ko mice exhibited disturbed neuronal projections from the cerebral cortex and reduced white matter tracks such as the corpus callosum. |
2017-06-05 |
2023-08-13 |
mouse |
| Henning Fröhlich, Rafiullah Rafiullah, Nathalie Schmitt, Sonja Abele, Gudrun A Rappol. Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization. Human molecular genetics. vol 26. issue 8. 2017-05-15. PMID:28204507. |
we show that foxp1 and the androgen receptor are co-expressed in striatal medium spiny neurons and that brain-specific androgen receptor ko (arnescre) mice exhibit reduced foxp1 expression in the striatum at e17.5 and p7.5 and an increased foxp2 level in the cortex at p7.5. |
2017-05-15 |
2023-08-13 |
mouse |
| Linming Zhang, Zhanrong Liang, Pingping Zhu, Meng Li, Yong-Hong Yi, Wei-Ping Liao, Tao S. Altered intrinsic properties and bursting activities of neurons in layer IV of somatosensory cortex from Fmr-1 knockout mice. Experimental neurology. vol 280. 2017-04-28. PMID:27048919. |
in this study, whole cell patch-clamp recordings were employed to characterize the membrane and firing properties of layer iv cells in slices of the somatosensory cortex of fmr-1 knockout (ko) mice. |
2017-04-28 |
2023-08-13 |
mouse |
| Sara Anna Bonini, Andrea Mastinu, Giuseppina Maccarinelli, Stefania Mitola, Marika Premoli, Luca Rosario La Rosa, Giulia Ferrari-Toninelli, Mariagrazia Grilli, Maurizio Mem. Cortical Structure Alterations and Social Behavior Impairment in p50-Deficient Mice. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 6. 2017-03-06. PMID:26946128. |
moreover, adult ko mice display abnormal columnar organization in the somatosensory cortex, a specific decrease in somatostatin- and parvalbumin-expressing interneurons, altered neurite orientation, and a decrease in synapsin i protein levels. |
2017-03-06 |
2023-08-13 |
mouse |
| Luis Varela, Michael L Schwartz, Tamas L Horvat. Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus. Neurobiology of disease. vol 90. 2016-12-27. PMID:26777666. |
in ucp2 ko mice, changing oxygen tension did not induce changes in mitochondrial parameters and function but decreased mitochondria-er contacts and resulted in loss of synapses both in the cortex and hippocampus. |
2016-12-27 |
2023-08-13 |
mouse |
| Laura Brandenstein, Michaela Schweizer, Jan Sedlacik, Jens Fiehler, Stephan Storc. Lysosomal dysfunction and impaired autophagy in a novel mouse model deficient for the lysosomal membrane protein Cln7. Human molecular genetics. vol 25. issue 4. 2016-12-13. PMID:26681805. |
generalized astrogliosis and microgliosis in the brain preceded neurodegeneration in the olfactory bulb, cerebral cortex and cerebellum in cln7 ko mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Jonathan W Lovelace, Teresa H Wen, Sarah Reinhard, Mike S Hsu, Harpreet Sidhu, Iryna M Ethell, Devin K Binder, Khaleel A Raza. Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome. Neurobiology of disease. vol 89. 2016-12-13. PMID:26850918. |
our studies demonstrate a significant up-regulation of mmp-9 levels in the auditory cortex of adult fmr1 ko mice, whereas a genetic deletion of mmp-9 reverses erp habituation deficits in fmr1 ko mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Weirui Guo, Laura Ceolin, Katie A Collins, Julie Perroy, Kimberly M Hube. Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. Cell reports. vol 13. issue 10. 2016-09-23. PMID:26670047. |
in fmr1 knockout (ko) cortex, homers are hyperphosphorylated as a result of elevated camkiiα protein. |
2016-09-23 |
2023-08-13 |
mouse |