| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniil Grinchii, Lubica Lacinova, Eliyahu Dremenco. Effects of the acute administration of delta-opioid receptor ligands on the excitability of rat hippocampal glutamate and brainstem monoamine neurons in vivo. General physiology and biophysics. vol 42. issue 3. 2023-04-26. PMID:37098742. |
the present study aimed to investigate the acute effects of these ligands on the firing activity of hippocampal cornu ammonis 1/3 (ca1/3) glutamate, dorsal raphe nucleus (drn) serotonin (5-ht), locus coeruleus (lc) noradrenaline, and ventral tegmental area (vta) dopamine neurons in in vivo conditions. |
2023-04-26 |
2023-08-14 |
rat |
| Latiful Akbar, Virgil Christian Garcia Castillo, Joshua Philippe Olorocisimo, Yasumi Ohta, Mamiko Kawahara, Hironari Takehara, Makito Haruta, Hiroyuki Tashiro, Kiyotaka Sasagawa, Masahiro Ohsawa, Yasemin M Akay, Metin Akay, Jun Oht. Multi-Region Microdialysis Imaging Platform Revealed Dorsal Raphe Nucleus Calcium Signaling and Serotonin Dynamics during Nociceptive Pain. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047627. |
multi-region microdialysis imaging platform revealed dorsal raphe nucleus calcium signaling and serotonin dynamics during nociceptive pain. |
2023-04-13 |
2023-08-14 |
mouse |
| Latiful Akbar, Virgil Christian Garcia Castillo, Joshua Philippe Olorocisimo, Yasumi Ohta, Mamiko Kawahara, Hironari Takehara, Makito Haruta, Hiroyuki Tashiro, Kiyotaka Sasagawa, Masahiro Ohsawa, Yasemin M Akay, Metin Akay, Jun Oht. Multi-Region Microdialysis Imaging Platform Revealed Dorsal Raphe Nucleus Calcium Signaling and Serotonin Dynamics during Nociceptive Pain. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047627. |
in this research, we combined our ultralight micro-imaging device for calcium imaging with microdialysis to simultaneously visualize neural activity in the dorsal raphe nucleus (drn) and measure serotonin release in the central nucleus of the amygdala (cea) and the anterior cingulate cortex (acc). |
2023-04-13 |
2023-08-14 |
mouse |
| Xiaoju Liu, Haijuan Wang, Xiaoyu Wang, Yinxia Ning, Wei Liu, Jie Ga. Baixiangdan capsule and Shuyu capsule regulate anger-out and anger-in, respectively: GB1-mediated GABA can regulate 5-HT levels in multiple brain regions. Aging. vol 15. 2023-03-29. PMID:36988497. |
on this basis, gaba content in the dorsal raphe nucleus (drn) and serotonin (5-ht) contents in these brain regions were detected using elisa after various time courses (0, 1, 3, 5, and 7 days) treated with bxd and sy. |
2023-03-29 |
2023-08-14 |
rat |
| Alexandra J Ng, Lindsay K Vincelette, Jiayi Li, Bridget H Brady, John P Christianso. Serotonin modulates social responses to stressed conspecifics via insular 5-HT bioRxiv : the preprint server for biology. 2023-02-24. PMID:36824837. |
we hypothesized that social reactions to stressed individuals engage the serotonergic dorsal raphe nucleus (drn) which promotes anxiety-like behavior via postsynaptic action of serotonin at serotonin 2c (5-ht |
2023-02-24 |
2023-08-14 |
Not clear |
| Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kanek. Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience. Cell reports. vol 42. issue 3. 2023-02-23. PMID:36821440. |
stimulating 5-ht neurons of the dorsal raphe nucleus (drn) or neuronal ensembles in the dorsal dentate gyrus (ddg) associated with positive memories reverses the stress-induced behavioral abnormalities. |
2023-02-23 |
2023-08-14 |
Not clear |
| Iltan Aklan, Nilufer Sayar Atasoy, Fei Deng, Hyojin Kim, Yavuz Yavuz, Jacob Rysted, Connor Laule, Debbie Davis, Yulong Li, Deniz Ataso. Dorsal Raphe Serotonergic Neurons Suppress Feeding Through Redundant Forebrain Circuits. Molecular metabolism. 2023-01-22. PMID:36682413. |
serotonin (5ht) is a well-known anorexigenic molecule, and 5ht neurons of dorsal raphe nucleus (drn) have been implicated in suppression of feeding; however, the downstream circuitry is poorly understood. |
2023-01-22 |
2023-08-14 |
Not clear |
| Emerson F Harkin, Michael B Lynn, Alexandre Payeur, Jean-François Boucher, Léa Caya-Bissonnette, Dominic Cyr, Chloe Stewart, André Longtin, Richard Naud, Jean-Claude Beiqu. Temporal derivative computation in the dorsal raphe network revealed by an experimentally-driven augmented integrate-and-fire modeling framework. eLife. vol 12. 2023-01-19. PMID:36655738. |
by means of an expansive innervation, the serotonin (5-ht) neurons of the dorsal raphe nucleus (drn) are positioned to enact coordinated modulation of circuits distributed across the entire brain in order to adaptively regulate behavior. |
2023-01-19 |
2023-08-14 |
mouse |
| Jiajia Dai, Hyangin Kim, Zerong You, Michael F McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Ma. Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment. Frontiers in pharmacology. vol 13. 2023-01-02. PMID:36588734. |
fluoxetine exposure induced upregulation of the 5-hydroxytryptamine 1a (5-ht1a) auto-receptor and indoleamine 2,3 dioxygenase 1 (ido1, a rate-limiting enzyme of tryptophan metabolism) in the brainstem dorsal raphe nucleus (drn), which shifted the tryptophan metabolism away from the 5-ht biosynthesis. |
2023-01-02 |
2023-08-14 |
Not clear |
| Anna Portugalov, Hiba Zaidan, Inna Gaisler-Salomon, Cecilia J Hillard, Irit Akira. FAAH Inhibition Restores Early Life Stress-Induced Alterations in PFC microRNAs Associated with Depressive-Like Behavior in Male and Female Rats. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555739. |
we compared the effects of treatment with the fatty acid amide hydrolase (faah) inhibitor urb597, and the selective serotonin reuptake inhibitor paroxetine, on els-induced depressive-like behavior and the expression of micrornas (mirs) associated with depression in the medial prefrontal cortex (mpfc), hippocampal ca1 area, lateral habenula and dorsal raphe in rats. |
2022-12-23 |
2023-08-14 |
rat |
| Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, Koji Toda, Hisashi Shirakawa, Kazuki Nagayasu, Yu Ohmura, Makoto Kondo, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Shuji Kanek. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nature communications. vol 13. issue 1. 2022-12-22. PMID:36550097. |
although a critical role of serotonergic neurons in the dorsal raphe nucleus (drn) in reward processing has been shown, the lack of rewarding effects with selective serotonin reuptake inhibitors (ssris) implies the presence of a discrete serotonergic system playing an opposite role to the drn in the processing of reward and aversive stimuli. |
2022-12-22 |
2023-08-14 |
mouse |
| Piergiorgio Salvan, Madalena Fonseca, Anderson M Winkler, Antoine Beauchamp, Jason P Lerch, Heidi Johansen-Ber. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature neuroscience. 2022-12-15. PMID:36522497. |
probing srns with optogenetics-functional magnetic resonance imaging (mri) and pharmacology in mice, we show that activation of dorsal raphe serotonin neurons differentially modulates the amplitude and functional connectivity of different srns, showing that receptors' spatial distributions can confer specificity not only at the local, but also at the brain-wide, network level. |
2022-12-15 |
2023-08-14 |
mouse |
| Carla V Argañaraz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England). 2022-12-02. PMID:36458556. |
selective refinement of glutamate and gaba synapses on dorsal raphe 5-ht neurons during postnatal life. |
2022-12-02 |
2023-08-14 |
mouse |
| Carla V Argañaraz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England). 2022-12-02. PMID:36458556. |
we investigated in mice the postnatal trajectory of glutamate and gaba synaptic inputs to dorsal raphe nucleus (drn) 5-ht neurons, the main source of forebrain 5-ht. |
2022-12-02 |
2023-08-14 |
mouse |
| Alexis M Ceasrine, Benjamin A Devlin, Jessica L Bolton, Lauren A Green, Young Chan Jo, Carolyn Huynh, Bailey Patrick, Kamryn Washington, Cristina L Sanchez, Faith Joo, A Brayan Campos-Salazar, Elana R Lockshin, Cynthia Kuhn, Susan K Murphy, Leigh Ann Simmons, Staci D Bilb. Maternal diet disrupts the placenta-brain axis in a sex-specific manner. Nature metabolism. 2022-11-28. PMID:36443520. |
in male offspring exposed to a maternal high-fat diet, increased macrophage toll-like receptor 4 signalling results in excess microglial phagocytosis of serotonin (5-ht) neurons in the developing dorsal raphe nucleus, decreasing 5-ht bioavailability in the fetal and adult brains. |
2022-11-28 |
2023-08-14 |
mouse |
| Junling Wang, Junyan Sun, Linlin Gao, Dongling Zhang, Lili Chen, Tao W. Common and unique dysconnectivity profiles of dorsal and median raphe in Parkinson's disease. Human brain mapping. 2022-11-05. PMID:36334274. |
the dorsal raphe (dr) and median raphe (mr) nuclei are the main source of 5-ht neurons, however, brain connectivity changes in these two nuclei have not been delineated in pd. |
2022-11-05 |
2023-08-14 |
Not clear |
| Nan Sun, Ya-Juan Qin, Chu Xu, Tian Xia, Zi-Wei Du, Li-Ping Zheng, An-An Li, Fan Meng, Yu Zhang, Jing Zhang, Xiao Liu, Ting-You Li, Dong-Ya Zhu, Qi-Gang Zho. Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science (New York, N.Y.). vol 378. issue 6618. 2022-10-27. PMID:36302033. |
we designed a fast-onset antidepressant that works by disrupting the interaction between the serotonin transporter (sert) and neuronal nitric oxide synthase (nnos) in the dorsal raphe nucleus (drn). |
2022-10-27 |
2023-08-14 |
mouse |
| HaiXiang Ma, Qian Yu, Yue Shen, XiTing Lian, LeYuan Gu, YuLing Wang, Qing Xu, Han Lu, HaiTing Zhao, Chang Zeng, Kazuki Nagayasu, HongHai Zhan. Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest. iScience. vol 25. issue 10. 2022-10-21. PMID:36267919. |
previous studies showed seizure-induced respiratory arrest (s-ira) is the main factor in sudep, and that enhancement of serotonin (5-ht) function in the dorsal raphe nucleus (dr) can significantly reduce the incidence of s-ira in the dba/1 mouse model of sudep. |
2022-10-21 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
both 5-ht and tryptophan hydroxylase-2 (tph2) were mainly present in the limbic systems of the cerebrum, such as the glomerular layer of the olfactory bulb, nucleus accumbens, cingulate, fimbria of the hippocampus, mediodorsal thalamic nucleus, habenular nucleus, ventromedial hypothalamus nucleus, lateral hypothalamus area, dorsal raphe nucleus and piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
tph2 and 5-ht were expressed in cell bodies in the dorsal raphe nucleus and piriform cortex, while in other regions they were distributed as filaments and clump shapes in axons. |
2022-10-20 |
2023-08-14 |
mouse |