| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
the ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of n-methyl-d-aspartate or its noncompetitive antagonist mk-801 into the ventral hippocampus. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
previous studies on hippocampal involvement in classical fear conditioning mainly focused on the dorsal hippocampus and conditioning to a context. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
however, in line with the strong interconnectivity of the ventral hippocampus with amygdala and nucleus accumbens, more recent studies indicated an even more global role for the ventral hippocampus in fear conditioning. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
the present study examined the formation of classical fear conditioning to explicit and contextual cues following stimulation or blockade of n-methyl-d-aspartate (nmda) receptors in the ventral hippocampus. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
nmda (0.5 microg/side) or the noncompetitive nmda antagonist mk-801 (dizocilpine; 6.25 microg/side) were bilaterally infused into the ventral hippocampus of wistar rats before fear conditioning to explicit and contextual cues. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
nmda stimulation of the ventral hippocampus blocked fear conditioning to both the tone and the context. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
our results support that the ventral hippocampus plays a role in the formation of classical fear conditioning. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
the specific anterograde amnesia for fear to a context after mk-801 infusion into the ventral hippocampus indicates that formation of classical fear conditioning to a context but not to a tone requires activation of nmda receptor-mediated processes in the ventral hippocampus. |
2002-01-22 |
2023-08-12 |
rat |
| W N Zhang, T Bast, J Feldo. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behavioural brain research. vol 126. issue 1-2. 2002-01-22. PMID:11704261. |
however, strong stimulation of the ventral hippocampus might also disrupt fear conditioning by interfering with processes in the projection areas of the ventral hippocampus, such as the amygdala or the nucleus accumbens. |
2002-01-22 |
2023-08-12 |
rat |
| T Bast, W N Zhang, J Feldo. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Experimental brain research. vol 139. issue 1. 2001-12-13. PMID:11482842. |
the ventral hippocampus and fear conditioning in rats. |
2001-12-13 |
2023-08-12 |
rat |
| T Bast, W N Zhang, J Feldo. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Experimental brain research. vol 139. issue 1. 2001-12-13. PMID:11482842. |
studies on the involvement of the rat hippocampus in classical fear conditioning have focused mainly on the dorsal hippocampus and conditioning to a context. |
2001-12-13 |
2023-08-12 |
rat |
| T Bast, W N Zhang, J Feldo. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Experimental brain research. vol 139. issue 1. 2001-12-13. PMID:11482842. |
however, the ventral hippocampus has intimate connections with the amygdala and the nucleus accumbens, which are involved in classical fear conditioning to explicit and contextual cues. |
2001-12-13 |
2023-08-12 |
rat |
| T Bast, W N Zhang, J Feldo. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Experimental brain research. vol 139. issue 1. 2001-12-13. PMID:11482842. |
consistently, a few recent lesion studies have indicated a role for the ventral hippocampus in classical fear conditioning to explicit and contextual cues. |
2001-12-13 |
2023-08-12 |
rat |
| T Bast, W N Zhang, J Feldo. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Experimental brain research. vol 139. issue 1. 2001-12-13. PMID:11482842. |
the present study examined whether neuronal activity within the ventral hippocampus is important for the formation of fear memory to explicit and contextual cues by classical fear conditioning. |
2001-12-13 |
2023-08-12 |
rat |
| T Bast, W N Zhang, J Feldo. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Experimental brain research. vol 139. issue 1. 2001-12-13. PMID:11482842. |
the data of the present study indicate that activity of neurons in the ventral hippocampus is necessary for the formation of fear memory to both explicit and contextual cues and that neurons in the ventral hippocampus that bear the gaba(a) receptor are important for the formation of fear conditioning to a context. |
2001-12-13 |
2023-08-12 |
rat |
| E J Weeber, D D Savage, R J Sutherland, K K Caldwel. Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex. Neurobiology of learning and memory. vol 76. issue 2. 2001-12-07. PMID:11502147. |
one hour following fear conditioning of untreated control rats, phospholipase c-beta1a protein level was increased in the hippocampal cytosolic fraction and decreased in the hippocampal membrane and cortical cytosolic and cortical membrane fractions. |
2001-12-07 |
2023-08-12 |
rat |
| E J Weeber, D D Savage, R J Sutherland, K K Caldwel. Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex. Neurobiology of learning and memory. vol 76. issue 2. 2001-12-07. PMID:11502147. |
twenty-four hours after fear conditioning, phospholipase c-beta1a protein level was reduced in the hippocampal cytosolic fraction and elevated in the cortical nuclear fraction; in addition, 24 h after conditioning, phospholipase c-beta1a activity in the cortical cytosolic fraction was increased. |
2001-12-07 |
2023-08-12 |
rat |
| E A Antoniadis, R J McDonal. Amygdala, hippocampus, and unconditioned fear. Experimental brain research. vol 138. issue 2. 2001-11-01. PMID:11417461. |
we have previously reported that rats with amygdala or hippocampal damage are impaired in discriminative fear conditioning to context. |
2001-11-01 |
2023-08-12 |
rat |
| E A Antoniadis, R J McDonal. Amygdala, hippocampus, and unconditioned fear. Experimental brain research. vol 138. issue 2. 2001-11-01. PMID:11417461. |
the impairment of discriminative fear conditioning to context, in combination with the present experiment, represents a dissociation where damage to specific memory structures (amygdala or hippocampus) debilitates the mnemonic processes involved in fear conditioning, but not the performance of the fear responses per se. |
2001-11-01 |
2023-08-12 |
rat |
| G V Wallenstein, D R Vag. Intrahippocampal scopolamine impairs both acquisition and consolidation of contextual fear conditioning. Neurobiology of learning and memory. vol 75. issue 3. 2001-08-23. PMID:11300731. |
lesions of the dorsal hippocampus have been shown to disrupt both the acquisition and the consolidation of memories associated with contextual fear (fear of the place of conditioning), but do not affect fear conditioning to discrete cues (e.g., a tone). |
2001-08-23 |
2023-08-12 |
Not clear |