| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anu Aonurm-Helm, Tamara Zharkovsky, Monika Jürgenson, Anti Kalda, Alexander Zharkovsk. Dysregulated CREB signaling pathway in the brain of neural cell adhesion molecule (NCAM)-deficient mice. Brain research. vol 1243. 2009-01-21. PMID:18817764. |
ncam-/- mice had also reduced levels of the phosphorylated camkii and camkiv in pfc/fc and the hippocampus, which are the downstream signaling molecules of ncam. |
2009-01-21 |
2023-08-12 |
mouse |
| Soon-Eng Ta. Roles of hippocampal NMDA receptors and nucleus accumbens D1 receptors in the amphetamine-produced conditioned place preference in rats. Brain research bulletin. vol 77. issue 6. 2008-12-29. PMID:18929625. |
our earlier reports showed that amph-cpp results in the enhancement of hippocampal camkii activity and it can be impaired by nmda antagonist (ap5). |
2008-12-29 |
2023-08-12 |
rat |
| A Wu, Z Ying, F Gomez-Pinill. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience. vol 155. issue 3. 2008-12-18. PMID:18620024. |
the levels of activated forms of hippocampal akt and camkii were increased by the dha-enriched diet, and with even greater elevation by a combination of diet and exercise. |
2008-12-18 |
2023-08-12 |
rat |
| Yu-Chih Lin, Lori Redmon. CaMKIIbeta binding to stable F-actin in vivo regulates F-actin filament stability. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 41. 2008-11-24. PMID:18840684. |
multiple roles of camkii have been identified in the hippocampus, yet its role in developing neurons is less well understood. |
2008-11-24 |
2023-08-12 |
Not clear |
| Sylvain Rama, Grigory Krapivinsky, David E Clapham, Igor Medin. The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Molecular and cellular neurosciences. vol 38. issue 2. 2008-09-09. PMID:18417361. |
at excitatory synapses of hippocampal neurons, the multi-pdz domain scaffolding protein, mupp1, assembles the nr2b subunit of the nmda receptor (nmdar), ca2+-calmodulin kinase (camkii), and the alpha1 isoform of the postsynaptic density gtpase activating protein, syngap (syngapalpha). |
2008-09-09 |
2023-08-12 |
Not clear |
| Henrik Viberg, Emma Pontén, Per Eriksson, Torsten Gordh, Anders Fredriksso. Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly. Toxicology. vol 249. issue 2-3. 2008-09-03. PMID:18550250. |
the protein analysis showed that camkii increased significantly in hippocampus, but not in cortex, in animals 24h after exposure to ketamine. |
2008-09-03 |
2023-08-12 |
mouse |
| Berta Sunyer, Ki-Shuk Shim, Harald Höger, Gert Lube. The cognitive enhancer SGS742 does not involve major known signaling cascades in OF1 mice. Neurochemical research. vol 33. issue 7. 2008-08-20. PMID:18322794. |
six hours following testing of1 mice in the morris water maze, hippocampal signaling proteins calmodulin kinase ii (camkii) (phosphorylated (p) and non-phosphorylated (np) form), creb (p, np), erk (p, np), bdnf, egr-1, trk-b and neuro-cytoskeleton elements drebrin and psd-95 were determined by immunoblotting. |
2008-08-20 |
2023-08-12 |
mouse |
| Feng Han, Norifumi Shioda, Shigeki Moriguchi, Yui Yamamoto, Alisa Y Ali Raie, Yoshimasa Yamaguchi, Masataka Hino, Kohji Fukunag. Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus. The Journal of pharmacology and experimental therapeutics. vol 326. issue 1. 2008-07-30. PMID:18388258. |
taken together, the cognition-enhancing effect of zset1446 is probably mediated in part by stimulation of camkii and pkc activities, which in turn rescue impaired hippocampal ltp in obx mice. |
2008-07-30 |
2023-08-12 |
mouse |
| Tao Song, Naoya Hatano, Toshie Kambe, Yoshiaki Miyamoto, Hideshi Ihara, Hideyuki Yamamoto, Katsuyoshi Sugimoto, Kodai Kume, Fuminori Yamaguchi, Masaaki Tokuda, Yasuo Watanab. Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18271754. |
in addition, treatment with glutamate caused an increase in camkii s-nitrosylation in rat hippocampal slices. |
2008-07-03 |
2023-08-12 |
rat |
| Karine Pelc, Stewart G Boyd, Guy Cheron, Bernard Da. Epilepsy in Angelman syndrome. Seizure. vol 17. issue 3. 2008-06-24. PMID:17904873. |
current hypotheses involve abnormal inhibitory transmission due to impaired regulation of gabaa receptors related to functional absence of ube3a and abnormal hippocampal camkii activity. |
2008-06-24 |
2023-08-12 |
Not clear |
| A Skibinska-Kijek, A Radwanska, M Kossu. Alpha calcium/calmodulin dependent protein kinase II in learning-dependent plasticity of mouse somatosensory cortex. Neuroscience. vol 151. issue 3. 2008-06-12. PMID:18164137. |
calcium/calmodulin dependent protein kinase ii (camkii), and more specifically its alpha subunit, is widely believed to be fundamental for hippocampal synaptic plasticity. |
2008-06-12 |
2023-08-12 |
mouse |
| Vladyslav V Vyazovskiy, Chiara Cirelli, Martha Pfister-Genskow, Ugo Faraguna, Giulio Tonon. Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nature neuroscience. vol 11. issue 2. 2008-05-08. PMID:18204445. |
we show that, in rat cortex and hippocampus, glur1-containing ampa receptor (ampar) levels are high during wakefulness and low during sleep, and changes in the phosphorylation states of ampars, camkii and gsk3beta are consistent with synaptic potentiation during wakefulness and depression during sleep. |
2008-05-08 |
2023-08-12 |
rat |
| Henrik Viberg, William Mundy, Per Eriksso. Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis. Neurotoxicology. vol 29. issue 1. 2008-05-02. PMID:18061678. |
the protein analysis showed that camkii increased significantly in hippocampus, but not in cortex, in animals 7 days after exposure to pbde 209. |
2008-05-02 |
2023-08-12 |
mouse |
| Pavan K Shetty, Freesia L Huang, Kuo-Ping Huan. Ischemia-elicited oxidative modulation of Ca2+/calmodulin-dependent protein kinase II. The Journal of biological chemistry. vol 283. issue 9. 2008-04-15. PMID:18174165. |
using two previously identified potential mediators of oxidants in the brain, glutathione disulfide s-monoxide (gs-dsmo) and glutathione disulfide s-dioxide (gs-dsdo), we showed that they oxidized and inhibited camkii in a manner partly related to those of the oxidant-treated synaptosomes as well as the ischemia-elicited oxidative stress in the acutely prepared hippocampal slices. |
2008-04-15 |
2023-08-12 |
mouse |
| M V Pletnikov, Y Ayhan, O Nikolskaia, Y Xu, M V Ovanesov, H Huang, S Mori, T H Moran, C A Ros. Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Molecular psychiatry. vol 13. issue 2. 2008-04-11. PMID:17848917. |
to evaluate the neuronal and behavioral effects of mutant disc1, the tet-off system under the regulation of the camkii promoter was used to generate transgenic mice with inducible expression of mutant human disc1 (hdisc1) limited to forebrain regions, including cerebral cortex, hippocampus and striatum. |
2008-04-11 |
2023-08-12 |
mouse |
| Yu Zhou, Eiki Takahashi, Weidong Li, Amy Halt, Brian Wiltgen, Dan Ehninger, Guo-Dong Li, Johannes W Hell, Mary B Kennedy, Alcino J Silv. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 50. 2008-01-22. PMID:18077696. |
the disruption decreases thr286 phosphorylation of alphacamkii, lowers phosphorylation of a key camkii substrate in the postsynaptic membrane (ampa receptor subunit glutamate receptor 1), and produces deficits in hippocampal long-term potentiation and spatial learning. |
2008-01-22 |
2023-08-12 |
mouse |
| Matthew Townsend, Tapan Mehta, Dennis J Selko. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. The Journal of biological chemistry. vol 282. issue 46. 2008-01-03. PMID:17855343. |
using mouse primary hippocampal neurons, we observed that a brief treatment with cell-derived, soluble, human abeta disrupted the activation of three kinases (erk/mapk, camkii, and the phosphatidylinositol 3-kinase-activated protein akt/protein kinase b) that are required for long term potentiation, whereas two other kinases (protein kinase a and protein kinase c) were stimulated normally. |
2008-01-03 |
2023-08-12 |
mouse |
| Tiziana Rubino, Mariaelvina Sala, Daniela Viganò, Daniela Braida, Chiara Castiglioni, Valeria Limonta, Cinzia Guidali, Natalia Realini, Daniela Parolar. Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 9. 2007-11-29. PMID:17287821. |
in the prefrontal cortex this increased activation was linked to an increase in erk activation, whereas in the hippocampus there was a drop in the activity of camkii, a kinase with inhibitory effect on creb activation. |
2007-11-29 |
2023-08-12 |
rat |
| Fabrizio Gardoni, Daniela Mauceri, Elena Marcello, Carlo Sala, Monica Di Luca, Andreas Jeromi. SAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: regulation by CaMKII. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17635915. |
sap97 directs the localization of kv4.2 to spines in hippocampal neurons: regulation by camkii. |
2007-11-08 |
2023-08-12 |
Not clear |
| Erik S Carlson, John D H Stead, Charles R Neal, Anna Petryk, Michael K Georgief. Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus. Hippocampus. vol 17. issue 8. 2007-10-31. PMID:17546681. |
id caused long-term diminished protein levels of four factors critical for hippocampal neuron differentiation and plasticity, including camkii alpha, fkbp1a (fkbp12), dlgh4 (psd-95), and vamp1 (synaptobrevin-1). |
2007-10-31 |
2023-08-12 |
human |