| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaofang Xue, Shuang Shao, Man Li, Feng Shao, Weiwen Wan. Maternal separation induces alterations of serotonergic system in different aged rats. Brain research bulletin. vol 95. 2014-02-10. PMID:23523983. |
in the present longitudinal study, we investigated the effects of repeated (4h/day) maternal separation during postnatal days 1-21 on serotonergic synthesis and activity in the prefrontal cortex (pfc), nucleus accumbens (nac) and hippocampus of juvenile (post-natal day 21, pnd 21), adolescent (pnd 35) and early adult (pnd 56) male wistar rats. |
2014-02-10 |
2023-08-12 |
rat |
| Mary Kay Lobo, Samir Zaman, Diane M Damez-Werno, Ja Wook Koo, Rosemary C Bagot, Jennifer A DiNieri, Alexandria Nugent, Eric Finkel, Dipesh Chaudhury, Ramesh Chandra, Efrain Riberio, Jacqui Rabkin, Ezekiell Mouzon, Roger Cachope, Joseph F Cheer, Ming-Hu Han, David M Dietz, David W Self, Yasmin L Hurd, Vincent Vialou, Eric J Nestle. ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 47. 2014-01-21. PMID:24259563. |
to explore the circuit-mediated induction of Δfosb in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to nac; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. |
2014-01-21 |
2023-08-12 |
mouse |
| Qian Bu, Lei Lv, Guangyan Yan, Pengchi Deng, Yanli Wang, Jiaqing Zhou, Yanzhu Yang, Yan Li, Xiaobo Ce. NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats. Neurotoxicology. vol 36. 2014-01-13. PMID:23462569. |
(1)h nmr spectroscopy was applied to investigate the changes of cerebral metabolites in brain hippocampus, nucleus accumbens (nac) and prefrontal cortex (pfc) of the rats subjected to subcutaneous twice-daily injections of 2.5mg/kg methamphetamine (map) for 7 days. |
2014-01-13 |
2023-08-12 |
rat |
| Qian Bu, Lei Lv, Guangyan Yan, Pengchi Deng, Yanli Wang, Jiaqing Zhou, Yanzhu Yang, Yan Li, Xiaobo Ce. NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats. Neurotoxicology. vol 36. 2014-01-13. PMID:23462569. |
the neurotransmitters glutamate, glutamine and gaba significantly decreased in hippocampus, nac and pfc. |
2014-01-13 |
2023-08-12 |
rat |
| Qian Bu, Lei Lv, Guangyan Yan, Pengchi Deng, Yanli Wang, Jiaqing Zhou, Yanzhu Yang, Yan Li, Xiaobo Ce. NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats. Neurotoxicology. vol 36. 2014-01-13. PMID:23462569. |
glutathione obviously decreased in above brain regions, whereas acetylcysteine declined in hippocampus and nac, and taurine declined in nac and pfc. |
2014-01-13 |
2023-08-12 |
rat |
| Qian Bu, Lei Lv, Guangyan Yan, Pengchi Deng, Yanli Wang, Jiaqing Zhou, Yanzhu Yang, Yan Li, Xiaobo Ce. NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats. Neurotoxicology. vol 36. 2014-01-13. PMID:23462569. |
homocysteic acid was elevated in hippocampus and nac by repeated map administration. |
2014-01-13 |
2023-08-12 |
rat |
| Qian Bu, Lei Lv, Guangyan Yan, Pengchi Deng, Yanli Wang, Jiaqing Zhou, Yanzhu Yang, Yan Li, Xiaobo Ce. NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats. Neurotoxicology. vol 36. 2014-01-13. PMID:23462569. |
these results indicate that repeated map treatment causes neurotransmitters disturbance, imbalance between oxidative stress and antioxidants, and gliosis in hippocampus, nac and pfc. |
2014-01-13 |
2023-08-12 |
rat |
| Man Li, Xiaofang Xue, Shuang Shao, Feng Shao, Weiwen Wan. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain research. vol 1518. 2014-01-07. PMID:23623774. |
previous studies have reported that ms affected prepulse inhibition (ppi), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4h/day) maternal separation during postnatal days 1-21 on ppi and anxiety-related behaviors in an elevated plus maze, as well as dopamine d2 receptor (drd2) and 5-ht1a receptor expression in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus in adolescent rats. |
2014-01-07 |
2023-08-12 |
rat |
| Man Li, Xiaofang Xue, Shuang Shao, Feng Shao, Weiwen Wan. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain research. vol 1518. 2014-01-07. PMID:23623774. |
our findings show that repeated ms results in reduced ppi, increased anxiety-related behaviors, decreased drd2 protein expression in the nac and hippocampus, and decreased 5-ht1a protein expression in the mpfc and hippocampus in adolescent rats. |
2014-01-07 |
2023-08-12 |
rat |
| Lucas Albrechet-Souza, Milene Cristina Carvalho, Marcus Lira Brandã. D(1)-like receptors in the nucleus accumbens shell regulate the expression of contextual fear conditioning and activity of the anterior cingulate cortex in rats. The international journal of neuropsychopharmacology. vol 16. issue 5. 2014-01-03. PMID:22964037. |
in fact, projection areas of the ventral tegmental area, such as the amygdala and hippocampus, are well established to be involved in the acquisition and expression of fear conditioning, while less is known about the role of the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) in these processes. |
2014-01-03 |
2023-08-12 |
rat |
| Aline Rideau Batista Novais, Janique Guiramand, Catherine Cohen-Solal, Nadine Crouzin, Marie Céleste de Jesus Ferreira, Michel Vignes, Gérard Barbanel, Gilles Camboni. N-acetyl-cysteine prevents pyramidal cell disarray and reelin-immunoreactive neuron deficiency in CA3 after prenatal immune challenge in rats. Pediatric research. vol 73. issue 6. 2013-12-18. PMID:23478644. |
in the present study, we evaluated the occurrence of pyramidal cell disarray and reelin neuronal deficit in the hippocampus, and the protective role of n-acetyl-cysteine (nac) in a rodent experimental model of prenatal immune challenge. |
2013-12-18 |
2023-08-12 |
rat |
| David S Tukey, Michelle Lee, Duo Xu, Sarah E Eberle, Yossef Goffer, Toby R Manders, Edward B Ziff, Jing Wan. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Molecular brain. vol 6. 2013-11-27. PMID:23835161. |
glutamate inputs to the nac arise primarily from prefrontal cortex, thalamus, amygdala, and hippocampus, and different glutamate projections provide distinct synaptic and ultimately behavioral functions. |
2013-11-27 |
2023-08-12 |
Not clear |
| Pauline Belujon, Mary H Patton, Anthony A Grac. Disruption of prefrontal cortical-hippocampal balance in a developmental model of schizophrenia: reversal by sulpiride. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:23067577. |
the nucleus accumbens (nac) receives converging inputs from the medial prefrontal cortex (mpfc) and the hippocampus which have competitive interactions in the nac to influence motivational drive. |
2013-10-31 |
2023-08-12 |
Not clear |
| Pauline Belujon, Mary H Patton, Anthony A Grac. Disruption of prefrontal cortical-hippocampal balance in a developmental model of schizophrenia: reversal by sulpiride. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:23067577. |
thus, because mpfc-hippocampal balance is known to be partially altered in this model, we investigated potential pathological changes in the hippocampal influence over cortex-driven nac spike activity. |
2013-10-31 |
2023-08-12 |
Not clear |
| Franciela P Della, Helena M Abelaira, Gislaine Z Réus, Altamir R Antunes, Maria Augusta B Dos Santos, Giovanni Zappelinni, Amanda V Steckert, Francieli Vuolo, Letícia S Galant, Felipe Dal-Pizzol, Flávio Kapczinski, João Queved. Tianeptine exerts neuroprotective effects in the brain tissue of rats exposed to the chronic stress model. Pharmacology, biochemistry, and behavior. vol 103. issue 2. 2013-06-11. PMID:23036485. |
additionally, il-6, il-1, tnf-α levels and oxidative stress parameters were assessed in the prefrontal cortex (pfc), hippocampus (hpc), amygdala (amy) and nucleus accumbens (nac) in all of the experimental groups studied. |
2013-06-11 |
2023-08-12 |
rat |
| Camila O Arent, Gislaine Z Réus, Helena M Abelaira, Karine F Ribeiro, Amanda V Steckert, Francielle Mina, Felipe Dal-Pizzol, João Queved. Synergist effects of n-acetylcysteine and deferoxamine treatment on behavioral and oxidative parameters induced by chronic mild stress in rats. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22898295. |
treatment with nac and dfx decreased the oxidative damage, which include superoxide and tbars production in submitochondrial particles, and also thiobarbituric acid reactive substances (tbars) levels and carbonyl proteins in the prefrontal cortex, amygdala and hippocampus. |
2013-06-05 |
2023-08-12 |
rat |
| Camila O Arent, Gislaine Z Réus, Helena M Abelaira, Karine F Ribeiro, Amanda V Steckert, Francielle Mina, Felipe Dal-Pizzol, João Queved. Synergist effects of n-acetylcysteine and deferoxamine treatment on behavioral and oxidative parameters induced by chronic mild stress in rats. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22898295. |
even so, a combined treatment with nac and dfx produced a stronger increase of antioxidant activities in the prefrontal cortex, amygdala and hippocampus. |
2013-06-05 |
2023-08-12 |
rat |
| Jamile F Gonçalves, Roselia M Spanevello, Amanda M Fiorenza, Cinthia M Mazzanti, Margarete D Bagatini, Cíntia S da Rosa, Lara V Becker, Pauline da Costa, Fátima H Abdalla, Vera M Morsch, Maria Rosa C Schetinge. NTPDase and 5'-nucleotidase activities from synaptosomes and platelets of rats exposed to cadmium and treated with N-acetylcysteine. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 1. 2013-05-30. PMID:23147562. |
in relation to hippocampus synaptosomes, no differences on the ntpdase and 5'-nucleotidase activities of cd-poisoned rats were observed and only the 5'-nucleotidase activity was increased by the administration of nac per se. |
2013-05-30 |
2023-08-12 |
rat |
| Andrey Sequeira-Cordero, Marianela Masís-Calvo, Andrea Mora-Gallegos, Jaime Fornaguera-Tría. Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats. Behavioural brain research. vol 237. 2013-04-26. PMID:23018125. |
this effect seems to be associated with the serotonergic systems in both nucleus accumbens (nac) and hippocampus (hpc), since offspring of low lg mothers showed decreased 5-ht neurotransmission in those brain regions compared with animals of high lg mothers. |
2013-04-26 |
2023-08-12 |
rat |
| R B Price, D A Eldreth, J Mohlma. Deficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigation. Translational psychiatry. vol 1. 2013-04-04. PMID:22833192. |
during negative words (in comparison with neutral), the nac group showed pfc activations, coupled with deactivation of task-irrelevant emotional processing regions such as the amygdala and hippocampus. |
2013-04-04 |
2023-08-12 |
human |