| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Chepurnov, N E Chepurnova, A A Ponomarenko, M O Pereverze. [Pituitary adenylate cyclase activating peptide (PACAP)--its polyfunctionality in the mechanisms of brain protection]. Uspekhi fiziologicheskikh nauk. vol 30. issue 2. 1999-08-18. PMID:10420472. |
pacap increase cytosolic free calcium and modifies the calcium-sensitive k(+)-channels, pacap protects cultures cortical and hippocampal neurons from glutamate-induced cytotoxicity. |
1999-08-18 |
2023-08-12 |
Not clear |
| Y Skoglösa, N Takei, D Lindhol. Distribution of pituitary adenylate cyclase activating polypeptide mRNA in the developing rat brain. Brain research. Molecular brain research. vol 65. issue 1. 1999-04-07. PMID:10036302. |
pacap mrna is expressed in distinct parts of the embryonic rat brain from embryonic day 13, with a robust expression in developing cortex, hippocampus, amygdala and hypothalamus as well as in spinal cord and dorsal root ganglia. |
1999-04-07 |
2023-08-12 |
rat |
| Y Skoglösa, N Takei, D Lindhol. Distribution of pituitary adenylate cyclase activating polypeptide mRNA in the developing rat brain. Brain research. Molecular brain research. vol 65. issue 1. 1999-04-07. PMID:10036302. |
in the mature brain, pacap mrna is located in alternating layers of cerebral cortex (layers i, iii and v), in the dentate gyrus, in ca4 and ca1 regions, but not in ca2 or ca3 of the hippocampus. |
1999-04-07 |
2023-08-12 |
rat |
| S Shioda, H Ozawa, K Dohi, H Mizushima, K Matsumoto, S Nakajo, A Takaki, C J Zhou, Y Nakai, A Arimur. PACAP protects hippocampal neurons against apoptosis: involvement of JNK/SAPK signaling pathway. Annals of the New York Academy of Sciences. vol 865. 1999-02-16. PMID:9928003. |
pacap protects hippocampal neurons against apoptosis: involvement of jnk/sapk signaling pathway. |
1999-02-16 |
2023-08-12 |
rat |
| S Shioda, H Ozawa, K Dohi, H Mizushima, K Matsumoto, S Nakajo, A Takaki, C J Zhou, Y Nakai, A Arimur. PACAP protects hippocampal neurons against apoptosis: involvement of JNK/SAPK signaling pathway. Annals of the New York Academy of Sciences. vol 865. 1999-02-16. PMID:9928003. |
we have demonstrated that the ischemia-induced apoptosis of neurons in the ca1 region of the rat hippocampus was prevented by either intracerebroventricular or intravenous infusion of pituitary adenylate cyclase-activating polypeptide (pacap). |
1999-02-16 |
2023-08-12 |
rat |
| W A Banks, D Uchida, A Arimura, A Somogyvári-Vigh, S Shiod. Transport of pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier and the prevention of ischemia-induced death of hippocampal neurons. Annals of the New York Academy of Sciences. vol 805. 1997-02-10. PMID:8993409. |
we found that pacap given intravenously could indeed prevent the death of ca1 hippocampal neurons, even if the administration of pacap was delayed for 24 h after the ischemic event. |
1997-02-10 |
2023-08-12 |
Not clear |
| V D'Agata, S Cavallaro, F Stivala, P L Canonic. Tissue-specific and developmental expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in rat brain. The European journal of neuroscience. vol 8. issue 2. 1996-10-22. PMID:8714702. |
we examined the expression of pacap receptors in the rat cortex, hippocampus, cerebellum and hypothalamus during postnatal development. |
1996-10-22 |
2023-08-12 |
rat |
| V D'Agata, S Cavallaro, F Stivala, P L Canonic. Tissue-specific and developmental expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in rat brain. The European journal of neuroscience. vol 8. issue 2. 1996-10-22. PMID:8714702. |
throughout development, the efficacy or pacap in stimulating camp formation slightly increased in the cortex and hypothalamus and decreased in the hippocampus and cerebellum; pacap stimulation of [3h]insp formation decreased in the cerebellum and remained steady in the hypothalamus. |
1996-10-22 |
2023-08-12 |
rat |
| K Köves, T J Görcs, M Kausz, A Arimur. Present status of knowledge about the distribution and colocalization of PACAP in the forebrain. Acta biologica Hungarica. vol 45. issue 2-4. 1995-05-25. PMID:7725824. |
in the central nervous system pacap immunoreactive neuronal elements have been observed in the hypothalamus (magno- and parvocellular cell groups), both layers of the median eminence, the septum, the thalamus, the amygdaloid complex, the hippocampus, and various regions of the cortex. |
1995-05-25 |
2023-08-12 |
Not clear |
| X Hou, A Vandermeers, P Gourlet, M C Vandermeers-Piret, P Robberech. Structural requirements for the occupancy of rat brain PACAP receptors and adenylate cyclase activation. Neuropharmacology. vol 33. issue 10. 1995-03-17. PMID:7862254. |
n-terminally shortened analogues of pacap(1-27) and pacap(1-38), and analogues modified in position 1,2 or 3 were compared for their ability to interact with pacap receptors and to activate or inhibit adenylate cyclase in rat brain hippocampus membranes. |
1995-03-17 |
2023-08-12 |
rat |
| H Hashimoto, T Ishihara, R Shigemoto, K Mori, S Nagat. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron. vol 11. issue 2. 1993-09-21. PMID:8394723. |
in situ hybridization revealed a high level of expression of pacap receptor mrna in the hippocampal dentate gyrus, olfactory bulb, and cerebellar cortex. |
1993-09-21 |
2023-08-12 |
rat |
| Y Masuo, Y Matsumoto, F Tokito, M Tsuda, M Fujin. Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis. Brain research. vol 611. issue 2. 1993-08-26. PMID:8334515. |
effects of vasoactive intestinal polypeptide (vip) and pituitary adenylate cyclase activating polypeptide (pacap) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis. |
1993-08-26 |
2023-08-12 |
rat |
| Y Masuo, Y Matsumoto, F Tokito, M Tsuda, M Fujin. Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis. Brain research. vol 611. issue 2. 1993-08-26. PMID:8334515. |
recently, a vip-related novel peptide, pituitary adenylate cyclase activating polypeptide (pacap) was isolated from the ovine hypothalamus, and we previously demonstrated in the rat that pacap binding site densities were high in the hippocampus. |
1993-08-26 |
2023-08-12 |
rat |
| Y Masuo, Y Matsumoto, F Tokito, M Tsuda, M Fujin. Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis. Brain research. vol 611. issue 2. 1993-08-26. PMID:8334515. |
in the present study, we investigated the effects of vip and pacap on the release of ach from the rat hippocampus. |
1993-08-26 |
2023-08-12 |
rat |
| Y Masuo, T Ohtaki, Y Masuda, M Tsuda, M Fujin. Binding sites for pituitary adenylate cyclase activating polypeptide (PACAP): comparison with vasoactive intestinal polypeptide (VIP) binding site localization in rat brain sections. Brain research. vol 575. issue 1. 1992-09-24. PMID:1324082. |
radiolabeled pacap and vip showed highly specific binding to sections at the level of the dorsal hippocampus. |
1992-09-24 |
2023-08-11 |
rat |
| Y Masuo, T Ohtaki, Y Masuda, M Tsuda, M Fujin. Binding sites for pituitary adenylate cyclase activating polypeptide (PACAP): comparison with vasoactive intestinal polypeptide (VIP) binding site localization in rat brain sections. Brain research. vol 575. issue 1. 1992-09-24. PMID:1324082. |
the specific binding of [125i]pacap was 10 times higher than that of [125i]vip in hippocampal sections. |
1992-09-24 |
2023-08-11 |
rat |
| A Cauvin, P Robberecht, P De Neef, P Gourlet, A Vandermeers, M C Vandermeers-Piret, J Christoph. Properties and distribution of receptors for pituitary adenylate cyclase activating peptide (PACAP) in rat brain and spinal cord. Regulatory peptides. vol 35. issue 2. 1992-02-06. PMID:1661904. |
a high density (in the pmol/mg protein range) of specific functional receptors for pacap (pituitary adenylate cyclase activating polypeptide) was observed in membranes from rat brain cortex, olfactory bulb, hypothalamus, hippocampus, striatum, cerebellum, pons and cervico-dorsal spinal cord, using [125i]pacap-27 (pacap 1-27). |
1992-02-06 |
2023-08-11 |
rat |
| Y Masuo, T Ohtaki, Y Masuda, Y Nagai, M Suno, M Tsuda, M Fujin. Autoradiographic distribution of pituitary adenylate cyclase activating polypeptide (PACAP) binding sites in the rat brain. Neuroscience letters. vol 126. issue 2. 1991-10-31. PMID:1922918. |
high densities of specific [125i]pacap binding were observed in the anterior pituitary, hippocampus (ca1-4 and dentate gyrus) and in the superior colliculus. |
1991-10-31 |
2023-08-11 |
rat |
| P Gourlet, M C Woussen-Colle, P Robberecht, P de Neef, A Cauvin, M C Vandermeers-Piret, A Vandermeers, J Christoph. Structural requirements for the binding of the pituitary adenylate-cyclase-activating peptide to receptors and adenylate-cyclase activation in pancreatic and neuronal membranes. European journal of biochemistry. vol 195. issue 2. 1991-04-02. PMID:1997328. |
pacap (pituitary adenylate-cyclase-activating peptide)-binding receptors were investigated in membranes from the rat pancreatic acinar cell line, ar 4-2j, the rat hippocampus and the human neuroblastoma cell line nb-ok, by 125i-pacap(1-27) (amino acid residues 1-27 of n-terminal amidated pacap) binding and adenylate cyclase activation. |
1991-04-02 |
2023-08-11 |
human |