| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amin Moqadami, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradara. Minocycline declines interleukin-1ß-induced apoptosis and matrix metalloproteinase expression in C28/I2 chondrocyte cells: an in vitro study on osteoarthritis. EXCLI journal. vol 23. 2024-03-15. PMID:38487083. |
minocycline declines interleukin-1ß-induced apoptosis and matrix metalloproteinase expression in c28/i2 chondrocyte cells: an in vitro study on osteoarthritis. |
2024-03-15 |
2024-03-17 |
human |
| Amin Moqadami, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradara. Minocycline declines interleukin-1ß-induced apoptosis and matrix metalloproteinase expression in C28/I2 chondrocyte cells: an in vitro study on osteoarthritis. EXCLI journal. vol 23. 2024-03-15. PMID:38487083. |
interleukin-1 beta (il-1β) is increased in the injured joints and contributes to the oa pathobiology by inducing chondrocyte apoptosis and up-regulation of matrix metalloproteinases (mmps). |
2024-03-15 |
2024-03-17 |
human |
| Yaling Yu, Yixin Jiang, Hongfan Ge, Xiaoli Fan, Hang Gao, Zhenlei Zho. HIF-1α in cartilage homeostasis, apoptosis, and glycolysis in mice with steroid-induced osteonecrosis of the femoral head. Journal of cellular physiology. 2024-03-14. PMID:38481029. |
in this study, sonfh models were established using methylprednisolone (mps) in mouse and its proliferating chondrocytes to investigate the role of hif-1α in cartilage differentiation, extracellular matrix (ecm) homeostasis, apoptosis and glycolysis in sonfh mice. |
2024-03-14 |
2024-03-16 |
mouse |
| Shuai Li, Jinpeng Du, Yunfei Huang, Shenglong Gao, Zhigang Zhao, Zhen Chang, Xuefang Zhang, BaoRong H. From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration. Frontiers in immunology. vol 15. 2024-03-06. PMID:38444852. |
diabetes and advanced glycation end products (ages) accumulation- can lead to various adverse effects on the ivd, including cell senescence, apoptosis, pyroptosis, proliferation, and extracellular matrix (ecm) degradation. |
2024-03-06 |
2024-03-08 |
Not clear |
| Anwesha Mukherjee, Bodhisatwa Da. The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis. Biomaterials and biosystems. vol 13. 2024-03-05. PMID:38440290. |
the critical role of inflammation in the pathogenesis of oa is discussed in detail along with the dysregulation within the cytokine networks composed of inflammatory and anti-inflammatory cytokines that drive catabolic pathways, inhibit matrix synthesis, and promote cellular apoptosis. |
2024-03-05 |
2024-03-07 |
Not clear |
| Ya-Ruo Lei, Xian-Lu He, Jun Li, Chun-Fen M. Drug Resistance in Hepatocellular Carcinoma: Theoretical Basis and Therapeutic Aspects. Frontiers in bioscience (Landmark edition). vol 29. issue 2. 2024-02-29. PMID:38420802. |
drug resistance exhibits multiple and complex molecular mechanisms to antagonize therapy under pharmacological pressure, including overexpression of drug efflux transporters, downstream adaptive response (such as apoptosis, autophagy, and endoplasmic reticulum stress), dysfunction of dna damage repair (ddr), epigenetic modification, tumor microenvironment (tme) as well as extracellular matrix (ecm). |
2024-02-29 |
2024-03-02 |
Not clear |
| Chao Song, Peixuan Hu, Renpeng Peng, Feng Li, Zhong Fang, Yong X. Bioenergetic dysfunction in the pathogenesis of intervertebral disc degeneration. Pharmacological research. 2024-02-28. PMID:38417775. |
hyperglycemia in diabetic diseases leads to cell senescence, the senescence-associated phenotype (sasp), apoptosis and catabolism of extracellualr matrix in ivds. |
2024-02-28 |
2024-03-02 |
human |
| Yan Zhang, Qiang Lyu, Xiao Han, Xu Wang, Ran Liu, Jing Hao, Li Zhang, Xiang-Mei Che. Proteomic analysis of multiple organ dysfunction induced by rhabdomyolysis. Journal of proteomics. 2024-02-25. PMID:38403185. |
serpina3n is a secreted protein and specifically inhibits a variety of proteases and participates in multiple physiological processes such as complement activation, inflammatory responses, apoptosis pathways, and extracellular matrix metabolism. |
2024-02-25 |
2024-02-28 |
rat |
| Nan Wang, Weihao Rong, Yimin Xie, Shuang Chen, Zhipeng Xi, Rongrong Den. Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration. Experimental gerontology. 2024-02-21. PMID:38382680. |
the progression of ivdd is linked to structural and functional alterations in tissues, where an imbalance in the inflammatory microenvironment can induce extracellular matrix (ecm) degradation, senescence, and apoptosis. |
2024-02-21 |
2024-02-24 |
Not clear |
| Jie Chen, Bin Zhang, Liwei Wu, Jiabin X. Ginsenoside Rg3 exhibits anti-catabolic and anti-apoptotic effects in IL-1β treated human disc nucleus pulposus cells and in a rat model of disc degeneration by inactivating the MAPK pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 1. 2024-02-19. PMID:38372089. |
idd is characterized by a large number of apoptosis of nucleus pulposus cells (npcs) and extracellular matrix (ecm) degradation. |
2024-02-19 |
2024-02-21 |
human |
| Xueqiang Tao, Fen Xue, Jiayuan Xu, Wenbo Wan. Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis. Cellular signalling. 2024-02-19. PMID:38373669. |
intervertebral disc degeneration (idd) is a main contributor to lower back pain, and compression stress-induced apoptosis of nucleus pulposus (np) cells and extracellular matrix (ecm) degradation has been implicated in the idd progression. |
2024-02-19 |
2024-02-22 |
mouse |
| Jian Wu, Chaoye Wang, Shuhui Sun, Tianmin Ren, Lijie Pan, Hongyi Liu, Simeng Hou, Shen Wu, Xuejing Yan, Jingxue Zhang, Xiaofang Zhao, Weihai Liu, Sirui Zhu, Shuwen Wei, Chi Zhang, Xu Jia, Qi Zhang, Ziyu Yu, Yehong Zhuo, Qi Zhao, Chenlong Yang, Ningli Wan. Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues. Protein & cell. 2024-02-17. PMID:38366188. |
our work further demonstrated that silencing the apoe gene could increase migration and reduce apoptosis by releasing the inhibition on the pi3k-akt pathway and downregulating the expression of extracellular matrix components, thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal range. |
2024-02-17 |
2024-02-19 |
monkey |
| Yi Sun, Yu Ren, Li-Yun Song, Yin-Ying Wang, Tian-Gang Li, Ying-Li Wu, Li Li, Zhong-Shan Yan. Targeting iron-metabolism:a potential therapeutic strategy for pulmonary fibrosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-16. PMID:38364737. |
dysregulation of iron can lead to iron overload, which increases the virulence of microbial colonisers and the occurrence of oxidative stress, causing alveolar epithelial cells to undergo necrosis and apoptosis, and form extracellular matrix. |
2024-02-16 |
2024-02-19 |
Not clear |
| Yan Wu, Luxin Li, Zuojun Ning, Changrong Li, Yongkui Yin, Kaiyuan Chen, Lu Li, Fei Xu, Jie Ga. Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration. Cell communication and signaling : CCS. vol 22. issue 1. 2024-02-15. PMID:38360732. |
this involves the regulation of autophagy in diverse cell types implicated in tissue regeneration, encompassing the modulation of inflammatory responses, oxidative stress, cell differentiation, proliferation, migration, apoptosis, and extracellular matrix formation. |
2024-02-15 |
2024-02-18 |
Not clear |
| Jie Li, Junqin Zhang, Zhaoping Chu, Hua Han, Yuan Zhan. FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway. Journal of biochemical and molecular toxicology. vol 38. issue 2. 2024-02-13. PMID:38348712. |
fzd3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the wnt signaling pathway. |
2024-02-13 |
2024-02-15 |
Not clear |
| Chen-Yu Li, Ru-Xin Xie, Shi-Wei Zhang, Jiao Yun, Ai Zhong, Ying Cen, Jun-Jie Che. Metabolism, fibrosis, and apoptosis: The effect of lipids and their derivatives on keloid formation. International wound journal. vol 21. issue 2. 2024-02-10. PMID:38339798. |
our research elucidates the pivotal roles of lipids and their derivatives in keloid development, driven by underlying mechanisms of abnormal cell proliferation, apoptosis, and extracellular matrix deposition. |
2024-02-10 |
2024-02-12 |
Not clear |
| Dominika Domagała, Krzysztof Data, Hubert Szyller, Maryam Farzaneh, Paul Mozdziak, Sławomir Woźniak, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempist. Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology. Cells. vol 13. issue 3. 2024-02-09. PMID:38334666. |
the loss of extracellular matrix (ecm) due to cell apoptosis and phenotype switching reduces tissue density and may contribute to aaa. |
2024-02-09 |
2024-02-11 |
Not clear |
| Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. |
pten hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through bcl-xl. |
2024-02-07 |
2024-02-10 |
Not clear |
| Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. |
the findings of our study provide validation for the role of pten in inhibiting the development of hypertrophic scars (hs) by modulating the expression of extracellular matrix (ecm) proteins and promoting apoptosis in hypertrophic scar fibroblasts (hsfs) via bcl-xl. |
2024-02-07 |
2024-02-10 |
Not clear |
| Deren Liu, Wei Mei, Junfeng Kang, Taiyang Liao, Yibao Wei, Lishi Jie, Lei Shi, Peimin Wang, Jun Mao, Peng W. Casticin ameliorates osteoarthritic cartilage damage in rats through PI3K/AKT/HIF-1α signaling. Chemico-biological interactions. 2024-02-03. PMID:38309612. |
in vivo, cas attenuated il-1β-induced cartilage matrix degradation, apoptosis and the inflammatory response. |
2024-02-03 |
2024-02-06 |
rat |