| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenqiang Yan, Yue Wu, Fengyuan Zhao, Ruilan Dai, Yunan Zhou, Dingge Liu, Jin Cheng, Xiaoqing Hu, Yingfang A. Anti-Apoptosis Therapy for Meniscal Avascular Zone Repair: A Proof-of-Concept Study in a Lapine Model. Bioengineering (Basel, Switzerland). vol 10. issue 12. 2023-12-23. PMID:38136013. |
we found the locally administered z-vad-fmk agent at the wound interface significantly alleviated meniscal cell apoptosis and matrix degradation, and enhanced meniscal repair in the avascular zone at 12 months after operation. |
2023-12-23 |
2023-12-25 |
Not clear |
| Nina Blazevic, Dunja Rogic, Stipe Pelajic, Marijana Miler, Goran Glavcic, Valentina Ratkajec, Nikolina Vrkljan, Dejan Bakula, Davor Hrabar, Tajana Pavi. YKL-40 as a biomarker in various inflammatory diseases: A review. Biochemia medica. vol 34. issue 1. 2023-12-21. PMID:38125621. |
although its accurate function is yet unknown, the pattern of its expression in the normal and disease states suggests its possible engagement in apoptosis, inflammation and remodeling or degradation of the extracellular matrix. |
2023-12-21 |
2023-12-23 |
Not clear |
| Chuan Guo, Yuheng Liu, Zhen Zhao, Ye Wu, Qingquan Kong, Yu Wan. Regulating inflammation and apoptosis: A smart microgel gene delivery system for repairing degenerative nucleus pulposus. Journal of controlled release : official journal of the Controlled Release Society. 2023-12-21. PMID:38128882. |
the progression of intervertebral disc degeneration (idd) is attributed to the gradual exacerbation of cellular apoptosis and impaired extracellular matrix (ecm) synthesis, both of which are induced by progressive inflammation. |
2023-12-21 |
2023-12-24 |
Not clear |
| Yufei Huang, Yafei Zhang, Sheng Yang, Yonghong Shi, Xiaoya Chu, Nisar Ahmed, Jingxian Wu, Qiusheng Che. Tembusu virus induced apoptosis in vacuolate spermatogenic cells is mediated by Cytc-mediated mitochondrial apoptotic signaling pathway. Theriogenology. vol 215. 2023-12-21. PMID:38128224. |
after dtmuv infection, a large amount of cytochrome c(cytc) was released from the mitochondrial matrix into the cytoplasm, activating downstream target proteins and causing apoptosis. |
2023-12-21 |
2023-12-24 |
Not clear |
| Lei Yang, Zhao-Yong Li, Lu Ma, Yan-Tao Guo, Shao-Feng Yang, Hui Xiong, Bo-Yu Wu, Jia-Hao Duan, En-Xu Liu, Chao Zhang, Ying Nie, Long Chen, Lin-Quan Li. [Aucubin combined with ADSCs-exos protects TBHP-induced nucleus pulposus cells via TLR4/NF-κB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 19. 2023-12-19. PMID:38114119. |
in summary, both aucubin and adscs-exos could exert protective effects by inhibiting inflammatory responses, reducing apoptosis and senescence of npcs, improving cell viability and proliferation as well as extracellular matrix synthesis, which may be associated with the inhibition of tlr4/nf-κb signaling pathway activation. |
2023-12-19 |
2023-12-23 |
Not clear |
| Arina Piechka, Sydney Sparanese, Luke Witherspoon, Faraz Hach, Ryan Flanniga. Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia. Nature reviews. Urology. 2023-12-18. PMID:38110528. |
these mechanisms include abnormalities in both somatic cells and germ cells in noa testes, such as somatic cell immaturity, aberrant growth factor signalling, increased inflammation, increased apoptosis and abnormal extracellular matrix regulation. |
2023-12-18 |
2023-12-21 |
Not clear |
| Shih-Ya Hung, Jen-Lung Chen, Yuan-Kun Tu, Hsin-Yi Tsai, Pin-Hsuan Lu, I-Ming Jou, Lulekiwe Mbuyisa, Ming-Wei Li. Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2/HO-1-mediated pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-13. PMID:38091640. |
the study findings reveal that cytokines markedly induced oxidative stress, the activation of matrix metalloproteinases, and apoptosis both in vitro and in vivo. |
2023-12-13 |
2023-12-17 |
human |
| Guilai Zuo, Pengzhen Zhuang, Xinghai Yang, Qi Jia, Zhengwei Cai, Jin Qi, Lianfu Deng, Zhenhua Zhou, Wenguo Cui, Jianru Xia. Regulating Chondro-Bone Metabolism for Treatment of Osteoarthritis via High-Permeability Micro/Nano Hydrogel Microspheres. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-12-12. PMID:38084002. |
in vitro experiments confirmed that the selenium atoms scavenged reactive oxygen species (ros) from the mitochondria of mononuclear macrophages, inhibited osteoclast differentiation and function, and suppressed early chondrocyte apoptosis to maintain a balance between cartilage matrix synthesis and catabolism. |
2023-12-12 |
2023-12-17 |
Not clear |
| Xiangrong Liu, Wenqi Bai, Jianrong Li, Jinfeng Ma, Yan Liu, Zhixiang Wang, Linjie Hu, Zheng Li, Dimitri Papukashvili, Nino Rcheulishvili, Fusheng Wang, Xiaoqing L. MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. The breast journal. vol 2023. 2023-12-11. PMID:38075552. |
moreover, cell migration and invasion, as well as the protein levels of phosphatidylinositol 3-kinase (pi3k), akt, matrix metalloproteinase (mmp) 2, and mmp9, were significantly lower in the groups treated with sirna while the apoptosis was augmented. |
2023-12-11 |
2023-12-17 |
Not clear |
| Huan Deng, Yao Wang, Yue Yin, Jun Shu, Junwei Zhang, Xuedong Shu, Fang Wu, Jing H. Effects of matrix viscoelasticity on cell-matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma MG-63 cells. Journal of materials chemistry. B. 2023-12-11. PMID:38079114. |
effects of matrix viscoelasticity on cell-matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma mg-63 cells. |
2023-12-11 |
2023-12-17 |
Not clear |
| Huan Deng, Yao Wang, Yue Yin, Jun Shu, Junwei Zhang, Xuedong Shu, Fang Wu, Jing H. Effects of matrix viscoelasticity on cell-matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma MG-63 cells. Journal of materials chemistry. B. 2023-12-11. PMID:38079114. |
besides the upregulation of mapk, ras, rap1 and pi3k-akt pathways commonly involved in mechanotransduction, the upregulation of the wnt pathway and inhibited endoplasmic reticulum stress-mediated apoptosis were observed for the viscous matrix with a low loss modulus. |
2023-12-11 |
2023-12-17 |
Not clear |
| Zhifang Tang, Jingyuan Li, Chuan L. Post-Transcriptional Regulator RBM47 Stabilizes FBXO2 mRNA to Advance Osteoarthritis Development: WGCNA Analysis and Experimental Validation. Biochemical genetics. 2023-12-09. PMID:38070024. |
functional analysis results from the mtt assay, flow cytometry, evaluation of ldh activities and inflammatory mediators, and western blot analysis of extracellular matrix (ecm) proteins, showed that rbm47 knockdown significantly alleviated inflammation, apoptosis, and ecm degradation in interleukin 1β (il-1β)-treated chondrocytes. |
2023-12-09 |
2023-12-17 |
Not clear |
| Zhaoni Wang, Wanshan Li, Shixing Chen, Xiao Xiao Tan. Role of ADAM and ADAMTS proteases in pathological tissue remodeling. Cell death discovery. vol 9. issue 1. 2023-12-09. PMID:38071234. |
mounting studies suggest that adam and adamts proteases contribute to the development of tissue remodeling in various diseases, mainly through the regulation of cell proliferation, apoptosis, migration and extracellular matrix remodeling. |
2023-12-09 |
2023-12-17 |
Not clear |
| Smriti Gaba, Utkarsh Jai. Advanced biosensors for nanomaterial-based detection of transforming growth factor alpha and beta, a class of major polypeptide regulators. International journal of biological macromolecules. 2023-12-08. PMID:38065462. |
transforming growth factors (tgfs) regulate several cellular processes including, differentiation, growth, migration, extracellular matrix production, and apoptosis. |
2023-12-08 |
2023-12-17 |
Not clear |
| Ruijie Liu, Qi Wang, Xiaoping Zhan. Identification of prognostic coagulation-related signatures in clear cell renal cell carcinoma through integrated multi-omics analysis and machine learning. Computers in biology and medicine. vol 168. 2023-12-07. PMID:38061153. |
it's also demonstrated that the specific expression patterns of coagulation signature genes driven by cnv and methylation were closely correlated with pathways including apoptosis, immune infiltration, angiogenesis, and the construction of extracellular matrix. |
2023-12-07 |
2023-12-17 |
Not clear |
| Dongxu Lin, Changcheng Luo, Pengyu Wei, An Zhang, Mengyang Zhang, Xiaoliang Wu, Bolang Deng, Zhipeng Li, Kai Cui, Zhong Che. YAP1 Recognizes Inflammatory and Mechanical Cues to Exacerbate Benign Prostatic Hyperplasia via Promoting Cell Survival and Fibrosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-12-05. PMID:38050650. |
yap1 silencing suppresses cell survival by decreasing cell proliferation and increasing apoptosis, and alleviates fibrosis by reversing epithelial-mesenchymal transition (emt) and extracellular matrix (ecm) deposition in prostatic bph-1 and wpmy-1 cells. |
2023-12-05 |
2023-12-10 |
human |
| Xiaochen Su, Menghao Teng, Yingang Zhang, Wenchen J. Decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through Wnt/ Biomedical materials (Bristol, England). vol 19. issue 1. 2023-12-04. PMID:38044745. |
decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through wnt/ spinal cord injury (sci) causes tissue destruction and neuronal apoptosis, which impede neural function recovery. |
2023-12-04 |
2023-12-10 |
Not clear |
| Daimin Wei, Yaxin Su, Peter C K Leung, Yan Li, Zi-Jiang Che. Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy. Human reproduction update. 2023-12-01. PMID:38037193. |
bone morphogenetic proteins (bmps), a subset of the transforming growth factor-β (tgf-β) superfamily, are multifunctional cytokines that regulate diverse cellular activities, such as differentiation, proliferation, apoptosis, and extracellular matrix synthesis, are now understood as integral to multiple reproductive processes in women. |
2023-12-01 |
2023-12-10 |
human |
| Yi-Bei Song, Wen-Guang Bao, Deng-He Liu, Li-Qiang Wei, Shu-Ting Yang, Xue-Jing Miao, Chun-Yu Lin, Hong-Jun Li, Dong Lan, Hui-Min H. Pan-cancer analysis of the prognostic significance and oncogenic role of GXYLT2. Medicine. vol 102. issue 46. 2023-11-27. PMID:37986328. |
go and kegg pathway analyses of gxylt2 co-expressed genes in stad suggested that gxylt2 possibly plays a role in epithelial-mesenchymal transition, extracellular matrix production and degradation, angiogenesis, apoptosis, as well as in tumor inflammation, such as cytokine production and t cell activation. |
2023-11-27 |
2023-11-28 |
Not clear |
| Chao Jiang, Youjun Liu, Weigong Zhao, Yimin Yang, Zhiwei Ren, Xiaohui Wang, Dingjun Hao, Heng Du, Si Yi. microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3. Journal of cellular and molecular medicine. 2023-11-27. PMID:38009813. |
microrna-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting efna3. |
2023-11-27 |
2023-11-29 |
rat |