| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karan Vishwanath, Erica J Secor, Amanda Watkins, Heidi L Reesink, Lawrence J Bonassa. Loss of effective lubricating viscosity is the primary mechanical marker of joint inflammation in equine synovitis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-01-30. PMID:38291343. |
synovitis involves the release of a wide variety of pro-inflammatory mediators in synovial fluid (sf) that damage the articular cartilage extracellular matrix and induce death and apoptosis in chondrocytes. |
2024-01-30 |
2024-02-02 |
Not clear |
| Jinjie Zhang, Xiaowei Qin, ZhiBin Bi, Ruilong Niu, Kangkang Zhang, Xianghuang Mei, Wei Gu. Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 14. 2024-01-27. PMID:38279460. |
wb was used to detect the satb1, as well as the expression levels of proteins involved in apoptosis, including caspase-3, bax, and bcl-2, as well as matrix metalloproteinase 2 and 9 (mmp-2 and mmp-9) in sw620 cells. |
2024-01-27 |
2024-01-29 |
human |
| Xuezhong Wang, Xuyang Li, Jianlin Zhou, Zheng Lei, Xiaoming Yan. Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6. Chemico-biological interactions. 2024-01-26. PMID:38278314. |
both the administration of fst and activation of sirt6 using mdl were found to rescue cartilage erosion, decrease extracellular matrix (ecm) degradation, prevent cartilage from apoptosis, and improve detrimental senescence-related phenotype. |
2024-01-26 |
2024-01-29 |
human |
| Qiwei Yang, Somayeh Vafaei, Ali Falahati, Azad Khosh, Maria Victoria Bariani, Mervat M Omran, Tao Bai, Hiba Siblini, Mohamed Ali, Chuan He, Thomas G Boyer, Ayman Al-Hend. Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255982. |
targeted inhibition of brd9 suppressed uf tumorigenesis with increased apoptosis and cell cycle arrest, decreased cell proliferation, and extracellular matrix deposition in uf cells. |
2024-01-23 |
2024-01-25 |
human |
| Brian D Cosgrove, Lexi R Bounds, Carson Key Taylor, Alan L Su, Anthony J Rizzo, Alejandro Barrera, Gregory E Crawford, Brenton D Hoffman, Charles A Gersbac. Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260455. |
these 'mechanoenhancers' could be active on either soft or stiff extracellular matrix contexts, and regulated transcription to influence critical cell functions including apoptosis, mechanotransduction, proliferation, and migration. |
2024-01-23 |
2024-01-25 |
Not clear |
| Piotr Pawlicki, Begum Yurdakok-Dikmen, Waclaw Tworzydlo, Malgorzata Kotula-Bala. Toward understanding the role of the interstitial tissue architects: Possible functions of telocytes in the male gonad. Theriogenology. vol 217. 2024-01-19. PMID:38241912. |
these establish a three-dimensional network enabling the maintenance of interstitial compartment homeostasis through regulation of extracellular matrix organization and activity, structural support, paracrine and juxtracrine communication, immunomodulation, immune surveillance, cell survival, and apoptosis. |
2024-01-19 |
2024-01-22 |
Not clear |
| Xin Jin, Qing Hu, Meiying Qin, Yitong Yin, Zhijun Xi. Balkan medical journal. 2024-01-17. PMID:38229336. |
apoptosis and the degradation of the extracellular matrix (ecm) in hvfs contribute to the progression of pop. |
2024-01-17 |
2024-01-19 |
human |
| Long Fang, Zhengyu Wang, Jisong Liu, Yongjie Lin, Wei Ha. General Control Non-derepressible 2 Alleviates Cartilage Degeneration and Inhibits NLRP3 Inflammasome Activation in Osteoarthritis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2024-01-12. PMID:38213081. |
similarly, we demonstrated that the upregulation of gcn2 could promote chondrocyte proliferation, suppress chondrocyte apoptosis, attenuate chondrocyte inflammation and extracellular matrix degradation, and promote chondrocyte autophagy. |
2024-01-12 |
2024-01-14 |
rat |
| Qichen Yang, Yanxuan Xu, Xin Bin, Kwok Ping Chan, Shaowan Chen, Zhen Qian, Yao Yao, Xiang-Ling Yuan, Kunliang Qiu, Yuqiang Huang, Tsz Kin N. Combined treatment of human mesenchymal stem cells and green tea extract on retinal ganglion cell regeneration in rats after optic nerve injury. Experimental eye research. 2024-01-11. PMID:38211683. |
treatment of 10 μg/ml gte would not induce hbm-msc apoptosis, but inhibited their proliferation, migration, and adipogenic and osteogenic differentiation in vitro with reducing matrix metalloproteinase secretions. |
2024-01-11 |
2024-01-14 |
human |
| Colin W Coutts, Ashley M Baldwin, Mahvash Jebeli, Grace E Jolin, Rozanne W Mungai, Kristen L Billia. The Role of Apoptosis and Oxidative Stress in a Cell Spheroid Model of Calcific Aortic Valve Disease. Cells. vol 13. issue 1. 2024-01-11. PMID:38201249. |
to determine the relative roles of oxidative stress and extracellular matrix (ecm) production in the induction of apoptosis and subsequent calcification, the media was supplemented with antioxidants with differing effects on ecm formation (ascorbic acid (aa), trolox, or methionine). |
2024-01-11 |
2024-01-13 |
Not clear |
| Shang Gao, Chenmoji Wang, Lijie Qi, Songlin Liang, Xintian Qu, Wei Liu, Nianhu L. Bushen Huoxue Formula Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation in the Nucleus Pulposus Cells and Improves Intervertebral Disc Degeneration in Rats. Journal of inflammation research. vol 17. 2024-01-11. PMID:38204990. |
bushen huoxue formula inhibits il-1β-induced apoptosis and extracellular matrix degradation in the nucleus pulposus cells and improves intervertebral disc degeneration in rats. |
2024-01-11 |
2024-01-13 |
rat |
| ZhenXing Zhang, PingHua Yu, LinGang Ba. Hsa_circular RNA_0045474 Facilitates Osteoarthritis Via Modulating microRNA-485-3p and Augmenting Transcription Factor 4. Molecular biotechnology. 2024-01-11. PMID:38206529. |
suppressing circ_0045474 restrained il-1β-stimulated extracellular matrix degradation, inflammatory cytokine secretion, and chondrocyte apoptosis. |
2024-01-11 |
2024-01-13 |
mouse |
| ZhenXing Zhang, PingHua Yu, LinGang Ba. Hsa_circular RNA_0045474 Facilitates Osteoarthritis Via Modulating microRNA-485-3p and Augmenting Transcription Factor 4. Molecular biotechnology. 2024-01-11. PMID:38206529. |
circ_0045474 modulated il-1β-stimulated extracellular matrix degradation, inflammatory cytokine secretion, and chondrocyte apoptosis via mir-485-3p/tcf4 axis. |
2024-01-11 |
2024-01-13 |
mouse |
| Haoqian Li, Lingan Huang, Ruipeng Zhao, Gaige Wu, Yukun Yin, Chengming Zhang, Pengcui Li, Li Guo, Xiaochun Wei, Xianda Che, Lu L. TSP-1 increases autophagy level in cartilage by upregulating HSP27 which delays progression of osteoarthritis. International immunopharmacology. vol 128. 2024-01-06. PMID:38183909. |
subsequently, tsp-1 was overexpressed or silenced to detect its effects on extracellular matrix (ecm) homeostasis, autophagy level, proliferation and apoptosis in chondrocytes. |
2024-01-06 |
2024-01-09 |
rat |
| Li Song, Wei Zhang, Shi-Yun Tang, Si-Min Luo, Pei-Yu Xiong, Jun-Yu Liu, Heng-Chang Hu, Ying-Qi Chen, Bo Jia, Qian-Hua Yan, Song-Qi Tang, Wei Huan. Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-29. PMID:38157643. |
its series of changes include excessive accumulation of extracellular matrix, epithelial-mesenchymal transition (emt) of renal tubular cells, fibroblast activation, immune cell infiltration, and renal cell apoptosis. |
2023-12-29 |
2024-01-05 |
Not clear |
| Jessica L Sacco, Zachary T Vaneman, Esther W Gome. Extracellular matrix viscoelasticity regulates TGFβ1-induced epithelial-mesenchymal transition and apoptosis via integrin linked kinase. Journal of cellular physiology. 2023-12-27. PMID:38149820. |
extracellular matrix viscoelasticity regulates tgfβ1-induced epithelial-mesenchymal transition and apoptosis via integrin linked kinase. |
2023-12-27 |
2023-12-29 |
Not clear |
| Jessica L Sacco, Zachary T Vaneman, Esther W Gome. Extracellular matrix viscoelasticity regulates TGFβ1-induced epithelial-mesenchymal transition and apoptosis via integrin linked kinase. Journal of cellular physiology. 2023-12-27. PMID:38149820. |
previous studies have revealed that tgfβ1 activation, signaling, and downstream cell responses including epithelial-mesenchymal transition (emt) and apoptosis are regulated by the elasticity or stiffness of the extracellular matrix. |
2023-12-27 |
2023-12-29 |
Not clear |
| Jessica L Sacco, Zachary T Vaneman, Esther W Gome. Extracellular matrix viscoelasticity regulates TGFβ1-induced epithelial-mesenchymal transition and apoptosis via integrin linked kinase. Journal of cellular physiology. 2023-12-27. PMID:38149820. |
we found that increasing matrix viscous dissipation reduces tgfβ1-induced cell spreading, f-actin stress fiber formation, and emt-associated gene expression changes, and promotes tgfβ1-induced apoptosis in mammary epithelial cells. |
2023-12-27 |
2023-12-29 |
Not clear |
| Jessica L Sacco, Zachary T Vaneman, Esther W Gome. Extracellular matrix viscoelasticity regulates TGFβ1-induced epithelial-mesenchymal transition and apoptosis via integrin linked kinase. Journal of cellular physiology. 2023-12-27. PMID:38149820. |
overexpression of ilk promotes tgfβ1-induced emt and reduces apoptosis in cells cultured on viscoelastic substrata, suggesting that ilk plays an important role in regulating cell fate downstream of tgfβ1 in response to matrix viscoelasticity. |
2023-12-27 |
2023-12-29 |
Not clear |
| Wenqiang Yan, Yue Wu, Fengyuan Zhao, Ruilan Dai, Yunan Zhou, Dingge Liu, Jin Cheng, Xiaoqing Hu, Yingfang A. Anti-Apoptosis Therapy for Meniscal Avascular Zone Repair: A Proof-of-Concept Study in a Lapine Model. Bioengineering (Basel, Switzerland). vol 10. issue 12. 2023-12-23. PMID:38136013. |
in the present study, 24 rabbits were firstly used to evaluate the apoptosis index and matrix degeneration after untreated adult meniscal tears. |
2023-12-23 |
2023-12-25 |
Not clear |