Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot analysis was performed to detect key proteins involved in ventricular remodeling, including transforming growth factor-β1(tgf-β1), α-smooth muscle actin(α-sma), wingless-type mmtv integration site family member 3a(wnt3a), β-catenin, matrix metallopeptidase 2(mmp2), matrix metallopeptidase 3(mmp3), timp metallopeptidase inhibitor 1(timp1), and timp metallopeptidase inhibitor 2(timp2). |
2023-12-19 |
2023-12-23 |
mouse |
Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot results showed that jiming powder reduced the expression of tgf-β1, α-sma, wnt3a, and β-catenin, decreased the levels of mmp2, mmp3, and timp2, and increased the level of timp1, suggesting its role in inhibiting cardiac fibroblast transformation, reducing extracellular matrix metabolism in myocardial cells, and lowering collagen Ⅰ and α-sma content, thus exerting an anti-myocardial fibrosis effect after myocardial infarction. |
2023-12-19 |
2023-12-23 |
mouse |
Suryaa Manoharan, Shreejit Saha, Krishnasanthiya Murugesan, Aksayakeerthana Santhakumar, Ekambaram Peruma. Natural bioactive compounds and STAT3 against hepatocellular carcinoma: An update. Life sciences. 2023-12-16. PMID:38103726. |
further, through stat3 inhibition, terpenes downregulate matrix metalloprotease 2 (mmp2), matrix metalloprotease 9 (mmp9) and vascular endothelial growth factor (vegf), modulating metastasis. |
2023-12-16 |
2023-12-21 |
Not clear |
Xiaoyan Shen, Xiaoping Xie, Qi Wu, Feng Shi, Yuanyang Chen, Shun Yuan, Kai Xing, Xu Li, Qingyi Zhu, Bowen Li, Zhiwei Wan. S-adenosylmethionine attenuates angiotensin II-induced aortic dissection formation by inhibiting vascular smooth muscle cell phenotypic switch and autophagy. Biochemical pharmacology. vol 219. 2023-12-10. PMID:38065291. |
meanwhile, sam also inhibited the cellular phenotypic switch, mainly by up regulating the expression levels of contractile marker proteins [α-smooth muscle actin (α-sma) and smooth muscle 22α (sm22α)] and down regulating the expression levels of synthetic marker proteins [osteoblast protein (opn), matrix metalloproteinase-2 (mmp2), and matrix metalloproteinase-9 (mmp9)]. |
2023-12-10 |
2023-12-17 |
mouse |
Rotem Kalev-Altman, Gal Becker, Tamar Levy, Svetlana Penn, Nahum Y Shpigel, Efrat Monsonego-Ornan, Dalit Sela-Donenfel. Mmp2 Deficiency Leads to Defective Parturition and High Dystocia Rates in Mice. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069145. |
the gelatinases subgroup of matrix metalloproteinases (mmps), mmp2 and mmp9, participate in uterine ecm remodeling throughout pregnancy and parturition. |
2023-12-09 |
2023-12-17 |
mouse |
Yi Wang, Sheng-Lin Qiao, Jie Wang, Meng-Zhen Yu, Nan-Nan Wang, Muhetaerjiang Mamuti, Hong-Wei An, Yao-Xin Lin, Hao Wan. Engineered CpG-Loaded Nanorobots Drive Autophagy-Mediated Immunity for TLR9-Positive Cancer Therapy. Advanced materials (Deerfield Beach, Fla.). 2023-12-06. PMID:37897408. |
the nanorobots are fabricated by co-self-assembly of two amphiphilic triblock polymer peptides: one containing the matrix metallopeptidase 2 (mmp2)-cleaved gplgvrgs motif to control the mechanical opening of the nanorobots and provide targeting capability for tlr-9-positive tumors and the other consisting of an arginine-rich grrrdrgrs sequence that can condense nuclear acid payloads through electrostatic interactions. |
2023-12-06 |
2023-12-10 |
mouse |
Mengfan Zhang, Yang Jing, Wenze Xu, Xiaojing Shi, Wenguang Zhang, Pengfei Chen, Xiaocang Cao, Xinwei Han, Xuhua Duan, Jianzhuang Re. The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis. Cell death & disease. vol 14. issue 11. 2023-11-30. PMID:38036508. |
surprisingly, the in vitro overexpression of colec10 in lx-2 cells promotes the mrna expression of extracellular matrix components including col1a1, col1a2 and col3a1 and the extracellular matrix degradation enzyme mmp2. |
2023-11-30 |
2023-12-10 |
mouse |
Yingyan Qin, Taixiang Liu, Zhaotian Zhang, Shuwen Xing, Li Gong, Yao N. Scleral remodeling in early adulthood: the role of FGF-2. Scientific reports. vol 13. issue 1. 2023-11-27. PMID:38012225. |
moreover, mature sfs displayed decreased cell proliferation but increased levels of α-sma, matrix metalloproteinase 2 (mmp2), and collagen 1, when compared to young sfs. |
2023-11-27 |
2023-11-29 |
Not clear |
Xinyu Chang, Qiuyu Tan, Jinwen Xu, Xu Wu, Ying Wang, Yuan Zhang, Hao Zhang, Haijun Liu, Liang Ya. Tumor-derived exosomal linc00881 induces lung fibroblast activation and promotes osteosarcoma lung migration. Cancer cell international. vol 23. issue 1. 2023-11-22. PMID:37990331. |
subsequently, we found that exosomal linc00881 secreted by os cells can regulate the expression of matrix metalloproteinase 2 (mmp2) in hfl-1 cells by sponging mir-29c-3p, thereby activating the nf-κb signaling in lung fibroblasts. |
2023-11-22 |
2023-11-29 |
Not clear |
Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchid. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging. vol 15. 2023-10-27. PMID:37889501. |
gelatin zymography indicated that the serum of ckd mice activated matrix metalloproteinase-2 (mmp2), while marimastat ameliorated the reduction of claudin-5 expression by urea in bend.3 cells. |
2023-10-27 |
2023-11-08 |
mouse |
Yi Wei, Xiao-Lin Zhou, Peng Chen, Tai-Hang Liu, Cheng Lu, Min-Hui Pa. Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin-like peptide. Insect science. 2023-10-17. PMID:37846892. |
herein, we found that matrix metalloproteinase 2 (mmp2) was highly expressed in the ovarian capsules and ovarioles, and the development was abnormal after knocking out mmp2 in bombyx mori. |
2023-10-17 |
2023-11-08 |
Not clear |
Syed K Imam, Dhekra Alnaqeb, Mohammad Bedaiwi, Ebtissal M Khou. Multicentric Osteolysis Nodulosis Arthropathy Syndrome Simulating Juvenile Idiopathic Arthritis in an Adult Female: A Case Report and a Literature Review. Cureus. vol 15. issue 9. 2023-10-16. PMID:37842447. |
mona syndrome includes diseases involving two genes: the matrix metalloproteinase 2 (mmp2) gene and matrix metalloproteinase 14 (mmp14). |
2023-10-16 |
2023-11-08 |
Not clear |
Tianyu Zhao, Xue Li, Mingfeng Li, Muhammad Jamil, Jingyu Zhan. Characterization and verification of MMP family members as potential biomarkers in kidney clear cell renal carcinoma. American journal of cancer research. vol 13. issue 9. 2023-10-11. PMID:37818055. |
by performing string and cytohubba analyses of the 24 mmp gene family members, mmp2 (matrix metallopeptidase 2), mmp9 (matrix metallopeptidase 9), mmp14 (matrix metallopeptidase 14), and mmp16 (matrix metallopeptidase 16) were recognized as hub genes having highest degree scores. |
2023-10-11 |
2023-10-15 |
human |
Xiao-Hui Meng, Sheng Zhong, Hai-Hui Han, Qi Shi, Song-Tao Sun, Lian-Bo Xia. [Effect of Juanbi Qianggu Formula on biological behaviors of fibroblast-like synoviocytes in rheumatoid arthritis by regulating FGFR1 signaling pathway based on network pharmacology and cell function experiments]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802828. |
the biological effect of jbqgf by inhibiting fgfr1 phosphorylation was preliminarily verified by western blot, transwell invasion assay, and pannus erosion assay, thereby inhibiting matrix metalloproteinase 2(mmp2) and receptor activator of nuclear factor-κb ligand(rankl) and suppressing the invasion of fibroblasts in rheumatoid arthritis and erosive effect of pannus bone. |
2023-10-06 |
2023-10-15 |
rat |
Simran Dayal, Anand Ramamurth. Assessing Efficacy of Afatinib towards Elastic Matrix Repair in Aortic Aneurysms. Tissue engineering. Part A. 2023-09-29. PMID:37772690. |
in in-vitro cell cultures, we have shown that safe doses of 0.5 and 1 nm afatinib inhibit egfr and p-erk1/2 protein expressions by 50-70% and downstream elastolytic matrix metalloprotease 2 (mmp2) vs. untreated control cultures. |
2023-09-29 |
2023-10-07 |
Not clear |
Yingbo Feng, Yingjun Qi, Qian Zhang, Mingming Zhan. Sevoflurane inhibits oral squamous carcinoma progression by modulating the circ_0000857/miR-145-5p axis. Chemical biology & drug design. 2023-09-28. PMID:37770418. |
sev inhibited the level of matrix metalloproteinases 2 (mmp2), mmp9, and vascular endothelial growth factor a (vegfa) protein by regulating the circ_0000857/mir-145-5p axis. |
2023-09-28 |
2023-10-07 |
Not clear |
Xiangbin Tan, Shuangyou Zou, Hui Chen, Dachao Che. Comparison of paclitaxel liposomes combined with carboplatin versus paclitaxel combined with carboplatin in the treatment of advanced ovarian cancer. The Journal of international medical research. vol 51. issue 9. 2023-09-27. PMID:37756606. |
to compare the efficacy of paclitaxel liposomes combined with carboplatin and paclitaxel combined with carboplatin in the treatment of advanced ovarian cancer and assess their effects on serum human epididymis protein 4 (he4), ca125, ca199, matrix metalloproteinase-2 (mmp2), mmp-7, and mmp-9 levels. |
2023-09-27 |
2023-10-07 |
human |
Tingting Xu, Yanglin Hu, Yanyan Zhao, Yanan Qi, Shanfeng Zhang, Pei L. Hsa_circ_0046534 accelerates esophageal squamous cell carcinoma proliferation and metastasis via regulating MMP2 expression by sponging miR-339-5p. Cellular signalling. 2023-09-25. PMID:37748540. |
in addition, the knockdown of circ_0046534 inhibited the expression of the downstream target gene matrix metalloproteinase 2 (mmp2) by releasing the adsorption of mir-339-5p. |
2023-09-25 |
2023-10-07 |
Not clear |
Jihua Wei, Zichun Song, Jiuying Cui, Yuanxun Gong, Qianli Tang, Kai Zhang, Xinlei Song, Xianjiu Lia. Inverting the DNA tetrahedron: A novel strategy for sensitive and stable detection of aging-related enzyme MMP2. Analytica chimica acta. vol 1278. 2023-09-14. PMID:37709470. |
in the current study, a novel electrochemiluminescence biosensor based on the entropy-driven dna tetrahedron for the detection of matrix metalloproteinase 2 (mmp2), an enzyme that regulates extracellular matrix remodeling and affects aging was reported. |
2023-09-14 |
2023-10-07 |
human |
Ran Hong, Sung-Chul Lim, Tae-Bum Lee, Song-Iy Ha. Anticancer Effect of Gallic Acid on Acidity-Induced Invasion of MCF7 Breast Cancer Cells. Nutrients. vol 15. issue 16. 2023-08-26. PMID:37630786. |
prolonged exposure to acidic culture conditions (over 12 weeks at ph 6.4) induced the acquisition of migratory and invasive properties in mcf7 cells, accompanied by increased expression of matrix metalloproteinase 2 and 9 (mmp2 and mmp9, respectively), together with alterations in e-cadherin, vimentin, and epithelial-to-mesenchymal transition markers. |
2023-08-26 |
2023-09-07 |
Not clear |