| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongcan Huang, Jing Xie, Jieya Wei, Siqun Xu, Demao Zhang, Xuedong Zho. Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65. Journal of bone and mineral metabolism. 2022-12-13. PMID:36512085. |
gelatinases, namely mmp2 and mmp9, are involved in the natural turnover of articular cartilage, as well as the loss of the cartilage matrix in osteoarthritis (oa). |
2022-12-13 |
2023-08-14 |
Not clear |
| Yongbin Jing, Mingkun Jia, Jinpeng Zhuang, Dong Han, Changlong Zhou, Jinglong Ya. TLR9 Exerts an Oncogenic Role in Promoting Osteosarcoma Progression Depending on the Regulation of NF-κB Signaling Pathway. Biological & pharmaceutical bulletin. vol 45. issue 12. 2022-11-30. PMID:36450527. |
furthermore, tlr9 overexpression could enhance the migration and invasion activities of the os cells by the upregulation of matrix metalloproteinases 2 (mmp2) and mmp9, and the opposite result was observed in tlr9-silenced cells. |
2022-11-30 |
2023-08-14 |
Not clear |
| Jen-Fu Yang, Tzu-Min Chen, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Wen-Yen Huang, Cheng-Hsiang Lo, Chun-Shu Lin, Po-Chien Shen, Ying Che. Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells. European journal of pharmacology. 2022-11-27. PMID:36436590. |
there was also concomitant decreased expression of focal adhesion complex, matrix metalloproteinase-2 (mmp2), mmp9 and cathepsin b. |
2022-11-27 |
2023-08-14 |
human |
| Kun Li, Jinfa Zheng, Han Liu, Qing Gao, Mengmeng Yang, Jiarong Tang, Hui Wang, Sheng Li, Yingbiao Sun, Xuhong Chan. Whole-transcriptome sequencing revealed differentially expressed mRNAs and non-coding RNAs played crucial roles in NiONPs-induced liver fibrosis. Ecotoxicology and environmental safety. vol 248. 2022-11-21. PMID:36410144. |
the results showed nionps induced the up-regulated protein expression of fibrotic factors collagen-1a1 (col-1a1) and matrix metalloproteinas2 (mmp2) and jnk/c-jun pathway activation. |
2022-11-21 |
2023-08-14 |
rat |
| Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Che. Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. Frontiers in oncology. vol 12. 2022-11-17. PMID:36387162. |
ectopic expression or knock down (kd) of pcdh9 with a lentivirus vector, we explored its effects on the proliferation, invasion, and apoptosis of melanoma and verified its regulatory effect on ras-related c3 botulinum toxin substrate 1 (rac1), proline-rich tyrosine kinase 2 (pyk2), cyclin d1, matrix metalloproteinase 2 (mmp2), and mmp9. |
2022-11-17 |
2023-08-14 |
human |
| Longxiang Huang, Zhenni Wei, Xiaohui Wang, Chunlin Lan, Yihua Zhu, Qin Y. AZD6738 Decreases Intraocular Pressure and Inhibits Fibrotic Response in Trabecular Meshwork through CHK1/P53 Pathway. Biochemical pharmacology. 2022-11-08. PMID:36347274. |
further, we demonstrated that azd6738 reduces cell viability and migration, and inhibit the expression of fibrosis-related factors including fibronectin (fn), α-smooth muscle actin (α-sma), laminin subunit beta 1 (lamb1), matrix metallopeptidase (mmp) family including mmp2 and mmp9, collagen Ⅰ (col1), and collagen Ⅳ (col4), reduce gap junctions, altered cytoskeleton and nitric oxide production in tgf-β1-induced human trabecular meshwork cells (htmcs) through the chk1/p53 pathway, which were affected aqueous humor (ah) production and outflow pathway. |
2022-11-08 |
2023-08-14 |
mouse |
| Aitor Benedicto, Beatriz Arteta, Andrea Duranti, Daniel Alonso-Alconad. The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297277. |
melanoma and crc cell migration was affected in a dose-dependent fashion as observed through scratch assay, whereas the secretion of matrix degrading proteins metalloprotease 2 (mmp2) and 9 (mmp9) in tumor cells did not significantly change. |
2022-10-27 |
2023-08-14 |
mouse |
| Te-Cheng Yueh, Yi-Chih Hung, Hsu-Tung Lee, Mei-Due Yang, Zhi-Hong Wang, Ya-Chen Yang, Tao-Wei Ke, Jen-Sheng Pei, Chia-Wen Tsai, DA-Tian Bau, Wen-Shin Chan. Role of Matrix Metallopeptidase-2 Genotypes in Taiwanese Patients With Colorectal Cancer. Anticancer research. vol 42. issue 11. 2022-10-26. PMID:36288896. |
matrix metalloproteinase-2 (mmp2) has been reported to plays a critical role in the metastatic behaviors of cancer via regulation of the extracellular matrix. |
2022-10-26 |
2023-08-14 |
Not clear |
| Rotem Kalev-Altman, Jerome Nicolas Janssen, Nir Ben-Haim, Tamar Levy, Astar Shitrit-Tovli, Joshua Milgram, Ron Shahar, Dalit Sela-Donenfeld, Efrat Monsonego-Orna. The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development. Matrix biology : journal of the International Society for Matrix Biology. 2022-10-19. PMID:36261075. |
the gelatinases, a subgroup of the matrix metalloproteinases (mmps) superfamily are composed of two members; mmp2 and mmp9. |
2022-10-19 |
2023-08-14 |
mouse |
| Maryam Sadri, Ali-Akbar Delbandi, Nesa Rashidi, Gholam Ali Kardar, Reza Fala. Cobalt Chloride-induced Hypoxia Can Lead SKBR3 and HEK293T Cell Lines toward Epithelial-mesenchymal Transition. Iranian journal of allergy, asthma, and immunology. vol 21. issue 4. 2022-10-16. PMID:36243933. |
additionally, the expression of emt-associated markers including snail, e-cadherin, n-cadherin, and vimentin, as well as invasion-related genes including matrix metalloproteinase-2 (mmp2) and mmp9 was measured. |
2022-10-16 |
2023-08-14 |
Not clear |
| Suzuko Kinoshita, Kazuki Takarada, Yuriko Kinoshita, Yoshihiro H Inou. Drosophila hemocytes recognize lymph gland tumors of mxc mutants and activate the innate immune pathway in reactive oxygen species-dependent manner. Biology open. 2022-10-13. PMID:36226812. |
matrix metalloproteinase 1 and 2 (mmp2) were highly expressed in the tumors. |
2022-10-13 |
2023-08-14 |
drosophila_melanogaster |
| Ming-Lian Luo, Jian-Wen Zhu, Xue-Mei Ga. Netrin-1 promotes the vasculogenic capacity of human adipose-derived stem cells. Cell and tissue banking. 2022-10-12. PMID:36222969. |
the transcript levels of pro-invasive proteins such as matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp-9), were measured to test migratory and invasive capabilities, and the levels of vascular endothelial growth factors were assayed to monitor angiogenic activity. |
2022-10-12 |
2023-08-14 |
human |
| Qiuyan Ma, Jacob R Beal, Xiangning Song, Arpita Bhurke, Indrani C Bagchi, Milan K Bagch. Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy. Endocrinology. 2022-10-11. PMID:36219207. |
we also established that matrix metalloproteinase-2 (mmp2), a prominent ev cargo protein, modulates uterine remodeling during decidualization. |
2022-10-11 |
2023-08-14 |
mouse |
| Chien-Rui Lai, Yu-Ling Tsai, Wen-Chiuan Tsai, Tzu-Min Chen, Hsin-Han Chang, Chih-Ying Changchien, Sheng-Tang Wu, Hisao-Hsien Wang, Ying Chen, Yu-Huei Li. Farnesoid X Receptor Overexpression Decreases the Migration, Invasion and Angiogenesis of Human Bladder Cancers via AMPK Activation and Cholesterol Biosynthesis Inhibition. Cancers. vol 14. issue 18. 2022-09-23. PMID:36139556. |
in a metastatic xenograft animal study, fxr overexpression suppressed bladder cancer lung metastasis by decreasing matrix metalloproteinase-2 (mmp2), srebp2 and hmgcr expression. |
2022-09-23 |
2023-08-14 |
human |
| Dazhi Tian, Yang Yu, Li Zhang, Jisan Sun, Wentao Jian. 23-hydroxybetulinic acid reduces tumorigenesis, metastasis and immunosuppression in a mouse model of hepatocellular carcinoma via disruption of the MAPK signaling pathway. Anti-cancer drugs. vol 33. issue 9. 2022-09-22. PMID:36136986. |
bioinformatics analysis revealed that matrix metalloproteinase 2 (mmp2) was a key target gene mediated by 23-hba in hcc, whereas kyoto encyclopedia of genes and genomes (kegg) enrichment analysis demonstrated that mmp2 mainly affects the development and metastasis of hcc. |
2022-09-22 |
2023-08-14 |
mouse |
| Dongliang Cheng, Zhiwei Wen, Hui Chen, Shiyuan Lin, Wei Zhang, Xin Tang, Wei W. Hepatocyte-targeting and tumor microenvironment-responsive liposomes for enhanced anti-hepatocarcinoma efficacy. Drug delivery. vol 29. issue 1. 2022-09-15. PMID:36104946. |
to increase the antitumor drug concentration in the liver tumor site and improve the therapeutic effects, a functionalized liposome (ppp-lip) with tumor targetability and enhanced internalization after matrix metalloproteinase-2 (mmp2)-triggered cell-penetrating peptide (tatp) exposure was modified with myrcludex b (a synthetic hbv pres-derived lipopeptide endowed with compelling liver tropism) for liver tumor-specific delivery. |
2022-09-15 |
2023-08-14 |
mouse |
| Yuji Kanazawa, Tatsuo Takahashi, Takashi Higuchi, Ryo Miyachi, Mamoru Nagano, Satoshi Koinuma, Yasufumi Shigeyosh. Effects of stretching on the basement membrane structure in the soleus muscle of Wistar rats. Medical molecular morphology. 2022-09-15. PMID:36107241. |
the results show that stretching increased the matrix metalloproteinase 14 (mmp14) expression and mmp2 activity, and decreased the collagen iv expression and width of the lamina densa in the soleus muscle. |
2022-09-15 |
2023-08-14 |
rat |
| Jeonghun Lee, Eun-Taex Oh, Hae-June Lee, Eunkyoung Lee, Ha Gyeong Kim, Heon Joo Park, Chulhee Ki. Tuning of Peptide Cytotoxicity with Cell Penetrating Motif Activatable by Matrix Metalloproteinase-2. ACS omega. vol 7. issue 34. 2022-09-05. PMID:36061651. |
here, we demonstrate the selective cytotoxicity tuning of an anticancer kla peptide with a cell penetrating motif activatable by matrix metalloproteinase-2 (mmp2). |
2022-09-05 |
2023-08-14 |
Not clear |
| Jianhua Guan, Bin Guan, Haixia Shang, Jun Peng, Hong Yang, Jiumao Li. Babao Dan inhibits lymphangiogenesis of gastric cancer in vitro and in vivo via lncRNA-ANRIL/VEGF-C/VEGFR-3 signaling axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2022-09-04. PMID:36058147. |
in addition, wb assay found that bbd decreased the expression levels of vegf-c, vegfr-3, matrix metallopeptidase 2 (mmp2) and matrix metallopeptidase 9 (mmp9), and rt-qpcr assay found that the mrna expression levels of lncrna-anril, vegf-c, vegfr-3, mmp2, mmp9, cdk4, cyclin d1, and bcl-2 were down-regulated, and the expression of p21 and bax were increased. |
2022-09-04 |
2023-08-14 |
Not clear |
| Atul Kumar Singh, Shashank Kuma. Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation approach. Natural product research. 2022-09-01. PMID:36047975. |
matrix metalloproteinase-2 (mmp2), an extracellular matrix remodulating protein's increased activity causes cancer-metastasis. |
2022-09-01 |
2023-08-14 |
Not clear |