| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zongang Liu, Mengnan Zhao, Xizi Jiang, Yao Zhang, Suning Zhang, Yitong Xu, Hongjiu Ren, Hongbo Su, Huanxi Wang, Xueshan Qi. Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway. Laboratory investigation; a journal of technical methods and pathology. 2022-08-17. PMID:35978057. |
overexpression of klhl17 in the cell lines of nsclc with klhl17-flag plasmid promoted the proliferation and migration of tumor cells, which was associated with elevated activation of rat sarcoma/mitogen-activated protein kinases (ras/mapk) signaling and increased expression of cyclin d1, cyclin d-dependent kinases 4 (cdk4), matrix metalloproteinase 2 (mmp2) and ras homolog gene family member a (rhoa). |
2022-08-17 |
2023-08-14 |
human |
| Anyu Xu, Jingchun Pei, Yunhong Yang, Baotong Hua, Jing Wan. IL-1β promotes A7r5 and HASMC migration and invasion via the p38-MAPK/Angpt-2 pathway. European journal of medical research. vol 27. issue 1. 2022-08-17. PMID:35978364. |
we pretreated a7r5 and hasmc with il-1β for 24 h, and measured the expression of il-1β, proliferating cell nuclear antigen (pcna), cyclin d1, matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 2 (mmp9) in the cells by western blotting. |
2022-08-17 |
2023-08-14 |
Not clear |
| Gang Deng, Tie-Jun Fu, Cui-Ping Li. Increased expression of Myosin X contributes to the metastasis in patients with laryngeal squamous cell carcinoma. Molecular genetics and genomics : MGG. 2022-08-11. PMID:35951144. |
myosin x augments the expression of cortactin, mmp2 and mmp9, which could upregulate the cell migration and the matrix degradation, and consequently reduce the expression of e-cadherin and β-catenin, thereby activating epithelial-mesenchymal transformation and promoting the metastasis of lscc. |
2022-08-11 |
2023-08-14 |
Not clear |
| Yingying Jiang, Wei Xu, Junzhen Ta. Circular RNA circVPRBP serves as a microRNA-106b-5p sponge to regulate proliferation and metastasis of cervical cancer cells via tripartite motif-containing protein 3. Anti-cancer drugs. 2022-08-10. PMID:35946546. |
protein levels of matrix metallopeptidase 2 (mmp2) and matrix mmp9, and trim3 were measured by western blot assay. |
2022-08-10 |
2023-08-14 |
human |
| Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Bal. Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine Chorioallantois during spontaneous term labor. Biology of reproduction. 2022-08-01. PMID:35913756. |
also, tl was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, mmp3, and mmp9) with subsequent extracellular matrix degradation and apoptosis, as reflected by upregulation of several apoptosis-related genes (atf3, atf4, fas, fos, and birc3). |
2022-08-01 |
2023-08-14 |
Not clear |
| Chao Chen, Jing Gao, Dan Chen, Jinyu Liu, Biwei He, Yan Chen, Huijuan Zhang, Xingyu Yang, Weiwei Chen. miR-4443/MMP2 suppresses the migration and invasion of trophoblasts through the HB-EGF/EGFR pathway in preeclampsia. Cell cycle (Georgetown, Tex.). 2022-07-28. PMID:35899982. |
matrix metallopeptidase 2 (mmp2), which is involved in the degradation of extracellular matrix (ecm) components and harbors a mir-4443-binding site within its 3'-utr as confirmed by a luciferase reporter assay, was identified to be directly inhibited by mir-4443. |
2022-07-28 |
2023-08-14 |
Not clear |
| Velmurugan Shanmugham, Ravi Subba. Capsanthin from Capsicum annum fruits exerts anti-glaucoma, antioxidant, anti-inflammatory activity, and corneal pro-inflammatory cytokine gene expression in a benzalkonium chloride-induced rat dry eye model. Journal of food biochemistry. 2022-07-27. PMID:35892258. |
capsanthin ameliorated in reducing oxidative stress by increasing serum antioxidant levels such as glutathione peroxidase (gpx), nitric oxide (no), and lactoferrin (ltf) and inhibiting matrix metalloproteinases 2 and 9 (mmp2 and mmp9) (p < .0001). |
2022-07-27 |
2023-08-14 |
rat |
| Yuji Sakai, Maki Taguchi, Yoshifumi Morikawa, Koichi Suenami, Emiko Yanase, Tomohiro Takayama, Akira Ikari, Toshiyuki Matsunag. Lowering of brain endothelial cell barrier function by exposure to 4'-iodo-α-pyrrolidinononanophenone. Chemico-biological interactions. 2022-07-25. PMID:35872046. |
in addition, i-α-pnp treatment up-regulated the expression and secretion of matrix metalloproteinase-2 (mmp2) and mmp9, and the addition of an mmp inhibitor reversed the degradation of cldn5 by i-α-pnp. |
2022-07-25 |
2023-08-14 |
human |
| Kai Wu, Yuan Liu, Hui Zhang, Yanhua Wang, Huiping Zhang, Yideng Jian. [DNA damage induced long non-coding RNA (DINO) down-regulates the expression of MMP2 and inhibits the invasion and migration of human chorionic trophoblast cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 8. 2022-07-19. PMID:35851088. |
objective to investigate the effect of dna damage induced long non-coding rna (dino) on the invasion and migration of human chorionic trophoblast cells via its regulating the expression of migration-related factor matrix metalloproteinase 2 (mmp2). |
2022-07-19 |
2023-08-14 |
human |
| Asli Karakilic, Servet Kizildag, Zeynep Yuce, Yasemin Seval Celik, Sevim Kandis, Hemdem Rodi Bozan, Basar Koc, Guven Guvendi, Mehmet Ates, Sevinc Inan, Nazan Uysa. Repeated acetaminophen administration damaged hippocampal tissue but did not affect prefrontal cortex or anxiety behaviors. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833816. |
insulin‑like growth factor‑1 (igf‑1) and matrix metalloproteinase‑2 (mmp2) are important for cellular survival, maintenance and tissue integrity. |
2022-07-14 |
2023-08-14 |
rat |
| Yingfeng Shi, Jinqing Li, Hui Chen, Yan Hu, Lunxian Tang, Xun Zhou, Min Tao, Zexin Lv, Si Chen, Andong Qiu, Na Li. Pharmacologic Inhibition of Histone Deacetylase 6 Prevents the Progression of Chlorhexidine Gluconate-Induced Peritoneal Fibrosis by Blockade of M2 Macrophage Polarization. Frontiers in immunology. vol 13. 2022-07-05. PMID:35784347. |
inhibition of hdac6 remarkably suppressed the expression of matrix metalloproteinases-2 (mmp2) and mmp-9. |
2022-07-05 |
2023-08-14 |
Not clear |
| Xin Zhang, Xuebing Zhou, Ming Gao, You Lyu, Ying Wang, Chunyu Yang, Yingshi Piao, Xiangshan Re. [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 6. 2022-06-22. PMID:35732609. |
the proliferation ability of mgc-803 and hgc-27 cells was detected by mtt assay and edu assay; the colony formation ability of cells was detected by colony formation assay; both wound healing assay and cell migration assay were applied to detect the cell migration ability of mgc-803 and hgc-27 cells; the chromatin agglutination was detected by hoechst 33342 staining; the apoptosis of gastric cancer cells was detected by annexin v-fitc/pi double labeling combined with flow cytometry; western blot was used to measure the protein expression levels of lipid metabolism-related proteins including sterol regulatory element binding transcription factor 1 (srebf1), fatty acid synthase (fasn), and acetyl coa carboxylase 1 (acc1), epithelial-mesenchymal transition (emt)-related proteins including e-cadherin, vimentin, snail, slug, matrix metalloproteinase 2 (mmp2), mmp9, ampk, and phosphorylated ampk (p-ampk), mapk signaling pathway-related proteins including jnk, phosphorylated jnk (p-jnk), p38 mapk, and p-p38 mapk, and apoptosis-related proteins including cleaved caspase-9 (c-caspase-9), c-caspase-3, and cleaved poly (adp-ribose) polymerase (c-parp). |
2022-06-22 |
2023-08-14 |
human |
| Xiaoling Xu, Xinmei Lan, Shuhua Fu, Qian Zhang, Fu Gui, Qifang Jin, Lin Xie, Yu Xion. Dickkopf-1 exerts protective effects by inhibiting PANoptosis and retinal neovascularization in diabetic retinopathy. Biochemical and biophysical research communications. vol 617. issue Pt 2. 2022-06-12. PMID:35691117. |
furthermore, retinal neovascularization and acellular vessel in dr rats were also considerably abolished after dkk1 injection, accompanied by reduced expression levels of retinal vascular endothelial growth factor (vegf), matrix metalloproteinase-2 (mmp2) and matrix metalloproteinase-9 (mmp9). |
2022-06-12 |
2023-08-14 |
rat |
| Tomoki Takeuchi, Masato Hayashi, Tomoko Tamita, Yusaku Nomura, Naoki Kojima, Akiko Mitani, Takuya Takeda, Kosuke Hitaka, Yuki Kato, Masafumi Kamitani, Masashi Mima, Hidetoh Toki, Masahiko Ohkubo, Akiko Nozoe, Hiroyuki Kakinum. Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. Journal of medicinal chemistry. 2022-06-10. PMID:35687819. |
matrix metalloproteinase-2 (mmp2) is a zinc-dependent endopeptidase that plays important roles in the degradation of extracellular matrix proteins. |
2022-06-10 |
2023-08-14 |
Not clear |
| Liu-Yi Lu, Ni Pan, Ze-Han Huang, Jing-Song Wang, Yong-Bo Tang, Hong-Shuo Sun, Hui Han, Han-Yan Yang, Jun-Zhen Zhu, Yong-Yuan Guan, Bin Zhang, Dong-Zhi Li, Guan-Lei Wan. CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells. Journal of cardiovascular pharmacology. vol 79. issue 6. 2022-06-08. PMID:35266910. |
mechanistically, cftr suppressed the phosphorylation of pdgf receptor β, serum and glucocorticoid-inducible kinase 1, jnk, p38 and erk induced by pdgf-bb, and the increased mrna expression of matrix metalloproteinase-9 and mmp2 induced by pdgf-bb. |
2022-06-08 |
2023-10-07 |
rat |
| Hang Yang, Zhen Xu, Sumei Tan, Chunyan Zhang, Xiaoqin Li, Xiangjun Len. In vitro effects of Eucommia ulmoides and its active components on the growth, lipid metabolism and collagen metabolism of grass carp (Ctenopharyngodon idellus) hepatocyte and intramuscular fibroblast. Journal of fish biology. 2022-06-06. PMID:35662011. |
in intramuscular fibroblasts, the ebe, ele, cga, qc and au supplementations significantly increased in vitro hydroxyproline concentrations, promoted the relative expressions of transforming growth factor-β1 (tgfβ1), connective tissue growth factor (ctgf), collagen type i alpha 1/2 chain (col1a1, col1a2), lysine oxidase (lox) and tissue inhibitor of matrix metalloproteinase-2 (timp2), and decreased matrix metalloproteinase-2 (mmp2) gene expression. |
2022-06-06 |
2023-08-14 |
drosophila_melanogaster |
| Liu Jinyu, Wang Shuying, Zheng Panchan, Chen Dan, Chen Chao, Yang Xingyu, Cheng Weiwe. Bone marrow stromal cell antigen 2(BST2) suppresses the migration and invasion of trophoblasts in preeclampsia by downregulating matrix metallopeptidase 2(MMP2). Bioengineered. vol 13. issue 5. 2022-05-31. PMID:35635087. |
bone marrow stromal cell antigen 2(bst2) suppresses the migration and invasion of trophoblasts in preeclampsia by downregulating matrix metallopeptidase 2(mmp2). |
2022-05-31 |
2023-08-13 |
Not clear |
| Christina Mark, Jay Warrick, Natalie S Callander, Peiman Hematti, Shigeki Miyamot. A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-κB Activation and Drug Resistance. Molecular cancer research : MCR. 2022-05-23. PMID:35604822. |
in our present study, we found that mm cells promote hapln1 expression and matrix metalloproteinase (mmp)2 activity in co-cultured bmscs and mmp2 activity is higher in bmscs established from mm patients' bone marrow aspirates relative to normal equivalents. |
2022-05-23 |
2023-08-13 |
Not clear |
| Zhu Zhong-Sheng, Yin Nuo, Huang Xiao-Yan, Ding Liang, Fang Rui, Xiao Hai-Ju. MMP2 promotes osteoblast differentiation and calcification of muscle-derived mesenchymal stem cells by interaction with miR-29b-3p. Tissue & cell. vol 76. 2022-05-20. PMID:35594585. |
matrix metalloproteinase 2 (mmp2) was previously reported to play important role in the process of stem cell migration and various differentiation behaviors of muscle-derived mesenchymal stem cells (m-mscs). |
2022-05-20 |
2023-08-13 |
Not clear |
| Kohta Asano, Takeshi Nakamura, Kengo Funakosh. Early mobilization in spinal cord injury promotes changes in microglial dynamics and recovery of motor function. IBRO neuroscience reports. vol 12. 2022-05-19. PMID:35586775. |
in addition, significantly more matrix metalloproteinase 2 (mmp2)-positive cells were observed at the lesion site 1 week after injury in the early-mobilized rats. |
2022-05-19 |
2023-08-13 |
rat |