| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Yano, H Kawano, H Mochizuki, O Doi, T Nakamura, Y Sait. Atherosclerotic plaques composed of a large core of foam cells covered with thin fibrous caps in twice-injured carotid arterial specimens obtained from high cholesterol diet-fed rabbits. Journal of atherosclerosis and thrombosis. vol 7. issue 2. 2001-08-09. PMID:11426587. |
gelatin proteolytic activities were found in homogenates containing either media or intima from the injured artery, and activated matrix metalloproteinase-2 (mmp2) was detected. |
2001-08-09 |
2023-08-12 |
Not clear |
| J A Martignetti, A A Aqeel, W A Sewairi, C E Boumah, M Kambouris, S A Mayouf, K V Sheth, W A Eid, O Dowling, J Harris, M J Glucksman, S Bahabri, B F Meyer, R J Desnic. Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Nature genetics. vol 28. issue 3. 2001-08-02. PMID:11431697. |
mutation of the matrix metalloproteinase 2 gene (mmp2) causes a multicentric osteolysis and arthritis syndrome. |
2001-08-02 |
2023-08-12 |
Not clear |
| N Théret, O Musso, B Turlin, D Lotrian, P Bioulac-Sage, J P Campion, K Boudjéma, B Clémen. Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas. Hepatology (Baltimore, Md.). vol 34. issue 1. 2001-07-26. PMID:11431737. |
matrix metalloproteinase-2 (mmp2) is a key enzyme in the process of extracellular matrix remodeling involved in tumor invasion and metastasis. |
2001-07-26 |
2023-08-12 |
human |
| Y Matsumoto, K Tanaka, K Harimaya, F Nakatani, S Matsuda, Y Iwamot. Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cells. Japanese journal of cancer research : Gann. vol 92. issue 4. 2001-07-05. PMID:11346466. |
the disruption of extracellular matrix (ecm) by matrix metalloproteinase 2 (mmp2) is also critical for tumor cell invasion. |
2001-07-05 |
2023-08-12 |
human |
| Z Yang, D K Strickland, P Bornstei. Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11113133. |
we have recently shown that the adhesive defect observed in dermal fibroblasts derived from thrombospondin 2 (tsp2)-null mice results from an increase in matrix metalloproteinase 2 (mmp2) levels (yang, z., kyriakides, t. r., and bornstein, p. (2000) mol. |
2001-06-21 |
2023-08-12 |
mouse |
| Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. |
this study was undertaken to investigate the mrna synthesis of mmp2, mmp9, membrane-type 1 (mt1)-mmp, and matrix metalloproteinase inhibitors timp1 and timp2 by in situ hybridization in a set of heart mitral and aortic valves operatively removed due to degenerative or inflammatory valvular diseases. |
2001-06-21 |
2023-08-12 |
Not clear |
| Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. |
the results show that matrix metalloproteinases mmp2 and mmp9, and matrix metalloproteinase inhibitors timp1 and timp2 mrnas are synthesized in diseased valves and suggest that they may contribute to matrix remodelling in valvular disease. |
2001-06-21 |
2023-08-12 |
Not clear |
| John Martin, Lisa Eynstone, Malcolm Davies, Robert Steadma. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology : JASN. vol 12. issue 1. 2001-05-24. PMID:11134254. |
the present study, therefore, investigated the effect of different matrix components on the adherence of hmc and on their secretion and activation of the gelatinases mmp2 and mmp9. |
2001-05-24 |
2023-08-12 |
human |
| John Martin, Lisa Eynstone, Malcolm Davies, Robert Steadma. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology : JASN. vol 12. issue 1. 2001-05-24. PMID:11134254. |
after the addition of these matrix proteins (0.1 microg/ml to 100 microg/ml) to growth-arrested hmc for 72 h, zymography of the conditioned medium established that only fibronectin and collagens i and iv dose-dependently increased latent (72 kd) mmp2 secretion and activation. |
2001-05-24 |
2023-08-12 |
human |
| John Martin, Lisa Eynstone, Malcolm Davies, Robert Steadma. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology : JASN. vol 12. issue 1. 2001-05-24. PMID:11134254. |
the results demonstrate that specific matrix components increased the secretion of mmp2 and mmp9 from hmc. |
2001-05-24 |
2023-08-12 |
human |
| S Silletti, T Kessler, J Goldberg, D L Boger, D A Cheres. Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 1. 2001-04-19. PMID:11134507. |
matrix metalloproteinase 2 (mmp2) can associate with integrin alpha(v)beta3 on the surface of endothelial cells, thereby promoting vascular invasion. |
2001-04-19 |
2023-08-12 |
Not clear |
| S Silletti, T Kessler, J Goldberg, D L Boger, D A Cheres. Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 1. 2001-04-19. PMID:11134507. |
although disrupting alpha(v)beta3/mmp2 complex formation, tsri265 has no effect on alpha(v)beta3 binding to its extracellular matrix ligand vitronectin and does not influence mmp2 activation or catalytic activity directly. |
2001-04-19 |
2023-08-12 |
Not clear |
| R L Robker, D L Russell, S Yoshioka, S C Sharma, J P Lydon, B W O'Malley, L L Espey, J S Richard. Ovulation: a multi-gene, multi-step process. Steroids. vol 65. issue 10-11. 2001-03-29. PMID:11108860. |
the matrix metalloproteinases (mmps: mmp2, mmp9, and mmp13) appear to be expressed in ovaries of prko mice in a manner similar to that in their wild-type littermates. |
2001-03-29 |
2023-08-12 |
mouse |
| P Bornstein, L C Armstrong, K D Hankenson, T R Kyriakides, Z Yan. Thrombospondin 2, a matricellular protein with diverse functions. Matrix biology : journal of the International Society for Matrix Biology. vol 19. issue 7. 2001-03-08. PMID:11102746. |
our laboratory has established that tsp2 binds matrix metalloproteinase 2 (mmp2) and that the adhesive defect in tsp2-null fibroblasts results from increased mmp2 activity. |
2001-03-08 |
2023-08-12 |
mouse |
| P Bornstein, T R Kyriakides, Z Yang, L C Armstrong, D E Bir. Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis. The journal of investigative dermatology. Symposium proceedings. vol 5. issue 1. 2001-03-08. PMID:11147677. |
thus, the structurally abnormal collagen fibrils detected in skin appear to be the consequence of the defective adhesion demonstrated by dermal fibroblasts in culture that, in turn, result from increased matrix metalloproteinase 2 (mmp2, gelatinase a) production by these cells. |
2001-03-08 |
2023-08-12 |
mouse |
| G E Terp, I T Christensen, F S Jørgense. Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. Journal of biomolecular structure & dynamics. vol 17. issue 6. 2000-12-28. PMID:10949161. |
a general approach to the homology modeling of matrix metalloproteinases, exemplified by the modeling of mmp2, mmp9, mmp12 and mmp14 is described. |
2000-12-28 |
2023-08-12 |
Not clear |
| I Kazes, I Elalamy, J D Sraer, M Hatmi, G Nguye. Platelet release of trimolecular complex components MT1-MMP/TIMP2/MMP2: involvement in MMP2 activation and platelet aggregation. Blood. vol 96. issue 9. 2000-12-11. PMID:11049985. |
matrix metalloproteinase 2 (mmp2) has been reported to be secreted by collagen-stimulated platelets, and active mmp2 has been shown to play a role in platelet aggregation. |
2000-12-11 |
2023-08-12 |
human |
| K Bein, M Simon. Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity. The Journal of biological chemistry. vol 275. issue 41. 2000-11-13. PMID:10900205. |
one of the proteins identified that interacted with both tsr was matrix metalloproteinase 2 (mmp2). |
2000-11-13 |
2023-08-12 |
Not clear |
| S E Wert, M Yoshida, A M LeVine, M Ikegami, T Jones, G F Ross, J H Fisher, T R Korfhagen, J A Whitset. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 11. 2000-06-30. PMID:10801980. |
these abnormalities were associated with increased activity of the matrix metalloproteinases, mmp2 and mmp9, and immunostaining for mmp9 and mmp12 in alveolar macrophages. |
2000-06-30 |
2023-08-12 |
mouse |
| P P Minghetti, W D Blackbur. Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts. The Journal of rheumatology. vol 27. issue 3. 2000-05-09. PMID:10743803. |
to determine the effects of sulfasalazine (sasp) and its metabolites sulfapyridine (sp) and 5-amino salicylic acid (5asa) on steady state mrna levels of inflammatory cytokines [interleukin 1beta (il-1beta), tumor necrosis factor alpha (tnf-alpha)], matrix metalloproteinases [collagenase (mmp1), stromelysin (mmp3), gelatinase 72 kda (mmp2)], tissue inhibitors of metalloproteinase (timp 1 and timp 2), and the tnf-alpha receptor in rheumatoid synovial fibroblasts. |
2000-05-09 |
2023-08-12 |
Not clear |