| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L P Adhikary, T Yamamoto, M Isome, Y Nakano, K Kawasaki, E Yaoita, I Kihar. Expression profile of extracellular matrix and its regulatory proteins during the process of interstitial fibrosis after anti-glomerular basement membrane antibody-induced glomerular sclerosis in Sprague-Dawley rats. Pathology international. vol 49. issue 8. 2000-01-05. PMID:10504539. |
accumulation of fibronectin, collagen type i and type iv was noted in the interstitium by immunofluorescence microscopy in association with enhanced expression of mrna for these ecm components and their regulatory molecules such as matrix metalloproteinase (mmp2), tissue inhibitor of metalloproteinase (timp)-1 and tgf-beta1 both in glomeruli and cortex. |
2000-01-05 |
2023-08-12 |
rat |
| W Zhao, Y O'Malley, M E Robbin. Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis. Radiation research. vol 152. issue 2. 1999-08-26. PMID:10409325. |
to determine the ability of radiation to modulate mesangial cell expression of various molecules involved in promoting extracellular matrix (ecm) accumulation [fibronectin, plasminogen activator-inhibitor 1 (pai1), and tissue inhibitor of metalloproteinase-2 (timp2)] and degradation (tgfb, plasminogen activators u-pa or t-pa, matrix metalloproteinases mmp2 and mmp9), primary cultures of rat mesangial cells (passage number 6-11) were placed in serum-free medium 24 h prior to irradiation with single doses of 0.5-20 gy (137)cs gamma rays. |
1999-08-26 |
2023-08-12 |
rat |
| N Théret, K Lehti, O Musso, B Clémen. MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology (Baltimore, Md.). vol 30. issue 2. 1999-08-12. PMID:10421655. |
in fibrotic livers, there is a markedly increased activity of matrix metalloproteinase 2 (mmp2), a major enzyme involved in extracellular matrix remodeling. |
1999-08-12 |
2023-08-12 |
human |
| N Théret, K Lehti, O Musso, B Clémen. MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology (Baltimore, Md.). vol 30. issue 2. 1999-08-12. PMID:10421655. |
we have previously shown that hepatic stellate cells secrete latent mmp2 and that mmp2 activation occurs in coculture of hepatic stellate cells and hepatocytes concomitantly with matrix deposition. |
1999-08-12 |
2023-08-12 |
human |
| N Théret, K Lehti, O Musso, B Clémen. MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology (Baltimore, Md.). vol 30. issue 2. 1999-08-12. PMID:10421655. |
in the present work we investigated the effects of various extracellular matrix components and concanavalin a, an inducer of immune-mediated liver injuries, on mmp2 activation in cultured human hepatic stellate cells. |
1999-08-12 |
2023-08-12 |
human |
| N Théret, K Lehti, O Musso, B Clémen. MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology (Baltimore, Md.). vol 30. issue 2. 1999-08-12. PMID:10421655. |
these results suggest that the accumulation of collagen i may specifically contribute to the remodeling of extracellular matrix in fibrotic livers by inducing mmp2 activation. |
1999-08-12 |
2023-08-12 |
human |
| M P Chenard, Y Lutz, A Mechine-Neuville, I Stoll, J P Bellocq, M C Rio, P Basse. Presence of high levels of MT1-MMP protein in fibroblastic cells of human invasive carcinomas. International journal of cancer. vol 82. issue 2. 1999-07-19. PMID:10389754. |
matrix metalloproteinase 2 (mmp2) activity is associated with the aggressiveness of human cancers. |
1999-07-19 |
2023-08-12 |
human |
| S Ishigaki, M Toi, T Ueno, H Matsumoto, M Muta, M Koike, M Seik. Significance of membrane type 1 matrix metalloproteinase expression in breast cancer. Japanese journal of cancer research : Gann. vol 90. issue 5. 1999-07-19. PMID:10391091. |
mt1-mmp (membrane type 1 matrix metalloproteinase), a membrane-type mmp, is responsible for the activation of mmp2. |
1999-07-19 |
2023-08-12 |
human |
| G Giannelli, A Pozzi, W G Stetler-Stevenson, H A Gardner, V Quarant. Expression of matrix metalloprotease-2-cleaved laminin-5 in breast remodeling stimulated by sex steroids. The American journal of pathology. vol 154. issue 4. 1999-06-10. PMID:10233857. |
we have shown that matrix metalloprotease-2 (mmp2) cleaves laminin-5 (ln-5), a basement membrane component, generating a fragment called gamma2x. |
1999-06-10 |
2023-08-12 |
human |
| I Kazes, F Delarue, J Hagège, L Bouzhir-Sima, E Rondeau, J D Sraer, G Nguye. Soluble latent membrane-type 1 matrix metalloprotease secreted by human mesangial cells is activated by urokinase. Kidney international. vol 54. issue 6. 1999-02-11. PMID:9853262. |
matrix metalloprotease 2 (mmp2) is secreted in a latent inactive form (pro-mmp2) that is activated on the cell surface by a membrane-type 1 mmp (mt1-mmp) in the presence of the tissue inhibitor of mmp (timp2). |
1999-02-11 |
2023-08-12 |
human |
| R Piedagnel, G Murphy, P M Ronco, B Lelong. Matrix metalloproteinase 2 (MMP2) and MMP9 are produced by kidney collecting duct principal cells but are differentially regulated by SV40 large-T, arginine vasopressin, and epidermal growth factor. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880540. |
matrix metalloproteinase 2 (mmp2) and mmp9 are produced by kidney collecting duct principal cells but are differentially regulated by sv40 large-t, arginine vasopressin, and epidermal growth factor. |
1999-02-11 |
2023-08-12 |
rabbit |
| R Piedagnel, G Murphy, P M Ronco, B Lelong. Matrix metalloproteinase 2 (MMP2) and MMP9 are produced by kidney collecting duct principal cells but are differentially regulated by SV40 large-T, arginine vasopressin, and epidermal growth factor. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880540. |
we analyzed the expression and regulation of matrix metalloproteinase 2 (mmp2) and mmp9 gelatinases in a rabbit kidney collecting duct principal cell line (rc.svtsa58) (prié, d., ronco, p. m., baudouin, b., géniteau-legendre, m., antoine, m., piedagnel, r., estrade, s., lelongt, b., verroust, p. j., cassingéna, r., and vandewalle, a. |
1999-02-11 |
2023-08-12 |
rabbit |
| P Paquet, B V Nusgens, G E Piérard, C M Lapièr. Gelatinases in drug-induced toxic epidermal necrolysis. European journal of clinical investigation. vol 28. issue 7. 1998-11-16. PMID:9726031. |
the matrix metalloproteinases (mmps) mmp2 and mmp9 play a significant role in epidermal detachment, inflammation and re-epithelialization. |
1998-11-16 |
2023-08-12 |
Not clear |
| N Théret, O Musso, A L'Helgoualc'h, J P Campion, B Clémen. Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers. The American journal of pathology. vol 153. issue 3. 1998-09-24. PMID:9736043. |
differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (mt-mmps) in association with mmp2 activation in injured human livers. |
1998-09-24 |
2023-08-12 |
human |
| N Théret, O Musso, A L'Helgoualc'h, J P Campion, B Clémen. Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers. The American journal of pathology. vol 153. issue 3. 1998-09-24. PMID:9736043. |
matrix metalloproteinase-2 (mmp2) activation is associated with basement membrane remodeling that occurs in injured tissues and during tumor invasion. |
1998-09-24 |
2023-08-12 |
human |
| G Répássy, C Forster-Horváth, A Juhász, R Adány, A Tamássy, J Tímá. Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma. Pathology oncology research : POR. vol 4. issue 1. 1998-08-18. PMID:9555115. |
twelve laryngeal squamous cell carcinoma cases (7 laryngeal and 5 hypopharyngeal cancer; 15 samples) were analysed by immunohistochemistry for the expression of invasion markers cd44v6/v3, nm23 and matrix metalloproteinase, mmp2. |
1998-08-18 |
2023-08-12 |
Not clear |
| G Giannelli, J Falk-Marzillier, O Schiraldi, W G Stetler-Stevenson, V Quarant. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science (New York, N.Y.). vol 277. issue 5323. 1997-07-30. PMID:9211848. |
specific cleavage of laminin-5 (ln-5) by matrix metalloprotease-2 (mmp2) was shown to induce migration of breast epithelial cells. |
1997-07-30 |
2023-08-12 |
Not clear |
| M Mori, K Mimori, T Shiraishi, T Fujie, K Baba, H Kusumoto, M Haraguchi, H Ueo, T Akiyosh. Analysis of MT1-MMP and MMP2 expression in human gastric cancers. International journal of cancer. vol 74. issue 3. 1997-07-24. PMID:9221811. |
membrane-type 1 matrix metalloproteinase (mt1-mmp) is a presumed activator of mmp2, which is one of the major proteinases in tumor cell invasion. |
1997-07-24 |
2023-08-12 |
human |
| A R Pickford, J R Potts, J R Bright, I Phan, I D Campbel. Solution structure of a type 2 module from fibronectin: implications for the structure and function of the gelatin-binding domain. Structure (London, England : 1993). vol 5. issue 3. 1997-06-11. PMID:9083105. |
the f2 modules of the matrix metalloproteinases mmp2 and mmp9 are responsible for the affinity of these proteins for gelatin. |
1997-06-11 |
2023-08-12 |
Not clear |
| O Musso, N Théret, J P Campion, B Turlin, S Milani, C Grappone, B Clémen. In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. Journal of hepatology. vol 26. issue 3. 1997-06-05. PMID:9075667. |
in situ detection of matrix metalloproteinase-2 (mmp2) and the metalloproteinase inhibitor timp2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. |
1997-06-05 |
2023-08-12 |
human |