| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenliang Tan, Yong Yang, Huogeng Bao, Xinjun Kang, Hong Zeng, Lang Hong, Liang Sha. MicroRNA-22-3p Restrains the Proliferation, Phenotypic Transformation, and Migration of Vascular Smooth Muscle Cells by Manipulating TOMM40. International heart journal. vol 63. issue 6. 2022-11-30. PMID:36450556. |
after mir-22-3p-inhibitor, oe-tomm40, and sh-tomm40 were transfected into vsmcs, cell counting kit (cck) -8 assay, scratch test, and western blot analysis were implemented to measure the vsmc proliferation, migration, and matrix metallopeptidase 9 (mmp9), α-smooth muscle actin (sma), smooth muscle-myosin heavy chain (sm-mhc), and osteopontin (opn) expressions, respectively. |
2022-11-30 |
2023-08-14 |
human |
| Jen-Fu Yang, Tzu-Min Chen, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Wen-Yen Huang, Cheng-Hsiang Lo, Chun-Shu Lin, Po-Chien Shen, Ying Che. Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells. European journal of pharmacology. 2022-11-27. PMID:36436590. |
there was also concomitant decreased expression of focal adhesion complex, matrix metalloproteinase-2 (mmp2), mmp9 and cathepsin b. |
2022-11-27 |
2023-08-14 |
human |
| Nannan Kang, Xue Liang, Buxi Fan, Chen Zhao, Beiyu Shen, Xuemei Ji, Yu Li. Endothelial-Specific Molecule 1 Inhibition Lessens Productive Angiogenesis and Tumor Metastasis to Overcome Bevacizumab Resistance. Cancers. vol 14. issue 22. 2022-11-26. PMID:36428773. |
furthermore, tnfα induced the upregulation of esm1, which promotes metastasis and angiogenesis and regulates matrix metalloprotease-9 (mmp9), vascular endothelial growth factor (vegf), and delta-like ligand-4 molecules (dll4). |
2022-11-26 |
2023-08-14 |
mouse |
| Agathe Quesnel, Nathan Coles, Tuomo M Polvikoski, George S Karagiannis, Claudio Angione, Meez Islam, Ahmad A Khundakar, Panagiota S Filippo. The diagnostic and prognostic potential of the EGFR/MUC4/MMP9 axis in glioma patients. Scientific reports. vol 12. issue 1. 2022-11-18. PMID:36400876. |
interactions between mucin 4 (muc4) and the epidermal growth factor receptor (egfr) are involved in carcinogenesis, and may lead to matrix metalloproteinase-9 (mmp9) overexpression, exacerbating cancer cell invasiveness. |
2022-11-18 |
2023-08-14 |
Not clear |
| Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Che. Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. Frontiers in oncology. vol 12. 2022-11-17. PMID:36387162. |
ectopic expression or knock down (kd) of pcdh9 with a lentivirus vector, we explored its effects on the proliferation, invasion, and apoptosis of melanoma and verified its regulatory effect on ras-related c3 botulinum toxin substrate 1 (rac1), proline-rich tyrosine kinase 2 (pyk2), cyclin d1, matrix metalloproteinase 2 (mmp2), and mmp9. |
2022-11-17 |
2023-08-14 |
human |
| Haowen Yin, Yuanyuan Liu, Hao Yue, Yingying Tian, Ping Dong, Changhu Xue, Yun-Tao Zhao, Zifang Zhao, Jingfeng Wan. DHA- and EPA-Enriched Phosphatidylcholine Suppress Human Lung Carcinoma 95D Cells Metastasis via Activating the Peroxisome Proliferator-Activated Receptor γ. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364935. |
furthermore, critical factors related to invasion, including matrix metallopeptidase 9 (mmp9), heparanase (hpa), and vascular endothelial growth factor (vegf), were drastically downregulated through the pparγ/nf-κb signaling pathway. |
2022-11-11 |
2023-08-14 |
human |
| Mingyue Jiang, You Sun, Kyung Son. Ginsenoside compound K suppresses tumor growth in the 22Rv1 xenograft model and inhibits androgenic responses via the transcriptional mechanism in human prostate cancer cells. The FEBS journal. 2022-11-09. PMID:36349420. |
gck downregulated epithelial-mesenchymal transition (emt) markers such as vimentin and matrix metalloproteinase 9 (mmp9), whereas e-cadherin was significantly increased in gck-stimulated lncap and 22rv1 cells. |
2022-11-09 |
2023-08-14 |
mouse |
| Longxiang Huang, Zhenni Wei, Xiaohui Wang, Chunlin Lan, Yihua Zhu, Qin Y. AZD6738 Decreases Intraocular Pressure and Inhibits Fibrotic Response in Trabecular Meshwork through CHK1/P53 Pathway. Biochemical pharmacology. 2022-11-08. PMID:36347274. |
further, we demonstrated that azd6738 reduces cell viability and migration, and inhibit the expression of fibrosis-related factors including fibronectin (fn), α-smooth muscle actin (α-sma), laminin subunit beta 1 (lamb1), matrix metallopeptidase (mmp) family including mmp2 and mmp9, collagen Ⅰ (col1), and collagen Ⅳ (col4), reduce gap junctions, altered cytoskeleton and nitric oxide production in tgf-β1-induced human trabecular meshwork cells (htmcs) through the chk1/p53 pathway, which were affected aqueous humor (ah) production and outflow pathway. |
2022-11-08 |
2023-08-14 |
mouse |
| Denes V Agoston, Jesse McCullough, Roxanne Aniceto, I-Hsuan Lin, Alaa Kamnaksh, Michael Eklund, Wallace M Graves, Cyrus Dunbar, James Engall, Eric B Schneider, Fabio Leonessa, Josh L Duckwort. Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study. Neurotrauma reports. vol 3. issue 1. 2022-11-07. PMID:36337080. |
we detected elevated serum levels of glial fibrillary acidic protein, ubiquitin c-terminal hydrolase l1 (uch-l1), nicotinic alpha 7 subunit (chrna7), occludin (ocln), claudin-5 (cldn5), matrix metalloprotease 9 (mmp9), and intereukin-6 (il-6). |
2022-11-07 |
2023-08-14 |
Not clear |
| Li-Fang Liu, Yun Hu, Yi-Nuo Liu, De-Wen Shi, Chang Liu, Xin Da, Si-Hui Zhu, Qian-Yun Zhu, Ji-Qian Zhang, Guang-Hong X. Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery. Frontiers in aging neuroscience. vol 14. 2022-11-07. PMID:36337710. |
cyclophilin a (cypa) is a specifically chemotactic leukocyte factor that can be secreted in response to ros, which activates matrix metalloproteinase 9 (mmp9) and mediates bbb breakdown. |
2022-11-07 |
2023-08-14 |
mouse |
| Jing Yu, Ling Guo, Si-Hai Zhang, Qun-Yin Zhu, Ru-Yi Chen, Boon Hui Wong, Guo-Hua Ding, Jie Che. Transcriptomic analysis of intermuscular bone development in barbel steed (Hemibarbus labeo). Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 44. 2022-11-07. PMID:36343604. |
in conclusion, we identified genes that may be related to ib development, such as kazal type serine peptidase inhibitor domain 1 (kazald1), extracellular matrix protein 1 (ecm1), tetranectin, bone morphogenetic protein 1 (bmp1), acid phosphatase 5 (acp5), collagen type xi alpha 1 chain (col11a1), matrix metallopeptidase 9 (mmp9), pannexin-3 (panx3), sp7 transcription factor (sp7), and c-x-c motif chemokine ligand 8 (cxcl8), by comparing the transcriptomes of epaxial muscle before and after ib ossification. |
2022-11-07 |
2023-08-14 |
Not clear |
| Hui-Seon Yun, Jong-Pyo Kim, Eun-Jung Kim, Byung-Gee Kim, Hee-Jin Jeon. A rapid ELISA for the detection of matrix metallopeptidase 9 using a recombinant Fab-type antibody. Biochemical and biophysical research communications. vol 636. issue Pt 1. 2022-11-05. PMID:36334443. |
matrix metalloproteinase 9 (mmp9) contributes to several aspects of inflammation and cancer pathology, including invasion, metastasis, and angiogenesis. |
2022-11-05 |
2023-08-14 |
Not clear |
| Hongkuan Han, Cheng Qian, Gangfan Zong, Huan Liu, Feihui Wang, Ruizhi Tao, Peng Cheng, Zhonghong Wei, Yang Zhao, Yin L. Systemic pharmacological verification of Salvia miltiorrhiza-Ginseng Chinese herb pair in inhibiting spontaneous breast cancer metastasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-29. PMID:36308918. |
then, based on systematic pharmacology combined with gene expression omnibus (geo) database, potential targets of drugs were identified such as vascular endothelial growth factor a (vegfa), matrix metalloproteinase (mmp9), prostaglandin endoperoxide synthase2 (ptgs2), etc. |
2022-10-29 |
2023-08-14 |
Not clear |
| Flávia Mendonça, Amanda Mara Teles, Maria DO Desterro Soares Brandão Nascimento, Ana Paula Azevedo Dos Santos, Fernanda Ferreira Lopes, Anselmo Paiva, Haissa O Brito, Rui Gil DA Cost. Human Papillomavirus Modulates Matrix Metalloproteinases During Carcinogenesis: Clinical Significance and Role of Viral Oncoproteins. In vivo (Athens, Greece). vol 36. issue 6. 2022-10-29. PMID:36309355. |
matrix metalloproteinases such as mmp1, mmp9 and mmp13 have been associated with patient prognosis in hpv-induced cancers and play a major role in the degradation of the extracellular matrix, tumor invasion and metastasis. |
2022-10-29 |
2023-08-14 |
human |
| Briliant Adhi Prabowo, Carole Sousa, Susana Cardoso, Paulo Freitas, Elisabete Fernande. Labeling on a Chip of Cellular Fibronectin and Matrix Metallopeptidase-9 in Human Serum. Micromachines. vol 13. issue 10. 2022-10-27. PMID:36296077. |
in this study, the device performance was tested using commercial serum samples from healthy donors spiked with the following target proteins: cellular fibronectin (c-fn) and matrix metallopeptidase 9 (mmp9). |
2022-10-27 |
2023-08-14 |
human |
| Briliant Adhi Prabowo, Carole Sousa, Susana Cardoso, Paulo Freitas, Elisabete Fernande. Labeling on a Chip of Cellular Fibronectin and Matrix Metallopeptidase-9 in Human Serum. Micromachines. vol 13. issue 10. 2022-10-27. PMID:36296077. |
the spiked proteins of c-fn and mmp9 in the human serum-based matrix, were successfully labeled by the functionalized magnetic nanoparticles (mnps). |
2022-10-27 |
2023-08-14 |
human |
| Aitor Benedicto, Beatriz Arteta, Andrea Duranti, Daniel Alonso-Alconad. The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297277. |
melanoma and crc cell migration was affected in a dose-dependent fashion as observed through scratch assay, whereas the secretion of matrix degrading proteins metalloprotease 2 (mmp2) and 9 (mmp9) in tumor cells did not significantly change. |
2022-10-27 |
2023-08-14 |
mouse |
| Majdolin Mohammed Eltayeb, Mohamed M Ali, Saeed M Omar, Nouh Saad Mohamed, Ishag Adam, Hamdan Z Hamda. Gene polymorphisms of cyclin-dependent kinase inhibitor and matrix metalloproteinase-9 in Sudanese patients with esophageal squamous cell carcinoma. Molecular genetics & genomic medicine. 2022-10-19. PMID:36259348. |
the polymorphisms of the cyclin-dependent kinase inhibitor (cdkn1a) gene and matrix metalloproteinase-9 (mmp9) gene may increase one's susceptibility to malignancies. |
2022-10-19 |
2023-08-14 |
Not clear |
| Rotem Kalev-Altman, Jerome Nicolas Janssen, Nir Ben-Haim, Tamar Levy, Astar Shitrit-Tovli, Joshua Milgram, Ron Shahar, Dalit Sela-Donenfeld, Efrat Monsonego-Orna. The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development. Matrix biology : journal of the International Society for Matrix Biology. 2022-10-19. PMID:36261075. |
the gelatinases, a subgroup of the matrix metalloproteinases (mmps) superfamily are composed of two members; mmp2 and mmp9. |
2022-10-19 |
2023-08-14 |
mouse |
| Hui Lu, Ryan Ashiqueali, Chin I Lin, Aashlesha Walchale, Victoria Clendaniel, Rudy Matheson, Marc Fisher, Eng H Lo, Magdy Selim, Amjad Shehada. Histone Deacetylase 3 Inhibition Decreases Cerebral Edema and Protects the Blood-Brain Barrier After Stroke. Molecular neurobiology. 2022-10-18. PMID:36258136. |
western blot for matrix metalloproteinase-9 (mmp9), mmp-9 zymography, and immunostaining for hdac3, gfap, iba-1, albumin, aquaporin-4, claudin-5, zo-1, and nf-kb were performed. |
2022-10-18 |
2023-08-14 |
rat |