| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuichi Tsukamoto, Yu-Ichiro Koma, Yu Kitamura, Kohei Tanigawa, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Masayoshi Hosono, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozak. Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor Prognosis. Cancers. vol 15. issue 11. 2023-06-11. PMID:37296952. |
we found that matrix metalloproteinase 9 (mmp9) was induced in escc cells by direct co-culture with tams, not by indirect co-culture. |
2023-06-11 |
2023-08-14 |
Not clear |
| Di Hu, Zenan Lin, Pan Li, Zhehuan Zhang, Junhong Jiang, Chenhao Yan. Investigation of Potential Crucial Genes and Key Pathways in Keratoconus: An Analysis of Gene Expression Omnibus Data. Biochemical genetics. 2023-05-26. PMID:37233843. |
the results revealed that extracellular matrix remodeling and immune inflammatory response could be the key links of keratoconus, tnf, il6, il1a, il1b, ccl3, mmp3, mmp9, mmp1, and tgfb1 may be potential crucial genes, and tnf signaling pathway and il-17 signaling pathway were the potential pathways accounting for pathogenesis and development of keratoconus. |
2023-05-26 |
2023-08-14 |
Not clear |
| Lihong Shi, Qiangsheng Zhang, Shirui Zhu, Qing Tang, Xin Chen, Rui Lan, Ningyu Wang, Yongxia Zh. Pharmacological inhibition of EZH2 using a covalent inhibitor suppresses human ovarian cancer cell migration and invasion. Molecular and cellular biochemistry. 2023-05-18. PMID:37199893. |
enhancer of zeste homolog 2 (ezh2), a histone-lysine n-methyltransferase enzyme, promotes oc cell migration and invasion by regulating the expression of tissue inhibitor of metalloproteinase-2 (timp2) and matrix metalloproteinases-9 (mmp9). |
2023-05-18 |
2023-08-14 |
human |
| Huixian Zheng, Chaoyi Hu, Yunyun Quan, Xiaoxia Ye, Xiangchao Shi, Zijian Guo, Xiaoyong Wan. A copper complex that combats triple negative breast cancer by restraining angiogenesis. Dalton transactions (Cambridge, England : 2003). 2023-05-17. PMID:37195167. |
moreover, cpt8 suppressed the expression of vascular endothelial cadherin and matrix metalloproteinases mmp2 and mmp9, leading to the inhibition of vasculogenic mimicry formation. |
2023-05-17 |
2023-08-14 |
human |
| Zhimin Shen, Peipei Zhang, Weiguang Zhang, Fei Luo, Hui Xu, Shuchen Chen, Mingqiang Kan. IL-1RA inhibits esophageal carcinogenesis and lymphangiogenesis via downregulating VEGF-C and MMP9. Functional & integrative genomics. vol 23. issue 2. 2023-05-17. PMID:37198330. |
il-1ra inhibits lymph node metastasis of escc by regulating the emt through activation of matrix metalloproteinase 9(mmp9) and lymphangiogenesis, driven by vegf-c and the nf-κb signaling pathway. |
2023-05-17 |
2023-08-14 |
Not clear |
| Satoru Shindo, Roodelyne Pierrelus, Atsushi Ikeda, Shin Nakamura, Alireza Heidari, Maria Rita Pastore, Elizabeth Leon, Sunniva Ruiz, Harsh Chheda, Rhea Khatiwala, Tomoki Kumagai, George Tolson, Islam Elderbashy, Kazuhisa Ouhara, Xiaozhe Han, Maria Hernandez, Saynur Vardar-Sengul, Hideki Shiba, Toshihisa Kawa. Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis. Cells. vol 12. issue 8. 2023-05-16. PMID:37190018. |
the cv-induced upregulation of oc-genesis was abrogated by the protein kinase c (pkc)-δ inhibitor rottlerin, accompanied by the downmodulation of oc-genesis-related genes, including osteoclast stimulatory transmembrane protein (oc-stamp), trap and matrix metallopeptidase 9 (mmp9) as well as extracellular signal-regulated kinase (erk) mitogen-activated protein (map)-kinase phosphorylation. |
2023-05-16 |
2023-08-14 |
mouse |
| Noureldien H E Darwish, Khaled A Hussein, Khaled Elmasry, Ahmed S Ibrahim, Julia Humble, Mohamed Moustafa, Fatma Awadalla, Mohamed Al-Shabrawe. Bone Morphogenetic Protein-4 Impairs Retinal Endothelial Cell Barrier, a Potential Role in Diabetic Retinopathy. Cells. vol 12. issue 9. 2023-05-14. PMID:37174679. |
the impact of bmp4 on matrix metalloproteinases (mmp2 and mmp9) was also evaluated using specific elisa kits. |
2023-05-14 |
2023-08-14 |
mouse |
| S Banerjee, S K Baidya, B Ghosh, T Jha, N Adhikar. Exploration of structural alerts and fingerprints for novel anticancer therapeutics: a robust classification-QSAR dependent structural analysis of drug-like MMP-9 inhibitors. SAR and QSAR in environmental research. 2023-05-12. PMID:37170840. |
among various matrix metalloproteinases (mmps), overexpression of mmp9 has been established as a key player in a variety of cancers. |
2023-05-12 |
2023-08-14 |
Not clear |
| Alaa Elmetwalli, Thoria Diab, Aisha Nawaf Albalawi, Sabry Ali El-Naggar, Ali H El-Far, Amira Radwan Ghedan, Eman Saad Alamri, Afrah Fatthi Salam. Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145126. |
the apoptosis-related gene (casp8), the apoptosis-related gene (p53), the anti-inflammatory genes (il-6), the migration-related gene matrix metalloprotease-9 (mmp9), and the angiogenesis-related gene vascular endothelial growth factor (vegf) were assessed using qrt-pcr in the hepatic tissue. |
2023-05-05 |
2023-08-14 |
mouse |
| Anis Barmada, Jon Klein, Anjali Ramaswamy, Nina N Brodsky, Jillian R Jaycox, Hassan Sheikha, Kate M Jones, Victoria Habet, Melissa Campbell, Tomokazu S Sumida, Amy Kontorovich, Dusan Bogunovic, Carlos R Oliveira, Jeremy Steele, E Kevin Hall, Mario Pena-Hernandez, Valter Monteiro, Carolina Lucas, Aaron M Ring, Saad B Omer, Akiko Iwasaki, Inci Yildirim, Carrie L Luca. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis. Science immunology. vol 8. issue 83. 2023-05-05. PMID:37146127. |
instead, unbiased systematic immune serum profiling revealed elevations in circulating interleukins (il-1β, il-1ra, and il-15), chemokines (ccl4, cxcl1, and cxcl10), and matrix metalloproteases (mmp1, mmp8, mmp9, and timp1). |
2023-05-05 |
2023-08-14 |
Not clear |
| Xavier Capó, Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabrés, Juan M Batle, Josep A Tur, Antoni Pons, Antoni Sureda, Silvia Tejad. Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108205. |
plasma levels of growth factors--platelet-derived growth factor (pdfg), transforming growth factor β (tgf-β) and hypoxia-inducible factor 1-alpha (hif-1α)-- were increased as a consequence of hbot and reduced 28 days after complete wound healing, whereas matrix metallopeptidase 9 (mmp9) progressively decreased with the hbot. |
2023-04-28 |
2023-08-14 |
human |
| Yen-Yu Yang, Ruthia Soh, Madeline Vera-Colón, Ming Huang, Nicole I Zur Nieden, Yinsheng Wan. Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation. Analytical chemistry. 2023-04-21. PMID:37083350. |
we also documented a previously unrecognized role of kras in osteogenesis, where it regulates the accumulation of extracellular matrix for mineralization through attenuating the activity of secreted matrix metalloproteinase 9 (mmp9). |
2023-04-21 |
2023-08-14 |
human |
| Joseph H McCart. MMP9 Clears the Way for Metastatic Cell Penetration Across the Blood-Brain Barrier. Cancer research. vol 83. issue 8. 2023-04-14. PMID:37057598. |
they show that matrix metalloprotease 9 (mmp9) plays a central role in these events. |
2023-04-14 |
2023-08-14 |
Not clear |
| Joseph H McCart. MMP9 Clears the Way for Metastatic Cell Penetration Across the Blood-Brain Barrier. Cancer research. vol 83. issue 8. 2023-04-14. PMID:37057598. |
surprisingly, extravasation and brain colonization does not involve significant degradation of canonical mmp9 protein targets such as collagen and laminin in vascular basement membranes, indicating the requirement for other extracellular matrix (ecm) or non-ecm substrates for mmp9. |
2023-04-14 |
2023-08-14 |
Not clear |
| Jing-Yu Qu, Hua-Tao Xie, Yu-Ting Xiao, Ying-Ying Zhang, Zhi-Xin Hu, Jia-Song Wang, Ming-Chang Zhang, Han X. The inhibition of p38 MAPK blocked inflammation to restore the functions of rat meibomian gland epithelial cells. Experimental eye research. 2023-04-14. PMID:37059216. |
cell proliferation, keratinization, lipid accumulation, and matrix metalloproteinases 9 (mmp9) expression were evaluated by mtt assay, polymerase chain reaction (pcr), immunofluorescence staining, apoptosis assay, lipid staining, and western blot analyses. |
2023-04-14 |
2023-08-14 |
mouse |
| Alaleh Mohammadi, Souzan Najafi, Mohammad Amini, Behzad Baradaran, Masoumeh Firouzamand. B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma. Melanoma research. 2023-04-13. PMID:37053079. |
b7h6 suppression combined with dacarbazine restrained cell migration through suppression of matrix metalloproteinase (mmp) expression, including mmp2, mmp3, and mmp9. |
2023-04-13 |
2023-08-14 |
Not clear |
| Qiang Zhang, Ting Luo, Dezheng Yuan, Jing Liu, Yi Fu, Jiali Yua. Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway. Scientific reports. vol 13. issue 1. 2023-04-12. PMID:37045911. |
further studies indicated that qlt reduced the mrnas and protein levels of interleukin 17 (il-17), c-c motif chemokine ligand 12 (ccl12), c-x-c motif chemokine ligand 5 (cxcl5), fos-like antigen 1 (fosl1), matrix metalloproteinase-9 (mmp9), and amphiregulin (areg), which are inflammation and fibrosis-related genes in the il-17 signal pathway. |
2023-04-12 |
2023-08-14 |
mouse |
| Eun-Gene Sun, Veena Vijayan, Mi-Ra Park, Kyung Hyun Yoo, Sang-Hee Cho, Woo-Kyun Bae, Hyun-Jeong Shim, Jun-Eul Hwang, In-Kyu Park, Ik-Joo Chun. Suppression of triple-negative breast cancer aggressiveness by LGALS3BP via inhibition of the TNF-α-TAK1-MMP9 axis. Cell death discovery. vol 9. issue 1. 2023-04-11. PMID:37041137. |
lgals3bp inhibited tnf-α-mediated gene expression of matrix metalloproteinase 9 (mmp9), which encodes a protein crucial for lung metastasis in tnbc patients. |
2023-04-11 |
2023-08-14 |
Not clear |
| Guo Zheng, Yu Su, Li Wei, Yingcheng Yao, Yizhe Wang, Xiaoting Luo, Xing Wang, Xiong Z Ruan, Danyang Li, Yaxi Che. SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice. Cell death & disease. vol 14. issue 4. 2023-04-06. PMID:37024487. |
mechanistically, we demonstrated that scap ablation in vsmcs leads to the upregulation of kiss-1 protein, consequently resulting in suppressed activation of the mapk/erk signaling pathway and downregulation of matrix metalloproteinase 9 (mmp9) and vascular endothelial-derived growth factor (vegf) expression to prevent angiogenesis. |
2023-04-06 |
2023-08-14 |
mouse |
| Yuye Wang, Luying Qiu, Shumin Deng, Fang Liu, Zhiyi He, Mengye Li, Yanzhe Wan. Ursolic Acid Promotes Microglial Polarization Toward the M2 Phenotype Via PPARγ Regulation of MMP2 Transcription. Neurotoxicology. 2023-04-05. PMID:37019307. |
additionally, ua increases tissue inhibitor matrix metalloproteinase 1 (timp1), while greatly reducing the release of matrix metalloproteinase 2 (mmp2) and mmp9 in a pparγ-dependent manner. |
2023-04-05 |
2023-08-14 |
rat |