| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| . NTP toxicology and carcinogenesis studies of trans-cinnamaldehyde (CAS No. 14371-10-9) in F344/N rats and B6C3F1 mice (feed studies). National Toxicology Program technical report series. issue 514. 2004-06-16. PMID:15146216. |
the incidence of squamous epithelial hyperplasia of the forestomach mucosa in 33,000 ppm females was significantly increased, and olfactory epithelial degeneration of the nasal cavity occurred in 16,500 and 33,000 ppm males and females. |
2004-06-16 |
2023-08-12 |
mouse |
| Jannis Constantinidis, Helmut Steinhart, Michael Koch, Michael Buchfelder, Anne Schaenzer, Manfred Weidenbecher, Heinrich Ir. Olfactory neuroblastoma: the University of Erlangen-Nuremberg experience 1975-2000. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. vol 130. issue 5. 2004-06-15. PMID:15138422. |
olfactory neuroblastoma constitutes a rare and, in clinical terms, biologically variable tumor of the nasal cavity, paranasal sinuses, and the base of the skull and presents a challenge to a modern multidisciplinary therapy. |
2004-06-15 |
2023-08-12 |
Not clear |
| Lisbeth Illu. Is nose-to-brain transport of drugs in man a reality? The Journal of pharmacy and pharmacology. vol 56. issue 1. 2004-06-01. PMID:14979996. |
in recent years interest has been expressed in the use of the nasal route for delivery of drugs to the brain, exploiting the olfactory pathway. |
2004-06-01 |
2023-08-12 |
human |
| Morten Bagger, Erik Bechgaar. A microdialysis model to examine nasal drug delivery and olfactory absorption in rats using lidocaine hydrochloride as a model drug. International journal of pharmaceutics. vol 269. issue 2. 2004-05-11. PMID:14706243. |
a microdialysis model to examine nasal drug delivery and olfactory absorption in rats using lidocaine hydrochloride as a model drug. |
2004-05-11 |
2023-08-12 |
rat |
| Morten Bagger, Erik Bechgaar. A microdialysis model to examine nasal drug delivery and olfactory absorption in rats using lidocaine hydrochloride as a model drug. International journal of pharmaceutics. vol 269. issue 2. 2004-05-11. PMID:14706243. |
in the present study, a model for olfactory drug absorption has been investigated using intravenous and unilateral nasal administration of lidocaine hydrochloride in rats. |
2004-05-11 |
2023-08-12 |
rat |
| Annika Brämerson, Leif Johansson, Lars Ek, Steven Nordin, Mats Bend. Prevalence of olfactory dysfunction: the skövde population-based study. The Laryngoscope. vol 114. issue 4. 2004-05-11. PMID:15064632. |
therefore, the objectives were to investigate the prevalence of olfactory dysfunction in an adult swedish population and to relate dysfunction to age, gender, diabetes mellitus, nasal polyps, and smoking habits. |
2004-05-11 |
2023-08-12 |
Not clear |
| Yoshiyuki Yamamoto, Luis Espinasa, David W Stock, William R Jeffer. Development and evolution of craniofacial patterning is mediated by eye-dependent and -independent processes in the cavefish Astyanax. Evolution & development. vol 5. issue 5. 2004-05-06. PMID:12950623. |
the size of the olfactory pits, which the nasal and antorbital bones define, and the size and positioning of the circumorbital bones were found to correlate with eye development. |
2004-05-06 |
2023-08-12 |
Not clear |
| Lilian Calderón-Garcidueñas, Robert R Maronpot, Ricardo Torres-Jardon, Carlos Henríquez-Roldán, Robert Schoonhoven, Hilda Acuña-Ayala, Anna Villarreal-Calderón, Jun Nakamura, Reshan Fernando, William Reed, Biagio Azzarelli, James A Swenber. DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Toxicologic pathology. vol 31. issue 5. 2004-05-03. PMID:14692621. |
respiratory tract inflammation, production of mediators of inflammation capable of reaching the brain, systemic circulation of pm, and disruption of the nasal respiratory and olfactory barriers are likely in these populations. |
2004-05-03 |
2023-08-12 |
Not clear |
| R Clark Lantz, Jason Orozco, Matthew S Bogdanff. Vinyl acetate decreases intracellular pH in rat nasal epithelial cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 75. issue 2. 2004-04-27. PMID:12883081. |
using an in vitro assay system, we have determined the effects of vinyl acetate exposure on phi in respiratory and olfactory nasal epithelial cells from rats. |
2004-04-27 |
2023-08-12 |
rat |
| Philip H Long, Ronald A Herbert, John C Peckham, Sondra L Grumbein, Cynthia C Shackelford, Kamal Abd. Morphology of nasal lesions in F344/N rats following chronic inhalation exposure to naphthalene vapors. Toxicologic pathology. vol 31. issue 6. 2004-04-27. PMID:14585734. |
91-20-3) administered by inhalation at concentrations of 10, 30, or 60 ppm for 6 hours per day, 5 days per week for 105 weeks caused nonneoplastic and neoplastic effects in nasal respiratory and olfactory regions of male and female f344/n rats. |
2004-04-27 |
2023-08-12 |
rat |
| Philip H Long, Ronald A Herbert, John C Peckham, Sondra L Grumbein, Cynthia C Shackelford, Kamal Abd. Morphology of nasal lesions in F344/N rats following chronic inhalation exposure to naphthalene vapors. Toxicologic pathology. vol 31. issue 6. 2004-04-27. PMID:14585734. |
neoplastic effects were characterized by the induction of two types of rare primary nasal tumors, olfactory neuroblastomas and respiratory epithelial adenomas. |
2004-04-27 |
2023-08-12 |
rat |
| Isabelle Comte, Muriel Mathonnet, Geneviève Chevalier, Christiane Ayer Le-Lievr. Developmental changes of keratin expression in chick embryo olfactory epithelium in relation to cellular differentiation and neurogenesis in vivo and in vitro. Brain research. Developmental brain research. vol 148. issue 1. 2004-04-19. PMID:14757513. |
olfactory placodes form at embryonic day 3 (ed3) in the anterior facial ectoderm and invaginate to form the nasal pits. |
2004-04-19 |
2023-08-12 |
chicken |
| Isabelle Comte, Muriel Mathonnet, Geneviève Chevalier, Christiane Ayer Le-Lievr. Developmental changes of keratin expression in chick embryo olfactory epithelium in relation to cellular differentiation and neurogenesis in vivo and in vitro. Brain research. Developmental brain research. vol 148. issue 1. 2004-04-19. PMID:14757513. |
in contrast, absence of keratin expression in the basal part of olfactory epithelial primordium, in the deeper nasal pit area, coincides with one of the critical first steps of olfactory neurogenesis. |
2004-04-19 |
2023-08-12 |
chicken |
| N Giannetti, E Moyse, A Ducray, J-R Bondier, F Jourdan, A Propper, A Kastne. Accumulation of Ym1/2 protein in the mouse olfactory epithelium during regeneration and aging. Neuroscience. vol 123. issue 4. 2004-04-12. PMID:14751284. |
western blotting analysis of ym1/2 confirmed the accumulation of this protein in the regenerating olfactory mucosa consecutively to olfactory axotomy or bulbectomy but also after znso4 irrigation of the nasal cavity. |
2004-04-12 |
2023-08-12 |
mouse |
| B A Stuck, A Blum, A E Hagner, T Hummel, L Klimek, K Hörman. Mometasone furoate nasal spray improves olfactory performance in seasonal allergic rhinitis. Allergy. vol 58. issue 11. 2004-04-09. PMID:14616133. |
mometasone furoate nasal spray improves olfactory performance in seasonal allergic rhinitis. |
2004-04-09 |
2023-08-12 |
Not clear |
| Patrick M Muzzall, Patrick L Hudso. Occurrence of Ergasilus megaceros Wilson, 1916, in the sea lamprey and other fishes from North America. The Journal of parasitology. vol 90. issue 1. 2004-04-06. PMID:15040691. |
ergasilus megaceros (copepoda: ergasilidae) was recovered from the nasal fossae (lamellae) of the olfactory sac in 1 (1.8%) of 56 sea lampreys, petromyzon marinus linne, 1758, collected in may 2002 from the cheboygan river, michigan. |
2004-04-06 |
2023-08-12 |
Not clear |
| . NTP toxicology and carcinogensis Studies of 2,4-hexadienal (89% trans,trans isomer, CAS No. 142-83-6; 11% cis,trans isomer) (Gavage Studies). National Toxicology Program technical report series. issue 509. 2004-03-16. PMID:14999299. |
the incidences of forestomach hyperplasia and nasal olfactory atrophy or necrosis were significantly increased in 120 mg/kg rats. |
2004-03-16 |
2023-08-12 |
mouse |
| . NTP toxicology and carcinogensis Studies of 2,4-hexadienal (89% trans,trans isomer, CAS No. 142-83-6; 11% cis,trans isomer) (Gavage Studies). National Toxicology Program technical report series. issue 509. 2004-03-16. PMID:14999299. |
the incidences of forestomach hyperplasia and/or nasal olfactory atrophy or necrosis were significantly increased in 120 mg/kg mice. |
2004-03-16 |
2023-08-12 |
mouse |
| H Breer, J Strotman. Olfactory receptor gene expression. Seminars in cell & developmental biology. vol 8. issue 2. 2004-03-15. PMID:15001095. |
the discovery of a large multigene family encoding odorant receptors allows us to approach various facets concerning the molecular basis of olfactory chemospecificity, ranging from chromosomal localization and control of expression of olfactory receptor genes to temporal and spatial expression patterns of various receptor types in the nasal neuroepithelium. |
2004-03-15 |
2023-08-12 |
Not clear |
| Xiaoliang Zhuo, Jun Gu, Melissa J Behr, Pam J Swiatek, Huadong Cui, Qing-Yu Zhang, Yingqiu Xie, Doris N Collins, Xinxin Din. Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression. The Journal of pharmacology and experimental therapeutics. vol 308. issue 2. 2004-03-11. PMID:14610229. |
targeted disruption of the olfactory mucosa-specific cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on cyp2a5 expression. |
2004-03-11 |
2023-08-12 |
mouse |