| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V David, L H Gold, G F Koob, P Cazal. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 3. 2001-04-19. PMID:11166520. |
to test the hypothesis that injections directly into a reward-relevant brain region might support consistent cocaine-seeking behavior, balb/cbyj mice implanted in the nucleus accumbens (nac) or the caudate-putamen nucleus (cpu) were trained to discriminate between the arm enabling a microinjection of cocaine (30 pmol/50 nl or 150 pmol/50 nl) and the neutral arm of a y-maze. |
2001-04-19 |
2023-08-12 |
mouse |
| J J Rodríguez, D R Garcia, Y Nakabeppu, V M Picke. FosB in rat striatum: normal regional distribution and enhanced expression after 6-month haloperidol administration. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180499. |
the nucleus accumbens (nac) core also serving motor functions had a higher basal expression than the limbic shell region in control animals. |
2001-04-19 |
2023-08-12 |
rat |
| M E Jackson, B Moghadda. Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 2. 2001-04-05. PMID:11160446. |
a dynamic interaction between the prefrontal cortex (pfc), amygdala, and nucleus accumbens (nac) may be fundamental to regulation of goal-directed behavior by affective and cognitive processes. |
2001-04-05 |
2023-08-12 |
rat |
| Z D You, J H Li, C Y Song, C H Wang, C L L. Chronic morphine treatment inhibits oxytocin synthesis in rats. Neuroreport. vol 11. issue 14. 2001-02-22. PMID:11043533. |
after chronic administration of morphine, the oxytocin content in supraoptic nucleus (son) and nucleus accumbens (nac) decreased, and increased in the ventral tegment area (vta) and locus coeruleus (lc), but did not change in other nuclei including the paraventricular nucleus (pvn), lateral septum (septum), raphe magnus nucleus (nrm) and periaquaductal gray (pag). |
2001-02-22 |
2023-08-12 |
rat |
| A M van Erp, K A Micze. Aggressive behavior, increased accumbal dopamine, and decreased cortical serotonin in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11125011. |
male long-evans rats were implanted with a microdialysis probe aimed at the nucleus accumbens (nac) or medial prefrontal cortex (pfc); next, 10 min samples were collected before, during, and after a 10 min confrontation. |
2001-02-22 |
2023-08-12 |
rat |
| B E Hildebrand, T H Svensso. Intraaccumbal mecamylamine infusion does not affect dopamine output in the nucleus accumbens of chronically nicotine-treated rats. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 8-9. 2001-02-15. PMID:11041268. |
recently we have shown that the nicotinic receptor (nachr) antagonist mecamylamine both when administered systemically and locally into the ventral tegmental area (vta) to chronically nicotine-treated rats reduces dopamine (da) output in the nucleus accumbens (nac) and elicits behavioral withdrawal signs. |
2001-02-15 |
2023-08-12 |
rat |
| S Tucci, Q Contreras, X Paez, L Gonzalez, P Rada, L Hernande. Medial prefrontal transection enhances social interaction. II: neurochemical studies. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134614. |
social interaction enhances dopaminergic activity in the nucleus accumbens (nac). |
2001-02-15 |
2023-08-12 |
rat |
| A F Hoffman, C R Lupic. Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids. Journal of neurophysiology. vol 85. issue 1. 2001-02-15. PMID:11152707. |
the nucleus accumbens (nac) represents a critical site for the rewarding and addictive properties of several classes of abused drugs. |
2001-02-15 |
2023-08-12 |
rat |
| K D Carr, G Y Kim, S Cabeza de Vac. Chronic food restriction in rats augments the central rewarding effect of cocaine and the delta1 opioid agonist, DPDPE, but not the delta2 agonist, deltorphin-II. Psychopharmacology. vol 152. issue 2. 2001-02-08. PMID:11057524. |
the increased expression of c-fos in nucleus accumbens (nac) shell, in particular, suggests that food restriction may augment drug reward by modulating dopamine (da) synaptic function in this area. |
2001-02-08 |
2023-08-12 |
rat |
| D Robbe, G Alonso, F Duchamp, J Bockaert, O J Manzon. Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150326. |
despite the role of excitatory transmission to the nucleus accumbens (nac) in the actions of most drugs of abuse, the presence and functions of cannabinoid receptors (cb1) on the glutamatergic cortical afferents to the nac have never been explored. |
2001-02-08 |
2023-08-12 |
mouse |
| A M Himmelheber, J P Bruno, M Sarte. Effects of intra-accumbens infusions of amphetamine or cis-flupenthixol on sustained attention performance in rats. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080543. |
as nucleus accumbens (nac) efferent projections have been hypothesized to modulate the excitability of basal forebrain corticopetal projections, the effects of drug-induced modulation of nac dopaminergic transmission on sustained attention performance in rats were assessed. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
in the present study, the in vivo microdialysis technique was used to directly manipulate extracellular dopamine concentrations in the nucleus accumbens (nac) shell and the amygdala (amy) in rats maintaining stable patterns of cocaine (1.5 mg/kg/infusion) intake under a fixed ratio 1 schedule of reinforcement. |
2001-02-02 |
2023-08-12 |
rat |
| S Herges, D A Taylo. Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat. British journal of pharmacology. vol 131. issue 7. 2001-02-01. PMID:11090100. |
the present study investigated the central effects of the selective serotonin reuptake inhibitor (ssri) fluoxetine and the role of 5-hydroxytryptamine(3) (5-ht(3)) receptors in the core of the nucleus accumbens (nac) on cocaine-induced behavioural changes in rats. |
2001-02-01 |
2023-08-12 |
rat |
| C L Nelson, M Sarter, J P Brun. Repeated pretreatment with amphetamine sensitizes increases in cortical acetylcholine release. Psychopharmacology. vol 151. issue 4. 2001-01-18. PMID:11026747. |
furthermore, neurochemical data have raised the possibility that increases in nucleus accumbens (nac) dopamine (da) release trans-synaptically increase the excitability of basal forebrain corticopetal cholinergic projections, thereby supporting speculations about relationships between the effects of repeated psychostimulant administration on nac da and cortical ach release. |
2001-01-18 |
2023-08-12 |
rat |
| M H Leszczuk, C F Flahert. Lesions of nucleus accumbens reduce instrumental but not consummatory negative contrast in rats. Behavioural brain research. vol 116. issue 1. 2001-01-08. PMID:11090886. |
neither snc nor anc or their recovery were influenced by electrolytic lesions of the nucleus accumbens (nac). |
2001-01-08 |
2023-08-12 |
rat |
| T R Franklin, J P Druha. Involvement of the nucleus accumbens and medial prefrontal cortex in the expression of conditioned hyperactivity to a cocaine-associated environment in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 6. 2001-01-04. PMID:11063919. |
this study examined the roles of the nucleus accumbens (nac), medial prefrontal cortex, basolateral amygdala, and ventral subiculum of the hippocampus in the expression of pavlovian conditioned hyperactivity responses to cocaine-related stimuli. |
2001-01-04 |
2023-08-12 |
rat |
| M H Beauchamp, B K Ormerod, K Jhamandas, R J Boegman, R J Beninge. Neurosteroids and reward: allopregnanolone produces a conditioned place aversion in rats. Pharmacology, biochemistry, and behavior. vol 67. issue 1. 2001-01-04. PMID:11113481. |
another study found that allopregnanolone reduced dopamine (da) output in the nucleus accumbens (nac) of rats. |
2001-01-04 |
2023-08-12 |
mouse |
| C M Brown, D V Coscina, P J Fletche. The rewarding properties of neuropeptide Y in perifornical hypothalamus vs. nucleus accumbens. Peptides. vol 21. issue 8. 2000-12-28. PMID:11035216. |
to clarify the role of npy in mediating reward processes and the possible interaction between reward and feeding, the present study examined the effects of injecting npy bilaterally into the perifornical hypothalamus (pfh) vs. the nucleus accumbens (nac) on intake of preferred vs. non-preferred food types, as well as on conditioned place preference (cpp) learning. |
2000-12-28 |
2023-08-12 |
Not clear |
| M A Sutton, K McGibney, R J Beninge. Conditioned locomotion in rats following amphetamine infusion into the nucleus accumbens: blockade by coincident inhibition of protein kinase A. Behavioural pharmacology. vol 11. issue 5. 2000-12-28. PMID:11103888. |
recent studies demonstrate a role for cyclic adenosine monophosphate (camp)-dependent protein kinase (pka) in the nucleus accumbens (nac) in reward-related learning. |
2000-12-28 |
2023-08-12 |
rat |
| M R Gerasimov, M Franceschi, N D Volkow, O Rice, W K Schiffer, S L Dewe. Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044890. |
it is thought that the reinforcing effects of cocaine and mp are due partly to increases in synaptic da in the nucleus accumbens (nac). |
2000-12-14 |
2023-08-12 |
Not clear |