| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Fink-Jense. Novel pharmacological approaches to the treatment of schizophrenia. Danish medical bulletin. vol 47. issue 3. 2000-11-30. PMID:10913983. |
the fos protein is regarded as a marker of cellular activity and was measured by use of immunohistochemical techniques i) in the medial prefrontal cortex (pfc), probably involved in the negative symptoms of schizophrenia, ii) in the nucleus accumbens (nac), probably involved in the positive symptoms of schizophrenia and iii) in the dorsolateral striatum (dlst), most likely involved in the motoric side effects of neuroleptics. |
2000-11-30 |
2023-08-12 |
human |
| G L Forster, C D Blah. Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area. The European journal of neuroscience. vol 12. issue 10. 2000-11-30. PMID:11029630. |
we measured the changes in dopamine oxidation current (corresponding with dopamine efflux) in the nucleus accumbens (nac) in response to electrical stimulation of the ldt using in vivo chronoamperometry in urethane-anaesthetized rats. |
2000-11-30 |
2023-08-12 |
rat |
| R M Liao, Y H Chang, S H Wang, C H La. Distinct accumbal subareas are involved in place conditioning of amphetamine and cocaine. Life sciences. vol 67. issue 17. 2000-11-09. PMID:11057753. |
in considering the heterogeneous function of the nucleus accumbens (nac), the present work evaluated the conditioned place preference (cpp) after local infusion of d-amphetamine (amp; 10, 15 microg/side) or cocaine (coc; 50, 100 microg/side) into two subareas of nac, core and shell. |
2000-11-09 |
2023-08-12 |
Not clear |
| E A Engleman, W J McBride, A A Wilber, S R Shaikh, R D Eha, L Lumeng, T K Li, J M Murph. Reverse microdialysis of a dopamine uptake inhibitor in the nucleus accumbens of alcohol-preferring rats: effects on dialysate dopamine levels and ethanol intake. Alcoholism, clinical and experimental research. vol 24. issue 6. 2000-11-07. PMID:10888067. |
this study examines the effects of local perfusion of the da uptake inhibitor gbr12909 (gbr) on (1) da levels in the nucleus accumbens (nac) and (2) etoh drinking in alcohol-preferring rats. |
2000-11-07 |
2023-08-12 |
rat |
| B K Tolliver, M W Sganga, F R Shar. Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference. The European journal of neuroscience. vol 12. issue 9. 2000-11-07. PMID:10998122. |
the c-fos immediate-early gene is induced by morphine and other drugs of abuse in the nucleus accumbens (nac), a mesolimbic region implicated in drug abuse and reward. |
2000-11-07 |
2023-08-12 |
rat |
| N D Halim, N R Swerdlo. Distributed neurodegenerative changes 2-28 days after ventral hippocampal excitotoxic lesions in rats. Brain research. vol 873. issue 1. 2000-10-12. PMID:10915811. |
amino-cupric-silver staining demonstrated degenerative changes throughout the hippocampus, and in hippocampal efferent projections to forebrain structures, including the septal nucleus and nucleus accumbens (nac), and within the olfactory tubercle (ot) and orbital cortex. |
2000-10-12 |
2023-08-12 |
rat |
| V David, P Cazal. Anatomical and pharmacological specificity of the rewarding effect elicited by microinjections of morphine into the nucleus accumbens of mice. Psychopharmacology. vol 150. issue 1. 2000-10-11. PMID:10867973. |
the involvement of nucleus accumbens (nac) in initiating opiate-induced reward has been difficult to demonstrate in rats, and has not been studied in mice. |
2000-10-11 |
2023-08-12 |
mouse |
| C L Walters, G Aston-Jones, J P Druha. Expression of fos-related antigens in the nucleus accumbens during opiate withdrawal and their attenuation by a D2 dopamine receptor agonist. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942854. |
previous studies from this laboratory indicated that d2 dopamine (da) receptors within the nucleus accumbens (nac) are important for regulating somatic signs of opiate withdrawal. |
2000-10-11 |
2023-08-12 |
Not clear |
| R Takahata, B Moghadda. Target-specific glutamatergic regulation of dopamine neurons in the ventral tegmental area. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987862. |
for example, da afferents to the prefrontal cortex (pfc) have a higher firing and transmitter turnover rate and are more responsive to some pharmacological and environmental stimuli than da projections to the nucleus accumbens (nac). |
2000-10-05 |
2023-08-12 |
Not clear |
| K K Szumlinski, C A McCafferty, I M Maisonneuve, S D Glic. Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitization. Brain research. vol 871. issue 2. 2000-10-04. PMID:10899291. |
in contrast, 18-mc abolished the sensitized dopamine (da) response in the nucleus accumbens (nac) to coc (20 mg/kg), without altering the da response of acute coc rats. |
2000-10-04 |
2023-08-12 |
rat |
| K D Carr, N Kutchukhidz. Effect of chronic food restriction on Fos-like immunoreactivity (FLI) induced in rat brain regions by intraventricular MK-801. Brain research. vol 873. issue 2. 2000-09-28. PMID:10930555. |
similar to amphetamine, mk-801 increased fli in cingulate cortex, central nucleus of the amygdala and nucleus accumbens (nac) core, but in none of these areas was the response augmented by food restriction. |
2000-09-28 |
2023-08-12 |
human |
| Z T Zhu, Y Fu, G Y Hu, G Z Ji. Modulation of medical prefrontal cortical D1 receptors on the excitatory firing activity of nucleus accumbens neurons elicited by (-)-Stepholidine. Life sciences. vol 67. issue 11. 2000-09-27. PMID:10972195. |
(-)-stepholidine (spd), with d1 agonistic action, elicited an excitatory firing activity of nucleus accumbens (nac) neurons by intravenous administration, but this effect was hardly observed by iontophoresis of spd into the nac. |
2000-09-27 |
2023-08-12 |
rat |
| M M Marcus, G G Nomikos, T H Svensso. Effects of atypical antipsychotic drugs on dopamine output in the shell and core of the nucleus accumbens: role of 5-HT(2A) and alpha(1)-adrenoceptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 4. 2000-09-14. PMID:10871706. |
the effects of acute intravenous administration of several new, atypical antipsychotic drugs (apds): olanzapine (0.05 and 1.0 mg/kg), sertindole (0.1 and 1.0 mg/kg) and quetiapine (0.25 and 2.5 mg/kg), a selective 5-ht(2a) receptor antagonist, m100907 (0.03 and 0.3 mg/kg), and an alpha(1)-adrenoceptor antagonist, prazosin (0.3 mg/kg), on regional dopamine output were examined in the two subdivisions of the nucleus accumbens (nac), the core and shell, which seem associated with motor control and limbic functions, respectively, by using in vivo differential normal pulse voltammetry in anaesthetised, pargyline-pretreated rats. |
2000-09-14 |
2023-08-12 |
rat |
| M S Todtenkopf, K R De Leon, J R Stella. Repeated cocaine treatment alters tyrosine hydroxylase in the rat nucleus accumbens. Brain research bulletin. vol 52. issue 5. 2000-09-14. PMID:10922520. |
after 2 or 14 days of withdrawal, sections of the nucleus accumbens (nac) were processed for tyrosine hydroxylase and the number of immunoreactive varicosities in the core and shell were quantified. |
2000-09-14 |
2023-08-12 |
rat |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
the present study sought to explore whether signals transmitted via the nmda subtype of glutamate receptors and via dopamine d(2) receptors in the nucleus accumbens (nac) are critical for the determination of reaction times (rts) of instrumental responses by the expectancy of future reward. |
2000-08-31 |
2023-08-12 |
rat |
| M P De Parada, M A Parada, P Rada, L Hernandez, B G Hoebe. Dopamine-acetylcholine interaction in the rat lateral hypothalamus in the control of locomotion. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880673. |
in experiment 2, the same doses of carbachol proportionately increased exctracellular da in the nucleus accumbens (nac) as monitored by brain microdialysis. |
2000-08-28 |
2023-08-12 |
rat |
| V M Pickel, J Douglas, J Chan, P D Gamp, N W Bunnet. Neurokinin 1 receptor distribution in cholinergic neurons and targets of substance P terminals in the rat nucleus accumbens. The Journal of comparative neurology. vol 423. issue 3. 2000-08-24. PMID:10870089. |
substance p (sp) is the major endogenous ligand for neurokinin 1 (nk1) receptors and, together with acetylcholine, has an important role in motivated behaviors involving the limbic shell and motor core of the nucleus accumbens (nac). |
2000-08-24 |
2023-08-12 |
rat |
| T R Franklin, J P Druha. The retrograde tracer fluoro-gold interferes with the expression of fos-related antigens. Journal of neuroscience methods. vol 98. issue 1. 2000-08-15. PMID:10837865. |
to examine this question, fg was microiontophoresed unilaterally into the nucleus accumbens (nac) of rats and fos-related antigens (fras) were examined in both hemispheres 12 days later. |
2000-08-15 |
2023-08-12 |
rat |
| D Nakahara, M Nakamura, H Furukawa, N Furun. Intracranial self-stimulation increases differentially in vivo hydroxylation of tyrosine but similarly in vivo hydroxylation of tryptophan in rat medial prefrontal cortex, nucleus accumbens and striatum. Brain research. vol 864. issue 1. 2000-08-11. PMID:10793194. |
we have examined using microdialysis the effect of intracranial self-stimulation (icss) on the in vivo hydroxylation rate of tyrosine and tryptophan in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and striatum (str). |
2000-08-11 |
2023-08-12 |
rat |
| T R Franklin, J P Druha. Expression of Fos-related antigens in the nucleus accumbens and associated regions following exposure to a cocaine-paired environment. The European journal of neuroscience. vol 12. issue 6. 2000-08-11. PMID:10886349. |
this study examined whether conditioned hyperactivity measured in a cocaine-paired environment was associated with increased expression of fos-related antigens (fra) within the nucleus accumbens (nac) and associated forebrain regions of rats. |
2000-08-11 |
2023-08-12 |
rat |