| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Thomas, R C Malenka, A Bonc. Modulation of long-term depression by dopamine in the mesolimbic system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908594. |
recent work suggests that long-term changes in synaptic strength at excitatory synapses in the two major components of this system, the nucleus accumbens (nac) and ventral tegmental area, may be particularly important for the development of drug-induced sensitization, a process that may contribute to addiction, as well as for normal response-reinforcement learning. |
2000-08-10 |
2023-08-12 |
Not clear |
| S M Nicola, S A Deadwyle. Firing rate of nucleus accumbens neurons is dopamine-dependent and reflects the timing of cocaine-seeking behavior in rats on a progressive ratio schedule of reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 14. 2000-08-03. PMID:10884336. |
we recorded neuronal spike activity from cells in the nucleus accumbens (nac) of rats responding on a pr schedule for cocaine reinforcement. |
2000-08-03 |
2023-08-12 |
rat |
| S Puglisi-Allegra, S Cabib, T Pascucci, R Ventura, F Cali, V Roman. Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817622. |
results indicated a significant reduction of 5-ht levels and metabolism in prefrontal cortex (pfc), cingulate cortex (cg), nucleus accumbens (nac), caudate putamen (cp), hippocampus (hip) and amygdala (amy). |
2000-07-17 |
2023-08-12 |
mouse |
| M F Salvatore, A Garcia-Espana, M Goldstein, A Y Deutch, J W Haycoc. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854265. |
the striatum (str), substantia nigra (sn), nucleus accumbens (nac), and ventral tegmental area (vta) from sprague-dawley rats were harvested 30-40 min after a single injection of either vehicle, haloperidol (2 mg/kg), raclopride (2 mg/kg), clozapine (30 mg/kg), or sch23390 (0.5 mg/kg). |
2000-07-17 |
2023-08-12 |
rat |
| M M Iravani, D Asari, J Patel, W J Wieczorek, Z L Kru. Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices. Synapse (New York, N.Y.). vol 36. issue 4. 2000-06-06. PMID:10819905. |
we examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine (mdma) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-ht) or dopamine (da) release in the caudate putamen (cpu), nucleus accumbens (nac), substantia nigra pars reticulata (snr), and the dorsal raphé nucleus (drn) brain slices of rat, using fast cyclic voltammetry (fcv). |
2000-06-06 |
2023-08-12 |
rat |
| D B Carr, S R Sesac. Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 10. 2000-05-25. PMID:10804226. |
to address whether pfc afferents innervate different populations of vta neurons that project to the nucleus accumbens (nac) or to the pfc, a triple labeling method was used that combined peroxidase markers for anterograde and retrograde tract-tracing with pre-embedding immunogold-silver labeling for either tyrosine hydroxylase (th) or gaba. |
2000-05-25 |
2023-08-12 |
rat |
| M F Olive, K K Mehmert, C W Hodg. Microdialysis in the mouse nucleus accumbens: a method for detection of monoamine and amino acid neurotransmitters with simultaneous assessment of locomotor activity. Brain research. Brain research protocols. vol 5. issue 1. 2000-05-24. PMID:10719261. |
microdialysis has been extensively used to characterize the effects of drugs of abuse on extracellular levels of various neurotransmitters in nucleus accumbens (nac) of the rat brain. |
2000-05-24 |
2023-08-12 |
mouse |
| M F Olive, K K Mehmert, C W Hodg. Microdialysis in the mouse nucleus accumbens: a method for detection of monoamine and amino acid neurotransmitters with simultaneous assessment of locomotor activity. Brain research. Brain research protocols. vol 5. issue 1. 2000-05-24. PMID:10719261. |
while an earlier study has shown the feasibility of measuring monoamines in the nac of behaving transgenic mice [i. sillaber, a. montkowski, r. landgraf, n. barden, f. holsboer, r. spanagel, enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type ii) receptor function: influence of long-term treatment with the antidepressant moclobemide, neuroscience, 85 (1998) 415-425 [16] ], in this protocol we demonstrate a method for measuring both monoamine and amino neurotransmitters from the nac of freely moving mice combined with open field locomotor activity monitoring. |
2000-05-24 |
2023-08-12 |
mouse |
| D W Johnson, P Eodice, H Winterbottom, D J Mokle. Decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764919. |
the effects of the competitive nmda receptor antagonist cpp on the initiation of behavioral sensitization to acute cocaine and basal and acute cocaine-induced dopamine (da) release in the nucleus accumbens (nac) were assessed in female sprague-dawley rats. |
2000-05-10 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens. Brain research. vol 858. issue 2. 2000-04-24. PMID:10708676. |
serotonin (5-ht)(1a) receptor agonism may be of interest in regard to both the antipsychotic action and extrapyramidal symptoms (eps) of antipsychotic drugs (apd) based, in part, on the effect of 5-ht(1a) receptor stimulation on the release of dopamine (da) in the nucleus accumbens (nac) and striatum (str), respectively. |
2000-04-24 |
2023-08-12 |
rat |
| W K Schiffer, M R Gerasimov, R A Bermel, J D Brodie, S L Dewe. Stereoselective inhibition of dopaminergic activity by gamma vinyl-GABA following a nicotine or cocaine challenge: a PET/microdialysis study. Life sciences. vol 66. issue 13. 2000-04-11. PMID:10737423. |
elevation of endogenous gaba by the racemic mixture of gamma vinyl-gaba (gvg, vigabatrin) decreases extracellular nucleus accumbens (nac) dopamine (da) levels and diminishes the response to many drugs of abuse known to elevate da in the mesocorticolimbic system. |
2000-04-11 |
2023-08-12 |
Not clear |
| S Ikemoto, N E Goeder. Intra-medial prefrontal cortex injections of scopolamine increase instrumental responses for cocaine: an intravenous self-administration study in rats. Brain research bulletin. vol 51. issue 2. 2000-03-30. PMID:10709961. |
the present experiments examined the effects of muscarinic cholinergic receptor blockade in the nucleus accumbens (nac) and medial prefrontal cortex (mpc) on intravenous cocaine self-administration. |
2000-03-30 |
2023-08-12 |
rat |
| A Tomie, A S Aguado, L A Pohorecky, D Benjami. Individual differences in pavlovian autoshaping of lever pressing in rats predict stress-induced corticosterone release and mesolimbic levels of monoamines. Pharmacology, biochemistry, and behavior. vol 65. issue 3. 2000-03-27. PMID:10683492. |
tail-blood samples were obtained before and after the 20th autoshaping session, then 24 h later the rats were sacrificed and dissection yielded tissue samples of nucleus accumbens (nac), prefrontal cortex (pfc), caudate putamen (cp), and ventral tegmental area (vta). |
2000-03-27 |
2023-08-12 |
rat |
| L F Callado, S E Hopwood, P J Hancock, J A Stamfor. Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake. Neuroreport. vol 11. issue 1. 2000-03-16. PMID:10683852. |
in the present study, we examined the actions of the nmda antagonist dizocilpine (mk801) on electrically evoked release and uptake of noradrenaline (na) in the locus coeruleus (lc), serotonin (5-ht) in the dorsal raphe nucleus (drn) and dopamine (da) in the nucleus accumbens (nac), measured by fast cyclic voltammetry (fcv) in rat brain slices. |
2000-03-16 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
dopamine release in the nucleus accumbens (nac) has been implicated as mediating the rewarding effects of stimulant drugs; however, recent studies suggest that 5-ht release may also contribute. |
2000-03-09 |
2023-08-12 |
rat |
| Q S Ya. Activation of 5-HT2A/2C receptors within the nucleus accumbens increases local dopaminergic transmission. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654584. |
this study was designed to assess the involvement of the 5-hydroxytryptamine (5-ht)2a/2c receptor subtypes in the regulation of in vivo dopamine release in the rat nucleus accumbens (nac). |
2000-02-18 |
2023-08-12 |
rat |
| S F Ali, N Thiriet, J Zwille. Acute ibogaine injection induces expression of the immediate early genes, egr-1 and c-fos, in mouse brain. Brain research. Molecular brain research. vol 74. issue 1-2. 2000-02-15. PMID:10640697. |
a single injection of ibo produced a significant increase of egr-1 messenger rna induction in nucleus accumbens (nac), caudate-putamen (cpu), frontal cortex (fcx), septum, dentate gyrus (dg) and ca3 region of hippocampus, whereas c-fos gene was induced in cpu, fcx, dg, septum and ca1 region of hippocampus. |
2000-02-15 |
2023-08-12 |
mouse |
| G Di Chiara, P Loddo, G Tand. Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression. Biological psychiatry. vol 46. issue 12. 2000-02-08. PMID:10624543. |
to investigate the role in depression of phasic dopamine transmission in cortical and limbic areas, we studied the effect of cms on the responsiveness of dopamine (da) transmission to aversive and rewarding stimuli in rats by microdialysis of the nucleus accumbens (nac) shell and of the medial prefrontal cortex (pfcx). |
2000-02-08 |
2023-08-12 |
human |
| D Paredes, P Rada, E Bonilla, L E Gonzalez, M Parada, L Hernande. Melatonin acts on the nucleus accumbens to increase acetylcholine release and modify the motor activity pattern of rats. Brain research. vol 850. issue 1-2. 2000-02-03. PMID:10629744. |
brain microdialysis coupled to high performance liquid chromatography with electrochemical detection (hplc-ed) was used to evaluate the influence of melatonin on extracellular concentration of acetylcholine (ach) in the nucleus accumbens (nac) of rats. |
2000-02-03 |
2023-08-12 |
rat |
| D Feifel, T L Rez. Effects of neurotensin administered into the ventral tegmental area on prepulse inhibition of startle. Behavioural brain research. vol 106. issue 1-2. 2000-01-11. PMID:10595435. |
neurotensin receptors have been identified in the nucleus accumbens (nac) and ventral tegmental area (vta). |
2000-01-11 |
2023-08-12 |
Not clear |