| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Rodríguez, D R Garcia, V M Picke. Subcellular distribution of 5-hydroxytryptamine2A and N-methyl-D-aspartate receptors within single neurons in rat motor and limbic striatum. The Journal of comparative neurology. vol 413. issue 2. 1999-12-21. PMID:10524335. |
the dorsolateral caudate-putamen nucleus (cpn) and the nucleus accumbens (nac) shell, respectively, are involved in many motor and limbic functions that are affected by activation of the 5-hydroxytryptamine2a receptor (5ht2ar) and the n-methyl-d-aspartate subtype of glutamate receptor (nmdar). |
1999-12-21 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526141. |
however, studies of the role of 5-ht(1a) receptor agonism in the ability of these drugs to modulate dopamine (da) release in the nucleus accumbens (nac), which may be relevant to antipsychotic action, are lacking. |
1999-12-21 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. The Journal of pharmacology and experimental therapeutics. vol 291. issue 3. 1999-12-20. PMID:10565846. |
the serotonin (5-ht)(2a/2c) receptor antagonist ritanserin has been reported to potentiate the dopamine (da) d(2/3) receptor antagonist raclopride-induced da release in medial prefrontal cortex (mpfc) and nucleus accumbens (nac) but not striatum (str). |
1999-12-20 |
2023-08-12 |
rat |
| V Bashkatova, M Kraus, H Prast, A Vanin, K Rayevsky, A Philipp. Influence of NOS inhibitors on changes in ACH release and NO level in the brain elicited by amphetamine neurotoxicity. Neuroreport. vol 10. issue 15. 1999-12-15. PMID:10574552. |
we studied the possible role of neurotoxicity in the d,l-amphetamine (amph)-induced release of acetylcholine (ach) in the nucleus accumbens (nac) and the involvement of endogenous no in this process. |
1999-12-15 |
2023-08-12 |
Not clear |
| Y Li, X T Hu, T G Berney, A J Vartanian, C D Stine, M E Wolf, F J Whit. Both glutamate receptor antagonists and prefrontal cortex lesions prevent induction of cocaine sensitization and associated neuroadaptations. Synapse (New York, N.Y.). vol 34. issue 3. 1999-12-10. PMID:10523754. |
behavioral sensitization to psychomotor stimulants is accompanied by a number of alterations in the mesoaccumbens dopamine (da) system, including da autoreceptor subsensitivity in the ventral tegmental area (vta) and da d1 receptor supersensitivity in the nucleus accumbens (nac). |
1999-12-10 |
2023-08-12 |
rat |
| A Rosin, S Lindholm, J Franck, J Georgiev. Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neuroscience letters. vol 275. issue 1. 1999-11-15. PMID:10554970. |
here, the effects of separately and concurrently administered ethanol and 'binge' cocaine on kappa opioid receptor (kor) mrna in the ventral tegmental area (vta) and nucleus accumbens (nac) of rats were studied. |
1999-11-15 |
2023-08-12 |
human |
| Q S Ya. Extracellular dopamine and serotonin after ethanol monitored with 5-minute microdialysis. Alcohol (Fayetteville, N.Y.). vol 19. issue 1. 1999-11-02. PMID:10487381. |
ethanol at the doses of 0.5, 1, and 2 g/kg was administered ip and extracellular da and 5-ht in 5-min dialysates from the nucleus accumbens (nac) of freely moving rats were determined. |
1999-11-02 |
2023-08-12 |
rat |
| M R Gerasimov, C R Ashby, E L Gardner, M J Mills, J D Brodie, S L Dewe. Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine. Synapse (New York, N.Y.). vol 34. issue 1. 1999-10-20. PMID:10459167. |
we examined the acute effect of the irreversible gaba-transaminase inhibitor, gamma-vinyl gaba (gvg, sabril((r)), vigabatrin((r))) on increases in nucleus accumbens (nac) dopamine (da) following acute administration of methamphetamine, heroin, or ethanol. |
1999-10-20 |
2023-08-12 |
Not clear |
| L R McMahon, K A Cunningha. Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490917. |
to test the hypothesis that cocaine-elicited behaviors were modulated by 5-ht(4) receptors in the nucleus accumbens (nac) shell, two separate groups of male rats were implanted with bilateral cannulas aimed at the nac shell. |
1999-10-12 |
2023-08-12 |
rat |
| B E Hildebrand, G Panagis, T H Svensson, G G Nomiko. Behavioral and biochemical manifestations of mecamylamine-precipitated nicotine withdrawal in the rat: role of nicotinic receptors in the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 4. 1999-10-08. PMID:10481840. |
the nachr antagonist mecamylamine administered systemically in chronically nicotine-treated rats elicits a behavioral withdrawal syndrome concomitant with a reduced da output in the nucleus accumbens (nac). |
1999-10-08 |
2023-08-12 |
rat |
| R D Myers, D E Robinso. Mmu and D2 receptor antisense oligonucleotides injected in nucleus accumbens suppress high alcohol intake in genetic drinking HEP rats. Alcohol (Fayetteville, N.Y.). vol 18. issue 2-3. 1999-10-07. PMID:10456575. |
a guide cannula for a microinjection needle was first implanted bilaterally above the nucleus accumbens (nac) of each rat. |
1999-10-07 |
2023-08-12 |
rat |
| J B Atkins, J Chlan-Fourney, H E Nye, N Hiroi, W A Carlezon, E J Nestle. Region-specific induction of deltaFosB by repeated administration of typical versus atypical antipsychotic drugs. Synapse (New York, N.Y.). vol 33. issue 2. 1999-09-27. PMID:10400890. |
a smaller induction was seen in the nucleus accumbens (nac) and prefrontal cortex (pfc), brain regions associated with the antipsychotic effects of the drug. |
1999-09-27 |
2023-08-12 |
Not clear |
| V M Pickel, J Cha. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460242. |
extracellular levels of serotonin [5-hydroxytryptamine (5-ht)] in the nucleus accumbens (nac) can influence both cognitive and motor functions involving extensive connections with the frontal cortex. |
1999-09-23 |
2023-08-12 |
rat |
| P J Hancock, J A Stamfor. Stereospecific effects of ketamine on dopamine efflux and uptake in the rat nucleus accumbens. British journal of anaesthesia. vol 82. issue 4. 1999-09-17. PMID:10472231. |
many, if not all, drugs of abuse have been shown to increase dopamine efflux in the nucleus accumbens (nac). |
1999-09-17 |
2023-08-12 |
rat |
| P De Deurwaerdère, U Spampinat. Role of serotonin(2A) and serotonin(2B/2C) receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461892. |
this study investigates, using in vivo microdialysis, the role of serotonin2a (5-ht2a) and 5-ht(2b/2c) receptors in the effect of dorsal raphe nucleus (drn) electrical stimulation on dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), and 5-hydroxyindoleacetic acid (5-hiaa) extracellular levels monitored in the nucleus accumbens (nac) and the striatum of halothane-anesthetized rats. |
1999-09-14 |
2023-08-12 |
rat |
| D A Cory-Slechta, D J O'Mara, B J Brocke. Learning versus performance impairments following regional administration of MK-801 into nucleus accumbens and dorsomedial striatum. Behavioural brain research. vol 102. issue 1-2. 1999-09-10. PMID:10403026. |
to further ascertain the relative contributions of nucleus accumbens (nac) and dorsomedial striatum (ds) to cognitive behaviors, the comparative effects in rats of mk-801 microinjections into these regions on a multiple schedule of repeated learning (rl) and performance (p) were examined. |
1999-09-10 |
2023-08-12 |
rat |
| W J McBride, J M Murphy, S Ikemot. Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behavioural brain research. vol 101. issue 2. 1999-08-23. PMID:10372570. |
activation of the vta dopamine (da) system may produce reinforcing effects in general because (a) neurotensin is self-administered into the vta, and injection of neurotensin into the vta produces cpp and enhances da release in the nucleus accumbens (nac), and (b) gaba(a) antagonists are self-administered into the anterior vta and injections of gaba(a) antagonists into the anterior vta enhance da release in the nac. |
1999-08-23 |
2023-08-12 |
rat |
| R D Myers, D E Robinso. Tetrahydropapaveroline injected in the ventral tegmental area shifts dopamine efflux differentially in the shell and core of nucleus accumbens in high-ethanol-preferring (HEP) rats. Alcohol (Fayetteville, N.Y.). vol 18. issue 1. 1999-08-17. PMID:10386670. |
further, thp evokes the extracellular efflux of dopamine in the nucleus accumbens (nac), which comprises, in part, the postulated alcohol drinking "circuit" of neurons. |
1999-08-17 |
2023-08-12 |
rat |
| C E Beyer, J D Stekete. Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine. Brain research. vol 833. issue 2. 1999-08-13. PMID:10375688. |
likewise, 6-ohda lesions of the mpfc produced a significant enhancement of cocaine-induced da transmission in the nucleus accumbens (nac) as estimated by in vivo microdialysis. |
1999-08-13 |
2023-08-12 |
Not clear |
| M Sarter, J P Bruno, J Turch. Basal forebrain afferent projections modulating cortical acetylcholine, attention, and implications for neuropsychiatric disorders. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415659. |
studies on the regulation of cortical ach efflux by nucleus accumbens (nac) dopamine (da) demonstrate that increases in cortical ach efflux are attenuated by intra-accumbens administration of d1 and, more potently, d2 receptor antagonists. |
1999-08-10 |
2023-08-12 |
rat |