| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Schober, N Wolf, N Kahane, C Kalcheim, K Krieglstein, K Unsicke. Expression of neurotrophin receptors trkB and trkC and their ligands in rat adrenal gland and the intermediolateral column of the spinal cord. Cell and tissue research. vol 296. issue 2. 1999-07-12. PMID:10382271. |
in order to provide the bases for understanding of putative functions of neurotrophins for the development and maintenance of chromaffin cells and their preganglionic innervation, in situ hybridization has been used to study the expression of brain-derived neurotrophic factor (bdnf) and nt-3, together with their cognate receptors trkb and trkc, in the adrenal gland and in the intermediolateral column (iml) of the spinal cord. |
1999-07-12 |
2023-08-12 |
rat |
| A Schober, N Wolf, N Kahane, C Kalcheim, K Krieglstein, K Unsicke. Expression of neurotrophin receptors trkB and trkC and their ligands in rat adrenal gland and the intermediolateral column of the spinal cord. Cell and tissue research. vol 296. issue 2. 1999-07-12. PMID:10382271. |
our data make it unlikely that bdnf and nt-3 serve as retrograde trophic factors for iml neurons but suggest roles of bdnf and nt-3 locally within the spinal cord and possibly for sensory nerves of the adrenal cortex. |
1999-07-12 |
2023-08-12 |
rat |
| B J Kerr, E J Bradbury, D L Bennett, P M Trivedi, P Dassan, J French, D B Shelton, S B McMahon, S W Thompso. Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366647. |
here we report that the neurotrophin, brain-derived neurotrophic factor (bdnf), is a modulator of excitability within the spinal cord and contributes to the mechanism of central sensitization. |
1999-06-28 |
2023-08-12 |
rat |
| B J Kerr, E J Bradbury, D L Bennett, P M Trivedi, P Dassan, J French, D B Shelton, S B McMahon, S W Thompso. Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366647. |
bdnf, localized in primary sensory neuron cell bodies and central terminals, potentiates nociceptive spinal reflex responses in an in vitro spinal cord preparation and induces c-fos expression in dorsal horn neurons. |
1999-06-28 |
2023-08-12 |
rat |
| B J Kerr, E J Bradbury, D L Bennett, P M Trivedi, P Dassan, J French, D B Shelton, S B McMahon, S W Thompso. Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366647. |
hence bdnf is appropriately localized and regulated in inflammatory states and is sufficient and necessary for the expression of central sensitization in the spinal cord. |
1999-06-28 |
2023-08-12 |
rat |
| B S Seebach, V Arvanov, L M Mendel. Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats. Journal of neurophysiology. vol 81. issue 5. 1999-06-14. PMID:10322075. |
we conclude that supplementary nt-3 and bdnf administered to neonates can influence developing ia/motoneuron synapses in the spinal cord but with opposite net effects. |
1999-06-14 |
2023-08-12 |
rat |
| E J Bradbury, V R King, L J Simmons, J V Priestley, S B McMaho. NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons. The European journal of neuroscience. vol 10. issue 10. 1999-06-07. PMID:9786200. |
nt-3, but not bdnf, prevents atrophy and death of axotomized spinal cord projection neurons. |
1999-06-07 |
2023-08-12 |
rat |
| X F Zho. Peripheral projections of primary sensory neurons immunoreactive for brain-derived neurotrophic factor. Neuroscience letters. vol 261. issue 3. 1999-06-07. PMID:10081971. |
brain-derived neurotrophic factor (bdnf) is synthesized in a subpopulation of primary sensory neurons and transported anterogradely to the spinal cord and peripheral targets. |
1999-06-07 |
2023-08-12 |
rat |
| C F Dreyfus, X Dai, L D Lercher, B R Racey, W J Friedman, I B Blac. Expression of neurotrophins in the adult spinal cord in vivo. Journal of neuroscience research. vol 56. issue 1. 1999-06-07. PMID:10213469. |
however, a number of recent studies suggest that adult spinal cord expresses neurotrophin receptors and responds to the neurotrophins, brain-derived neurotrophic factor (bdnf) and neurotrophin 3 (nt3), particularly after injury. |
1999-06-07 |
2023-08-12 |
rat |
| C F Dreyfus, X Dai, L D Lercher, B R Racey, W J Friedman, I B Blac. Expression of neurotrophins in the adult spinal cord in vivo. Journal of neuroscience research. vol 56. issue 1. 1999-06-07. PMID:10213469. |
to approach this problem, we examined whether spinal cord glia express bdnf and nt3 in vivo and have begun to define cellular distribution. |
1999-06-07 |
2023-08-12 |
rat |
| C F Dreyfus, X Dai, L D Lercher, B R Racey, W J Friedman, I B Blac. Expression of neurotrophins in the adult spinal cord in vivo. Journal of neuroscience research. vol 56. issue 1. 1999-06-07. PMID:10213469. |
initial studies indicated that small cells in the white matter of adult rat spinal cord express bdnf and nt3. |
1999-06-07 |
2023-08-12 |
rat |
| C F Dreyfus, X Dai, L D Lercher, B R Racey, W J Friedman, I B Blac. Expression of neurotrophins in the adult spinal cord in vivo. Journal of neuroscience research. vol 56. issue 1. 1999-06-07. PMID:10213469. |
in the white matter of adult spinal cord, gfap-positive and gfap-negative cells expressed bdnf and nt3. |
1999-06-07 |
2023-08-12 |
rat |
| G Terengh. Peripheral nerve regeneration and neurotrophic factors. Journal of anatomy. vol 194 ( Pt 1). 1999-05-18. PMID:10227662. |
after axotomy and during peripheral nerve regeneration, the neurotrophins ngf, nt-3 and bdnf show a well defined and selective beneficial effect on the survival and phenotypic expression of primary sensory neurons in dorsal root ganglia and of motoneurons in spinal cord. |
1999-05-18 |
2023-08-12 |
human |
| M J Eaton, J A Plunkett, S Karmally, M A Martinez, K Montane. Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors. Journal of chemical neuroanatomy. vol 16. issue 1. 1999-04-13. PMID:9924973. |
these cells survive longer than 7 weeks after transplantation into the subarachnoid space of the lumbar spinal cord and synthesize 5ht and bdnf. |
1999-04-13 |
2023-08-12 |
rat |
| D M Bradley, F D Beaman, D B Moore, K Kidd, M B Heato. Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo. Brain research. Developmental brain research. vol 112. issue 1. 1999-04-13. PMID:9974163. |
neurotrophic factors bdnf and gdnf protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo. |
1999-04-13 |
2023-08-12 |
chicken |
| D M Bradley, F D Beaman, D B Moore, K Kidd, M B Heato. Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo. Brain research. Developmental brain research. vol 112. issue 1. 1999-04-13. PMID:9974163. |
ntfs such as brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) have been shown to support developing spinal cord motoneurons, and when exogenously applied, decrease naturally occurring cell death, and protect against axotomy. |
1999-04-13 |
2023-08-12 |
chicken |
| D M Bradley, F D Beaman, D B Moore, K Kidd, M B Heato. Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo. Brain research. Developmental brain research. vol 112. issue 1. 1999-04-13. PMID:9974163. |
analysis of motoneuron numbers indicated that both bdnf and gdnf provided protection to developing spinal cord motoneurons from ethanol toxicity, restoring motoneuron numbers to control levels. |
1999-04-13 |
2023-08-12 |
chicken |
| J M Conner, J C Lauterborn, Q Yan, C M Gall, S Varo. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 7. 1999-02-25. PMID:9065491. |
these combined data revealed (1) groups of cell bodies containing diffuse bdnf-ir throughout the cns that were strongly correlated with fields of cells containing bdnf mrna; (2) varying degrees of bdnf-ir outside of cell bodies, in what appeared to be fibers and/or terminals; and (3) many regions containing extremely heavy bdnf-immunoreactive fiber/terminal labeling that lacked bdnf mrna (e.g., medial habenula, central nucleus of the amygdala, bed nucleus of stria terminalis, lateral septum, and spinal cord). |
1999-02-25 |
2023-08-12 |
rat |
| K Uchida, H Baba, Y Maezawa, S Furukawa, N Furusawa, S Imur. Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factors. Journal of neurology. vol 245. issue 12. 1999-02-11. PMID:9840350. |
we examined the morphology of spinal accessory motoneurons and immunoreactivity to neurotrophins, brain-derived neurotropic factor (bdnf) and neurotrophin (nt)-3, as well as the presence of reactive astrocytosis in 70 tiptoe walking yoshimura (twy) mice that develop calcification at c1-c2 vertebral level compressing the spinal cord. |
1999-02-11 |
2023-08-12 |
mouse |
| L B Jakeman, P Wei, Z Guan, B T Stoke. Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury. Experimental neurology. vol 154. issue 1. 1999-01-19. PMID:9875278. |
the present study determined whether exogenous administration of one such factor, brain-derived neurotrophic factor (bdnf), could effect behavioral recovery and/or histopathological changes after spinal cord injury. |
1999-01-19 |
2023-08-12 |
rat |