| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kiyoshi Kikuchi, Hisaaki Uchikado, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Rokudai Sakamoto, Chiemi Kikuchi, Narumi Iida, Naoto Shiomi, Terukazu Kuramoto, Naohisa Miyagi, Ko-Ichi Kawahar. HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development. Experimental and therapeutic medicine. vol 2. issue 5. 2021-10-21. PMID:22977572. |
hmgb1 as a therapeutic target in spinal cord injury: a hypothesis for novel therapy development. |
2021-10-21 |
2023-08-12 |
Not clear |
| Kiyoshi Kikuchi, Hisaaki Uchikado, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Rokudai Sakamoto, Chiemi Kikuchi, Narumi Iida, Naoto Shiomi, Terukazu Kuramoto, Naohisa Miyagi, Ko-Ichi Kawahar. HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development. Experimental and therapeutic medicine. vol 2. issue 5. 2021-10-21. PMID:22977572. |
various studies have shown that hmgb1 plays a critical role in sci and that inhibition of hmgb1 release may be a novel therapeutic target for sci and may support spinal cord repair. |
2021-10-21 |
2023-08-12 |
Not clear |
| Kiyoshi Kikuchi, Hisaaki Uchikado, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Rokudai Sakamoto, Chiemi Kikuchi, Narumi Iida, Naoto Shiomi, Terukazu Kuramoto, Naohisa Miyagi, Ko-Ichi Kawahar. HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development. Experimental and therapeutic medicine. vol 2. issue 5. 2021-10-21. PMID:22977572. |
taken together, our findings suggest that anti-hmgb1 monoclonal antibodies or short hairpin rna-mediated hmgb1 could be administered for spinal cord repair in sci patients. |
2021-10-21 |
2023-08-12 |
Not clear |
| Zhou Zhenzhen, Liu Fenghao, Ma Meina, Li Rui, Sun Wenbo, Wang Q. Targeting HMGB1-TLR4 signaling by miR-216a-5p elevation alleviates the inflammatory behavioral hypersensitivity. Neuroscience letters. vol 759. 2021-08-06. PMID:34118309. |
concomitantly, overexpressing mir-216a-5p also restrained the inflammatory response and microglia activation in cfa-induced inflammatory mouse models, concomitant with the decreases in the expression of hmgb1, tlr4 and p-p65 nf-kb in spinal cord. |
2021-08-06 |
2023-08-13 |
mouse |
| Erxian Zhao, Liying Bai, Shurong Li, Li Li, Zhongci Dou, Yunli Huang, Yan Li, Yunqi L. Dexmedetomidine Alleviates CCI-Induced Neuropathic Pain via Inhibiting HMGB1-Mediated Astrocyte Activation and the TLR4/NF-κB Signaling Pathway in Rats. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32607919. |
immunohistochemical and immunofluorescence analyses were used to detect the expression of high mobility group box-1 (hmgb1) protein and glial fibrillary acidic protein (gfap), and protein fluorescence intensity of gfap in spinal cord tissue, respectively. |
2021-07-09 |
2023-08-13 |
rat |
| Erxian Zhao, Liying Bai, Shurong Li, Li Li, Zhongci Dou, Yunli Huang, Yan Li, Yunqi L. Dexmedetomidine Alleviates CCI-Induced Neuropathic Pain via Inhibiting HMGB1-Mediated Astrocyte Activation and the TLR4/NF-κB Signaling Pathway in Rats. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32607919. |
the expression of hmgb1, gfap, tlr4, traf6, myd88, and p-p65 were greatly downregulated in the spinal cord tissues of the cci rats. |
2021-07-09 |
2023-08-13 |
rat |
| Hongyan Zhang, Jingjing Liu, Chengming Ling, Xin Chen, Jiangkai Lin, Hua Feng, Weihua Ch. High mobility group box 1 promotes the differentiation of spinal ependymal cells into astrocytes rather than neurons. Neuroreport. vol 32. issue 5. 2021-06-21. PMID:33661806. |
ependymal cells extracted and cultured from the spinal cord of mice were separately treated with astrocyte culture medium (acm), il-1β, acm (il-1β) and the hmgb1 protein, and the proliferation and differentiation of ependymal cells were detected. |
2021-06-21 |
2023-08-13 |
mouse |
| Junliang Qian, Yanan Zhu, Liying Bai, Yan Gao, Mingjun Jiang, Fei Xing, Jian Zhang, Wenchao Zhao, Hanwen Gu, Yang Mi, Yuan-Xiang Tao, Ji-Tian X. Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 2. 2021-06-04. PMID:31879851. |
intrathecal coadministration of morphine with tak-242 or pdtc (inhibitor of nf-κb activation) also reduced hmgb1 expression in the spinal cord. |
2021-06-04 |
2023-08-13 |
rat |
| Xinxin Cai, Xi Xi, Xiangming Li, Xiaomei Zhang, Xiaolina Zhang, Zhangxiang Huang, Zhiwen Ya. Antinociceptive effects of macrophage-derived extracellular vesicles by carrying microRNA-216a. American journal of translational research. vol 13. issue 4. 2021-05-23. PMID:34017370. |
subsequent bioinformatics, gsea and kegg enrichment analyses demonstrated that hmgb1 and tlr4-nf-κb pathway were the downstream effectors of mir-216a and were both downregulated in spinal cord tissues of cibp mice treated with m2φ-evs. |
2021-05-23 |
2023-08-13 |
mouse |
| Yaojuan Chu, Yilei Jing, Xiaoyu Zhao, Mengru Wang, Mingliang Zhang, Rui Ma, Wendi Ma, Ying Lv, Lin Zh. Modulation of the HMGB1/TLR4/NF-κB signaling pathway in the CNS by matrine in experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 352. 2021-05-21. PMID:33493985. |
moreover, mat administration significantly reduced the protein and rna expression of hmgb1 and tlr4 in the spinal cord, particularly in astrocytes and microglia/infiltrating macrophages. |
2021-05-21 |
2023-08-13 |
rat |
| Hong-di Zhao, Si-Qin Huang, Cheng-Lin Tang, Ni Dai, Pan Dai, Yan-Ling Ta. [Influence of electroacupuncture on locomotor function and expression of spinal HMGB1 and TLR4 in mice with spinal cord injury]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 4. 2021-05-04. PMID:33931988. |
[influence of electroacupuncture on locomotor function and expression of spinal hmgb1 and tlr4 in mice with spinal cord injury]. |
2021-05-04 |
2023-08-13 |
mouse |
| Hong-di Zhao, Si-Qin Huang, Cheng-Lin Tang, Ni Dai, Pan Dai, Yan-Ling Ta. [Influence of electroacupuncture on locomotor function and expression of spinal HMGB1 and TLR4 in mice with spinal cord injury]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 4. 2021-05-04. PMID:33931988. |
to observe the effect of electroacupuncture(ea)on locomotor activity and the expression of high-mobility group box-1(hmgb1) and toll-like receptor 4(tlr4) in mice with spinal cord injury(sci), so as to explore its mechanisms underlying improvement of sci at the acute stage. |
2021-05-04 |
2023-08-13 |
mouse |
| Yajun He, Lin Sun, Haoyu Feng, Jisheng Li, Nan Zhang, Zhiqiang Wan. [Effect and mechanism of glycyrrhizin on glial scar formation after spinal cord injury in rats]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 34. issue 10. 2020-10-19. PMID:33063497. |
to explore the effect and potential mechanism of glycyrrhizin (gl) by inhibiting high mobility group box 1 (hmgb1) on glial scar formation after spinal cord injury (sci) in rats. |
2020-10-19 |
2023-08-13 |
rat |
| Liliana Brambilla, Francesca Martorana, Giulia Guidotti, Daniela Ross. Dysregulation of Astrocytic HMGB1 Signaling in Amyotrophic Lateral Sclerosis. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30210286. |
here, we show that the interaction of hmgb1 with normal spinal cord astrocytes induces the astrocytic production of neurotrophic factors, particularly brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf). |
2020-09-30 |
2023-08-13 |
Not clear |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
high mobility group box-1 (hmgb1) could function as an early trigger for pro-inflammatory activation after spinal cord injury (sci). |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
this study was designed to evaluate the roles of hmgb1 on the regulation of early spinal cord edema, astrocyte activation, and aquaporin-4 (aqp4) expression in a rat sci model. |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
the effects of hmgb1 inhibition on the early spinal cord edema, astrocyte activation (glial fibrillary acidic protein [gfap] expression), and aqp4 expression after sci (12 h-3 days) were analyzed. |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
the results showed that ep or gl effectively inhibited hmgb1 expression in the spinal cord and hmgb1 levels in the serum of sci rats. |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
hmgb1 inhibition improved motor function, reduced spinal cord water content, and attenuated spinal cord edema in sci rats. |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
hmgb1 inhibition decreased sci-associated gfap and aqp4 overexpression in the spinal cord. |
2020-04-10 |
2023-08-13 |
rat |