| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
these results implicate that hmgb1 inhibition improved locomotor function and reduced early spinal cord edema, which was associated with a downregulation of astrocyte activation (gfap expression) and aqp4 expression in sci rats. |
2020-04-10 |
2023-08-13 |
rat |
| Hongguang Chen, Keliang Xie, Yajun Chen, Yaoqi Wang, Yuzun Wang, Naqi Lian, Kai Zhang, Yonghao Y. Nrf2/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats. International immunopharmacology. vol 75. 2020-03-05. PMID:31325725. |
in the present research, neuropathic pain induced nrf2 and ho-1 expression in the microglial cells of the spinal cord; nrf2 and ho-1 were necessary to alleviate the hyperalgesia of cci-induced rats; nahs mitigated the hyperalgesia and allodynia induced by the cci operation; and nahs mitigated the excessive release of the cytokines tnf-α, il-1β, il-6 and hmgb1 via the nrf2/ho-1 pathway in the microglial cells of the spinal cord. |
2020-03-05 |
2023-08-13 |
rat |
| Ha Sen Ta Na, Ming Nuo, Qing-Tao Meng, Zhong-Yuan Xi. The Pathway of Let-7a-1/2-3p and HMGB1 Mediated Dexmedetomidine Inhibiting Microglia Activation in Spinal Cord Ischemia-Reperfusion Injury Mice. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:31190218. |
the pathway of let-7a-1/2-3p and hmgb1 mediated dexmedetomidine inhibiting microglia activation in spinal cord ischemia-reperfusion injury mice. |
2020-01-21 |
2023-08-13 |
mouse |
| Ha Sen Ta Na, Ming Nuo, Qing-Tao Meng, Zhong-Yuan Xi. The Pathway of Let-7a-1/2-3p and HMGB1 Mediated Dexmedetomidine Inhibiting Microglia Activation in Spinal Cord Ischemia-Reperfusion Injury Mice. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:31190218. |
mice sciri model was established, and microglia from spinal cord were isolated and cultured for subsequent molecule analysis of let-7a-1-3p, let-7a-2-3p, hmgb1, tnf-α, and il-6. |
2020-01-21 |
2023-08-13 |
mouse |
| Fei Ma, Katherine L Meyer-Siegler, Lin Leng, Richard Bucala, Pedro L Ver. Spinal macrophage migration inhibitory factor and high mobility group box 1 mediate persistent bladder pain. Neuroscience letters. vol 699. 2019-12-17. PMID:30708129. |
on day 4, spinal cord (l6-s1) changes in c-fos (non-specific marker of spinal activation) was assessed with immunofluorescence while mif and hmgb1 were assessed with immunofluorescence, western blotting and real-time pcr. |
2019-12-17 |
2023-08-13 |
mouse |
| Kristina A Kigerl, Wenmin Lai, Lindsay M Wallace, Huan Yang, Phillip G Popovic. High mobility group box-1 (HMGB1) is increased in injured mouse spinal cord and can elicit neurotoxic inflammation. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29175543. |
high mobility group box-1 (hmgb1) is increased in injured mouse spinal cord and can elicit neurotoxic inflammation. |
2019-07-15 |
2023-08-13 |
mouse |
| Kristina A Kigerl, Wenmin Lai, Lindsay M Wallace, Huan Yang, Phillip G Popovic. High mobility group box-1 (HMGB1) is increased in injured mouse spinal cord and can elicit neurotoxic inflammation. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29175543. |
future studies will need to identify better methods to deliver optimal concentrations of hmgb1 antagonists to the injured spinal cord. |
2019-07-15 |
2023-08-13 |
mouse |
| A Uzawa, M Mori, H Masuda, R Ohtani, T Uchida, S Kuwabar. Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing high mobility group box 1 and inflammatory cytokines. Clinical and experimental immunology. vol 193. issue 1. 2019-06-26. PMID:29509323. |
an immunohistochemical study of the spinal cord showed weaker cytoplasmic hmgb1 staining in the rtm-treated eae mice than in the untreated eae mice. |
2019-06-26 |
2023-08-13 |
mouse |
| Kang An, Hui Rong, Huadong Ni, Chunyan Zhu, Longsheng Xu, Qianying Liu, Yajing Chen, Ying Zheng, Bing Huang, Ming Ya. Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats. Experimental neurology. vol 303. 2018-12-20. PMID:29428215. |
however, the underlying mechanisms and functions of hmgb1 release in spinal cord, and its contributions to the development of bcp as well, are poorly understood. |
2018-12-20 |
2023-08-13 |
rat |
| Xiaolei Wang, Chang Feng, Yong Qiao, Xin Zha. Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain. Neuroscience letters. vol 668. 2018-11-09. PMID:29421543. |
sigma 1 receptor mediated hmgb1 expression in spinal cord is involved in the development of diabetic neuropathic pain. |
2018-11-09 |
2023-08-13 |
Not clear |
| Lin Sun, Man Li, Xun Ma, Haoyu Feng, Junlai Song, Cong Lv, Yajun H. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner. Journal of neuroinflammation. vol 14. issue 1. 2018-07-27. PMID:29178911. |
inhibition of hmgb1 reduces rat spinal cord astrocytic swelling and aqp4 expression after oxygen-glucose deprivation and reoxygenation via tlr4 and nf-κb signaling in an il-6-dependent manner. |
2018-07-27 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Haoyu Feng, Junlai Song, Cong Lv, Yajun H. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner. Journal of neuroinflammation. vol 14. issue 1. 2018-07-27. PMID:29178911. |
given this, we sought to identify both the role and underlying mechanisms of hmgb1 in cellular swelling and aquaporin 4 (aqp4) expression in cultured rat spinal cord astrocytes after oxygen-glucose deprivation/reoxygenation (ogd/r). |
2018-07-27 |
2023-08-13 |
rat |
| Xiao-Qian Li, Feng-Shou Chen, Wen-Fei Tan, Bo Fang, Zai-Li Zhang, Hong M. Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway. Journal of neuroinflammation. vol 14. issue 1. 2018-06-18. PMID:29061187. |
here, we investigated the role of mir-129-5p after spinal cord ir, particularly in regulating high-mobility group box-1 (hmgb1) and the toll-like receptor (tlr)-3 pathway. |
2018-06-18 |
2023-08-13 |
Not clear |
| Angelos Papatheodorou, Adam Stein, Matthew Bank, Cristina P Sison, Katie Gibbs, Peter Davies, Ona Bloo. High-Mobility Group Box 1 (HMGB1) Is Elevated Systemically in Persons with Acute or Chronic Traumatic Spinal Cord Injury. Journal of neurotrauma. vol 34. issue 3. 2018-01-12. PMID:27673428. |
high-mobility group box 1 (hmgb1) is elevated systemically in persons with acute or chronic traumatic spinal cord injury. |
2018-01-12 |
2023-08-13 |
Not clear |
| Angelos Papatheodorou, Adam Stein, Matthew Bank, Cristina P Sison, Katie Gibbs, Peter Davies, Ona Bloo. High-Mobility Group Box 1 (HMGB1) Is Elevated Systemically in Persons with Acute or Chronic Traumatic Spinal Cord Injury. Journal of neurotrauma. vol 34. issue 3. 2018-01-12. PMID:27673428. |
it is elevated in pre-clinical models of traumatic spinal cord injury (sci), where it promotes secondary injury, and strategies that block hmgb1 improve functional recovery. |
2018-01-12 |
2023-08-13 |
Not clear |
| Xiao-Ling Zhu, Xin Chen, Wei Wang, Xu Li, Jia Huo, Yu Wang, Yu-Yuan Min, Bin-Xiao Su, Jian-Ming Pe. Electroacupuncture pretreatment attenuates spinal cord ischemia-reperfusion injury via inhibition of high-mobility group box 1 production in a LXA Brain research. vol 1659. 2017-08-07. PMID:28089662. |
hmgb1 has been recognized as a key mediator in spinal inflammatory response after spinal cord injury. |
2017-08-07 |
2023-08-13 |
Not clear |
| Xiao-Ling Zhu, Xin Chen, Wei Wang, Xu Li, Jia Huo, Yu Wang, Yu-Yuan Min, Bin-Xiao Su, Jian-Ming Pe. Electroacupuncture pretreatment attenuates spinal cord ischemia-reperfusion injury via inhibition of high-mobility group box 1 production in a LXA Brain research. vol 1659. 2017-08-07. PMID:28089662. |
therefore, the present study aims to test the hypothesis that ea pretreatment protects against spinal cord ischemia-reperfusion (i/r) injury via inhibition of hmgb1 release. |
2017-08-07 |
2023-08-13 |
Not clear |
| Xiao-Ling Zhu, Xin Chen, Wei Wang, Xu Li, Jia Huo, Yu Wang, Yu-Yuan Min, Bin-Xiao Su, Jian-Ming Pe. Electroacupuncture pretreatment attenuates spinal cord ischemia-reperfusion injury via inhibition of high-mobility group box 1 production in a LXA Brain research. vol 1659. 2017-08-07. PMID:28089662. |
we found that spinal i/r significantly increased mrna and cytosolic protein levels of hmgb1 after reperfusion in the spinal cord. |
2017-08-07 |
2023-08-13 |
Not clear |
| Xiao-Ling Zhu, Xin Chen, Wei Wang, Xu Li, Jia Huo, Yu Wang, Yu-Yuan Min, Bin-Xiao Su, Jian-Ming Pe. Electroacupuncture pretreatment attenuates spinal cord ischemia-reperfusion injury via inhibition of high-mobility group box 1 production in a LXA Brain research. vol 1659. 2017-08-07. PMID:28089662. |
the ea-pretreated animals displayed better motor performance after reperfusion along with the decrease of apoptosis, hmgb1, tnf-α and il-1β expressions in the spinal cord, whereas these effects by ea pretreatment was reversed by rhmgb1 administration. |
2017-08-07 |
2023-08-13 |
Not clear |
| Ye-song Wang, Yuan-yuan Li, Li-hua Wang, Ying Kang, Jie Zhang, Zi-quan Liu, Kun Wang, Alan David Kaye, Lei Che. Tanshinone IIA Attenuates Chronic Pancreatitis-Induced Pain in Rats via Downregulation of HMGB1 and TRL4 Expression in the Spinal Cord. Pain physician. vol 18. issue 4. 2016-02-24. PMID:26218952. |
tanshinone iia attenuates chronic pancreatitis-induced pain in rats via downregulation of hmgb1 and trl4 expression in the spinal cord. |
2016-02-24 |
2023-08-13 |
rat |