| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nilesh M Agalave, Max Larsson, Sally Abdelmoaty, Jie Su, Azar Baharpoor, Peter Lundbäck, Karin Palmblad, Ulf Andersson, Helena Harris, Camilla I Svensso. Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis. Pain. vol 155. issue 9. 2015-10-26. PMID:24954167. |
immunohistochemistry showed that hmgb1 is expressed in neurons and glial cells in the spinal cord. |
2015-10-26 |
2023-08-13 |
mouse |
| Nilesh M Agalave, Max Larsson, Sally Abdelmoaty, Jie Su, Azar Baharpoor, Peter Lundbäck, Karin Palmblad, Ulf Andersson, Helena Harris, Camilla I Svensso. Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis. Pain. vol 155. issue 9. 2015-10-26. PMID:24954167. |
subsequent to induction of collagen antibody-induced arthritis (caia), hmgb1 mrna and extranuclear protein levels were significantly increased in the lumbar spinal cord. |
2015-10-26 |
2023-08-13 |
mouse |
| Liangyun Shen, Ziwei Cui, Yue Lin, Shuqin Wang, Dongfeng Zheng, Qian Ta. Anti-inflammative effect of glycyrrhizin on rat thermal injury via inhibition of high-mobility group box 1 protein. Burns : journal of the International Society for Burn Injuries. vol 41. issue 2. 2015-10-09. PMID:25440843. |
glycyrrhizin (gly) has been reported as an inhibitor of extracellular hmgb1 (high-mobility group box 1 protein) cytokine's activity, and protects spinal cord, liver, heart and brain against ischemia-reperfusion-induced injury in rats. |
2015-10-09 |
2023-08-13 |
rat |
| Zhenyu Zhang, Mingchao Li, Yan Wang, Jian Wu, Jiaping L. Higenamine promotes M2 macrophage activation and reduces Hmgb1 production through HO-1 induction in a murine model of spinal cord injury. International immunopharmacology. vol 23. issue 2. 2015-07-28. PMID:25445960. |
higenamine promotes m2 macrophage activation and reduces hmgb1 production through ho-1 induction in a murine model of spinal cord injury. |
2015-07-28 |
2023-08-13 |
mouse |
| Yan Sun, Huoying Chen, Jiapei Dai, Huijuan Zou, Ming Gao, Hao Wu, Bingxia Ming, Lin Lai, Yifan Xiao, Ping Xiong, Yong Xu, Feili Gong, Fang Zhen. HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 280. 2015-05-12. PMID:25773152. |
hmgb1 is expressed in the nuclei of spinal cord resident cells such as some astrocytes, microglia and a few neurons in normal situation. |
2015-05-12 |
2023-08-13 |
mouse |
| Yan Sun, Huoying Chen, Jiapei Dai, Huijuan Zou, Ming Gao, Hao Wu, Bingxia Ming, Lin Lai, Yifan Xiao, Ping Xiong, Yong Xu, Feili Gong, Fang Zhen. HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 280. 2015-05-12. PMID:25773152. |
during eae progression, the total and extracellular hmgb1 in the spinal cord are increased, more hmgb1 positive astrocytes and microglia are observed, and the intra-neurons hmgb1 in the ventral horn and around the central canal localize majorly in the cytoplasm accompanied by the increasing extracellular hmgb1. |
2015-05-12 |
2023-08-13 |
mouse |
| Yan Sun, Huoying Chen, Jiapei Dai, Huijuan Zou, Ming Gao, Hao Wu, Bingxia Ming, Lin Lai, Yifan Xiao, Ping Xiong, Yong Xu, Feili Gong, Fang Zhen. HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 280. 2015-05-12. PMID:25773152. |
our findings indicate that the hmgb1 expression pattern in the spinal cord is associated with the progression of eae. |
2015-05-12 |
2023-08-13 |
mouse |
| Ping Fang, Hong-Chao Pan, Stanley Li Lin, Wen-Qing Zhang, Heikki Rauvala, Melitta Schachner, Yan-Qin She. HMGB1 contributes to regeneration after spinal cord injury in adult zebrafish. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23996344. |
hmgb1 contributes to regeneration after spinal cord injury in adult zebrafish. |
2014-10-27 |
2023-08-12 |
zebrafish |
| Ping Fang, Hong-Chao Pan, Stanley Li Lin, Wen-Qing Zhang, Heikki Rauvala, Melitta Schachner, Yan-Qin She. HMGB1 contributes to regeneration after spinal cord injury in adult zebrafish. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23996344. |
we explored whether hmgb1 contributes to recovery after complete spinal cord transection in adult zebrafish. |
2014-10-27 |
2023-08-12 |
zebrafish |
| Ping Fang, Hong-Chao Pan, Stanley Li Lin, Wen-Qing Zhang, Heikki Rauvala, Melitta Schachner, Yan-Qin She. HMGB1 contributes to regeneration after spinal cord injury in adult zebrafish. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23996344. |
quantitative pcr and in situ hybridization revealed that hmgb1 mrna levels decreased between 12 h to 11 days after spinal cord injury (sci), then returned to basal levels by 21 days. |
2014-10-27 |
2023-08-12 |
zebrafish |
| Jing Yang, Xuehua Liu, Yi Zhou, Guozhong Wang, Chunjin Gao, Qingjun S. Hyperbaric oxygen alleviates experimental (spinal cord) injury by downregulating HMGB1/NF-κB expression. Spine. vol 38. issue 26. 2014-09-26. PMID:24335635. |
we presented an insight into the effect of hyperbaric oxygen (hbo) on spinal cord injury (sci), aiming to uncover the dynamics of high-mobility group protein b1 (hmgb1) and nuclear factor κb (nf-κb) after hbo intervention in rats with acute sci. |
2014-09-26 |
2023-08-12 |
rat |
| Yu-Qing Ma, Yi-Rong Chen, Yu-Fang Leng, Zhi-Wei W. Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-08-14. PMID:25120576. |
high-mobility group box 1 (hmgb1) and toll-like receptor 4 (tlr4) mrna and protein expression in the spinal cord were measured. |
2014-08-14 |
2023-08-13 |
rat |
| Chi-Shin Hwang, Guan-Ting Liu, Margaret Dah-Tsyr Chang, I-Lin Liao, Hao-Teng Chan. Elevated serum autoantibody against high mobility group box 1 as a potent surrogate biomarker for amyotrophic lateral sclerosis. Neurobiology of disease. vol 58. 2014-04-23. PMID:23639787. |
as high mobility group box 1 (hmgb1) is elevated in spinal cord tissues of patients with als, we hypothesized, therefore, that serum autoantibody against hmgb1 (hmgb1 autoab) might represent an effective biomarker for als. |
2014-04-23 |
2023-08-12 |
human |
| Leshun Zhou, Xiaowu Wang, Weining Xue, Keliang Xie, Yi Huang, Hongguang Chen, Gu Gong, Yi Zen. Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain research. vol 1517. 2014-01-17. PMID:23603405. |
moreover, we showed that the beneficial effects of 10ml/kg hs treatment against spinal cord i/r damage were associated with the decreased levels of oxidative products [8-iso-prostaglandin f2α (8-iso-pgf2α) and malondialdehyde (mda)] and pro-inflammatory cytokines [tumor necrosis factor-alpha (tnf-α) and high-mobility group box 1 (hmgb1)], as well as the increased activities of antioxidant enzymes [superoxide dismutase (sod) and catalase (cat)] in serum at 6h, 12h, 24h, 48h and 72h after reperfusion and in spinal cord at 72h after reperfusion. |
2014-01-17 |
2023-08-12 |
cat |
| Chang-lin Zhai, Mei-qi Zhang, Yun Zhang, Hong-xia Xu, Jing-min Wang, Gui-peng An, Yuan-yuan Wang, Li L. Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway. Acta pharmacologica Sinica. vol 33. issue 12. 2013-11-15. PMID:23064724. |
glycyrrhizin (gl) has been found to inhibit extracellular hmgb1 cytokine's activity, and protect spinal cord, liver and brain against i/r-induced injury in experimental animals. |
2013-11-15 |
2023-08-12 |
rat |
| Yingying Dong, Yun Gu, Youjuan Huan, Yingjie Wang, Yan Liu, Mei Liu, Fei Ding, Xiaosong Gu, Yongjun Wan. HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration. The Journal of biological chemistry. vol 288. issue 25. 2013-09-06. PMID:23649623. |
hmgb1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for cns regeneration. |
2013-09-06 |
2023-08-12 |
Not clear |
| Yingying Dong, Yun Gu, Youjuan Huan, Yingjie Wang, Yan Liu, Mei Liu, Fei Ding, Xiaosong Gu, Yongjun Wan. HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration. The Journal of biological chemistry. vol 288. issue 25. 2013-09-06. PMID:23649623. |
uncontrolled, excessive inflammation contributes to the secondary tissue damage of traumatic spinal cord, and hmgb1 is highlighted for initiation of a vicious self-propagating inflammatory circle by release from necrotic cells or immune cells. |
2013-09-06 |
2023-08-12 |
Not clear |
| Yingying Dong, Yun Gu, Youjuan Huan, Yingjie Wang, Yan Liu, Mei Liu, Fei Ding, Xiaosong Gu, Yongjun Wan. HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration. The Journal of biological chemistry. vol 288. issue 25. 2013-09-06. PMID:23649623. |
several regenerative-competent vertebrates have evolved to circumvent the second damages during the spontaneous spinal cord regeneration with an unknown hmgb1 regulatory mechanism. |
2013-09-06 |
2023-08-12 |
Not clear |
| Yingying Dong, Yun Gu, Youjuan Huan, Yingjie Wang, Yan Liu, Mei Liu, Fei Ding, Xiaosong Gu, Yongjun Wan. HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration. The Journal of biological chemistry. vol 288. issue 25. 2013-09-06. PMID:23649623. |
our results reveal that hmgb1 does not mediate the inflammatory response in spontaneous spinal cord regeneration, but it promotes cns regeneration. |
2013-09-06 |
2023-08-12 |
Not clear |
| Peng-Cheng Ren, Yong Zhang, Xu-Dong Zhang, Li-Jun An, Hai-Gang Lv, Jun He, Chang-Jun Gao, Xu-De Su. High-mobility group box 1 contributes to mechanical allodynia and spinal astrocytic activation in a mouse model of type 2 diabetes. Brain research bulletin. vol 88. issue 4. 2012-10-23. PMID:22459482. |
our results indicate that hmgb1 is significantly up-regulated in the spinal cord of type 2 diabetes, and inhibiting hmgb1 may provide a novel treatment for diabetic pain. |
2012-10-23 |
2023-08-12 |
mouse |