| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Fang, Melitta Schachner, Yan-Qin She. HMGB1 in development and diseases of the central nervous system. Molecular neurobiology. vol 45. issue 3. 2012-10-17. PMID:22580958. |
during adulthood, hmgb1 serves to induce neuroinflammation after injury, such as lesions in the spinal cord and brain. |
2012-10-17 |
2023-08-12 |
Not clear |
| Gu Gong, Li-bang Yuan, Ling Hu, Wei Wu, Liang Yin, Jing-li Hou, Ying-hai Liu, Le-shun Zho. Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1. Acta pharmacologica Sinica. vol 33. issue 1. 2012-06-04. PMID:22158106. |
glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and hmgb1. |
2012-06-04 |
2023-08-12 |
rat |
| Gu Gong, Li-bang Yuan, Ling Hu, Wei Wu, Liang Yin, Jing-li Hou, Ying-hai Liu, Le-shun Zho. Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1. Acta pharmacologica Sinica. vol 33. issue 1. 2012-06-04. PMID:22158106. |
to investigate the neuroprotective effect of glycyrrhizin (gly) against the ischemic injury of rat spinal cord and the possible role of the nuclear protein high-mobility group box 1 (hmgb1) in the process. |
2012-06-04 |
2023-08-12 |
rat |
| Xin Kuang, Yan Huang, Hong-Feng Gu, Xu-Yu Zu, Wang-Yuan Zou, Zong-Bin Song, Qu-Lian Gu. Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. European journal of pharmacology. vol 676. issue 1-3. 2012-05-18. PMID:22173123. |
lumbar spinal cord was sampled and the mrna and protein expressions of tlr4 and high mobility group 1 protein (hmgb1) were detected, the contents of tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β) and interleukin-10 (il-10) were measured by elisa, and immunohistochemistry for nuclear factor kappa b (nf-κb) was also carried out. |
2012-05-18 |
2023-08-12 |
rat |
| Xin Kuang, Yan Huang, Hong-Feng Gu, Xu-Yu Zu, Wang-Yuan Zou, Zong-Bin Song, Qu-Lian Gu. Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. European journal of pharmacology. vol 676. issue 1-3. 2012-05-18. PMID:22173123. |
after intrathecal injection of egcg (1mg/kg) once daily from 1day before to 3days after cci surgery, the expressions of tlr4, nf-κb, hmgb1, tnf-α and il-1β were markedly decreased while the content of il-10 in the spinal cord increased significantly accompanied by dramatical improvement of pain behaviors in cci rats (p<0.05). |
2012-05-18 |
2023-08-12 |
rat |
| M Casula, A M Iyer, W G M Spliet, J J Anink, K Steentjes, M Sta, D Troost, E Aronic. Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue. Neuroscience. vol 179. 2011-07-13. PMID:21303685. |
in the present study we investigated the expression and cellular distribution of tlr2, tlr4, rage and their endogenous ligand high mobility group box 1 (hmgb1) in the spinal cord of control (n=6) and sporadic als (n=12) patients. |
2011-07-13 |
2023-08-12 |
human |
| M Casula, A M Iyer, W G M Spliet, J J Anink, K Steentjes, M Sta, D Troost, E Aronic. Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue. Neuroscience. vol 179. 2011-07-13. PMID:21303685. |
in als spinal cord, hmgb1 signal is increased in the cytoplasm of reactive glia, indicating a possible release of this molecule from glial cells. |
2011-07-13 |
2023-08-12 |
human |
| M Casula, A M Iyer, W G M Spliet, J J Anink, K Steentjes, M Sta, D Troost, E Aronic. Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue. Neuroscience. vol 179. 2011-07-13. PMID:21303685. |
our findings show increased expression of tlr2, tlr4, rage and hmgb1 in reactive glia in human als spinal cord, suggesting activation of the tlr/rage signaling pathways. |
2011-07-13 |
2023-08-12 |
human |
| Yi Huang, Keliang Xie, Jipeng Li, Ning Xu, Gu Gong, Guolin Wang, Yonghao Yu, Hailong Dong, Lize Xion. Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain research. vol 1378. 2011-06-13. PMID:21195696. |
furthermore, we found that the beneficial effects of h₂ treatment against spinal cord i/r injury were associated with the decreased levels of oxidative products [8-iso-prostaglandin f2α (8-iso-pgf2α) and malondialdehyde (mda)] and pro-inflammatory cytokines [tumor necrosis factor-alpha (tnf-α) and high-mobility group box 1 (hmgb1)], as well as increased activities of antioxidant enzymes [superoxide dismutase (sod) and catalase (cat)] in serum and spinal cord. |
2011-06-13 |
2023-08-12 |
cat |
| Hideyuki Kawabata, Takao Setoguchi, Kazunori Yone, Masakazu Souda, Hiroki Yoshida, Ko-ichi Kawahara, Ikuro Maruyama, Setsuro Komiy. High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Spine. vol 35. issue 11. 2010-08-13. PMID:20195207. |
cerebrocortical culture and rat spinal cord injury (sci) model were used to examine the expression of high mobility group box 1 (hmgb1), tnf-alpha, and rage by reverse transcription polymerase chain reaction (rt-pcr) and immunohistochemical examination. |
2010-08-13 |
2023-08-12 |
rat |
| Qiang Wang, Qian Ding, Yiming Zhou, Xingchun Gou, Lichao Hou, Shaoyang Chen, Zhenghua Zhu, Lize Xion. Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. Anesthesiology. vol 110. issue 6. 2009-06-16. PMID:19417608. |
this study was designed to investigate the neuroprotective effect of ep against spinal cord ischemic injury and the potential role of hmgb1 in this process. |
2009-06-16 |
2023-08-12 |
Not clear |
| Daniele Lo Coco, Pietro Veglianese, Elisa Allievi, Caterina Bendott. Distribution and cellular localization of high mobility group box protein 1 (HMGB1) in the spinal cord of a transgenic mouse model of ALS. Neuroscience letters. vol 412. issue 1. 2007-03-27. PMID:17196331. |
distribution and cellular localization of high mobility group box protein 1 (hmgb1) in the spinal cord of a transgenic mouse model of als. |
2007-03-27 |
2023-08-12 |
mouse |
| Daniele Lo Coco, Pietro Veglianese, Elisa Allievi, Caterina Bendott. Distribution and cellular localization of high mobility group box protein 1 (HMGB1) in the spinal cord of a transgenic mouse model of ALS. Neuroscience letters. vol 412. issue 1. 2007-03-27. PMID:17196331. |
to investigate whether this protein may play a role in the inflammatory events in als, we examined both expression and localization of hmgb1 in the lumbar spinal cord of sod1g93a transgenic mice, a well established mouse model of familial als, at different stages of the disease. |
2007-03-27 |
2023-08-12 |
mouse |
| Daniele Lo Coco, Pietro Veglianese, Elisa Allievi, Caterina Bendott. Distribution and cellular localization of high mobility group box protein 1 (HMGB1) in the spinal cord of a transgenic mouse model of ALS. Neuroscience letters. vol 412. issue 1. 2007-03-27. PMID:17196331. |
these results suggest that hmgb1 may have a different involvement in the motor neurons and glial cells in response to the neurotoxic environment in the spinal cord of sod1g93a mice, and it may contribute to the progression of inflammatory and neurodegenerative processes. |
2007-03-27 |
2023-08-12 |
mouse |