| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Gao, Shengyou Li, Yujie Yang, Shijie Yang, Beibei Yu, Zhijie Zhu, Teng Ma, Yi Zheng, Bin Wei, Yiming Hao, Haining Wu, Yongfeng Zhang, Lingli Guo, Xueli Gao, Yitao Wei, Borui Xue, Jianzhong Li, Xue Feng, Lei Lu, Bing Xia, Jinghui Huan. A Novel Magnetic Responsive miR-26a@SPIONs-OECs for Spinal Cord Injury: Triggering Neural Regeneration Program and Orienting Axon Guidance in Inhibitory Astrocytic Environment. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-10-04. PMID:37789583. |
addressing the challenge of promoting directional axonal regeneration in a hostile astrocytic scar, which often impedes recovery following spinal cord injury (sci), remains a daunting task. |
2023-10-04 |
2023-10-07 |
rat |
| Bao-Lei Zhang, Xi-Liang Gu. Electroacupuncture promotes nerve regeneration and functional recovery in rats with spinal cord contusion through the coordinate interaction of CD4 and BDNF. Ibrain. vol 8. issue 3. 2023-10-03. PMID:37786738. |
lastly, the expression of cd4 and brain-derived neurotrophic factor (bdnf) in spinal cord scar was verified by quantitative reverse-transcription polymerase chain reaction (qrt-pcr). |
2023-10-03 |
2023-10-07 |
rat |
| Yi-Ting Tu, Yung-Hsiao Chiang, Jiann-Her Li. Delta Cord as a Radiological Localization Sign of Postoperative Adhesive Arachnoiditis: A Case Report and Literature Review. Diagnostics (Basel, Switzerland). vol 13. issue 18. 2023-09-28. PMID:37761311. |
during intraoperative examination, we identified the presence of the delta cord sign, which had been formed by an arachnoid scar that tethered the dorsal spinal cord to the dura. |
2023-09-28 |
2023-10-07 |
Not clear |
| Tao Jiang, Shitong Li, Benchang Xu, Kun Liu, Tong Qiu, Honglian Da. IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation. Behavioural brain research. 2023-09-26. PMID:37751807. |
ikvav peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation. |
2023-09-26 |
2023-10-07 |
rat |
| Tao Jiang, Shitong Li, Benchang Xu, Kun Liu, Tong Qiu, Honglian Da. IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation. Behavioural brain research. 2023-09-26. PMID:37751807. |
fibrous scar is one of the major factors that hinder functional recovery in patients with spinal cord injury (sci). |
2023-09-26 |
2023-10-07 |
rat |
| Chananan Chaidaroon, Phichayut Phinyo, Sintip Pattanakuhar, Siam Tongpraser. Minimal clinically important difference (MCID) and minimal detectable change (MDC) of Spinal Cord Ability Ruler (SCAR). Spinal cord. 2023-09-26. PMID:37752176. |
minimal clinically important difference (mcid) and minimal detectable change (mdc) of spinal cord ability ruler (scar). |
2023-09-26 |
2023-10-07 |
Not clear |
| Farzaneh Sorouri, Parastoo Hosseini, Mohammad Sharifzadeh, Sahar Kiani, Mehdi Khoob. ACS applied materials & interfaces. 2023-08-30. PMID:37647536. |
dysfunctional clinical outcomes following spinal cord injury (sci) result from glial scar formation, leading to the inhibition of new axon growth and impaired regeneration. |
2023-08-30 |
2023-09-07 |
Not clear |
| Ronghua Wu, Haixu Lin, Wei Zhang, Ying Sun, Xiaowei Qian, Ge Lin, Chao Ma, Zhangji Dong, Bin Yu, Liu Yang, Yan Liu, Mei Li. Cooperation of long noncoding RNA LOC100909675 and transcriptional regulator CTCF modulates Cdk1 transcript to control astrocyte proliferation. The Journal of biological chemistry. 2023-08-11. PMID:37567476. |
astrocyte activation and proliferation contribute to glial scar formation during spinal cord injury (sci), which limits nerve regeneration. |
2023-08-11 |
2023-08-16 |
Not clear |
| Heng Wang, Qin Tang, Yang Lu, Cheng Chen, Yu-Lin Zhao, Tao Xu, Chang-Wei Yang, Xiao-Qing Che. Berberine-loaded MSC-derived sEVs encapsulated in injectable GelMA hydrogel for spinal cord injury repair. International journal of pharmaceutics. 2023-08-03. PMID:37536642. |
after spinal cord injury (sci), local inflammatory response and fibrous scar formation severely hinder nerve regeneration. |
2023-08-03 |
2023-08-14 |
human |
| Lucila Perez-Gianmarco, Maria Kukle. Understanding the Role of the Glial Scar through the Depletion of Glial Cells after Spinal Cord Injury. Cells. vol 12. issue 14. 2023-07-29. PMID:37508505. |
understanding the role of the glial scar through the depletion of glial cells after spinal cord injury. |
2023-07-29 |
2023-08-14 |
Not clear |
| Zhihao Zhang, Zhiwen Song, Liang Luo, Zhijie Zhu, Xiaoshuang Zuo, Cheng Ju, Xuankang Wang, Yangguang Ma, Tingyu Wu, Zhou Yao, Jie Zhou, Beiyu Chen, Tan Ding, Zhe Wang, Xueyu H. Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488865. |
both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment. |
2023-07-25 |
2023-08-14 |
mouse |
| Chenxi Zhao, Tiangang Zhou, Ming Li, Jie Liu, Xiaoqing Zhao, Yilin Pang, Xinjie Liu, Jiawei Zhang, Lei Ma, Wenxiang Li, Xue Yao, Shiqing Fen. Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488908. |
argatroban also inhibited the activation and proliferation of astrocytes and reduced glial scar formation in the spinal cord. |
2023-07-25 |
2023-08-14 |
rat |
| Vaibhav Patil, Raghvendra Bohara, Vijaya Krishna Kanala, Siobhan McMahon, Abhay Pandi. Models and approaches to comprehend and address glial inflammation following spinal cord injury. Drug discovery today. 2023-07-23. PMID:37482236. |
spinal cord injury (sci) culminates in chronic inflammation and glial scar formation driven by the activation of microglia and astrocytes. |
2023-07-23 |
2023-08-14 |
Not clear |
| Shu-Jun Li, Guo-Dong Qi, Wei Qi, Zhu-Xin Yang, Zhi-Juan Yu, Qiong Jian. [Neuroprotective effect of tetramethylpyrazine on mice after spinal cord injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475076. |
in conclusion, tetramethylpyrazine can promote the improvement of motor function and play a neuroprotective role in mice after spinal cord injury, and its mechanism may be related to inhibiting inflammatory response and improving the hyperplasia of glial scar. |
2023-07-20 |
2023-08-14 |
mouse |
| Di Wang, Man Zhao, Xiao Tang, Man Gao, Wenjing Liu, Minghui Xiang, Jian Ruan, Jie Chen, Bin Long, Jun L. Transcriptomic analysis of spinal cord regeneration after injury in Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449639. |
immunofluorescence staining showed that glial fibrillary acidic protein was up-regulated in axolotl ependymoglial cells after injury, similar to what is observed in mammalian astrocytes after spinal cord injury, even though axolotls do not form a glial scar during regeneration. |
2023-07-14 |
2023-08-14 |
Not clear |
| Lena Mungenast, Ronya Nieminen, Carine Gaiser, Ana Bela Faia-Torres, Jürgen Rühe, Laura Suter-Dic. Electrospun decellularized extracellular matrix scaffolds promote the regeneration of injured neurons. Biomaterials and biosystems. vol 11. 2023-07-10. PMID:37427248. |
traumatic injury to the spinal cord (sci) causes the transection of neurons, formation of a lesion cavity, and remodeling of the microenvironment by excessive extracellular matrix (ecm) deposition and scar formation leading to a regeneration-prohibiting environment. |
2023-07-10 |
2023-08-14 |
human |
| Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashim. Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. Scientific reports. vol 13. issue 1. 2023-07-10. PMID:37429920. |
after spinal cord injury (sci), inflammatory cells such as macrophages infiltrate the injured area, and astrocytes migrate, forming a glial scar around macrophages. |
2023-07-10 |
2023-08-14 |
mouse |
| Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashim. Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. Scientific reports. vol 13. issue 1. 2023-07-10. PMID:37429920. |
chimeric mice with bone marrow lacking irf8, which controls macrophage centripetal migration after sci, showed widely scattered macrophages in the injured spinal cord with the formation of a huge glial scar around the macrophages. |
2023-07-10 |
2023-08-14 |
mouse |
| Ao Fang, Yifan Wang, Naiyu Guan, Yanming Zuo, Lingmin Lin, Binjie Guo, Aisheng Mo, Yile Wu, Xurong Lin, Wanxiong Cai, Xiangfeng Chen, Jingjia Ye, Zeinab Abdelrahman, Xiaodan Li, Hanyu Zheng, Zhonghan Wu, Shuang Jin, Kan Xu, Yan Huang, Xiaosong Gu, Bin Yu, Xuhua Wan. Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury. Nature communications. vol 14. issue 1. 2023-07-07. PMID:37419902. |
we evaluate the efficacy of our device in a contusive spinal cord injury model and find that it reduces the cavity and scar tissue formation, promotes angiogenesis, and improves survival of nearby tissues and axons. |
2023-07-07 |
2023-08-14 |
Not clear |
| Taibang Chen, Xiaoqing He, Jing Wang, Di Du, Yongqing X. NT-3 Combined with TGF-β Signaling Pathway Enhance the Repair of Spinal Cord Injury by Inhibiting Glial Scar Formation and Promoting Axonal Regeneration. Molecular biotechnology. 2023-06-15. PMID:37318740. |
nt-3 combined with tgf-β signaling pathway enhance the repair of spinal cord injury by inhibiting glial scar formation and promoting axonal regeneration. |
2023-06-15 |
2023-08-14 |
mouse |