| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Yao, Yang Luo, Yan-Chang Liu, Yi-Hao Chen, Yi-Teng Li, Xu-Yang Hu, Xing-Yu You, Shui-Sheng Yu, Zi-Yu Li, Lei Chen, Da-Sheng Tian, Mei-Ge Zheng, Li Cheng, Jue-Hua Jin. Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury. Inflammation and regeneration. vol 42. issue 1. 2022-09-26. PMID:36163271. |
fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (sci) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in permanent functional recovery failure. |
2022-09-26 |
2023-08-14 |
Not clear |
| Ce Zhang, Jianning Kang, Xiaodi Zhang, Ying Zhang, Nana Huang, Bin Nin. Spatiotemporal dynamics of the cellular components involved in glial scar formation following spinal cord injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076590. |
spatiotemporal dynamics of the cellular components involved in glial scar formation following spinal cord injury. |
2022-09-09 |
2023-08-14 |
Not clear |
| Ce Zhang, Jianning Kang, Xiaodi Zhang, Ying Zhang, Nana Huang, Bin Nin. Spatiotemporal dynamics of the cellular components involved in glial scar formation following spinal cord injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076590. |
spinal cord injury (sci) triggers complex inflammatory and pathological processes that ultimately lead to scar formation, thus resulting in the severe and irreversible loss of function. |
2022-09-09 |
2023-08-14 |
Not clear |
| Christopher T Tsui, Preet Lal, Katelyn V R Fox, Matthew A Churchward, Kathryn G Tod. The effects of electrical stimulation on glial cell behaviour. BMC biomedical engineering. vol 4. issue 1. 2022-09-03. PMID:36057631. |
development of invasive implant materials designed to directly interface with brain or spinal cord tissue has focussed on mitigation of glial scar reactivity toward the implant itself, but little exists in the literature that directly documents the effects of electrical stimulation on glial cells. |
2022-09-03 |
2023-08-14 |
Not clear |
| Jianfeng Li, Xizhe Liu, Huachuan Wu, Peng Guo, Baoliang Li, Jianmin Wang, Wei Tian, Dafu Chen, Manman Gao, Zhiyu Zhou, Shaoyu Li. Identification of hub genes related to the innate immune response activated during spinal cord injury. FEBS open bio. 2022-09-01. PMID:36047918. |
two major factors that hinder spinal cord repair are local inflammation and glial scar formation after sci, and thus appropriate immunotherapy may alleviate damage. |
2022-09-01 |
2023-08-14 |
Not clear |
| Jiahuan Wu, Xiangzhe Li, Qinghua Wang, Sheng Wang, Wenhua He, Qinfeng Wu, Chuanming Don. LncRNA/miRNA/mRNA ceRNA network analysis in spinal cord injury rat with physical exercise therapy. PeerJ. vol 10. 2022-08-04. PMID:35923891. |
noncoding rnas have been implicated in the pathophysiology of spinal cord injury (sci), including cell death, glial scar formation, axonal collapse and demyelination, and inflammation. |
2022-08-04 |
2023-08-14 |
rat |
| Yang Xu, Xiuying He, Yangyang Wang, Jiao Jian, Xia Peng, Lie Zhou, Yi Kang, Tinghua Wan. 5-Fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury. CNS neuroscience & therapeutics. 2022-08-03. PMID:35918897. |
5-fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury. |
2022-08-03 |
2023-08-14 |
Not clear |
| Zhengxin Jin, Lige Tian, Ying Zhang, Xiaodi Zhang, Jianning Kang, Hui Dong, Nana Huang, Liuzhu Pan, Bin Nin. Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway. CNS neuroscience & therapeutics. 2022-07-30. PMID:35906830. |
apigenin inhibits fibrous scar formation after acute spinal cord injury through tgfβ/smads signaling pathway. |
2022-07-30 |
2023-08-14 |
mouse |
| Zhengxin Jin, Lige Tian, Ying Zhang, Xiaodi Zhang, Jianning Kang, Hui Dong, Nana Huang, Liuzhu Pan, Bin Nin. Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway. CNS neuroscience & therapeutics. 2022-07-30. PMID:35906830. |
to investigate the effect of apigenin on fibrous scar formation after mouse spinal cord injury (sci). |
2022-07-30 |
2023-08-14 |
mouse |
| Ri-Yun Yang, Rui Chai, Jing-Ying Pan, Jing-Yin Bao, Pan-Hui Xia, Yan-Kai Wang, Ying Chen, Yi Li, Jian Wu, Gang Che. Knockdown of polypyrimidine tract binding protein facilitates motor function recovery after spinal cord injury. Neural regeneration research. vol 18. issue 2. 2022-07-28. PMID:35900436. |
after spinal cord injury (sci), a fibroblast- and microglia-mediated fibrotic scar is formed in the lesion core, and a glial scar is formed around the fibrotic scar as a result of the activation and proliferation of astrocytes. |
2022-07-28 |
2023-08-14 |
mouse |
| Guixin Zhang, Li-Qing Jin, William Rodemer, Jianli Hu, Zachary D Root, Daniel M Medeiros, Michael E Selze. The Composition and Cellular Sources of CSPGs in the Glial Scar After Spinal Cord Injury in the Lamprey. Frontiers in molecular neuroscience. vol 15. 2022-07-14. PMID:35832392. |
the composition and cellular sources of cspgs in the glial scar after spinal cord injury in the lamprey. |
2022-07-14 |
2023-08-14 |
Not clear |
| Xuyang Hu, Jinxin Huang, Yiteng Li, Lei Dong, Yihao Chen, Fangru Ouyang, Jianjian Li, Ziyu Li, Juehua Jing, Li Chen. TAZ Induces Migration of Microglia and Promotes Neurological Recovery After Spinal Cord Injury. Frontiers in pharmacology. vol 13. 2022-07-14. PMID:35833021. |
following spinal cord injury (sci), microglia gradually migrate to the edge of the lesion, interweaving around the border of the lesion to form the microglial scar, which performs inflammatory limiting and neuroprotective functions. |
2022-07-14 |
2023-08-14 |
mouse |
| Longkuo Xia, Jianhuan Qi, Mingming Tang, Jing Liu, Da Zhang, Yanbing Zhu, Baoyang H. Continual Deletion of Spinal Microglia Reforms Astrocyte Scar Favoring Axonal Regeneration. Frontiers in pharmacology. vol 13. 2022-07-14. PMID:35833026. |
astrocyte scar formation after spinal cord injury (sci) efficiently limits the accurate damage but physically restricts the following axon regeneration. |
2022-07-14 |
2023-08-14 |
mouse |
| Longkuo Xia, Jianhuan Qi, Mingming Tang, Jing Liu, Da Zhang, Yanbing Zhu, Baoyang H. Continual Deletion of Spinal Microglia Reforms Astrocyte Scar Favoring Axonal Regeneration. Frontiers in pharmacology. vol 13. 2022-07-14. PMID:35833026. |
here, utilizing an improved drug administration approach, we show that in a mouse model of spinal cord injury, continual deletion of microglia, especially upon scar formation, by pexidartinib decreases the amount of microglia-derived collagen i and reforms the astrocyte scar. |
2022-07-14 |
2023-08-14 |
mouse |
| Jinxing Hou, Huiru Bi, Qiting Ge, Huajian Teng, Guoqiang Wan, Bin Yu, Qing Jiang, Xiaosong G. Heterogeneity analysis of astrocytes following spinal cord injury at single-cell resolution. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 8. 2022-07-11. PMID:35816276. |
astrocytes play many important functions in response to spinal cord injury (sci) in an activated manner, including clearance of necrotic tissue, formation of protective barrier, maintenance of microenvironment balance, interaction with immune cells, and formation of the glial scar. |
2022-07-11 |
2023-08-14 |
mouse |
| Leilei Gong, Yun Gu, Xiaoxiao Han, Chengcheng Luan, Chang Liu, Xinghui Wang, Yufeng Sun, Mengru Zheng, Mengya Fang, Shuhai Yang, Lai Xu, Hualin Sun, Bin Yu, Xiaosong Gu, Songlin Zho. Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury. Neuroscience bulletin. 2022-07-05. PMID:35788904. |
spatiotemporal dynamics of the molecular expression pattern and intercellular interactions in the glial scar response to spinal cord injury. |
2022-07-05 |
2023-08-14 |
mouse |
| Leilei Gong, Yun Gu, Xiaoxiao Han, Chengcheng Luan, Chang Liu, Xinghui Wang, Yufeng Sun, Mengru Zheng, Mengya Fang, Shuhai Yang, Lai Xu, Hualin Sun, Bin Yu, Xiaosong Gu, Songlin Zho. Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury. Neuroscience bulletin. 2022-07-05. PMID:35788904. |
nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors - the glial scar is triggered by injury and inhibits or promotes regeneration. |
2022-07-05 |
2023-08-14 |
mouse |
| Leilei Gong, Yun Gu, Xiaoxiao Han, Chengcheng Luan, Chang Liu, Xinghui Wang, Yufeng Sun, Mengru Zheng, Mengya Fang, Shuhai Yang, Lai Xu, Hualin Sun, Bin Yu, Xiaosong Gu, Songlin Zho. Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury. Neuroscience bulletin. 2022-07-05. PMID:35788904. |
here, we first constructed the tissue-wide gene expression patterns of mouse spinal cords over the course of scar formation using st after spinal cord injury from 32 samples. |
2022-07-05 |
2023-08-14 |
mouse |
| Xuegang He, Ying Li, Bo Deng, Aixin Lin, Guangzhi Zhang, Miao Ma, Yonggang Wang, Yong Yang, Xuewen Kan. The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities. Cell proliferation. 2022-06-27. PMID:35754255. |
the pi3k/akt signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: mechanisms and therapeutic opportunities. |
2022-06-27 |
2023-08-14 |
Not clear |
| Can Zhao, Jia-Sheng Rao, Hongmei Duan, Peng Hao, Junkui Shang, Yubo Fan, Wen Zhao, Yudan Gao, Zhaoyang Yang, Yi Eve Sun, Xiaoguang L. Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar. Signal transduction and targeted therapy. vol 7. issue 1. 2022-06-17. PMID:35710784. |
chronic spinal cord injury repair by nt3-chitosan only occurs after clearance of the lesion scar. |
2022-06-17 |
2023-08-14 |
rat |