| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akihito Takeda, Ami Kanemura, Kengo Funakosh. Expression of matrix metalloproteinases during axonal regeneration in the goldfish spinal cord. Journal of chemical neuroanatomy. vol 118. 2021-12-07. PMID:34774721. |
spinal cord injury in fish produces fibrous scar, but spontaneous axonal regeneration beyond the scar sometimes occurs. |
2021-12-07 |
2023-08-13 |
Not clear |
| Javad Alizadeh, Matthew M Kochan, Vanessa D Stewart, Dennis A Drewnik, Sari S Hannila, Saeid Ghavam. Inhibition of Autophagy Flux Promotes Secretion of Chondroitin Sulfate Proteoglycans in Primary Rat Astrocytes. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34449046. |
following spinal cord injury (sci), reactive astrocytes in the glial scar produce high levels of chondroitin sulfate proteoglycans (cspgs), which are known to inhibit axonal regeneration. |
2021-12-03 |
2023-08-13 |
rat |
| Yuan-Huan Ma, Hui-Juan Shi, Qing-Shuai Wei, Qing-Wen Deng, Jia-Hui Sun, Zhou Liu, Bi-Qin Lai, Ge Li, Ying Ding, Wan-Ting Niu, Yuan-Shan Zeng, Xiang Zen. Developing a mechanically matched decellularized spinal cord scaffold for the in situ matrix-based neural repair of spinal cord injury. Biomaterials. vol 279. 2021-12-02. PMID:34700225. |
however, a bioscaffold with mechanical properties that match those of the pathological spinal cord tissue and a pro-regenerative matrix that allows robust neurogenesis for overcoming post-sci scar formation has yet to be developed. |
2021-12-02 |
2023-08-13 |
Not clear |
| Ruihua Fan, Yong Zhang, Benson O A Botchway, Xuehong Li. Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34410605. |
in particular, the alteration of astrocytes in sci causes glial scar formation that impedes spinal cord injury recovery. |
2021-11-18 |
2023-08-13 |
Not clear |
| Nora H Rentsch, Ruslan Rus. 'Scary' pericytes: the fibrotic scar in brain and spinal cord lesions. Trends in neurosciences. 2021-11-14. PMID:34774344. |
'scary' pericytes: the fibrotic scar in brain and spinal cord lesions. |
2021-11-14 |
2023-08-13 |
Not clear |
| Yu Zhang, Shuhai Yang, Chang Liu, Xiaoxiao Han, Xiaosong Gu, Songlin Zho. Deciphering glial scar after spinal cord injury. Burns & trauma. vol 9. 2021-11-12. PMID:34761050. |
deciphering glial scar after spinal cord injury. |
2021-11-12 |
2023-08-13 |
Not clear |
| Shui-Sheng Yu, Zi-Yu Li, Xin-Zhong Xu, Fei Yao, Yang Luo, Yan-Chang Liu, Li Cheng, Mei-Ge Zheng, Jue-Hua Jin. M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558535. |
after spinal cord injury (sci), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon regeneration. |
2021-11-10 |
2023-08-13 |
Not clear |
| Abhishek Roy, Zarna Pathak, Hemant Kuma. Strategies to neutralize RhoA/ROCK pathway after spinal cord injury. Experimental neurology. vol 343. 2021-11-09. PMID:34166685. |
hypertrophic scarring, insignificant intrinsic axon-growth activity, and axon-growth inhibitory molecules such as myelin inhibitors and scar inhibitors constitute a significant hindrance to spinal cord repair. |
2021-11-09 |
2023-08-13 |
Not clear |
| C Chalfouh, C Guillou, J Hardouin, Q Delarue, X Li, C Duclos, D Schapman, J-P Marie, P Cosette, N Guérou. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 4. 2021-10-28. PMID:32856173. |
we demonstrate that rtsms modulates the lesion scar by decreasing fibrosis and inflammation and increases proliferation of spinal cord stem cells. |
2021-10-28 |
2023-08-13 |
Not clear |
| Xianpeng Huang, Chenggui Wang, Xiaopeng Zhou, Jingkai Wang, Kaishun Xia, Biao Yang, Zhe Gong, Liwei Ying, Chao Yu, Kesi Shi, Jiawei Shu, Feng Cheng, Bin Han, Chengzhen Liang, Fangcai Li, Qixin Che. Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury. CNS neuroscience & therapeutics. vol 26. issue 9. 2021-10-26. PMID:32449258. |
astrogliosis and glial scar formation following spinal cord injury (sci) are viewed as major obstacles that hinder axonal regeneration and functional recovery. |
2021-10-26 |
2023-08-13 |
Not clear |
| Patricia Zadnik Sullivan, Ahmed AlBayar, Justin C Burrell, Kevin D Browne, John Arena, Victoria Johnson, Douglas H Smith, D Kacy Cullen, Ali K Oztur. Implantation of Engineered Axon Tracts to Bridge Spinal Cord Injury Beyond the Glial Scar in Rats. Tissue engineering. Part A. vol 27. issue 19-20. 2021-10-25. PMID:33430694. |
implantation of engineered axon tracts to bridge spinal cord injury beyond the glial scar in rats. |
2021-10-25 |
2023-08-13 |
rat |
| Patricia Zadnik Sullivan, Ahmed AlBayar, Justin C Burrell, Kevin D Browne, John Arena, Victoria Johnson, Douglas H Smith, D Kacy Cullen, Ali K Oztur. Implantation of Engineered Axon Tracts to Bridge Spinal Cord Injury Beyond the Glial Scar in Rats. Tissue engineering. Part A. vol 27. issue 19-20. 2021-10-25. PMID:33430694. |
regeneration after spinal cord injury (sci) is limited by the presence of a glial scar and inhibitory cell signaling pathways that favor scar formation over regrowth of endogenous neurons. |
2021-10-25 |
2023-08-13 |
rat |
| Jian Wu, Zhen-Yu Zhu, Zhi-Wei Fan, Ying Chen, Ri-Yun Yang, Yi L. Downregulation of EphB2 by RNA interference attenuates glial/fibrotic scar formation and promotes axon growth. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269211. |
the rapid formation of a glial/fibrotic scar is one of the main factors hampering axon growth after spinal cord injury. |
2021-10-22 |
2023-08-13 |
Not clear |
| Bin Lin, Yang Xu, Bi Zhang, Yong He, Yun Yan, Ming-Chang H. MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury. Experimental and therapeutic medicine. vol 7. issue 1. 2021-10-21. PMID:24348766. |
mek inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury. |
2021-10-21 |
2023-08-12 |
rat |
| Wu-Sheng Deng, Kun Yang, Bing Liang, Ying-Fu Liu, Xu-Yi Chen, Sai Zhan. Collagen/heparin sulfate scaffold combined with mesenchymal stem cells treatment for canines with spinal cord injury: A pilot feasibility study. Journal of orthopaedic surgery (Hong Kong). vol 29. issue 2. 2021-10-06. PMID:34060363. |
due to endogenous neuronal deficiency and glial scar formation, spinal cord injury (sci) often leads to irreversible neurological loss. |
2021-10-06 |
2023-08-13 |
Not clear |
| Amanda Phuong Tran, Philippa Mary Warren, Jerry Silve. New insights into glial scar formation after spinal cord injury. Cell and tissue research. 2021-10-06. PMID:34076775. |
new insights into glial scar formation after spinal cord injury. |
2021-10-06 |
2023-08-13 |
Not clear |
| Azizul Haque, Kelsey P Drasites, April Cox, Mollie Capone, Ali I Myatich, Ramsha Shams, Denise Matzelle, Dena P Garner, Mikhail Bredikhin, Donald C Shields, Alexey Vertegel, Naren L Bani. Protective Effects of Estrogen via Nanoparticle Delivery to Attenuate Myelin Loss and Neuronal Death after Spinal Cord Injury. Neurochemical research. vol 46. issue 11. 2021-10-04. PMID:34269965. |
we have also demonstrated that nanoparticle-mediated focal delivery of e2 to the injured spinal cord decreases lesion size, reactive gliosis, and glial scar formation. |
2021-10-04 |
2023-08-13 |
rat |
| Caijie Li, Sudhanshu Sahu, Guanhua Kou, Nataraj Jagadeesan, Thomson Patrick Joseph, Stanley Li Lin, Melitta Schachne. Chondroitin 6-sulfate-binding peptides improve recovery in spinal cord-injured mice. European journal of pharmacology. vol 910. 2021-10-04. PMID:34391768. |
we further investigated these peptides in a mouse model of spinal cord injury, since upregulation of c6s expression in the glial scar following injury has been associated with reduced axonal regrowth and functional recovery. |
2021-10-04 |
2023-08-13 |
mouse |
| Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Re. Transplantation of a vascularized pedicle of hemisected spinal cord to establish spinal cord continuity after removal of a segment of the thoracic spinal cord: A proof-of-principle study in dogs. CNS neuroscience & therapeutics. vol 27. issue 10. 2021-09-29. PMID:34184402. |
glial scar formation impedes nerve regeneration/reinnervation after spinal cord injury (sci); therefore, removal of scar tissue is essential for sci treatment. |
2021-09-29 |
2023-08-13 |
Not clear |
| Ziyu Li, Shuisheng Yu, Xuyang Hu, Yiteng Li, Xingyu You, Dasheng Tian, Li Cheng, Meige Zheng, Juehua Jin. Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism. Frontiers in cellular neuroscience. vol 15. 2021-09-21. PMID:34539350. |
fibrotic scar after spinal cord injury: crosstalk with other cells, cellular origin, function, and mechanism. |
2021-09-21 |
2023-08-13 |
Not clear |