| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shao-Ming Wang, Jung-Yu C Hsu, Chiung-Yuan Ko, Hsiang-En Wu, Yu-Wei Hsiao, Ju-Ming Wan. Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation After Spinal Cord Injury. Molecular neurobiology. 2023-01-12. PMID:36633805. |
in particular, the fibrotic scar is a main barrier that disrupts neuronal regeneration after spinal cord injury. |
2023-01-12 |
2023-08-14 |
Not clear |
| Shao-Ming Wang, Jung-Yu C Hsu, Chiung-Yuan Ko, Hsiang-En Wu, Yu-Wei Hsiao, Ju-Ming Wan. Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation After Spinal Cord Injury. Molecular neurobiology. 2023-01-12. PMID:36633805. |
we have previously demonstrated that the transcriptional factor cebpd contributes to astrogliosis, which promotes glial scar formation after spinal cord injury. |
2023-01-12 |
2023-08-14 |
Not clear |
| Małgorzata Zawadzka, Marine Yeghiazaryan, Sylwia Niedziółka, Krzysztof Miazga, Anna Kwaśniewska, Marek Bekisz, Urszula Sławińsk. Forced Remyelination Promotes Axon Regeneration in a Rat Model of Spinal Cord Injury. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613945. |
our findings indicate that enhanced remyelination per se, without substantial inhibition of glial scar formation, is an important component of spinal cord injury regeneration. |
2023-01-08 |
2023-08-14 |
rat |
| Zhi-Lai Zhou, Huan Xie, Xiao-Bo Tian, Hua-Li Xu, Wei Li, Shun Yao, Hui Zhan. Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury. Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453419. |
microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting stat3 phosphorylation in astrocytes after spinal cord injury. |
2022-12-01 |
2023-08-14 |
mouse |
| Xing-Xing Bao, Can Zhao, Shu-Sheng Bao, Jia-Sheng Rao, Zhao-Yang Yang, Xiao-Guang L. Recognition of necrotic regions in MRI images of chronic spinal cord injury based on superpixel. Computer methods and programs in biomedicine. vol 228. 2022-11-26. PMID:36434959. |
the cystic cavity and its surrounding dense glial scar formed in chronic spinal cord injury (sci) hinder the regeneration of nerve axons. |
2022-11-26 |
2023-08-14 |
Not clear |
| Xiumin Sun, Haiqian Liu, Zan Tan, Yuhui Hou, Mao Pang, Shengfeng Chen, Longyou Xiao, Qiuju Yuan, Bin Liu, Limin Rong, Liumin H. Remodeling Microenvironment for Endogenous Repair through Precise Modulation of Chondroitin Sulfate Proteoglycans Following Spinal Cord Injury. Small (Weinheim an der Bergstrasse, Germany). 2022-11-18. PMID:36398653. |
the fluid-filled cystic cavity sealed by a dense scar developed following traumatic spinal cord injury (sci) has been a major obstacle to neural regeneration and functional recovery. |
2022-11-18 |
2023-08-14 |
Not clear |
| Vaibhav Patil, Raghvendra Bohara, Carla Winter, Michelle Kilcoyne, Siobhan McMahon, Abhay Pandi. An insight into new glycotherapeutics in glial inflammation: Understanding the role of glycosylation in mitochondrial function and acute to the chronic phases of inflammation. CNS neuroscience & therapeutics. 2022-11-15. PMID:36377513. |
glycosylation plays a critical role during inflammation and glial scar formation upon spinal cord injury (sci) disease progression. |
2022-11-15 |
2023-08-14 |
Not clear |
| Yuqi Cao, Shunxing Zhu, Bin Yu, Chun Ya. Single-cell RNA sequencing for traumatic spinal cord injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 12. 2022-11-14. PMID:36374259. |
traumatic spinal cord injury (tsci) is a severe injury of the central nervous system (cns) with complicated pathological microenvironment that results in hemorrhage, inflammation, and scar formation. |
2022-11-14 |
2023-08-14 |
Not clear |
| Lapo Bonosi, Manikon Poullay Silven, Antonio Alessandro Biancardino, Andrea Sciortino, Giuseppe Roberto Giammalva, Alba Scerrati, Carmelo Lucio Sturiale, Alessio Albanese, Silvana Tumbiolo, Massimiliano Visocchi, Domenico Gerardo Iacopino, Rosario Mauger. Stem Cell Strategies in Promoting Neuronal Regeneration after Spinal Cord Injury: A Systematic Review. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361786. |
this is thought to be due to scar formation, axonal degeneration and a strong inflammatory response inducing a loss of neurons followed by a cascade of events that leads to further spinal cord damage. |
2022-11-11 |
2023-08-14 |
Not clear |
| Tetsuya Tamaru, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Ken Kijima, Shingo Yoshizaki, Kazuhiro Hata, Hirotaka Iura, Gentaro Ono, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, Kensuke Kubota, Takeshi Maeda, Seiji Okada, Yasuharu Nakashim. Glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury. Experimental neurology. 2022-11-06. PMID:36336030. |
glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury. |
2022-11-06 |
2023-08-14 |
Not clear |
| Tetsuya Tamaru, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Ken Kijima, Shingo Yoshizaki, Kazuhiro Hata, Hirotaka Iura, Gentaro Ono, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, Kensuke Kubota, Takeshi Maeda, Seiji Okada, Yasuharu Nakashim. Glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury. Experimental neurology. 2022-11-06. PMID:36336030. |
spinal cord injury (sci) causes reactive astrogliosis, the sequential phenotypic change of astrocytes in which naïve astrocytes (nas) transform into reactive astrocytes (ras) and subsequently become scar-forming astrocytes (sas), resulting in glial scar formation around the lesion site and thereby limiting axonal regeneration and motor/sensory functional recovery. |
2022-11-06 |
2023-08-14 |
Not clear |
| Tetsuya Tamaru, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Ken Kijima, Shingo Yoshizaki, Kazuhiro Hata, Hirotaka Iura, Gentaro Ono, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, Kensuke Kubota, Takeshi Maeda, Seiji Okada, Yasuharu Nakashim. Glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury. Experimental neurology. 2022-11-06. PMID:36336030. |
in addition, we found that col-i-sas transplanted into a naïve spinal cord formed glial scar again by maintaining a high expression of genes involved in the integrin-n-cadherin pathway and a low expression of cspg-related genes. |
2022-11-06 |
2023-08-14 |
Not clear |
| Georgii B Telegin, Aleksandr S Chernov, Alexey N Minakov, Maksim V Rodionov, Vitaly A Kazakov, Viktor A Palikov, Irina P Balmasova, Dmitry S Asyutin, Yuri M Poluektov, Nikolay A Konovalov, Anna A Kudriaeva, Aldo Spallone, Alexander G Gabibov, Alexey A Beloguro. Plasma Cytokines Level and Spinal Cord MRI Predict Clinical Outcome in a Rat Glial Scar Cryoinjury Model. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289607. |
plasma cytokines level and spinal cord mri predict clinical outcome in a rat glial scar cryoinjury model. |
2022-10-27 |
2023-08-14 |
human |
| Baoguo Liu, Guoqing Liu, Changyang Li, Sumei Liu, Dejun Su. Resection of scar tissue in rats with spinal cord injury can promote the expression of βⅢ-tubulin in the injured area. World neurosurgery. 2022-10-24. PMID:36280047. |
resection of scar tissue in rats with spinal cord injury can promote the expression of βⅢ-tubulin in the injured area. |
2022-10-24 |
2023-08-14 |
rat |
| Baoguo Liu, Guoqing Liu, Changyang Li, Sumei Liu, Dejun Su. Resection of scar tissue in rats with spinal cord injury can promote the expression of βⅢ-tubulin in the injured area. World neurosurgery. 2022-10-24. PMID:36280047. |
previously research shows the scar tissue formed in the injured area after spinal cord injury blocks nerve regeneration and functional recovery. |
2022-10-24 |
2023-08-14 |
rat |
| Baoguo Liu, Guoqing Liu, Changyang Li, Sumei Liu, Dejun Su. Resection of scar tissue in rats with spinal cord injury can promote the expression of βⅢ-tubulin in the injured area. World neurosurgery. 2022-10-24. PMID:36280047. |
however, the researchers tried to prevent the formation of scar after spinal cord injury to promote nerve regeneration, but it ran counter to their desire, indicating the formation of scar might play roles on functional recovery after spinal cord injury. |
2022-10-24 |
2023-08-14 |
rat |
| Kang-Zhen Chen, Shu-Xian Liu, Yan-Wei Li, Tao He, Jie Zhao, Tao Wang, Xian-Xiu Qiu, Hong-Fu W. Vimentin as a potential target for diverse nervous system diseases. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254976. |
reduced glial scar, increased axonal regeneration, and improved motor function have been noted after spinal cord injury in vimentin and glial fibrillary acidic protein knockout (gfap |
2022-10-18 |
2023-08-14 |
Not clear |
| Yang Lu, Cheng Chen, Heng Wang, Rong Du, Jiawei Ji, Tao Xu, Changwei Yang, Xiaoqing Che. Astrocyte-derived sEVs alleviate fibrosis and promote functional recovery after spinal cord injury in rats. International immunopharmacology. vol 113. issue Pt A. 2022-10-18. PMID:36257256. |
after spinal cord injury (sci), there are complex pathological states in which the formation of scar tissues is a great obstacle to nerve repair. |
2022-10-18 |
2023-08-14 |
rat |
| Derong Liu, Baoyou Fan, Jinze Li, Tao Sun, Jun Ma, Xianhu Zhou, Shiqing Fen. N6-methyladenosine modification: A potential regulatory mechanism in spinal cord injury. Frontiers in cellular neuroscience. vol 16. 2022-10-10. PMID:36212687. |
the biological processes involved included cell death, axon regeneration, and scar formation, which provides new insight for future research on the role of m6a modification in sci and the clinical transformation of strategies for promoting recovery of spinal cord function. |
2022-10-10 |
2023-08-14 |
Not clear |
| Yue-Peng Fang, Zi-Han Qin, Ying Zhang, Bin Nin. Implications of microglial heterogeneity in spinal cord injury progression and therapy. Experimental neurology. 2022-10-10. PMID:36216123. |
in the event of spinal cord injury (sci), severe changes in the microenvironment and glial scar formation lead to axonal regeneration failure. |
2022-10-10 |
2023-08-14 |
Not clear |