| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Ye, Hao Cheng, Yan Wang, Yan Sun, Li-Dong Zhang, Jun Tan. Macrophage: A key player in neuropathic pain. International reviews of immunology. 2024-04-25. PMID:38661566. |
apart from microglia (resident macrophages of both the spinal cord and brain), which are required for the neuropathic pain processing of the cns, neuropathic pain signals in pns are influenced by the interaction of tissue-resident macrophages and bm infiltrating macrophages with primary afferent neurons. |
2024-04-25 |
2024-04-28 |
Not clear |
| Zhanyang Qian, Mingjie Xia, Tianyu Zhao, You Li, Guangshen Li, Yanan Zhang, Haijun Li, Lei Yan. ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion. Clinical and translational medicine. vol 14. issue 4. 2024-04-22. PMID:38644791. |
acod1, rather than itaconate, facilitates p62-mediated activation of nrf2 in microglia post spinal cord contusion. |
2024-04-22 |
2024-04-24 |
Not clear |
| Shiyu Chen, Siyao Liu, Yalun Huang, Shiwen Huang, Wanzhou Zhang, Huifang Xie, Lingli L. 5Z-7-Oxozaenol attenuates cuprizone-induced demyelination in mice through microglia polarization regulation. Brain and behavior. vol 14. issue 4. 2024-04-22. PMID:38648385. |
knockout of microglia tak1 can inhibit autoimmune inflammation of the brain and spinal cord and improve the outcome of ms. |
2024-04-22 |
2024-04-26 |
mouse |
| Junjie Shen, Liangzhi Gong, Yi Sun, Junqing Lin, Wencheng Hu, Jiabao Wei, Xin Miao, Tao Gao, Jinlong Suo, Jia Xu, Yimin Chai, Bingbo Bao, Yun Qian, Xianyou Zhen. Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury. iScience. vol 27. issue 5. 2024-04-19. PMID:38638567. |
semaphorin3c identified as mediator of neuroinflammation and microglia polarization after spinal cord injury. |
2024-04-19 |
2024-04-21 |
Not clear |
| Serena Boccella, Michela Perrone, Antimo Fusco, Roozbe Bonsale, Rosmara Infantino, Silvia Nuzzo, Giovanni Pecoraro, Federica Ricciardi, Andrea Maria Morace, Gianluca Petrillo, Ilaria Leone, Monica Franzese, Vito de Novellis, Francesca Guida, Marco Salvatore, Sabatino Maione, Livio Luong. Spinal neuronal activity and neuroinflammatory component in a mouse model of CFA-induced vestibulodynia. Brain, behavior, and immunity. 2024-04-18. PMID:38636564. |
in this study, we have used a model of vestibulodynia induced by complete freund's adjuvant (cfa) focusing our investigation on the spinal cord neurons and microglia. |
2024-04-18 |
2024-04-21 |
mouse |
| Serena Boccella, Michela Perrone, Antimo Fusco, Roozbe Bonsale, Rosmara Infantino, Silvia Nuzzo, Giovanni Pecoraro, Federica Ricciardi, Andrea Maria Morace, Gianluca Petrillo, Ilaria Leone, Monica Franzese, Vito de Novellis, Francesca Guida, Marco Salvatore, Sabatino Maione, Livio Luong. Spinal neuronal activity and neuroinflammatory component in a mouse model of CFA-induced vestibulodynia. Brain, behavior, and immunity. 2024-04-18. PMID:38636564. |
furthermore, we examined microglia activation in the l6-s1 dorsal horn using immunofluorescence, unveiling hypertrophic phenotypes indicative of neuroinflammation in the spinal cord. |
2024-04-18 |
2024-04-21 |
mouse |
| Mousumi Ghosh, Jinyoung Lee, Ashley N Burke, Thomas A Strong, Jacqueline Sagen, Damien D Pears. Sex Dependent Disparities in the Central Innate Immune Response after Moderate Spinal Cord Contusion in Rat. Cells. vol 13. issue 7. 2024-04-12. PMID:38607084. |
we demonstrate that activated microglia from the injured spinal cord of female rats exhibited a significantly diminutive pro-inflammatory response, but enhanced anti-inflammatory activity compared to males. |
2024-04-12 |
2024-04-14 |
rat |
| Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing, Li Chen. Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. Journal of neuroinflammation. vol 21. issue 1. 2024-04-10. PMID:38600569. |
however, the critical mechanical characterization of injured spinal cord that harmonizes neuroprotective function of microglia remains poorly understood. |
2024-04-10 |
2024-04-13 |
Not clear |
| Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing, Li Chen. Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. Journal of neuroinflammation. vol 21. issue 1. 2024-04-10. PMID:38600569. |
fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. |
2024-04-10 |
2024-04-13 |
Not clear |
| Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing, Li Chen. Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. Journal of neuroinflammation. vol 21. issue 1. 2024-04-10. PMID:38600569. |
microglia, a crucial cellular component of the glial scar, facilitate neuronal survival and neurological recovery after spinal cord injury (sci). |
2024-04-10 |
2024-04-13 |
Not clear |
| Romina Barreto-Núñez, Louis-Charles Béland, Hejer Boutej, Vincent Picher-Martel, Nicolas Dupré, Luis Barbeito, Jasna Kri. Chronically activated microglia in ALS gradually lose their immune functions and develop unconventional proteome. Glia. 2024-04-05. PMID:38577970. |
functional analyses of microglia derived from the lumbar spinal cord of symptomatic mice revealed: (i) remarkably high mitotic index (close to 100% cells are ki67+) (ii) significant decrease in phagocytic capacity when compared to age-matched control microglia, and (iii) diminished response to innate immune challenges in vitro and in vivo. |
2024-04-05 |
2024-04-07 |
mouse |
| Haocong Zhang, Liangbi Xiang, Hong Yuan, Hailong Y. PTPRO inhibition ameliorates spinal cord injury through shifting microglial M1/M2 polarization via the NF-κB/STAT6 signaling pathway. Biochimica et biophysica acta. Molecular basis of disease. 2024-04-02. PMID:38565385. |
here, a t7 spinal cord compression injury model was established in sprague-dawley (sd) rats, and ptpro expression was upregulated in injured spinal cord and microglia after sci. |
2024-04-02 |
2024-04-05 |
human |
| Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei L. Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain. European journal of pharmacology. 2024-03-29. PMID:38552937. |
the spinal cord microglia play a pivotal role in neuroinflammation and neuropathic pain (np). |
2024-03-29 |
2024-04-01 |
rat |
| Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehran. A disintegrin and Metalloprotease 10 expression within the murine central nervous system. Brain research. 2024-03-28. PMID:38548249. |
here, we described the regional and cellular adam10 protein expression in c57bl/6 mice examined by immunofluorescence 1) throughout the adult mouse brain, cerebellum and spinal cord in vivo and 2) in different cell types as neurons, astrocytes, oligodendrocytes and microglia in vitro. |
2024-03-28 |
2024-03-31 |
mouse |
| Chenxia Duan, Yi Zhu, Zhuoliang Zhang, Tiantian Wu, Mengwei Shen, Jinfu Xu, Wenxin Gao, Jianhua Pan, Lei Wei, Huibin Su, Chenghuan Sh. Esketamine inhibits the JNK-c-Jun pathway in the spinal dorsal horn to relieve bone cancer pain in rats. Molecular pain. 2024-02-28. PMID:38417838. |
immunofluorescence images showed activated microglia in the spinal cord on day 14 after tci and co-expression of cxcl12/cxcr4, p-mapks (p-jnk, p-erk, p-p38 mapk), and p-c-jun in microglia. |
2024-02-28 |
2024-03-02 |
rat |
| Chenxia Duan, Yi Zhu, Zhuoliang Zhang, Tiantian Wu, Mengwei Shen, Jinfu Xu, Wenxin Gao, Jianhua Pan, Lei Wei, Huibin Su, Chenghuan Sh. Esketamine inhibits the JNK-c-Jun pathway in the spinal dorsal horn to relieve bone cancer pain in rats. Molecular pain. 2024-02-28. PMID:38417838. |
overall, our data suggest that the cxcl12/cxcr4-jnk-c-jun signaling pathway of microglia in the spinal cord mediates neuronal sensitization and pain hypersensitivity in cancer-induced bone pain and that esketamine exerts its analgesic effect by inhibiting the jnk-c-jun pathway. |
2024-02-28 |
2024-03-02 |
rat |
| Hu Lv, Jiaojiao Huang, Xin Zhang, Zhiyong He, Jun Zhang, Wei Che. Xenon ameliorates chronic post-surgical pain by regulating mitophagy in microglia and rats mediated by PINK1/Parkin pathway. PeerJ. vol 12. 2024-02-23. PMID:38390390. |
chronic post-surgical pain (cpsp) is one of the important causes of poor postoperative outcomes, the activation of microglia in the spinal cord is closely related to the generation, transmission and maintenance of cpsp. |
2024-02-23 |
2024-02-25 |
rat |
| Anup Bhusal, Jae-Hong Kim, Seung-Chan Kim, Eun Mi Hwang, Hoon Ryu, Md Sekendar Ali, Seung-Chun Park, Won-Ha Lee, Kyoungho Su. The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes. Cell reports. vol 43. issue 3. 2024-02-23. PMID:38393947. |
we observed the upregulation of pglyrp1 in inflamed human and mouse spinal cord and brain, with microglia being the primary cellular source. |
2024-02-23 |
2024-02-26 |
mouse |
| Jing Zhang, Xiaoyue Zhang, Qi Jiang, Di Qu, Yusheng Hu, Chao Qi, Haitao F. [Experimental study of M2 microglia transplantation promoting spinal cord injury repair in mice]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 38. issue 2. 2024-02-22. PMID:38385233. |
[experimental study of m2 microglia transplantation promoting spinal cord injury repair in mice]. |
2024-02-22 |
2024-02-24 |
mouse |
| Jing Zhang, Xiaoyue Zhang, Qi Jiang, Di Qu, Yusheng Hu, Chao Qi, Haitao F. [Experimental study of M2 microglia transplantation promoting spinal cord injury repair in mice]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 38. issue 2. 2024-02-22. PMID:38385233. |
to investigate the effect of m2 microglia (m2-mg) transplantation on spinal cord injury (sci) repair in mice. |
2024-02-22 |
2024-02-24 |
mouse |