| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julie J Ahn, Robert H Miller, Yusra Isla. Isolation of Pure Astrocytes and Microglia from the Adult Mouse Spinal Cord For In Vitro Assays and Transcriptomic Studies. Journal of visualized experiments : JoVE. issue 200. 2023-11-06. PMID:37930016. |
this protocol presents an efficient method for isolating astrocytes and microglia from the adult mouse spinal cord, facilitating immediate or future analysis with potential applications in functional, molecular, or proteomic downstream studies. |
2023-11-06 |
2023-11-08 |
mouse |
| Shuhui Sun, Jiaming Li, Si Wang, Jingyi Li, Jie Ren, Zhaoshi Bao, Le Sun, Xibo Ma, Fangshuo Zheng, Shuai Ma, Liang Sun, Min Wang, Yan Yu, Miyang Ma, Qiaoran Wang, Zhiyuan Chen, He Ma, Xuebao Wang, Zeming Wu, Hui Zhang, Kaowen Yan, Yuanhan Yang, Yixin Zhang, Sheng Zhang, Jinghui Lei, Zhao-Qian Teng, Chang-Mei Liu, Ge Bai, Yan-Jiang Wang, Jian Li, Xiaoqun Wang, Guoguang Zhao, Tao Jiang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Li. CHIT1-positive microglia drive motor neuron aging in the primate spinal cord. Nature. 2023-10-31. PMID:37907096. |
chit1-positive microglia drive motor neuron aging in the primate spinal cord. |
2023-10-31 |
2023-11-08 |
Not clear |
| Christina B Schroeter, Antonia Henes, Anna Vogelsang, Alexander M Herrmann, Stefanie Lichtenberg, Derya Cengiz, Vera Dobelmann, Niklas Huntemann, Christopher Nelke, Susann Eichler, Philipp Albrecht, Sven G Meuth, Tobias Ruc. Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice. Journal of visualized experiments : JoVE. issue 200. 2023-10-26. PMID:37870321. |
the dissociation of the brain and the spinal cord from adult mice is followed by magnetic-activated cell sorting (macs) to isolate microglia, oligodendrocytes, astrocytes, and neurons. |
2023-10-26 |
2023-11-08 |
mouse |
| Si-Ying Qu, Han-Zhi Wang, Qun-Qi Hu, Yi-Qi Ma, Yu-Rong Kang, Li-Qian Ma, Xiang Li, Lu-Hang Chen, Bo-Yu Liu, Xiao-Mei Shao, Bo-Yi Liu, Jun-Ying Du, Yi Liang, Hong-Li Zhao, Yong-Liang Jiang, Jian-Qiao Fang, Xiao-Fen H. Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation. Purinergic signalling. 2023-10-23. PMID:37870716. |
intrathecal injection of a p2x4r antagonist or microglia inhibitor attenuated stz-induced nociceptive thermal hyperalgesia and reduced the overexpression of brain-derived neurotrophic factor (bdnf), interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α) in the spinal cord. |
2023-10-23 |
2023-11-08 |
rat |
| Si-Ying Qu, Han-Zhi Wang, Qun-Qi Hu, Yi-Qi Ma, Yu-Rong Kang, Li-Qian Ma, Xiang Li, Lu-Hang Chen, Bo-Yu Liu, Xiao-Mei Shao, Bo-Yi Liu, Jun-Ying Du, Yi Liang, Hong-Li Zhao, Yong-Liang Jiang, Jian-Qiao Fang, Xiao-Fen H. Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation. Purinergic signalling. 2023-10-23. PMID:37870716. |
in terms of mechanism, ea reduced the upregulation of p2x4r on activated microglia and decreased bdnf, il-1β and tnf-α in the spinal cord. |
2023-10-23 |
2023-11-08 |
rat |
| Hayder Jaffer, Syed Suhail Andrabi, Marianne Petro, Youzhi Kuang, Michael P Steinmetz, Vinod Labhasetwa. Catalytic antioxidant nanoparticles mitigate secondary injury progression and promote functional recovery in spinal cord injury model. Journal of controlled release : official journal of the Controlled Release Society. 2023-10-22. PMID:37866402. |
histological analysis revealed activated microglia in the spinal cord displaying a rod-shaped anti-inflammatory and regenerative phenotype in treated animals, contrasting with the amoeboid inflammatory and degenerative phenotype in untreated control. |
2023-10-22 |
2023-11-08 |
rat |
| D R De Paula, M S França, L K R Leão, A A Maciel, T A A Moura, S A S de Moraes, C P Bahia, R S Borges, E J O Batista, A C F Passos, K R H M Oliveira, A M Herculan. Total rupture of Achilles tendon induces inflammatory response and glial activation on the spinal cord of mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 56. 2023-10-21. PMID:37851789. |
this phenomenon was accompanied by overexpression of cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase-2 (nos-2) as well as hyperactivation of astrocytes and microglia in nociceptive areas of l5 spinal cord as evidenced by intense gfap and iba-1 immunostaining, respectively. |
2023-10-21 |
2023-11-08 |
mouse |
| Lei Yang, Xiaoming Gao, Demin Tian, Wenjie Yang, Song Xue, Zhenxin Cao, Tao Su. Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats. Experimental neurology. 2023-10-20. PMID:37858697. |
resolvin d2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats. |
2023-10-20 |
2023-11-08 |
rat |
| Chang Sun, Junhao Deng, Yifei Ma, Fanqi Meng, Xiang Cui, Ming Li, Jiantao Li, Jia Li, Pengbin Yin, Lingjie Kong, Licheng Zhang, Peifu Tan. The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects. Experimental neurology. vol 370. 2023-10-20. PMID:37852469. |
the dual role of microglia in neuropathic pain after spinal cord injury: detrimental and protective effects. |
2023-10-20 |
2023-11-08 |
Not clear |
| Jee Youn Lee, Chan Sol Park, Kyung Jin Seo, In Yi Kim, Sungmin Han, Inchan Youn, Tae Young Yun. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Experimental neurology. 2023-10-20. PMID:37863306. |
il-6/jak2/stat3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. |
2023-10-20 |
2023-11-08 |
rat |
| Jee Youn Lee, Chan Sol Park, Kyung Jin Seo, In Yi Kim, Sungmin Han, Inchan Youn, Tae Young Yun. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Experimental neurology. 2023-10-20. PMID:37863306. |
after spinal cord injury (sci), the control of activated glial cells such as microglia and astrocytes has emerged as a promising strategy for neuropathic pain management. |
2023-10-20 |
2023-11-08 |
rat |
| Jee Youn Lee, Chan Sol Park, Kyung Jin Seo, In Yi Kim, Sungmin Han, Inchan Youn, Tae Young Yun. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Experimental neurology. 2023-10-20. PMID:37863306. |
one month after contusive sci, the activation of jak2/stat3 pathway was markedly upregulated in both microglia and astrocyte in nociceptive processing regions of the lumbar spinal cord. |
2023-10-20 |
2023-11-08 |
rat |
| Yuanlong Li, Hua Fan, Xiong Han, Jun Sun, Ming Ni, Xiaodan Hou, Fengqin Fang, Wei Zhang, Peizhi M. Long Non-Coding RNA MALAT1 Protects Against Spinal Cord Injury via Suppressing microRNA-125b-5p Mediated Microglial M1 Polarization, Neuroinflammation, and Neural Apoptosis. Molecular neurobiology. 2023-10-19. PMID:37858031. |
this study aimed to further explore the relationship between lncrna malat1 and mir-125b-5p, as well as their effect on microglial activation, neuroinflammation, and neural apoptosis in spinal cord injury (sci). primary microglia from sprague dawley rats were stimulated with lipopolysaccharide (lps). |
2023-10-19 |
2023-11-08 |
rat |
| Yi Luo, You-Zhi He, Yong-Fu Wang, Yu-Xia Xu, Li Yan. Adipose-derived mesenchymal stem cell exosomes ameliorate spinal cord injury in rats by activating the Nrf2/HO-1 pathway and regulating microglial polarization. Folia neuropathologica. vol 61. issue 3. 2023-10-11. PMID:37818693. |
moreover, admsc-exo inhibited the expression of both inflammatory factors in the spinal cord tissues and m1 microglia, promoted the expression of m2 microglia, and activated the nrf2/ho-1 pathway. |
2023-10-11 |
2023-10-15 |
rat |
| Claudia I Gutiérrez-Román, María E Meléndez Camargo, Cuauhtémoc C García Rojas, Miguel Jimenez Olvera, Sandra H Gutiérrez Román, Oscar Medina-Contrera. Rapid and Efficient Enrichment of Mouse Spinal Cord Microglia. Journal of visualized experiments : JoVE. issue 199. 2023-10-09. PMID:37811962. |
rapid and efficient enrichment of mouse spinal cord microglia. |
2023-10-09 |
2023-10-15 |
mouse |
| Claudia I Gutiérrez-Román, María E Meléndez Camargo, Cuauhtémoc C García Rojas, Miguel Jimenez Olvera, Sandra H Gutiérrez Román, Oscar Medina-Contrera. Rapid and Efficient Enrichment of Mouse Spinal Cord Microglia. Journal of visualized experiments : JoVE. issue 199. 2023-10-09. PMID:37811962. |
microglia display heterogeneity and multifunctionality, enabling distinct gene expression and behavior within the spinal cord and brain. |
2023-10-09 |
2023-10-15 |
mouse |
| Claudia I Gutiérrez-Román, María E Meléndez Camargo, Cuauhtémoc C García Rojas, Miguel Jimenez Olvera, Sandra H Gutiérrez Román, Oscar Medina-Contrera. Rapid and Efficient Enrichment of Mouse Spinal Cord Microglia. Journal of visualized experiments : JoVE. issue 199. 2023-10-09. PMID:37811962. |
however, the purification of microglia from the spinal cord in mice lacks a comprehensive description. |
2023-10-09 |
2023-10-15 |
mouse |
| Claudia I Gutiérrez-Román, María E Meléndez Camargo, Cuauhtémoc C García Rojas, Miguel Jimenez Olvera, Sandra H Gutiérrez Román, Oscar Medina-Contrera. Rapid and Efficient Enrichment of Mouse Spinal Cord Microglia. Journal of visualized experiments : JoVE. issue 199. 2023-10-09. PMID:37811962. |
this approach effectively produced substantial spinal cord microglia populations. |
2023-10-09 |
2023-10-15 |
mouse |
| Hao Xue, Bo Ran, Jie Li, Guorui Wang, Baolin Chen, Honggang Ma. Bone marrow mesenchymal stem cell exosomes-derived microRNA-216a-5p on locomotor performance, neuronal injury, and microglia inflammation in spinal cord injury. Frontiers in cell and developmental biology. vol 11. 2023-09-28. PMID:37766965. |
bone marrow mesenchymal stem cell exosomes-derived microrna-216a-5p on locomotor performance, neuronal injury, and microglia inflammation in spinal cord injury. |
2023-09-28 |
2023-10-07 |
Not clear |
| Wenhao Chen, Xianlei Gao, Wanliang Yang, Xun Xiao, Xin Pan, Hao L. Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling. Molecular neurobiology. 2023-09-25. PMID:37747614. |
htr2b promotes m1 microglia polarization and neuroinflammation after spinal cord injury via inhibition of neuregulin-1/erbb signaling. |
2023-09-25 |
2023-10-07 |
rat |