| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minna Christiansen Lund, Ditte Gry Ellman, Pernille Vinther Nielsen, Stefano Raffaele, Marta Fumagalli, Raphael Guzman, Matilda Degn, Roberta Brambilla, Morten Meyer, Bettina Hjelm Clausen, Kate Lykke Lambertse. Selective Inhibition of Soluble Tumor Necrosis Factor Alters the Neuroinflammatory Response following Moderate Spinal Cord Injury in Mice. Biology. vol 12. issue 6. 2023-06-28. PMID:37372129. |
this was complemented by a decrease in the number of infiltrated leukocytes (macrophages and neutrophils) in the lesioned area of the spinal cord and an increase in the number of microglia in the peri-lesion area 14 days after sci, followed by a decrease in microglial activation in the peri-lesion area 21 days after sci. |
2023-06-28 |
2023-08-14 |
mouse |
| Tatsuyuki Matsudaira, Sosuke Nakano, Yusuke Konishi, Shimpei Kawamoto, Ken Uemura, Tamae Kondo, Koki Sakurai, Takaaki Ozawa, Takatoshi Hikida, Okiru Komine, Koji Yamanaka, Yuki Fujita, Toshihide Yamashita, Tomonori Matsumoto, Eiji Har. Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. Communications biology. vol 6. issue 1. 2023-06-23. PMID:37353538. |
here, through comprehensive investigations utilising single-cell transcriptome analysis and various mouse models, we show that microglia, particularly in the white matter, undergo cellular senescence in the brain and spinal cord during ageing and in disease models involving demyelination. |
2023-06-23 |
2023-08-14 |
mouse |
| Wen-Ming Zhou, Ze-Yuan Lei, Yong-Qiang Shi, Chao-Yang Gong, Zhang Kai, Nan Wei, Lin-Na Wang, Cheng-Jun Zhang, Hai-Hong Zhan. Intrathecal Injection of Botulinum Toxin Type A has an Analgesic Effect in Male Rats CCI Model by Inhibiting the Activation of Spinal P2X4R. Neurochemical research. 2023-06-19. PMID:37336823. |
in addition, we found that microglia and astrocytes in the spinal cord of rats injected with botulinum toxin type a were reactivated after administration of the p2x4r activator. |
2023-06-19 |
2023-08-14 |
rat |
| Jiawei Fu, Chunshuai Wu, Guanhua Xu, Jinlong Zhang, Jiajia Chen, Chu Chen, Hongxiang Hong, Pengfei Xue, Jiawei Jiang, Jiayi Huang, Chunyan Ji, Zhiming Cu. Protective effect of TNIP2 on the inflammatory response of microglia after spinal cord injury in rats. Neuropeptides. vol 101. 2023-06-17. PMID:37329819. |
protective effect of tnip2 on the inflammatory response of microglia after spinal cord injury in rats. |
2023-06-17 |
2023-08-14 |
rat |
| Jiawei Fu, Chunshuai Wu, Guanhua Xu, Jinlong Zhang, Jiajia Chen, Chu Chen, Hongxiang Hong, Pengfei Xue, Jiawei Jiang, Jiayi Huang, Chunyan Ji, Zhiming Cu. Protective effect of TNIP2 on the inflammatory response of microglia after spinal cord injury in rats. Neuropeptides. vol 101. 2023-06-17. PMID:37329819. |
our study's intention was to evaluate the effect of tnip2 on the inflammatory response of microglia after spinal cord injury in rats. |
2023-06-17 |
2023-08-14 |
rat |
| Xiao Xiao, Xing-Yu Chen, Yin-Hui Dong, Hao-Ru Dong, Long-Nian Zhou, Yuan-Qing Ding, Gong Chen, Jian-Lan Zhao, Rong Xi. Pre-treatment of rapamycin transformed M2 microglia alleviates traumatic cervical spinal cord injury via AIM2 signaling pathway in vitro and in vivo. International immunopharmacology. vol 121. 2023-06-09. PMID:37295027. |
pre-treatment of rapamycin transformed m2 microglia alleviates traumatic cervical spinal cord injury via aim2 signaling pathway in vitro and in vivo. |
2023-06-09 |
2023-08-14 |
Not clear |
| Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Ron. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell reports. vol 42. issue 6. 2023-06-08. PMID:37289590. |
here, we identify two distinct phenotypes of microglia and infiltrating myeloid populations dependent on trem2 expression levels at the acute stage and elucidate how they mediate the opposing effects of trem2 in spinal cord injury (sci) versus multiple sclerosis animal models (experimental autoimmune encephalomyelitis [eae]). |
2023-06-08 |
2023-08-14 |
Not clear |
| Xin Jia, Ziyang Li, Xiafeng Shen, Yu Zhang, Li Zhang, Ling Zhan. High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic post-ischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282487. |
finally, shrna-mediated silencing of chemerin receptor 23 in the spinal cord reversed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammatory polarization of microglia in the dorsal horn of the spinal cord. |
2023-06-07 |
2023-08-14 |
mouse |
| Jinhong Jiang, Lingfei Xu, Long Yang, Su Liu, Zhe Wan. Mitochondrial-Derived Peptide MOTS-c Ameliorates Spared Nerve Injury-Induced Neuropathic Pain in Mice by Inhibiting Microglia Activation and Neuronal Oxidative Damage in the Spinal Cord ACS chemical neuroscience. 2023-06-07. PMID:37285113. |
mitochondrial-derived peptide mots-c ameliorates spared nerve injury-induced neuropathic pain in mice by inhibiting microglia activation and neuronal oxidative damage in the spinal cord mots-c, a recently discovered mitochondrial-derived peptide, plays an important role in many physiological and pathological functions |
2023-06-07 |
2023-08-14 |
mouse |
| Yang Zhao, Yunpeng Luo, Ziru Liu, Yuanyuan Chen, Liling Wei, Xi Luo, Gang Zhou, Jian Lai, Jiemei Ji, Yunan Lin, Jingchen Li. Ferrostatin-1 Ameliorates Bupivacaine-Induced Spinal Neurotoxicity in rats by Inhibiting Ferroptosis. Neuroscience letters. 2023-05-27. PMID:37244447. |
furthermore, double-immunofluorescence staining revealed that gpx4 is primarily localized in the neurons instead of microglia or astroglia in the spinal cord. |
2023-05-27 |
2023-08-14 |
rat |
| Luise A Seeker, Nadine Bestard-Cuche, Sarah Jäkel, Nina-Lydia Kazakou, Sunniva M K Bøstrand, Laura J Wagstaff, Justyna Cholewa-Waclaw, Alastair M Kilpatrick, David Van Bruggen, Mukund Kabbe, Fabio Baldivia Pohl, Zahra Moslehi, Neil C Henderson, Catalina A Vallejos, Gioele La Manno, Goncalo Castelo-Branco, Anna William. Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function. Acta neuropathologica communications. vol 11. issue 1. 2023-05-22. PMID:37217978. |
spinal cord microglia exhibit a more activated phenotype compared to brain microglia, suggesting that the spinal cord is a more pro-inflammatory environment, a difference that intensifies with age. |
2023-05-22 |
2023-08-14 |
mouse |
| Emily A B Gilbert, Jessica Livingston, Emilio Garcia-Flores, Tarlan Kehtari, Cindi M Morshea. Metformin Improves Functional Outcomes, Activates Neural Precursor Cells, and Modulates Microglia in a Sex-Dependent Manner After Spinal Cord Injury. Stem cells translational medicine. 2023-05-20. PMID:37209417. |
metformin improves functional outcomes, activates neural precursor cells, and modulates microglia in a sex-dependent manner after spinal cord injury. |
2023-05-20 |
2023-08-14 |
Not clear |
| Songbin Wu, Shaomin Yang, Rongzhen Li, Xiyuan Ba, Changyu Jiang, Donglin Xiong, Lizu Xiao, Wuping Su. HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism. Journal of medical virology. vol 95. issue 4. 2023-05-16. PMID:37185840. |
besides, hsv-1 inoculation induced an up-regulation of atf3, cgrp, and gal in drg and activation of astrocytes and microglia in the spinal cord. |
2023-05-16 |
2023-08-14 |
mouse |
| Baicheng Yang, Xinming Yan. Autophagy exerts a protective role in cervical spinal cord injury by microglia inhibition through the NF-κB pathway. Folia morphologica. 2023-05-15. PMID:37183514. |
autophagy exerts a protective role in cervical spinal cord injury by microglia inhibition through the nf-κb pathway. |
2023-05-15 |
2023-08-14 |
mouse |
| Andreia G Pinho, Andreia Monteiro, Sara Fernandes, Nídia de Sousa, António J Salgado, Nuno A Silva, Susana Monteir. The Central Nervous System Source Modulates Microglia Function and Morphology In Vitro. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175391. |
we cultured microglia isolated from the cortex and spinal cord and analyzed the effect of the cns spatial source on behavior in vitro by applying the same experimental protocol and culture conditions. |
2023-05-14 |
2023-08-14 |
Not clear |
| Elvira Ruslanovna Akhmetzyanova, Margarita Nikolaevna Zhuravleva, Anna Viktorovna Timofeeva, Leisan Gazinurovna Tazetdinova, Ekaterina Evgenevna Garanina, Albert Anatolevich Rizvanov, Yana Olegovna Mukhamedshin. Severity- and Time-Dependent Activation of Microglia in Spinal Cord Injury. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37176001. |
severity- and time-dependent activation of microglia in spinal cord injury. |
2023-05-14 |
2023-08-14 |
Not clear |
| K M Koss, T Son, C Li, Y Hao, J Cao, M A Churchward, Z J Zhang, J A Wertheim, R Derda, K G Tod. Towards discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes. Journal of neurochemistry. 2023-05-12. PMID:37171455. |
microglia are an immune-derived cell critical to development and healthy function of the brain and spinal cord, yet are implicated in the active pathology of many neuropsychiatric disorders. |
2023-05-12 |
2023-08-14 |
rat |
| Andrea Francesca M Salvador, Taitea Dykstra, Justin Rustenhoven, Wenqing Gao, Susan M Blackburn, Kesshni Bhasiin, Michael Q Dong, Rafaela Mano Guimarães, Sriharsha Gonuguntla, Igor Smirnov, Jonathan Kipnis, Jasmin Her. Age-dependent immune and lymphatic responses after spinal cord injury. Neuron. 2023-05-06. PMID:37148871. |
we revealed substantial infiltration of myeloid cells to the spinal cord in young animals, accompanied by changes in the activation state of microglia. |
2023-05-06 |
2023-08-14 |
mouse |
| Amer Imraish, Tuqa Abu-Thiab, Hana Hamma. P Pharmacy practice. vol 21. issue 1. 2023-04-24. PMID:37090457. |
however, it is not known if blocking p2x4, p2x7 and p2y12 receptors is associated with the expression and the release of interleukin-1b (il-1β), interleukin-6 (il-6), or tumor necrosis factor-α (tnf-α) in cultured neonatal spinal cord microglia. |
2023-04-24 |
2023-08-14 |
Not clear |
| Mingliang Tan, Zhou Feng, Hui Chen, Lingxia Min, Huizhong Wen, Hongliang Liu, Jingming Ho. Transcranial direct current stimulation regulates phenotypic transformation of microglia to relieve neuropathic pain induced by spinal cord injury. Frontiers in behavioral neuroscience. vol 17. 2023-04-21. PMID:37081929. |
transcranial direct current stimulation regulates phenotypic transformation of microglia to relieve neuropathic pain induced by spinal cord injury. |
2023-04-21 |
2023-08-14 |
Not clear |