| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenhao Chen, Xianlei Gao, Wanliang Yang, Xun Xiao, Xin Pan, Hao L. Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling. Molecular neurobiology. 2023-09-25. PMID:37747614. |
htr2b promotes m1 microglia polarization and neuroinflammation after spinal cord injury via inhibition of neuregulin-1/erbb signaling. |
2023-09-25 |
2023-10-07 |
rat |
| Wenhao Chen, Xianlei Gao, Wanliang Yang, Xun Xiao, Xin Pan, Hao L. Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling. Molecular neurobiology. 2023-09-25. PMID:37747614. |
the secondary injury of spinal cord injury (sci) is dominated by neuroinflammation, which was caused by microglia m1 polarization. |
2023-09-25 |
2023-10-07 |
rat |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. |
2023-09-22 |
2023-10-07 |
mouse |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
however, it remains unknown whether microglia exhibit similar phenotypic heterogeneity in the spinal cord. |
2023-09-22 |
2023-10-07 |
mouse |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
here, we performed a regional analysis of spinal cord microglia in 3-, 16-, 23-, and 30-month-old mice. |
2023-09-22 |
2023-10-07 |
mouse |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
using light and electron microscopy, we discovered that spinal cord microglia acquire an increasingly activated phenotype during the course of aging regardless of regional location. |
2023-09-22 |
2023-10-07 |
mouse |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
to generate additional insights about aging spinal cord microglia, we performed rna-sequencing on facs-isolated microglia from 3-, 18-, 22-, and 29-month-old mice. |
2023-09-22 |
2023-10-07 |
mouse |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
we found that spinal cord microglia acquire a similar transcriptional identity as those in the brain during aging that includes altered expression of genes with roles in microglia-neuron interactions and inflammation. |
2023-09-22 |
2023-10-07 |
mouse |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
by 29 months of age, spinal cord microglia exhibit additional and unique transcriptional changes known and predicted to cause senescence and to alter lysosomal and ribosomal regulation. |
2023-09-22 |
2023-10-07 |
mouse |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
altogether, this work provides the foundation to target microglia to ameliorate aged-related changes in the spinal cord, and particularly on the motor circuit. |
2023-09-22 |
2023-10-07 |
mouse |
| Min-Jia Wang, Xin-Yu Jing, Yao-Zheng Wang, Bi-Ru Yang, Qu Lu, Hao Hu, Liang Kan. Exercise, Spinal Microglia and Neuropathic Pain: Potential Molecular Mechanisms. Neurochemical research. 2023-09-19. PMID:37725293. |
in recent years, the role of spinal cord microglia in the pathogenesis of neuropathic pain has been widely recognized, and they are being explored as potential therapeutic targets. |
2023-09-19 |
2023-10-07 |
Not clear |
| Junping Bao, Shu Yan. ScRNA analysis and ferroptosis-related ceRNA regulatory network investigation in microglia cells at different time points after spinal cord injury. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-09-19. PMID:37726826. |
scrna analysis and ferroptosis-related cerna regulatory network investigation in microglia cells at different time points after spinal cord injury. |
2023-09-19 |
2023-10-07 |
mouse |
| Junping Bao, Shu Yan. ScRNA analysis and ferroptosis-related ceRNA regulatory network investigation in microglia cells at different time points after spinal cord injury. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-09-19. PMID:37726826. |
microglia have been shown to be the key player in the immune inflammatory response after spinal cord injury, but the mechanisms of immune regulation at different time points after spinal cord injury remain unclear. |
2023-09-19 |
2023-10-07 |
mouse |
| Junping Bao, Shu Yan. ScRNA analysis and ferroptosis-related ceRNA regulatory network investigation in microglia cells at different time points after spinal cord injury. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-09-19. PMID:37726826. |
as ferroptosis is a newly identified non-apoptotic programmed cell death, microglia establish a bridge between ferroptosis and cns inflammation and may play an important role in spinal cord injury. |
2023-09-19 |
2023-10-07 |
mouse |
| Junping Bao, Shu Yan. ScRNA analysis and ferroptosis-related ceRNA regulatory network investigation in microglia cells at different time points after spinal cord injury. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-09-19. PMID:37726826. |
we then screened for genes differentially expressed in microglia during 3- and 14-days after spinal cord injury and associated with iron death, named stmn1 and fgfbr1, respectively, and verified that these pivotal genes are closely related to the immune cells. |
2023-09-19 |
2023-10-07 |
mouse |
| Junping Bao, Shu Yan. ScRNA analysis and ferroptosis-related ceRNA regulatory network investigation in microglia cells at different time points after spinal cord injury. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-09-19. PMID:37726826. |
our results predict key genes in the immune inflammatory process associated with microglia at different time points after spinal cord injury at the single-cell level and provide a molecular basis for better treatment of sci. |
2023-09-19 |
2023-10-07 |
mouse |
| Aihua Xu, Yang Yang, Yang Shao, Manyu Jiang, Yongxin Sun, Bo Fen. FHL2 regulates microglia M1/M2 polarization after spinal cord injury via PARP14-depended STAT1/6 pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-14. PMID:37708708. |
fhl2 regulates microglia m1/m2 polarization after spinal cord injury via parp14-depended stat1/6 pathway. |
2023-09-14 |
2023-10-07 |
mouse |
| Aihua Xu, Yang Yang, Yang Shao, Manyu Jiang, Yongxin Sun, Bo Fen. FHL2 regulates microglia M1/M2 polarization after spinal cord injury via PARP14-depended STAT1/6 pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-14. PMID:37708708. |
indeed, fhl2 deficiency increased the secretion of tnf-α and il-6, m1 microglia polarization, and the activation of stat1 pathway but decreased the secretion of il-10 and il-4, m2 microglia polarization, and the activation of the stat6 pathway in the spinal cord. |
2023-09-14 |
2023-10-07 |
mouse |
| Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T Supura. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia. European journal of medicinal chemistry. vol 260. 2023-09-07. PMID:37678143. |
by means of repeated treatment of 3 daily administrations for 17 days, fentanyl (0.1 mg/kg, subcutaneously) led to tolerance development, pain threshold alterations and withdrawal symptoms in cd-1 mice, as well as astrocyte and microglia activation in the dorsal horn of the lumbar spinal cord. |
2023-09-07 |
2023-10-07 |
mouse |
| Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, Anand Veeravag. Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury. Scientific reports. vol 13. issue 1. 2023-09-07. PMID:37679500. |
sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury. |
2023-09-07 |
2023-10-07 |
mouse |