| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengchun Wu, Yu Lin, Lili Xiao, Qiyong Chen, Fengfei Lin, Renbin L. Administration with curcumin alleviates spinal cord ischemia-reperfusion injury by regulating anti-oxidative stress and microglia activation-mediated neuroinflammation via Nrf2/NF-κB axis. In vitro cellular & developmental biology. Animal. 2024-01-16. PMID:38228998. |
in vivo, curcumin improved histopathologic injury and neurologic motor function in scii rats and attenuated oxidative stress, microglia activation and neuroinflammation in spinal cord tissues, and activation of the nrf2/nf-κb pathway. |
2024-01-16 |
2024-01-19 |
rat |
| Chunhe Sha, Feng Pan, Zhiqing Wang, Guohui Liu, Hua Wang, Tianwei Huang, Kai Huan. Nrf2 Inhibits GAPDH/Siah1 Axis to Reduce Inflammatory Reactions and Proliferation of Microglia After Simulating Spinal Cord Injury. Current molecular medicine. 2024-01-12. PMID:38213136. |
nrf2 inhibits gapdh/siah1 axis to reduce inflammatory reactions and proliferation of microglia after simulating spinal cord injury. |
2024-01-12 |
2024-01-14 |
Not clear |
| Yingchao Shi, Luwei Huang, Hao Dong, Meng Yang, Wenyu Ding, Xiang Zhou, Tian Lu, Zeyuan Liu, Xin Zhou, Mengdi Wang, Bo Zeng, Yinuo Sun, Suijuan Zhong, Bosong Wang, Wei Wang, Chonghai Yin, Xiaoqun Wang, Qian W. Decoding the spatiotemporal regulation of transcription factors during human spinal cord development. Cell research. 2024-01-04. PMID:38177242. |
interestingly, we detected disease-associated microglia (dam)-like microglia groups in the developing human spinal cord, which are predicted to be vulnerable to als and engaged in the tyrobp causal network and response to unfolded proteins. |
2024-01-04 |
2024-01-07 |
human |
| Maria Virginia Centeno, Md Suhail Alam, Kasturi Haldar, Apkar Vania Apkaria. Long-range action of an HDAC inhibitor treats chronic pain in a spared nerve injury rat model. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168166. |
this was achieved at less than 1% of the total dose of vo approved for 4 weeks of tumor treatment and associated with decreased levels of major inflammatory markers and microglia in ipsilateral (but not contralateral) spinal cord regions. |
2024-01-03 |
2024-01-06 |
mouse |
| Stefano Raffaele, Estrid Thougaard, Cathrine C H Laursen, Han Gao, Katrine M Andersen, Pernille V Nielsen, Natalia Ortí-Casañ, Morten Blichfeldt-Eckhardt, Simon Koch, Milani Deb-Chatterji, Tim Magnus, Jane Stubbe, Kirsten Madsen, Morten Meyer, Matilda Degn, Ulrich L M Eisel, Agnieszka Wlodarczyk, Marta Fumagalli, Bettina H Clausen, Roberta Brambilla, Kate L Lambertse. Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion. Brain, behavior, and immunity. 2023-12-24. PMID:38142915. |
microglia, the resident immune cells of the central nervous system (cns), play a major role in damage progression and tissue remodeling after acute cns injury, including ischemic stroke (is) and spinal cord injury (sci). |
2023-12-24 |
2023-12-27 |
Not clear |
| Kevin J Pollard, Vicki Traina-Dorge, Stephen M Medearis, Alexander Bosak, Gregory J Bix, Michael J Moore, Giovanni Piedimont. Respiratory syncytial virus infects peripheral and spinal nerves and induces chemokine-mediated neuropathy. The Journal of infectious diseases. 2023-12-22. PMID:38135285. |
in spinal cord cultures, rsv infected microglia and dendritic cells but not neurons, producing a moderate chemokine expression pattern. |
2023-12-22 |
2023-12-25 |
Not clear |
| Liyan Yan, Xiaonan Han, Mingkang Zhang, Hongwei Kou, Hongjian Liu, Tian Chen. Melatonin exerts neuroprotective effects in mice with spinal cord injury by activating the Nrf2/Keap1 signaling pathway via the MT2 receptor. Experimental and therapeutic medicine. vol 27. issue 1. 2023-12-21. PMID:38125360. |
furthermore, melatonin treatment promoted the polarization of microglia toward the m2 type, increased the number of neutrophil-positive cells, and modulated the transcription of bax and bcl2 in the injured spinal cord. |
2023-12-21 |
2023-12-23 |
mouse |
| Dan-Jie Wang, Xiao Wang, Shu-le Li, Tong-Tong Zhang, Ya-Chen Yang, Yu-Meng Wang, Xiao-Qiang Zhao, Kun-Yu Li, Yan-Qing Wang, Yan Li, Ke-Ying Zhu, Jun Wan. Sanguinarine modulates microglial function via PPARγ activation and protects against CNS demyelination. International immunopharmacology. vol 127. 2023-12-21. PMID:38128309. |
at the cellular level, san reduces the accumulation of microglia in the spinal cord. |
2023-12-21 |
2023-12-24 |
mouse |
| Dan-Jie Wang, Xiao Wang, Shu-le Li, Tong-Tong Zhang, Ya-Chen Yang, Yu-Meng Wang, Xiao-Qiang Zhao, Kun-Yu Li, Yan-Qing Wang, Yan Li, Ke-Ying Zhu, Jun Wan. Sanguinarine modulates microglial function via PPARγ activation and protects against CNS demyelination. International immunopharmacology. vol 127. 2023-12-21. PMID:38128309. |
morphological analyses and immunophenotyping reveal a less activated state of microglia following san administration, supported by decreased inflammatory cytokine production in the spinal cord. |
2023-12-21 |
2023-12-24 |
mouse |
| Fudong Li, Xiaofei Sun, Kaiqiang Sun, Fanqi Kong, Xin Jiang, Qingjie Kon. Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway. Neural regeneration research. vol 19. issue 8. 2023-12-16. PMID:38103247. |
lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa b pathway. |
2023-12-16 |
2023-12-19 |
mouse |
| Sydney Brockie, Cindy Zhou, Michael G Fehling. Resident immune responses to spinal cord injury: role of astrocytes and microglia. Neural regeneration research. vol 19. issue 8. 2023-12-16. PMID:38103231. |
resident immune responses to spinal cord injury: role of astrocytes and microglia. |
2023-12-16 |
2023-12-19 |
Not clear |
| E R Akhmetzyanova, A A Rizvanov, Y O Mukhamedshin. Current methods for the microglia isolation: Overview and comparative analysis of approaches. Cell and tissue research. 2023-12-15. PMID:38099956. |
microglia are not only the first stage of immune defense against injury and infection, contributing to both the innate and adaptive local immune response, but also play a vital role in maintaining homeostasis of the brain and spinal cord. |
2023-12-15 |
2023-12-17 |
Not clear |
| Bhavani Gopalakrishnan, Uri Galili, August Dunbar, Luis Solorio, Riyi Shi, Jianming L. α-Gal Nanoparticles in CNS Trauma: I. In Vitro Activation of Microglia Towards a Pro-Healing State. Tissue engineering and regenerative medicine. 2023-12-15. PMID:38099990. |
macrophages and microglia play critical roles after spinal cord injury (sci), with the pro-healing, anti-inflammatory (m2) subtype being implicated in tissue repair. |
2023-12-15 |
2023-12-17 |
human |
| Sabrina de Souza, Jesús Rosario-Claudio, Jaewon Sim, Kufreobong E Inyang, Andrew Dagenais, Karli Monahan, Beenhwa Lee, Hariharan Ramakrishnan, Visha Parmar, Matan Geron, Grégory Scherrer, Joseph K Folger, Geoffroy Laume. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response. Brain, behavior, and immunity. 2023-12-11. PMID:38081433. |
we showed that mice that lack il-10r1 specifically on advillin-positive neurons have exaggerated blood nitric oxide levels, spinal microglia activation, and cytokine upregulation in the spinal cord, liver, and gut compared to wild-type (wt) counterparts in response to systemic lipopolysaccharide (lps) injection. |
2023-12-11 |
2023-12-17 |
mouse |
| Wei Zhu, Zhengliang M. SIRT2 overexpression decreases remifentanil-stimulated post-surgical hyperalgesia via microglia. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063126. |
furthermore, sirt2 overexpression suppressed microglia activation in the spinal cord of model animals, and starkly relieved incision- and/or remi-associated pronociceptive processes as well as spinal microglia activation. |
2023-12-08 |
2023-12-17 |
rat |
| Marc-Philipp Weyer, Jenny Strehle, Michael K E Schäfer, Irmgard Tegede. Repurposing of pexidartinib for microglia depletion and renewal. Pharmacology & therapeutics. 2023-12-05. PMID:38052308. |
the phenotypic switch may fail, and disease-associated microglia contribute to the pathophysiology in neurodegenerative or neuropsychiatric diseases or long-lasting detrimental brain inflammation after brain, spinal cord or nerve injury or ischemia/hemorrhage. |
2023-12-05 |
2023-12-10 |
Not clear |
| Kai Sun, Hao Zhang, Ting Zhang, Nan Sun, Jingru Hao, Zhiping Wang, Can Ga. Spinal HDAC6 mediates nociceptive behaviors induced by CCI via neuronal activation and neuroinflammation. Molecular pain. 2023-11-20. PMID:37982151. |
hdac6 is primarily expressed in neurons and microglia in the spinal cord. |
2023-11-20 |
2023-11-29 |
Not clear |
| Fumihiro Saika, Yohji Fukazawa, Shiroh Kishioka, Norikazu Kiguch. Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis. Journal of pharmacological sciences. vol 153. issue 4. 2023-11-16. PMID:37973215. |
hypertrophic (activated) microglia were observed throughout the spinal cord after the topical application of imq. |
2023-11-16 |
2023-11-20 |
mouse |
| Jing Wang, Qiao-Min Ru, Xiao-Hui Yu, Changlong Wang, Kai Li, Chao-Zhen-Yi Han, Na Li, Jing Zhao, John N Wood, Xin Liu, Rui Wang, Yuan Wan. Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity. European journal of pharmacology. 2023-11-11. PMID:37951488. |
mel-0614 also downregulated the activation of microglia and related proinflammatory cytokines in the spinal cord. |
2023-11-11 |
2023-11-20 |
mouse |
| Julie J Ahn, Robert H Miller, Yusra Isla. Isolation of Pure Astrocytes and Microglia from the Adult Mouse Spinal Cord For In Vitro Assays and Transcriptomic Studies. Journal of visualized experiments : JoVE. issue 200. 2023-11-06. PMID:37930016. |
isolation of pure astrocytes and microglia from the adult mouse spinal cord for in vitro assays and transcriptomic studies. |
2023-11-06 |
2023-11-08 |
mouse |