| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Tsuda, Keita Kohn. [Neuropathic pain decoded by microglial heterogeneity]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 158. issue 5. 2023-09-06. PMID:37673611. |
upon sensing nerve damage, spinal cord microglia alter their morphology, gene expression and function, which lead to an increase in the excitability of pain-transmission neural pathway, causing the pain onset. |
2023-09-06 |
2023-10-07 |
Not clear |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. |
curcumin-activated olfactory ensheathing cells improve functional recovery after spinal cord injury by modulating microglia polarization through apoe/trem2/nf-κb signaling pathway. |
2023-09-02 |
2023-09-07 |
rat |
| Ellane Barcelon, Seohyun Chung, Jaesung Lee, Sung Joong Le. Sexual Dimorphism in the Mechanism of Pain Central Sensitization. Cells. vol 12. issue 16. 2023-08-26. PMID:37626838. |
we further discuss putative mechanisms for the sexual dimorphism in pain sensitization, which involves sex hormones, spinal cord microglia, and peripheral immune cells. |
2023-08-26 |
2023-09-07 |
Not clear |
| Maryam W Alhadlaq, Willias Masoch. Microglia and p38 MAPK Inhibitors Suppress Development of Mechanical Allodynia in Both Sexes in a Mouse Model of Antiretroviral-Induced Neuropathic Pain. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628987. |
microglia activation in the spinal cord play a major role in the pathogenesis of neuropathic pain. |
2023-08-26 |
2023-09-07 |
mouse |
| Ohoud A Alomari, Safaa Qusti, Maha Balgoon, Fadwa Aljoud, Khalid A Alamry, Mahmoud A Hussei. Modified TPP-MoS Neurology international. vol 15. issue 3. 2023-08-22. PMID:37606394. |
microglia are resident macrophages of the brain and spinal cord which play an important role in maintaining brain homeostasis through a variety of phenotypes, including the pro-inflammatory phenotype and anti-inflammatory phenotypes. |
2023-08-22 |
2023-09-07 |
Not clear |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
furthermore, microglia and the p2x7 receptor (p2x7r) in the ipsilateral spinal cord were measured with immunofluorescence and western blotting, respectively. |
2023-08-14 |
2023-08-16 |
Not clear |
| J E Sanchez, S Noor, M S Sun, J Zimmerly, A Pasmay, J J Sanchez, A G Vanderwall, M K Haynes, L A Sklar, P R Escalona, E D Milliga. The clinically-approved compounds, pramipexole and dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture. Neuroscience letters. 2023-08-09. PMID:37558176. |
consequently, glial cells (astrocytes and microglia) in the spinal cord are activated and mediate the release of proinflammatory cytokines that act to enhance pain transmission and sensitize mechanical non-nociceptive fibers which ultimately results in light touch hypersensitivity, clinically observed as allodynia. |
2023-08-09 |
2023-08-16 |
mouse |
| Jean-Christophe Perez, Gaetan Poulen, Maida Cardoso, Hassan Boukhaddaoui, Chloé Marie Gazard, Gilles Courtand, Sandrine Sylvie Bertrand, Yannick Nicolas Gerber, Florence Evelyne Perri. CSF1R inhibition at chronic stage after spinal cord injury modulates microglia proliferation. Glia. 2023-08-04. PMID:37539655. |
csf1r inhibition at chronic stage after spinal cord injury modulates microglia proliferation. |
2023-08-04 |
2023-08-14 |
Not clear |
| Jean-Christophe Perez, Gaetan Poulen, Maida Cardoso, Hassan Boukhaddaoui, Chloé Marie Gazard, Gilles Courtand, Sandrine Sylvie Bertrand, Yannick Nicolas Gerber, Florence Evelyne Perri. CSF1R inhibition at chronic stage after spinal cord injury modulates microglia proliferation. Glia. 2023-08-04. PMID:37539655. |
in a translational aim, we investigated whether microglia proliferation persists at chronic stage after spinal cord hemisection and whether a brief pharmacological treatment could modulate microglial responses. |
2023-08-04 |
2023-08-14 |
Not clear |
| Zhi-Ling Zhang, Zhi-Tong Wang, Jing Shi, Xiao-Ping Pu, Suo-Di Zha. Tetrandrine attenuates SNI-induced mechanical allodynia by inhibiting spinal CKLF1. Neuropharmacology. 2023-07-30. PMID:37517461. |
moreover, immunofluorescence double-labeling results revealed that cklf1 was predominantly colocalized with microglia of the spinal cord (sc) in sni mice. |
2023-07-30 |
2023-08-14 |
mouse |
| Changran Niu, Xinpei Yue, Juan Ji An, Haifei Xu, Baoji X. Genetic dissection of BDNF and TrkB expression in glial cells. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37503044. |
surprisingly, we found no bdnf- or trkb- expressing microglia in the brain and spinal cord. |
2023-07-28 |
2023-08-14 |
mouse |
| Laura Meleady, Morgan Towriss, Jennifer Kim, Vince Bacarac, Vivien Dang, Megan E Rowland, Annie Vogel Cierni. Histone deacetylase 3 regulates microglial function through histone deacetylation. Epigenetics. vol 18. issue 1. 2023-07-28. PMID:37506371. |
inhibition of histone deacetylase 3 (hdac3) has been utilized in pre-clinical models of depression, stroke, and spinal cord injury to improve recovery following injury, but the molecular mechanisms underlying hdac3's regulation of inflammatory gene expression in microglia is not well understood. |
2023-07-28 |
2023-08-14 |
Not clear |
| Piyun Sun, Tianshu Zhao, Jinlong Zhou, Huiping Qi, Guibin Qia. Phosphodiesterase 4 Inhibitor Roflupram Suppresses Inflammatory Responses Using Reducing Inflammasome in Microglia After Spinal Cord Injury. Alternative therapies in health and medicine. 2023-07-27. PMID:37499151. |
phosphodiesterase 4 inhibitor roflupram suppresses inflammatory responses using reducing inflammasome in microglia after spinal cord injury. |
2023-07-27 |
2023-08-14 |
Not clear |
| Thomas Jacobus Geus, Glenn Franken, Bert Bert Jooste. Conventional, High Frequency and Differential Targeted Multiplexed Spinal Cord Stimulation in experimental Painful Diabetic Peripheral Neuropathy: pain behavior and role of the central inflammatory balance. Molecular pain. 2023-07-25. PMID:37488684. |
the inflammatory balance and glial response were analyzed in the dorsal spinal cord based on rna expression of pro- and anti-inflammatory cytokines (tnf-α, il-1ß, il-4, il-10), a microglia marker (itgam), an astrocyte marker (gfap), a t-cell marker (cd3d), microglia proliferation markers (irf8, adgre1) and p2x4, p13-mapk, bdnf signaling markers (p2x4, mapk14, bdnf). |
2023-07-25 |
2023-08-14 |
Not clear |
| David Ramos, Célia Duarte Cru. Involvement of microglia in chronic neuropathic pain associated with spinal cord injury - a systematic review. Reviews in the neurosciences. 2023-07-25. PMID:37490300. |
involvement of microglia in chronic neuropathic pain associated with spinal cord injury - a systematic review. |
2023-07-25 |
2023-08-14 |
Not clear |
| David Ramos, Célia Duarte Cru. Involvement of microglia in chronic neuropathic pain associated with spinal cord injury - a systematic review. Reviews in the neurosciences. 2023-07-25. PMID:37490300. |
the contribution of microglia to chronic pain arising after injury to the central nervous system, such as spinal cord injury (sci), has been less studied, but there is evidence supporting microglial contribution to central neuropathic pain. |
2023-07-25 |
2023-08-14 |
Not clear |
| David Ramos, Célia Duarte Cru. Involvement of microglia in chronic neuropathic pain associated with spinal cord injury - a systematic review. Reviews in the neurosciences. 2023-07-25. PMID:37490300. |
many mechanisms and cellular interactions are yet to be fully understood, although several studies report an increase of density and activity of microglia in the spinal cord, both in the vicinity of the injury and in the spared spinal tissue, as well as in the brain. |
2023-07-25 |
2023-08-14 |
Not clear |
| Vaibhav Patil, Raghvendra Bohara, Vijaya Krishna Kanala, Siobhan McMahon, Abhay Pandi. Models and approaches to comprehend and address glial inflammation following spinal cord injury. Drug discovery today. 2023-07-23. PMID:37482236. |
spinal cord injury (sci) culminates in chronic inflammation and glial scar formation driven by the activation of microglia and astrocytes. |
2023-07-23 |
2023-08-14 |
Not clear |
| Y Sun, Y Xu, L Xiao, G Zhu, J Li, X Song, L Xu, J H. [Acetylcorynoline inhibits microglia activation by regulating EGFR/MAPK signaling to promote functional recovery of injured mouse spinal cord]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 6. 2023-07-13. PMID:37439163. |
[acetylcorynoline inhibits microglia activation by regulating egfr/mapk signaling to promote functional recovery of injured mouse spinal cord]. |
2023-07-13 |
2023-08-14 |
mouse |
| Ilida Suleymanova, Dmitrii Bychkov, Jaakko Kopr. A deep convolutional neural network for efficient microglia detection. Scientific reports. vol 13. issue 1. 2023-07-10. PMID:37429956. |
we applied this method to analyse the number of microglia in different spinal cord and brain regions of rats exposed to opioid-induced hyperalgesia/tolerance. |
2023-07-10 |
2023-08-14 |
rat |